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1. 发明申请

US20060216746A1 Novel protein and DNA thereof 审中-公开
标题翻译：新型蛋白质及其DNA
公开(公告)号：US20060216746A1
公开(公告)日：2006-09-28
申请号：US11447913
申请日：2006-06-07
申请人： Koji Yoshimura , Yuichi Hikichi , Atsushi Nishimura
发明人： Koji Yoshimura , Yuichi Hikichi , Atsushi Nishimura
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , A61K38/48 , C12N9/64
CPC分类号： C12N9/6489 , A61K38/00 , C07K16/40 , G01N2500/00
摘要： The present invention relates to a novel protein belonging to an ADAM family, a partial peptide thereof or a salt thereof, a DNA encoding the protein, a recombinant vector comprising the DNA, a transformant, a method for producing the protein, a medicine comprising the protein or the DNA, an antibody against the protein, a method/kit for screening for a compound or a salt thereof which promotes or inhibits the protease activity or the extracellular metric degrading enzyme activity (preferably, the peptidoglycan degrading enzyme activity) of the protein, a compound obtained by the screening, and a medicine comprising the compound. The present protein and a DNA encoding it can be used, for example, as an agent for treating or preventing various diseases such as disc herniation, ischialgia, glomerular nephritis, diabetic nephropathy, hepatic fibrosis, pulmonary fibrosis or osteopetrosis. In addition, the present antibody can be used for quantitating the present protein in a test solution. Further, the present protein is useful as a reagent for screening for a compound which promotes or inhibits the protease activity of the present protein.
摘要翻译：本发明涉及属于ADAM家族的新蛋白，其部分肽或其盐，编码该蛋白质的DNA，包含DNA的重组载体，转化体，该蛋白质的制备方法，包含蛋白质或DNA，针对蛋白质的抗体，用于筛选其蛋白质活性或蛋白酶活性或细胞外度量降解酶活性（优选肽聚糖降解酶活性）的化合物或其盐的方法/试剂盒，通过筛选获得的化合物和包含该化合物的药物。本发明的蛋白质和编码该DNA的DNA可用于例如治疗或预防椎间盘突出症，坐骨神经痛，肾小球肾炎，糖尿病肾病，肝纤维化，肺纤维化或骨硬化等各种疾病的药剂。此外，本抗体可用于定量试验溶液中的本发明蛋白质。此外，本发明的蛋白质可用作筛选促进或抑制本发明蛋白质的蛋白酶活性的化合物的试剂。

2. 发明申请

US20050186618A1 Novel protein and DNA thereof 失效
标题翻译：新型蛋白质及其DNA
公开(公告)号：US20050186618A1
公开(公告)日：2005-08-25
申请号：US11088999
申请日：2005-03-24
申请人： Koji Yoshimura , Yuichi Hikichi , Atsushi Nishimura
发明人： Koji Yoshimura , Yuichi Hikichi , Atsushi Nishimura
IPC分类号： C07K16/40 , C12N1/21 , C12N9/64 , C12N15/12 , C12P21/08 , C12Q1/68 , A61K48/00 , C07H21/04
CPC分类号： C12N9/6489 , A61K38/00 , C07K16/40 , G01N2500/00
摘要： The present invention relates to a novel protein belonging to an ADAM family, a partial peptide thereof or a salt thereof, a DNA encoding the protein, a recombinant vector comprising the DNA, a transformant, a method for producing the protein, a medicine comprising the protein or the DNA, an antibody against the protein, a method/kit for screening for a compound or a salt thereof which promotes or inhibits the protease activity or the extracellular metric degrading enzyme activity (preferably, the peptidoglycan degrading enzyme activity) of the protein, a compound obtained by the screening, and a medicine comprising the compound. The present protein and a DNA encoding it can be used, for example, as an agent for treating or preventing various diseases such as disc herniation, ischialgia, glomerular nephritis, diabetic nephropathy, hepatic fibrosis, pulmonary fibrosis or osteopetrosis. In addition, the present antibody can be used for quantitating the present protein in a test solution. Further, the present protein is useful as a reagent for screening for a compound which promotes or inhibits the protease activity of the present protein.
摘要翻译：本发明涉及属于ADAM家族的新蛋白，其部分肽或其盐，编码该蛋白质的DNA，包含DNA的重组载体，转化体，该蛋白质的制备方法，包含蛋白质或DNA，针对蛋白质的抗体，用于筛选其蛋白质活性或蛋白酶活性或细胞外度量降解酶活性（优选肽聚糖降解酶活性）的化合物或其盐的方法/试剂盒，通过筛选获得的化合物和包含该化合物的药物。本发明的蛋白质和编码该DNA的DNA可用于例如治疗或预防椎间盘突出症，坐骨神经痛，肾小球肾炎，糖尿病肾病，肝纤维化，肺纤维化或骨硬化等各种疾病的药剂。此外，本抗体可用于定量试验溶液中的本发明蛋白质。此外，本发明的蛋白质可用作筛选促进或抑制本发明蛋白质的蛋白酶活性的化合物的试剂。

3. 发明授权

US07144720B2 Protein and DNA thereof 失效
公开(公告)号：US07144720B2
公开(公告)日：2006-12-05
申请号：US11088999
申请日：2005-03-24
申请人： Koji Yoshimura , Yuichi Hikichi , Atsushi Nishimura
发明人： Koji Yoshimura , Yuichi Hikichi , Atsushi Nishimura
IPC分类号： C12N9/50 , C12N15/00 , C12N1/20 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/6489 , A61K38/00 , C07K16/40 , G01N2500/00
摘要： The present invention relates to a novel protein belonging to an ADAM family, a partial peptide thereof or a salt thereof, a DNA encoding the protein, a recombinant vector comprising the DNA, a transformant, a method for producing the protein, a medicine comprising the protein or the DNA, an antibody against the protein, a method/kit for screening for a compound or a salt thereof which promotes or inhibits the protease activity or the extracellular metric degrading enzyme activity (preferably, the peptidoglycan degrading enzyme activity) of the protein, a compound obtained by the screening, and a medicine comprising the compound. The present protein and a DNA encoding it can be used, for example, as an agent for treating or preventing various diseases such as disc herniation, ischialgia, glomerular nephritis, diabetic nephropathy, hepatic fibrosis, pulmonary fibrosis or osteopetrosis. In addition, the present antibody can be used for quantitating the present protein in a test solution. Further, the present protein is useful as a reagent for screening for a compound which promotes or inhibits the protease activity of the present protein.

4. 发明授权

US07070975B2 Protein and DNA thereof 失效
标题翻译：蛋白质和DNA
公开(公告)号：US07070975B2
公开(公告)日：2006-07-04
申请号：US10726148
申请日：2003-12-02
申请人： Koji Yoshimura , Yuichi Hikichi , Atsushi Nishimura
发明人： Koji Yoshimura , Yuichi Hikichi , Atsushi Nishimura
IPC分类号： C12N9/50 , C12N1/20 , C12N15/00 , C07K1/00 , C12Q1/68
CPC分类号： C12N9/6489 , A61K38/00 , C07K16/40 , G01N2500/00
摘要： The present invention relates to a novel protein belonging to an ADAM family, a partial peptide thereof or a salt thereof, a DNA encoding the protein, a recombinant vector comprising the DNA, a transformant, a method for producing the protein, a medicine comprising the protein or the DNA, an antibody against the protein, a method/kit for screening for a compound or a salt thereof which promotes or inhibits the protease activity or the extracellular metric degrading enzyme activity (preferably, the peptidoglycan degrading enzyme activity) of the protein, a compound obtained by the screening, and a medicine comprising the compound. The present protein and a DNA encoding it can be used, for example, as an agent for treating or preventing various diseases such as disc herniation, ischialgia, glomerular nephritis, diabetic nephropathy, hepatic fibrosis, pulmonary fibrosis or osteopetrosis. In addition, the present antibody can be used for quantitating the present protein in a test solution. Further, the present protein is useful as a reagent for screening for a compound which promotes or inhibits the protease activity of the present protein.
摘要翻译：本发明涉及属于ADAM家族的新蛋白，其部分肽或其盐，编码该蛋白质的DNA，包含DNA的重组载体，转化体，该蛋白质的制备方法，包含蛋白质或DNA，针对蛋白质的抗体，用于筛选其蛋白质活性或蛋白酶活性或细胞外度量降解酶活性（优选肽聚糖降解酶活性）的化合物或其盐的方法/试剂盒，通过筛选获得的化合物和包含该化合物的药物。本发明的蛋白质和编码该DNA的DNA可用于例如治疗或预防椎间盘突出症，坐骨神经痛，肾小球肾炎，糖尿病肾病，肝纤维化，肺纤维化或骨硬化等各种疾病的药剂。此外，本抗体可用于定量试验溶液中的本发明蛋白质。此外，本发明的蛋白质可用作筛选促进或抑制本发明蛋白质的蛋白酶活性的化合物的试剂。

5. 发明授权

US06680189B1 Protein and DNA thereof 失效
标题翻译：蛋白质和DNA
公开(公告)号：US06680189B1
公开(公告)日：2004-01-20
申请号：US09786256
申请日：2001-05-10
申请人： Koji Yoshimura , Yuichi Hikichi , Atsushi Nishimura
发明人： Koji Yoshimura , Yuichi Hikichi , Atsushi Nishimura
IPC分类号： C12N950
CPC分类号： C12N9/6489 , A61K38/00 , C07K16/40 , G01N2500/00
摘要： The present invention relates to a novel protein belonging to an ADAM family, a partial peptide thereof or a salt thereof, a DNA encoding the protein, a recombinant vector comprising the DNA, a transformant, a method for producing the protein, a medicine comprising the protein or the DNA, an antibody against the protein, a method/kit for screening for a compound or a salt thereof which promotes or inhibits the protease activity or the extracellular metric degrading enzyme activity (preferably, the peptidoglycan degrading enzyme activity) of the protein, a compound obtained by the screening, and a medicine comprising the compound. The present protein and a DNA encoding it can be used, for example, as an agent for treating or preventing various diseases such as disc herniation, ischialgia, glomerular nephritis, diabetic nephropathy, hepatic fibrosis, pulmonary fibrosis or osteopetrosis. In addition, the present antibody can be used for quantitating the present protein in a test solution. Further, the present protein is useful as a reagent for screening for a compound which promotes or inhibits the protease activity of the present protein.
摘要翻译：本发明涉及属于ADAM家族的新蛋白，其部分肽或其盐，编码该蛋白质的DNA，包含DNA的重组载体，转化体，该蛋白质的制备方法，包含蛋白质或DNA，针对蛋白质的抗体，用于筛选其蛋白质活性或蛋白酶活性或细胞外度量降解酶活性（优选肽聚糖降解酶活性）的化合物或其盐的方法/试剂盒，通过筛选获得的化合物和包含该化合物的药物。本发明的蛋白质和编码该DNA的DNA可用于例如治疗或预防椎间盘突出症，坐骨神经痛，肾小球肾炎，糖尿病肾病，肝纤维化，肺纤维化或骨硬化等各种疾病的药剂。此外，本抗体可用于定量试验溶液中的本发明蛋白质。此外，本发明的蛋白质可用作筛选促进或抑制本发明蛋白质的蛋白酶活性的化合物的试剂。

6. 发明授权

US07241860B1 Transcription factor polypeptide that regulates Chondromodulin-I expression 失效
标题翻译：调节软骨调节蛋白-1表达的转录因子多肽
公开(公告)号：US07241860B1
公开(公告)日：2007-07-10
申请号：US10130872
申请日：2000-11-24
申请人： Koji Yoshimura , Yuichi Hikichi , Kenichi Noguchi
发明人： Koji Yoshimura , Yuichi Hikichi , Kenichi Noguchi
IPC分类号： A61K38/17 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/51
摘要： The polypeptide of the present invention has an activity of binding specifically to the cis-element of Chondromodulin-I (ChM-I) gene promoter and promoting the transcription of the ChM-I gene. The polypeptide of the present invention is usable in screening for a compound that promotes or inhibits the activity of the polypeptide.
摘要翻译：本发明的多肽具有特异性结合Chondromodulin-1（ChM-1）基因启动子的顺式元件并促进ChM-1基因的转录的活性。本发明的多肽可用于筛选促进或抑制多肽活性的化合物。

7. 发明申请

US20050171012A1 Preventives/remedies for bone/joint diseases 审中-公开
标题翻译：骨/关节疾病的预防/补救措施
公开(公告)号：US20050171012A1
公开(公告)日：2005-08-04
申请号：US10489125
申请日：2002-09-09
申请人： Yuichi Hikichi , Masakuza Inazuka , Koji Yoshimura
发明人： Yuichi Hikichi , Masakuza Inazuka , Koji Yoshimura
IPC分类号： A61K38/00 , A61P19/02 , A61P19/10 , C07K14/52 , C12N9/64 , A61K38/17 , C07K14/47
CPC分类号： C12N9/6491 , A61K38/00 , C07K14/52
摘要： The present invention provides compounds or salts thereof that regulate the activity of a protein comprising an amino acid sequence identical or substantially identical to the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11 or SEQ ID NO: 13, and antisense polynucleotides comprising a nucleotide sequence, or a part thereof, complementary or substantially complementary to the nucleotide sequence of a DNA encoding a protein, or a partial peptide thereof, comprising an amino acid sequence identical or substantially identical to the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, SEQ ID NO: 9, SEQ ID NO: 11 or SEQ ID NO: 13. These compounds, salts and antisense poly nucleotides may be used as prophylactic and/or therapeutic agents for bone and/or arthropathy diseases such as arthritis.
摘要翻译：本发明提供了调节蛋白质活性的化合物或其盐，该蛋白质包含与SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5，SEQ ID NO：5所示的氨基酸序列相同或基本相同的氨基酸序列 ID NO：7，SEQ ID NO：9，SEQ ID NO：11或SEQ ID NO：13，以及包含与编码蛋白质的DNA的核苷酸序列互补或基本互补的核苷酸序列或其部分的反义多核苷酸或其部分肽，其包含与SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5，SEQ ID NO：7，SEQ ID NO所示的氨基酸序列相同或基本相同的氨基酸序列：9，SEQ ID NO：11或SEQ ID NO：13。这些化合物，盐和反义多核苷酸可用作骨和/或关节病疾病如关节炎的预防和/或治疗剂。

8. 发明授权

US09311956B2 Information processing device, information processing method, and program 有权
标题翻译：信息处理装置，信息处理方法和程序
公开(公告)号：US09311956B2
公开(公告)日：2016-04-12
申请号：US13155638
申请日：2011-06-08
申请人： Kenjiro Ueda , Koji Yoshimura , Hiroshi Kuno , Takamichi Hayashi , Munetake Ebihara
发明人： Kenjiro Ueda , Koji Yoshimura , Hiroshi Kuno , Takamichi Hayashi , Munetake Ebihara
IPC分类号： G11B20/00 , H04L9/08 , H04L9/32 , G06F7/04
CPC分类号： G11B20/00086 , G11B20/00166 , G11B20/00173 , G11B20/0021 , G11B20/00731 , G11B20/00855 , H04L9/0866 , H04L9/3268 , H04L2209/603
摘要： An information processing device includes: a data processing unit that executes a process of reproducing content recorded in a medium, wherein the data processing unit acquires a token from the medium, the token being management data corresponding to content recorded in the medium, compares a server ID recorded in the acquired token with a server ID recorded in a server certificate acquired from a server from which the management data is acquired, and halts reproduction of content when the two server IDs are not identical.
摘要翻译：信息处理装置包括：数据处理单元，执行再现记录在介质中的内容的处理，其中数据处理单元从介质获取令牌，令牌是与记录在介质中的内容对应的管理数据，将服务器 ID记录在记录在从其获取管理数据的服务器获得的服务器证书中的服务器ID的所获取的令牌中，并且当两个服务器ID不相同时停止内容的再现。

9. 发明授权

US08996186B2 System and method for managing power consumption 有权
标题翻译：用于管理功耗的系统和方法
公开(公告)号：US08996186B2
公开(公告)日：2015-03-31
申请号：US13372592
申请日：2012-02-14
申请人： Wei-Peng Chen , Koji Yoshimura , Ryusuke Masuoka , Sung Lee
发明人： Wei-Peng Chen , Koji Yoshimura , Ryusuke Masuoka , Sung Lee
IPC分类号： G05D3/12 , G05D5/00 , G05D9/00 , G05D11/00 , G05D17/00 , H02J3/14 , H02J3/00 , G05B11/01
CPC分类号： H02J3/14 , H02J3/008 , H02J2003/143 , H02J2003/146 , Y02B70/3225 , Y02B70/3266 , Y04S20/222 , Y04S20/224 , Y04S20/242 , Y04S50/10
摘要： In accordance with a particular embodiment, a method for managing power consumption includes receiving power rate information and receiving power usage information. The method also includes receiving a plurality of personal preference profiles. Each personal preference profile of the plurality of personal preference profiles is associated with a different user of a plurality of users and includes at least one preferred state associated with a respective user. The method further includes detecting a presence of at least one user within a room. The method additionally includes adjusting at least one state associated with the room based on the at least one preferred state associated with the at least one user within the room, the power rate information, and the power usage information.
摘要翻译：根据特定实施例，一种用于管理功耗的方法包括接收功率速率信息和接收功率使用信息。该方法还包括接收多个个人偏好简档。多个个人偏好简档的每个个人偏好简档与多个用户的不同用户相关联，并且包括与相应用户相关联的至少一个优选状态。该方法还包括检测房间内至少一个用户的存在。该方法还包括基于与房间内的至少一个用户相关联的至少一个优选状态，功率速率信息和功率使用信息来调整与房间相关联的至少一个状态。

10. 发明申请

US20060235956A1 INFORMATION PROCESS DISTRIBUTION SYSTEM, INFORMATION PROCESSING APPARATUS AND INFORMATION PROCESS DISTRIBUTION METHOD 审中-公开
标题翻译：信息流程分配系统，信息处理设备和信息流程分配方法
公开(公告)号：US20060235956A1
公开(公告)日：2006-10-19
申请号：US11277689
申请日：2006-03-28
申请人： Hiroshi Kawaguchi , Yoji Kawamoto , Yutaka Nagao , Koji Yoshimura , Manabu Kimura
发明人： Hiroshi Kawaguchi , Yoji Kawamoto , Yutaka Nagao , Koji Yoshimura , Manabu Kimura
IPC分类号： G06F15/16 , G06F15/173
CPC分类号： G06F21/10 , G06F2221/2145
摘要： An apparatus and method is disclosed wherein a process of information relating to a content which applies a high load to a CPU can be processed efficiently in a distributed manner. A request source information processing apparatus transmits a process type of the process to be executed, and receives identification information of different information processing apparatus in accordance with the process type and apparatus information associated with the identification information including resource information. Then, the request source apparatus acquires load information of the apparatus, and determines a particular apparatus to which a request to execute a process is to be issued based on the resource information and the load information. Then, the request source apparatus issues a request to execute the process and transmits information relating to the content to the particular apparatus.
摘要翻译：公开了一种装置和方法，其中可以以分布式方式有效地处理与向CPU施加高负载的内容有关的信息的处理。请求源信息处理装置发送要执行的处理的处理类型，并且根据与包括资源信息的标识信息相关联的处理类型和装置信息接收不同信息处理装置的标识信息。然后，请求源装置获取装置的负载信息，并根据资源信息和负载信息确定要发出执行处理请求的特定装置。然后，请求源装置发出执行处理的请求，并将与该内容相关的信息发送到特定装置。

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