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1. 发明申请

WO2011012966A1 SYSTEMS AND METHODS FOR CONTINUOUS NON-INVASIVE BLOOD PRESSURE MONITORING 审中-公开
标题翻译：连续不间断血液压力监测的系统和方法
公开(公告)号：WO2011012966A1
公开(公告)日：2011-02-03
申请号：PCT/IB2010/001820
申请日：2010-07-20
申请人： NELLCOR PURITAN BENNETT IRELAND , SETHI, Rakesh , WATSON, James, N. , ADDISON, Paul, Stanley
发明人： SETHI, Rakesh , WATSON, James, N. , ADDISON, Paul, Stanley
IPC分类号： A61B5/021
CPC分类号： A61B5/021 , A61B5/02125
摘要： Systems and methods are disclosed herein for continuous non-invasive blood pressure (CNIBP) monitoring. Multiple reference blood pressure values may be obtained using a calibration device. These multiple reference blood pressure values may be used as calibration points for determining a relationship between the blood pressure of a patient and photoplethysmograph (PPG) signals.
摘要翻译：本文公开了用于连续非侵入性血压（CNIBP）监测的系统和方法。可以使用校准装置获得多个参考血压值。这些多个参考血压值可以用作用于确定患者的血压与光电体积描记器（PPG）信号之间的关系的校准点。

2. 发明申请

WO2011012947A1 SYSTEMS AND METHODS FOR NON-INVASIVE DETERMINATION OF BLOOD PRESSURE 审中-公开
标题翻译：用于非侵入性确定血压的系统和方法
公开(公告)号：WO2011012947A1
公开(公告)日：2011-02-03
申请号：PCT/IB2010/001758
申请日：2010-07-19
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, N.
发明人： ADDISON, Paul, Stanley , WATSON, James, N.
IPC分类号： A61B5/022 , G06F17/00
CPC分类号： A61B5/726 , A61B5/02225 , A61B5/7203 , A61B5/7225
摘要： Methods and systems for determining blood pressure from a pressure signal are disclosed. A patient's blood pressure may be determined by analyzing features of a wavelet transformation of a pressure signal obtained during an occlusion procedure. Ridges in a scalogram of the transformed signal may be identified and used to determine an envelope of a pressure oscillation signal, to which oscillometric blood pressure determination techniques may be applied.
摘要翻译：公开了用于从压力信号确定血压的方法和系统。可以通过分析在闭塞过程中获得的压力信号的小波变换的特征来确定患者的血压。变换信号的标尺中的脊可以被识别并用于确定压力振荡信号的包络，可应用示波血压测定技术。

3. 发明申请

WO2010149951A1 METHODS AND APPARATUS FOR MEASURING RESPIRATORY FUNCTION USING AN EFFORT SIGNAL 审中-公开
标题翻译：用于测量呼吸功能的方法和装置
公开(公告)号：WO2010149951A1
公开(公告)日：2010-12-29
申请号：PCT/GB2010/001195
申请日：2010-06-18
申请人： NELLCOR PURITAN BENNETT IRELAND , WATSON, James, N. , ADDISON, Paul, Stanley
发明人： WATSON, James, N. , ADDISON, Paul, Stanley
IPC分类号： A61B5/00 , A61B5/024 , A61B5/08
CPC分类号： A61B5/02416 , A61B5/08 , A61B5/0816 , A61B5/087 , A61B5/14551 , A61B5/726
摘要： Breathing effort of a patient, as determined (for example) from a photoplethysmograph ("PPG") signal from the patient, can be used in conjunction with signals from a spirometer being used by the patient to provide additional information about various characteristics of the patient's breathing. For example, such additional information may include the relationship between the patient's breathing effort and breath volume. As another example, the additional information may include the relationship between the patient's breathing effort and rate of breath flow. Still other such additional information may be derived from various combinations of spirometer and PPG output signals.
摘要翻译：患者的呼吸努力（例如来自患者的光电体积描记器（“PPG”）信号确定（例如）可以与来自患者使用的肺活量计的信号结合使用，以提供关于患者的各种特征的附加信息呼吸。例如，这样的附加信息可以包括患者的呼吸努力和呼吸量之间的关系。作为另一示例，附加信息可以包括患者的呼吸努力和呼吸气流之间的关系。还可以从肺活量计和PPG输出信号的各种组合导出另外的其它信息。

4. 发明申请

WO2010133820A1 SIGNAL PROCESSING TECHNIQUES FOR DETERMINING SIGNAL QUALITY USING A WAVELET TRANSFORM RATIO SURFACE 审中-公开
标题翻译：使用小波变换比表面法确定信号质量的信号处理技术
公开(公告)号：WO2010133820A1
公开(公告)日：2010-11-25
申请号：PCT/GB2010/000838
申请日：2010-04-26
申请人： NELLCOR PURITAN BENNETT IRELAND , WATSON, James N. , ADDISON, Paul Stanley
发明人： WATSON, James N. , ADDISON, Paul Stanley
IPC分类号： A61B5/00 , A61B5/024
CPC分类号： A61B5/14551 , A61B5/0002 , A61B5/02416 , A61B5/7203 , A61B5/7207 , A61B5/7221 , A61B5/726 , A61B2562/08
摘要： A method and system for defermining signal quality of photoplethysmograph signals are disclosed. A wavelet transform ratio surface measure signal is generated from two PPG signals (710). Values of the wavelet transform ratio surface measure signal at a given moment of time (i.e., instantaneous values) may be indicative of localized signal discrepancies within and/or between the PPG signals such as noise and signal artifacts. Spikes (735) in the instantaneous values of the wavelet transform ratio surface measure signal are located and used to determine a signal quality measure for the PPG signals. Characteristics of the spikes such as number, location, grouping, distribution, amplitude, and polarity may be used in the signal quality determination.
摘要翻译：公开了一种用于识别光电体积描记信号的信号质量的方法和系统。从两个PPG信号（710）生成小波变换比表面测量信号。在给定时刻（即瞬时值）的小波变换比表面测量信号的值可以指示PPG信号之内和/或之间的区域性信号差异，例如噪声和信号伪像。小波变换比表面测量信号的瞬时值中的峰值（735）被定位并用于确定PPG信号的信号质量测量。尖峰的特征，如数量，位置，分组，分布，振幅和极性可用于信号质量确定。

5. 发明申请

WO2010038121A3 EXTRACTION OF PHYSIOLOGICAL MEASUREMENTS FROM A PHOTOPLETHYSMOGRAPH (PPG) SIGNAL 审中-公开
标题翻译：光学血红蛋白（PPG）信号中生理测量的提取
公开(公告)号：WO2010038121A3
公开(公告)日：2010-07-29
申请号：PCT/IB2009006897
申请日：2009-09-17
申请人： NELLCOR PURITAN BENNETT IRELAN , ADDISON PAUL STANLEY
发明人： ADDISON PAUL STANLEY
IPC分类号： A61B5/00 , G06F17/00
CPC分类号： A61B5/14551 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/7239
摘要： The present disclosure relates to signal processing and, more particularly, to determining the value of a physiological parameter, such as the blood oxygen saturation (SpO2) of a subject. In an embodiment, a first baseline for a first waveform and a second baseline for a second waveform are determined. In this embodiment, the first and second waveforms are indicative of the physiological parameter of the subject. The first and second waveforms are filtered to obtain a first direct-current (DC) component for the first waveform and a second DC component for the second waveform. A measured value for the physiological parameter is derived from the first and second baseline signals, and the first and second DC components, hi an embodiment, the measured value for the physiological parameter is determined based on a ratio of the normalized difference between the DC component and the baseline signal for the first waveform with respect to same for the second waveform.
摘要翻译：本公开涉及信号处理，并且更具体地涉及确定生理参数的值，诸如对象的血氧饱和度（SpO2）。在一个实施例中，确定第一波形的第一基线和第二波形的第二基线。在该实施例中，第一和第二波形指示对象的生理参数。对第一和第二波形进行滤波以获得第一波形的第一直流（DC）分量和第二波形的第二DC分量。从第一和第二基线信号以及第一和第二DC分量导出生理参数的测量值。在一个实施例中，生理参数的测量值基于DC分量之间的归一化差的比率来确定以及第一波形的基线信号相对于第二波形的相同。

6. 发明申请

WO2010001247A2 METHODS AND SYSTEMS FOR DISCRIMINATING BANDS IN SCALOGRAMS 审中-公开
标题翻译：用于分类标准中银行的方法和系统
公开(公告)号：WO2010001247A2
公开(公告)日：2010-01-07
申请号：PCT/IB2009/006181
申请日：2009-06-29
申请人： NELLCOR PURITAN BENNETT IRELAND , WATSON, James, Nicholas , ADDISON, Paul, Stanley , CLIFTON, David
发明人： WATSON, James, Nicholas , ADDISON, Paul, Stanley , CLIFTON, David
CPC分类号： G06K9/00516 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/14551 , A61B5/7207 , A61B5/7225 , A61B5/7239 , A61B5/726
摘要： The present disclosure is directed towards embodiments of systems and methods for discriminating (e.g., masking out) scale bands that are determined to be not of interest from a scalogram derived from a continuous wavelet transform of a signal. Techniques for determining whether a scale band is not of interest include, for example, determining whether a scale band's amplitude is being modulated by one or more other bands in the scalogram. Another technique involves determining whether a scale band is located between two other bands and has energy less than that of its neighboring bands. Another technique involves determining whether a scale band is located at about half the scale of another, more dominant (i.e., higher energy) band.
摘要翻译：本公开涉及用于从由信号的连续小波变换导出的标尺来鉴别（例如，屏蔽）被确定为不感兴趣的标度带的系统和方法的实施例。用于确定缩放带是否不感兴趣的技术包括例如确定缩放带的幅度是否正在由缩放图中的一个或多个其他频带调制。另一种技术涉及确定尺度带是位于两个其他频带之间，并且具有小于其相邻频带的能量的能量。另一种技术涉及确定刻度带是否位于另一个（更高的能量）带的大约一半的尺度。

7. 发明申请

WO2010001243A1 SIGNAL PROCESSING MIRRORING TECHNIQUE 审中-公开
标题翻译：信号处理仿真技术
公开(公告)号：WO2010001243A1
公开(公告)日：2010-01-07
申请号：PCT/IB2009/006153
申请日：2009-06-29
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, Nicholas
发明人： ADDISON, Paul, Stanley , WATSON, James, Nicholas
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/7207 , A61B5/7225 , A61B5/7232 , A61B5/726
摘要： Embodiments may include systems and methods capable of processing an original signal by selecting and mirroring portions of the signal to create a new signal for further analysis. In an embodiment, the signal may be a photoplethysmograph (PPG) signal and the new signal may be further analyzed using continuous wavelet transforms. Any suitable number of reconstructed new signals may be created from the original signal and scalograms may be derived at least in part from the new signals. Ridges may be extracted from the scalograms of the new signals and secondary scalograms may be further derived from the ridges. A sum along amplitudes technique may be applied to a selected scalogram and may be plotted as a function of the scale of the scalogram. Desired information, such as respiration information within the original signal, may be identified from the plot.
摘要翻译：实施例可以包括能够通过选择和镜像信号的部分来处理原始信号以创建用于进一步分析的新信号的系统和方法。在一个实施例中，信号可以是光电容积描记器（PPG）信号，并且可以使用连续小波变换进一步分析新信号。可以从原始信号创建任何合适数量的重构的新信号，并且可以至少部分地从新的信号导出缩略图。可以从新信号的缩放图中提取脊，并且可以从脊进一步导出二次标尺。沿着幅度技术的和可以应用于所选择的标尺，并且可以作为缩放图的尺度的函数来绘制。可以从绘图中识别所需的信息，例如原始信号内的呼吸信息。

8. 发明申请

WO2010001232A1 SYSTEMS AND METHODS FOR DETERMINING EFFORT 审中-公开
标题翻译：用于确定效果的系统和方法
公开(公告)号：WO2010001232A1
公开(公告)日：2010-01-07
申请号：PCT/IB2009/006135
申请日：2009-06-29
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, Nicholas
发明人： ADDISON, Paul, Stanley , WATSON, James, Nicholas
IPC分类号： A61B5/00
CPC分类号： A61B5/08 , A61B5/0816 , A61B5/087 , A61B5/14551 , A61B5/726
摘要： According to embodiments, methods and systems for determining effort is disclosed. Effort may relate to a measure of strength of at least one repetitive feature in a signal. Effort may also relate to physical effort or work of a process (e.g., respiratory effort) that may affect the signal (e.g., a PPG signal). Effort may be determined through feature analysis of a transformed signal that has been transformed via a continuous wavelet transform. For example, respiratory effort may be determined using a scalogram generated based at least in part on a wavelet transform of a physiological signal and analyzing features of the scalogram.
摘要翻译：根据实施例，公开了用于确定努力的方法和系统。努力可能涉及信号中至少一个重复特征的强度的度量。努力还可能涉及可能影响信号（例如，PPG信号）的过程的体力或工作（例如呼吸努力）。可以通过经由连续小波变换变换的变换信号的特征分析来确定努力。例如，可以使用至少部分地基于生理信号的小波变换产生的标尺来确定呼吸努力并分析标尺的特征。

9. 发明申请

WO2012131290A1 SYSTEMS AND METHODS FOR AUTONOMIC NERVOUS SYSTEM MONITORING 审中-公开
标题翻译：用于自动神经系统监测的系统和方法
公开(公告)号：WO2012131290A1
公开(公告)日：2012-10-04
申请号：PCT/GB2012/000269
申请日：2012-03-22
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, Nicholas
发明人： ADDISON, Paul, Stanley , WATSON, James, Nicholas
IPC分类号： A61B5/024
CPC分类号： A61B5/14551 , A61B5/0205 , A61B5/02405 , A61B5/02416 , A61B5/0816 , A61B5/091 , A61B5/4035 , A61B5/7257 , A61B5/726 , A61B2562/085
摘要： Methods and systems are disclosed for determining physiological information about a patient's autonomic nervous system based on at least one physiological signal measured from the patient and at least one known characteristic of a patient's respiration. Respiration protocol may be provided to guide characteristics of the patient's respiration. The physiological signal measured from the patient may be transformed using a wavelet transform to create a transformed signal, and a scalogram may be generated based at least in part on the transformed signal. A metric that may indicate information about the patient's autonomic nervous system may be determined from the scalogram and the known characteristic of the patient's respiration.
摘要翻译：公开了用于基于从患者测量的至少一个生理信号和患者呼吸的至少一个已知特征来确定关于患者的自主神经系统的生理信息的方法和系统。可以提供呼吸方案以指导患者呼吸的特征。可以使用小波变换来变换从患者测量的生理信号以产生变换的信号，并且可以至少部分地基于变换的信号来生成缩略图。可以指示关于患者的自主神经系统的信息的度量可以从患者呼吸的标尺和已知特征确定。

10. 发明申请

WO2011001133A2 DETERMINING A CHARACTERISTIC BLOOD PRESSURE 审中-公开
标题翻译：确定特征血压
公开(公告)号：WO2011001133A2
公开(公告)日：2011-01-06
申请号：PCT/GB2010001186
申请日：2010-06-18
申请人： NELLCOR PURITAN BENNETT IE , ADDISON PAUL STANLEY , WATSON JAMES N , SETHI RAKESH
发明人： ADDISON PAUL STANLEY , WATSON JAMES N , SETHI RAKESH
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/0215 , A61B5/022 , A61B5/02416 , A61B5/0816 , A61B5/14551 , A61B5/16 , A61B5/165 , A61B5/6816 , A61B5/6826 , A61B5/6829 , A61B5/6838 , A61B5/726
摘要： The present disclosure relates to monitoring a characteristic physiological parameter of a patient during a suitable time period that either precedes or follows a triggering event, such as a clinician/patient interaction, that may negatively impact the physiological parameter. In some embodiments, physiological parameter values falling between one or more pre-set thresholds may be used to derive the characteristic physiological parameter. In some embodiments, tracking the physiological parameter may provide additional information about the patient's status. In some embodiments, confidence measures may be associated with, or may be used to analyze features of the patient signal to derive information about, the characteristic physiological parameter. The patient signal used to derive a patient's physiological parameter may be of an oscillatory nature or may include oscillatory features that may be analyzed to derive a characteristic respiration rate.
摘要翻译：本公开涉及在可能对生理参数产生不利影响的触发事件（例如临床医生/患者相互作用）之前或之后的合适时间段期间监测患者的特征生理参数。在一些实施例中，可以使用落在一个或多个预设阈值之间的生理参数值来导出特征生理参数。在一些实施例中，跟踪生理参数可以提供关于患者状态的附加信息。在一些实施例中，置信度度量可以与患者信号的特征相关联或者可以用于分析特征生理参数的信息。用于导出患者生理参数的患者信号可以是振荡性质的，或者可以包括可以分析以产生特征呼吸速率的振荡特征。

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