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1. 发明申请

WO1998042745A1 IRON-CASEIN COMPLEX AND PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：铁 - 壳复合物及其制备方法
公开(公告)号：WO1998042745A1
公开(公告)日：1998-10-01
申请号：PCT/JP1997000963
申请日：1997-03-24
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , SAKURAI, Toshio , UCHIDA, Toshiaki , HAMASHITA, Kazumasa , TOMIZAWA, Akira
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K14/47
CPC分类号： C07K14/4732 , A61K38/1709 , A61K47/62 , Y10S530/832 , A61K2300/00
摘要： An iron-casein complex which does not give an astringent taste peculiar to iron even upon heat sterilization and has a high iron-replenishing effect. It can be prepared by mixing three solutions, that is, a solution (A) containing carbonic acid, bicarbonic acid, or a mixture of them, a solution (B1) containing iron, and a solution (B2) containing a casein, in a suitable order. In this case, however, the coexistence of carbonic acid, bicarbonic acid and iron only should be avoided. The iron-casein complex contains 1 to 1,000 atoms of iron and at least one molecule of each of carbonic and bicarbonic acids per molecule of the casein, and does not give an astringent taste even upon heat sterilization. It has a higher antianemic effect than inorganic iron salts.
摘要翻译：铁 - 酪蛋白复合物即使在加热灭菌时也不会产生铁特有的涩味，并且具有高的铁补充效果。可以通过混合三种溶液，即含有碳酸，碳酸或它们的混合物的溶液（A），含铁溶液（B1）和含有酪蛋白的溶液（B2），在合适的订单。但在这种情况下，应避免碳酸，碳酸氢和铁的共存。铁酪蛋白复合物每分子酪蛋白含有1至1,000个铁原子和至少一个碳酸和碳酸氢根分子，即使加热灭菌也不会产生涩味。它比无机铁盐具有更高的抗血吸虫作用。

2. 发明申请

WO1998005648A1 NOVEL ISOQUINOLINE DERIVATIVES 审中-公开
标题翻译：新型异喹啉衍生物
公开(公告)号：WO1998005648A1
公开(公告)日：1998-02-12
申请号：PCT/JP1997002765
申请日：1997-08-07
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , ISHIGURO, Susumu , SHIMADA, Shinichi , SEYA, Motohide , OKUE, Masayuki , YAGI, Yuzo , OGANE, Nobuo , SAITOU, Yasunari
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07D217/02
CPC分类号： C07D231/12 , C07D217/02 , C07D233/56 , C07D249/08 , C07D401/12 , C07D413/12 , C07D417/12
摘要： Novel isoquinoline derivatives represented by general formula (I) or pharmaceutically acceptable acid-addition salts thereof, prepared by aiming at providing novel compounds which have an inhibitory activity on nerve cell death of the apoptosis type, wherein Ar represents an optionally substituted aromatic ring; and n is 0, 1 or 2. Because of the inhibitory effect on cell death, these compounds are useful as preventives and remedies for neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's chorea and amyotrophic lateral sclerosis, ischemic cerebral diseases such as cerebral stroke, and peripheral nerve disorders observed in diabetes, etc.
摘要翻译：通过旨在提供对细胞凋亡类型的神经细胞死亡具有抑制活性的新化合物而制备的由通式（I）表示的新型异喹啉衍生物或其药学上可接受的酸加成盐，其中Ar表示任选取代的芳环; n为0,1或2.由于对细胞死亡的抑制作用，这些化合物可用作神经变性疾病如阿尔茨海默病，帕金森病，亨廷顿氏舞蹈病和肌萎缩性侧索硬化症，脑缺血性脑疾病中风和周围神经功能障碍等。

3. 发明申请

WO1996029859A1 PROCESS FOR PREPARING PRECUT FAT OR OIL FOOD IN WATER-IN-OIL TYPE EMULSION FORM AND APPARATUS THEREFOR 审中-公开
标题翻译：油脂类型乳液形式的预处理油脂的制备方法及其设备
公开(公告)号：WO1996029859A1
公开(公告)日：1996-10-03
申请号：PCT/JP1996000607
申请日：1996-03-12
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , OKAMOTO, Kiyotaka , HONDA, Yoshihiko , MURAKAMI, Motoi , ONIKI, Shigeru , SUZUKI, Koji
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： A01J23/00
CPC分类号： A23D7/04 , A01J21/00 , A01J23/00 , A23P30/10
摘要： Conventional fat or oil foods in water-in-oil type emulsion form are fluid immediately after the preparation, but become very hard upon cooling. This necessitates preheating before the division of the foods, resulting in poor working efficiency and, even when the remaining portion is again cooled and stored, the deterioration in quality is unavoidable because the surface and the other portion have been melted. All the above problems have now been solved by filling a fat or oil food in fluid water-in-oil type emulsion form into a mold with a partitioning frame consisting of a plurality of partitioning plates provided therein, moving the filled food from a filling position to a discharging position, and extruding and discharging the food from the mold by means of an extruding die which has been partitioned into the same configuration as the partitioning frame and has grooves for entrance of the partitioning plates, thereby precutting the food.
摘要翻译：油包水型乳液形式的常规脂肪或油性食品在制备后立即是流体，但在冷却时变得非常困难。这在食品分配之前需要预热，导致差的工作效率，并且即使剩余部分再次被冷却和储存，质量的劣化也是不可避免的，因为表面和其它部分已经熔化。所有上述问题现在已经通过将脂肪或油性食品以流体油包水型乳液形式填充到具有由设置在其中的多个分隔板组成的分隔框架的模具中来解决，将填充的食物从填充位置移动到达排出位置，并且通过已经被分隔成与分隔框架相同的构造的挤压模具从模具中挤出和排出食物，并具有用于分隔板的入口的槽，从而预先切割食物。

4. 发明申请

WO1996000240A1 NOVEL PROTEIN AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：新型蛋白质及其生产方法
公开(公告)号：WO1996000240A1
公开(公告)日：1996-01-04
申请号：PCT/JP1995001270
申请日：1995-06-26
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , GOTO, Masaaki , TSUDA, Eisuke , YANO, Kazuki , KOBAYASHI, Fumie , YAMAGUCHI, Kyoji , WASHIDA, Naohiro , SATAKE, Toshiko , MORINAGA, Tomonori , UEDA, Masatsugu , HIGASHIO, Kanji
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K14/51
CPC分类号： C07K14/51 , A61K38/00 , Y02A50/473
摘要： A protein having an osteoblast proliferating activity, originating in human fibroblasts, and having the amino acid sequence represented by SEQ ID No: 1 in the Sequence Listing as the N-terminal amino acid sequence thereof and a molecular weight of about 15kD as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under both reducing and non-reducing conditions; a protein having an osteoblast proliferating activity and the amino acid sequence represented by SEQ ID No: 9 in the Sequence Listing; and a process for producing the proteins by culturing human fibroblasts and purifying the culture medium by adsorption on a cation exchanger and heparin. The proteins can be produced also by genetic engineering techniques. They are used for treating bone weight reducing diseases such as osteoporosis and as an antigen for the immunological diagnosis of these diseases.
摘要翻译：具有成骨细胞增殖活性的蛋白质，源于人成纤维细胞，并且具有序列表中SEQ ID No：1所示的氨基酸序列作为其N-末端氨基酸序列，分子量约为15kD，由钠还原和非还原条件下的十二烷基硫酸盐 - 聚丙烯酰胺凝胶电泳; 具有成骨细胞增殖活性的蛋白质和序列表中SEQ ID No：9所示的氨基酸序列; 以及通过培养人成纤维细胞并通过在阳离子交换剂和肝素上吸附来纯化培养基来生产蛋白质的方法。蛋白质也可以通过基因工程技术生产。它们用于治疗骨量减少疾病如骨质疏松症和作为这些疾病免疫诊断的抗原。

5. 发明申请

WO1991017036A1 CONTAINER SUBJECTED TO IN-MOLD LABELING AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：容纳在模具标签上的容器及其制造方法
公开(公告)号：WO1991017036A1
公开(公告)日：1991-11-14
申请号：PCT/JP1991000596
申请日：1991-05-01
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , NIPPLA CO., LTD. , HIRATA, Masanori , MAEKAWA, Koji , KATAYAMA, Ken , MIZUKOSHI, Kohbu
发明人： SNOW BRAND MILK PRODUCTS CO., LTD. , NIPPLA CO., LTD.
IPC分类号： B29C45/26
CPC分类号： B65D25/36 , B29C45/0046 , B29C45/14 , B29C45/14475 , B29C2045/14918 , B29C2045/14934 , B65D2203/02
摘要： Cut-ins are formed in extensions of an edge of a bottom surface portion on the side of a side wall surface portion of a label consisting of the bottom surface portion and the side wall surface portion. A bent line or a cut-away portion is formed in a direction perpendicular to the forward ends of the cut-ins of the side wall surface portion and the side wall surface portion is bend from the bottom surface portion, whereby the bottom end of the label is positioned below the inner bottom surface of a container at the outer surface of a corner portion of a curved surface. This label is loaded into a mold consisting of a core and a cavity and subjected to in-mold labeling by injected resin. Furthermore, a thick wall portion may be formed on the bent portion of the label with grooves for introducing the injected resin and so forth of the core on the bottom surface portion of the container, or grooves for directing the flows of the injected resin may be provided in the bottom surface portion of the container on the mold's core side.

6. 发明申请

WO1990010651A1 GLYCOPROTEIN OF HUMAN ORIGIN, PHYSIOLOGICALLY ACTIVE FACTOR COMPRISING THE SAME, AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译：人造血液蛋白酶，包含其的生理活性因子和含有该成分的药物制剂作为活性成分
公开(公告)号：WO1990010651A1
公开(公告)日：1990-09-20
申请号：PCT/JP1990000314
申请日：1990-03-09
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , HIGASHIO, Kanji , MITSUDA, Shinjiro , SHIMA, Nobuyuki , ITAGAKI, Yasuharu , NAGAO, Masaya
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K15/14
CPC分类号： C07K14/4753 , A61K38/00 , C07K14/475
摘要： A glycoprotein is obtained from a supernatant of a culture medium of the fibroblasts of human origin. It has an antitumor activity and activities of inducing the differentiation of leukemia cells, enhancing cell-mediated immunity, accelerating the proliferation of endothelial cells of human blood vessel, and proliferating hepatic parenchymal cells.

7. 发明申请

WO1997005784A1 MODIFIED WHEY PROTEIN AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：改良的蛋白质及其生产方法
公开(公告)号：WO1997005784A1
公开(公告)日：1997-02-20
申请号：PCT/JP1995002553
申请日：1995-12-13
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , SATO, Kaoru , IMAI, Hiroshi , HORIKAWA, Masakazu , KAWANARI, Masami
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： A23J03/08
CPC分类号： A23J3/08 , A23V2002/00 , A23V2200/228 , A23V2300/08 , A23V2250/54252 , A23V2250/54246
摘要： A modified whey protein having improved keeping qualities and comprising a partly heat-denatured whey protein and a casein protein optionally together with an undenatured whey protein. The partly heat-denatured whey protein can be prepared by heating a whey protein, the protein concentration and pH value of which have been adjusted respectively to 0.5 to 15 % by weight and 6 to 8, at 55 to 120 DEG C for 1 to 120 minutes. The process for producing the modified protein comprises adding a casein protein to the partly heat-denatured whey protein or adding a casein protein to an undenatured whey protein to partly denature the same by heating. The modified whey protein having improved keeping qualities can provide a gel which has a good water retention and a high elasticity and is useful as a food material.
摘要翻译：一种改良的乳清蛋白，其具有改善的保持质量并且包含部分热变性乳清蛋白和酪蛋白蛋白，任选地与未变性的乳清蛋白一起。部分热变性乳清蛋白可以通过加热乳清蛋白，其蛋白质浓度和pH值分别调整为0.5〜15重量％，6〜8，在55〜120℃下加热1〜120 分钟。制备修饰蛋白的方法包括将酪蛋白加入到部分热变性乳清蛋白中，或将酪蛋白加入到未变性的乳清蛋白中，通过加热使其部分变性。具有改进的保持质量的改性乳清蛋白可以提供具有良好保水性和高弹性的凝胶，并且可用作食品材料。

8. 发明申请

WO1997001964A1 MODIFIED WHEY PROTEIN 审中-公开
标题翻译：改良的蛋白质
公开(公告)号：WO1997001964A1
公开(公告)日：1997-01-23
申请号：PCT/JP1995002552
申请日：1995-12-13
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , IMAI, Hiroshi , SATO, Kaoru , HORIKAWA, Masakazu , KAWANARI, Masami
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： A23J03/08
CPC分类号： A23C15/16 , A23J3/08
摘要： A modified whey protein powder having an improved solubility and comprising a partly heat-denatured whey protein and an undenatured whey protein; and a process for producing a modified whey protein powder having an improved solubility which comprises adding an undenatured whey protein to a solution of a partly heat-denatured whey protein and drying the resultant solution. From 0.2 to 10 parts by weight of the undenatured whey protein is used per part by weight of the partly heat-denatured whey protein. The obtained powder has a hydrophobicity of 50 FI/mg protein or above or an insolubility of 1 ml or below. A gel obtained from this powder has a good water retention, a high elasticity and a smooth texture, which makes it useful as a food material.
摘要翻译：一种改良的乳清蛋白粉，其具有改善的溶解度并且包含部分热变性乳清蛋白和未变性的乳清蛋白; 以及制备具有改善的溶解度的改性乳清蛋白粉末的方法，其包括将未变性的乳清蛋白加入到部分热变性乳清蛋白的溶液中并干燥所得溶液。每份重量份的部分热变性乳清蛋白使用0.2至10重量份的未变性乳清蛋白。得到的粉末具有50 FI / mg蛋白质或以上的疏水性或1ml以下的不溶性。从该粉末获得的凝胶具有良好的保水性，高弹性和光滑的质感，因此可用作食品。

9. 发明申请

WO1996026217A1 NOVEL PROTEIN AND METHODS FOR THE PRODUCTION OF THE SAME 审中-公开
标题翻译：新型蛋白质及其生产方法
公开(公告)号：WO1996026217A1
公开(公告)日：1996-08-29
申请号：PCT/JP1996000374
申请日：1996-02-20
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , GOTO, Masaaki , TSUDA, Eisuke , MOCHIZUKI, Shin' ichi , YANO, Kazuki , KOBAYASHI, Fumie , SHIMA, Nobuyuki , YASUDA, Hisataka , NAKAGAWA, Nobuaki , MORINAGA, Tomonori , UEDA, Masatsugu , HIGASHIO, Kanji
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K14/52
CPC分类号： C07K14/70578
摘要： A novel protein having the activity of suppressing the differentiation and/or maturation of osteoclasts and methods of the production of the same. This protein is produced from human fetal pulmonary fibroblasts and has a molecular weight of about 60 KD under reductive conditions or about 120 KD under nonreductive conditions. It can be isolated and purified from the culture medium of the above-mentioned cells. Alternatively, it can be produced by genetic engineering techniques. The invention also provides a cDNA for the genetic engineering production of the protein, an antibody showing an affinity specifically for the protein, and a method for assaying the protein with the use of this antibody.
摘要翻译：具有抑制破骨细胞的分化和/或成熟的活性的新型蛋白质及其制造方法。该蛋白质由人胎儿肺成纤维细胞产生，在还原条件下分子量为约60KD，在非还原条件下为约120KD。可以从上述细胞的培养基中分离纯化。或者，它可以通过基因工程技术生产。本发明还提供了用于蛋白质的遗传工程生产的cDNA，显示出对蛋白质的亲和力的抗体，以及使用该抗体测定蛋白质的方法。

10. 发明申请

WO1996020004A1 THERAPEUTIC AGENT FOR DISORDER OF LIPID METABOLISM 审中-公开
标题翻译：用于脂质代谢紊乱的治疗剂
公开(公告)号：WO1996020004A1
公开(公告)日：1996-07-04
申请号：PCT/JP1995002707
申请日：1995-12-27
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , SHIOTA, Akira , FUJISE, Nobuaki , MASUNAGA, Hiroaki , HIGASHIO, Kanji
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： A61K38/18
CPC分类号： A61K38/1833
摘要： The present invention relates to a therapeutic agent for treatment of disorder of lipid metabolism comprising TCF-II as an effective ingredient. The therapeutic agent of the present invention is useful for treatment of disorder of lipid metabolism caused by diabetes, endocrinological diseases, such as thyroid dysfunction and adrenal dysfunction, chronic metabolism disorder, chronic renal failure including nephrosis, uremia, cancer, dyscrasia, adverted effects of antitumor agents, gastrointestinal (including hepatic and pancreatic) impairment and so on. Hypercholesterolemia, hypolipidemia or hypo-high-density-lipoproteinemia is exemplified as a disorder of lipid metabolism. The therapeutic agent of the present invention normalizes not only hyperlipidemia but also hypolipidemia. In addition, it improves fatty liver.
摘要翻译：本发明涉及用于治疗包含TCF-II作为有效成分的脂质代谢紊乱的治疗剂。本发明的治疗剂可用于治疗由糖尿病引起的脂质代谢异常，内分泌疾病如甲状腺功能障碍和肾上腺功能障碍，慢性代谢障碍，慢性肾功能衰竭，包括肾病，尿毒症，癌症，dyscrasia，广告效应抗肿瘤药，胃肠（包括肝，胰腺）损伤等。高胆固醇血症，低脂血症或低高密度脂蛋白血症被列为脂质代谢紊乱。本发明的治疗剂不仅使高脂血症也降低血脂异常。此外，它改善脂肪肝。

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