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1. 发明申请

WO2010146326A1 FLUID RESPONSIVENESS MEASURE 审中-公开
标题翻译：流体响应测量
公开(公告)号：WO2010146326A1
公开(公告)日：2010-12-23
申请号：PCT/GB2010/000840
申请日：2010-04-26
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, N.
发明人： ADDISON, Paul, Stanley , WATSON, James, N.
IPC分类号： A61B5/00 , A61M16/00
CPC分类号： A61B5/14551 , A61B5/02416 , A61B5/4839 , A61B5/7257 , A61B5/726 , A61M5/1723 , A61M2005/14208
摘要： A method and system for measuring fluid responsiveness of a patient is disclosed. Information related to fluid responsiveness of a patient may be derived from a PPG signal, for example, by analyzing the PPG signal transformed by a continuous wavelet transform. Other techniques for deriving information related to fluid responsiveness of a patient include, for example, analyzing the amplitude modulation, frequency modulation, and/or baseline changes of a PPG signal.
摘要翻译：公开了一种用于测量患者的液体反应性的方法和系统。与患者的液体反应性相关的信息可以从PPG信号得到，例如通过分析通过连续小波变换变换的PPG信号。用于导出与患者的流体反应性相关的信息的其它技术包括例如分析PPG信号的幅度调制，频率调制和/或基线变化。

2. 发明申请

WO2010128275A1 SELECTION OF SIGNAL REGIONS FOR PARAMETER EXTRACTION 审中-公开
标题翻译：选择参数提取的信号区域
公开(公告)号：WO2010128275A1
公开(公告)日：2010-11-11
申请号：PCT/GB2010/000839
申请日：2010-04-26
申请人： NELLCOR PURITAN BENNETT IRELAND , MCGONIGLE, Scott , ADDISON, Paul, Stanley , WATSON, James, N.
发明人： MCGONIGLE, Scott , ADDISON, Paul, Stanley , WATSON, James, N.
IPC分类号： A61B5/08
CPC分类号： A61B5/14551 , A61B5/02416 , A61B5/0816 , A61B5/7203 , A61B5/7225 , A61B5/7239 , A61B5/726
摘要： Techniques for extracting a signal parameter from a selected region of a generally repetitive signal are disclosed. A pulse oximetry system including a sensor or probe is used to obtain an original photoplethysmograph (PPG) signal from a subject. A filter transformation is applied to the original PPG signal to produce a baseline PPG signal (705). The baseline PPG signal (705) may contain artifacts and/or noise, and a region (760) of the baseline PPG signal suitable for extracting the signal parameter is selected by applying one or more thresholds (750,755) to the baseline PPG signal, where the values of the thresholds may be set based on derivative values, amplitude-based percentiles, and/or local minima and maxima of the baseline PPG signal. A portion of the original PPG signal corresponding to the selected region is processed, and the signal parameter is extracted from the processed region. In an embodiment, the signal parameter may correspond to the respiration rate of a patient.
摘要翻译：公开了从通常重复信号的选定区域提取信号参数的技术。使用包括传感器或探针的脉搏血氧饱和度测定系统来获得来自受试者的原始光学体积描记术（PPG）信号。将滤波器变换应用于原始PPG信号以产生基线PPG信号（705）。基线PPG信号（705）可以包含伪像和/或噪声，并且通过将一个或多个阈值（750,755）应用于基线PPG信号来选择适合于提取信号参数的基线PPG信号的区域（760），其中可以基于导数值，基于振幅的百分位数和/或基线PPG信号的局部最小值和最大值来设置阈值。处理对应于所选区域的原始PPG信号的一部分，并且从处理区域中提取信号参数。在一个实施例中，信号参数可以对应于患者的呼吸速率。

3. 发明申请

WO2011001134A1 SYSTEMS AND METHODS FOR DETECTING EFFORT EVENTS 审中-公开
标题翻译：用于检测活动的系统和方法
公开(公告)号：WO2011001134A1
公开(公告)日：2011-01-06
申请号：PCT/GB2010/001194
申请日：2010-06-18
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, N. , CASSIDY, Andrew
发明人： ADDISON, Paul, Stanley , WATSON, James, N. , CASSIDY, Andrew
IPC分类号： A61B5/00 , A61B5/08
CPC分类号： A61B5/14551 , A61B5/02028 , A61B5/08 , A61B5/4818 , A61B5/7239 , A61B5/726
摘要： A method and system for detecting effort events is disclosed. Effort may be determined through feature analysis of the signal as transformed by a continuous wavelet transform, which may be compared against a reference effort measure to trigger an effort event flag that signals the onset and/or severity of an effort event. For example, a respiratory effort measure may be determined based at least in part on a wavelet transform of a photoplethysmograph (PPG) signal and features of the transformed signal. A respiratory reference effort measure may be based at least in part on past values of the respiratory effort measure, and a threshold test may be used to trigger an effort event flag, which may indicate a marked change in respiratory effort exerted by a patient.
摘要翻译：公开了一种用于检测努力事件的方法和系统。可以通过由连续小波变换变换的信号的特征分析来确定努力，其可以与参考努力量度进行比较以触发用于表示努力事件的发作和/或严重性的努力事件标志。例如，可以至少部分地基于光电体积描记器（PPG）信号的小波变换和变换信号的特征来确定呼吸努力测量。呼吸参考努力测量可以至少部分地基于呼吸努力测量的过去值，并且可以使用阈值测试来触发努力事件标志，其可以指示由患者施加的呼吸力的显着变化。

4. 发明申请

WO2011001133A3 DETERMINING A CHARACTERISTIC BLOOD PRESSURE 审中-公开
公开(公告)号：WO2011001133A3
公开(公告)日：2011-01-06
申请号：PCT/GB2010/001186
申请日：2010-06-18
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, N. , SETHI, Rakesh
发明人： ADDISON, Paul, Stanley , WATSON, James, N. , SETHI, Rakesh
IPC分类号： A61B5/02 , A61B5/08 , A61B5/1455 , A61B5/021
摘要： The present disclosure relates to monitoring a characteristic physiological parameter of a patient during a suitable time period that either precedes or follows a triggering event, such as a clinician/patient interaction, that may negatively impact the physiological parameter. In some embodiments, physiological parameter values falling between one or more pre-set thresholds (R1, R2) may be used to derive the characteristic physiological parameter. In some embodiments, tracking the physiological parameter may provide additional information about the patient's status. In some embodiments, confidence measures may be associated with, or may be used to analyze features of the patient signal to derive information about, the characteristic physiological parameter. The patient signal used to derive a patient's physiological parameter may be of an oscillatory nature or may include oscillatory features (455) that may be analyzed to derive a characteristic respiration rate.

5. 发明申请

WO2010146327A1 DETERMINING DISEASE STATE USING AN INDUCED LOAD 审中-公开
标题翻译：使用诱导负荷确定疾病状态
公开(公告)号：WO2010146327A1
公开(公告)日：2010-12-23
申请号：PCT/GB2010/000841
申请日：2010-04-26
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, N.
发明人： ADDISON, Paul, Stanley , WATSON, James, N.
IPC分类号： A61B5/00 , A61B5/024
CPC分类号： A61B5/02007 , A61B5/02416 , A61B5/14551 , A61B5/4884 , A61B5/726
摘要： The present disclosure relates to determining a patient's disease state based at least in part on obtaining or determining certain underlying characteristics, such as vasotone, venous compliance, or ability of the vascular system to drain venous blood, of the patient's vascular system. The characteristics may be obtained by analyzing changes to a patient signal, such as the overall signal change, the rate of change, the shape of the change, changes in signal energy, or changes in the baseline and/or the amplitude of the signal, and/or the time period(s) over which the signal changes, that are caused by inducing a load on the vascular system. In some embodiments, the signal changes may be analyzed by transforming the signal using, for example, a continuous wavelet transform. The patient's health status or disease state may be determined using the one or more vascular system characteristics that influenced the signal change.
摘要翻译：本公开涉及至少部分地基于获得或确定患者血管系统的某些潜在特征（例如血管舒张，静脉顺应性或血管系统排出静脉血的能力）来确定患者的疾病状态。可以通过分析患者信号的变化（例如整体信号变化，变化率，变化的形状，信号能量的变化，或基线的变化和/或信号的幅度）来获得特征，和/或通过在血管系统上引起负载而引起的信号变化的时间段。在一些实施例中，可以使用例如连续小波变换来变换信号来分析信号变化。可以使用影响信号变化的一种或多种血管系统特征来确定患者的健康状况或疾病状态。

6. 发明申请

WO2010142936A1 SIGNAL PROCESSING TECHNIQUES FOR AIDING THE INTERPRETATION OF RESPIRATION SIGNALS 审中-公开
标题翻译：用于消除呼叫信号解释的信号处理技术
公开(公告)号：WO2010142936A1
公开(公告)日：2010-12-16
申请号：PCT/GB2010/000837
申请日：2010-04-26
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, N. , MCGONIGLE, Scott
发明人： ADDISON, Paul, Stanley , WATSON, James, N. , MCGONIGLE, Scott
IPC分类号： A61B5/08
CPC分类号： A61B5/08 , A61B5/0002 , A61B5/02416 , A61B5/0816 , A61B5/14551 , A61B5/7203 , A61B5/7207 , A61B5/726 , A61B5/7278 , A61B2562/08
摘要： The present disclosure is related to signal processing systems and methods for processing respiration signals. A respiration signal (505) is processed to normalize respiratory feature values in order to improve and/or simplify the interpretation and subsequent analysis of the signal. Data indicative of a signal is received at a sensor and is used to generate a respiration signal. Signal peaks (511, 512, 513, 514) in the respiration signal are identified and signal peak thresholds (510) are determined. The identified signal peaks are adjusted (511a, 512a, 513a, 514a) based on the signal peak threshold values to normalize the respiration signal.
摘要翻译：本公开涉及用于处理呼吸信号的信号处理系统和方法。处理呼吸信号（505）以使呼吸特征值归一化，以改善和/或简化信号的解释和随后的分析。在传感器处接收表示信号的数据，并用于产生呼吸信号。识别呼吸信号中的信号峰值（511,512,513,514），并确定信号峰值阈值（510）。基于信号峰值阈值来调整所识别的信号峰值（511a，512a，513a，514a）以归一化呼吸信号。

7. 发明申请

WO2011012966A1 SYSTEMS AND METHODS FOR CONTINUOUS NON-INVASIVE BLOOD PRESSURE MONITORING 审中-公开
标题翻译：连续不间断血液压力监测的系统和方法
公开(公告)号：WO2011012966A1
公开(公告)日：2011-02-03
申请号：PCT/IB2010/001820
申请日：2010-07-20
申请人： NELLCOR PURITAN BENNETT IRELAND , SETHI, Rakesh , WATSON, James, N. , ADDISON, Paul, Stanley
发明人： SETHI, Rakesh , WATSON, James, N. , ADDISON, Paul, Stanley
IPC分类号： A61B5/021
CPC分类号： A61B5/021 , A61B5/02125
摘要： Systems and methods are disclosed herein for continuous non-invasive blood pressure (CNIBP) monitoring. Multiple reference blood pressure values may be obtained using a calibration device. These multiple reference blood pressure values may be used as calibration points for determining a relationship between the blood pressure of a patient and photoplethysmograph (PPG) signals.
摘要翻译：本文公开了用于连续非侵入性血压（CNIBP）监测的系统和方法。可以使用校准装置获得多个参考血压值。这些多个参考血压值可以用作用于确定患者的血压与光电体积描记器（PPG）信号之间的关系的校准点。

8. 发明申请

WO2011012947A1 SYSTEMS AND METHODS FOR NON-INVASIVE DETERMINATION OF BLOOD PRESSURE 审中-公开
标题翻译：用于非侵入性确定血压的系统和方法
公开(公告)号：WO2011012947A1
公开(公告)日：2011-02-03
申请号：PCT/IB2010/001758
申请日：2010-07-19
申请人： NELLCOR PURITAN BENNETT IRELAND , ADDISON, Paul, Stanley , WATSON, James, N.
发明人： ADDISON, Paul, Stanley , WATSON, James, N.
IPC分类号： A61B5/022 , G06F17/00
CPC分类号： A61B5/726 , A61B5/02225 , A61B5/7203 , A61B5/7225
摘要： Methods and systems for determining blood pressure from a pressure signal are disclosed. A patient's blood pressure may be determined by analyzing features of a wavelet transformation of a pressure signal obtained during an occlusion procedure. Ridges in a scalogram of the transformed signal may be identified and used to determine an envelope of a pressure oscillation signal, to which oscillometric blood pressure determination techniques may be applied.
摘要翻译：公开了用于从压力信号确定血压的方法和系统。可以通过分析在闭塞过程中获得的压力信号的小波变换的特征来确定患者的血压。变换信号的标尺中的脊可以被识别并用于确定压力振荡信号的包络，可应用示波血压测定技术。

9. 发明申请

WO2010149951A1 METHODS AND APPARATUS FOR MEASURING RESPIRATORY FUNCTION USING AN EFFORT SIGNAL 审中-公开
标题翻译：用于测量呼吸功能的方法和装置
公开(公告)号：WO2010149951A1
公开(公告)日：2010-12-29
申请号：PCT/GB2010/001195
申请日：2010-06-18
申请人： NELLCOR PURITAN BENNETT IRELAND , WATSON, James, N. , ADDISON, Paul, Stanley
发明人： WATSON, James, N. , ADDISON, Paul, Stanley
IPC分类号： A61B5/00 , A61B5/024 , A61B5/08
CPC分类号： A61B5/02416 , A61B5/08 , A61B5/0816 , A61B5/087 , A61B5/14551 , A61B5/726
摘要： Breathing effort of a patient, as determined (for example) from a photoplethysmograph ("PPG") signal from the patient, can be used in conjunction with signals from a spirometer being used by the patient to provide additional information about various characteristics of the patient's breathing. For example, such additional information may include the relationship between the patient's breathing effort and breath volume. As another example, the additional information may include the relationship between the patient's breathing effort and rate of breath flow. Still other such additional information may be derived from various combinations of spirometer and PPG output signals.
摘要翻译：患者的呼吸努力（例如来自患者的光电体积描记器（“PPG”）信号确定（例如）可以与来自患者使用的肺活量计的信号结合使用，以提供关于患者的各种特征的附加信息呼吸。例如，这样的附加信息可以包括患者的呼吸努力和呼吸量之间的关系。作为另一示例，附加信息可以包括患者的呼吸努力和呼吸气流之间的关系。还可以从肺活量计和PPG输出信号的各种组合导出另外的其它信息。

10. 发明申请

WO2011001280A1 METHOD AND APPARATUS FOR DETERMINING BREATHING EFFORT CHARACTERISTIC MEASURES 审中-公开
标题翻译：用于确定呼吸功能特征的方法和装置
公开(公告)号：WO2011001280A1
公开(公告)日：2011-01-06
申请号：PCT/IB2010/001675
申请日：2010-07-02
申请人： NELLCOR PURITAIN BENNETT IRELAND , ADDISON, Paul, Stanley , CASSIDY, Andrew , WATSON, James, N.
发明人： ADDISON, Paul, Stanley , CASSIDY, Andrew , WATSON, James, N.
IPC分类号： A61B5/00 , A61B5/08
CPC分类号： A61B5/08 , A61B5/087 , A61B5/1455 , A61B5/726
摘要： One or more respiratory characteristics of a patient are measured by coupling patient monitor apparatus (e.g., a photoplethysmograph ("PPG") ) to the patient in order to produce a patient monitor signal that includes signal indicia indicative of effort the patient is exerting to breathe. A breathing or respiratory effort signal for the patient is extracted from the patient monitor signal. A respiratory characteristic signal is extracted (at least in part) from the effort signal. This may be done, for example, on the basis of an amplitude feature of the effort signal and a relative time of occurrence of that amplitude feature. Alternatively, the respiratory characteristic signal may be based on a relationship between two amplitude features of the effort signal, with or without regard for specifics of the times of occurrence of those amplitude features. A breath air flow meter may also be coupled to the patient, if desired, in order to produce a flow signal. One or more of the respiratory characteristic measures may also be partly based on the flow signal.
摘要翻译：患者的一个或多个呼吸特征通过将患者监视器装置（例如，光电容积描记器（“PPG”））与患者联接来测量，以产生包括指示患者正在呼吸的努力的信号标记的患者监护仪信号。从患者监护仪信号中提取患者的呼吸或呼吸努力信号。从努力信号中提取（至少部分地）呼吸特征信号。这可以例如基于努力信号的幅度特征和该幅度特征的相对发生时间来完成。或者，呼吸特征信号可以基于努力信号的两个振幅特征之间的关系，有或没有考虑那些幅度特征的发生时间的细节。如果需要，呼吸空气流量计也可以联接到患者，以产生流动信号。一个或多个呼吸特征测量还可以部分地基于流量信号。

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