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1. 发明申请

WO1998005648A1 NOVEL ISOQUINOLINE DERIVATIVES 审中-公开
标题翻译：新型异喹啉衍生物
公开(公告)号：WO1998005648A1
公开(公告)日：1998-02-12
申请号：PCT/JP1997002765
申请日：1997-08-07
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , ISHIGURO, Susumu , SHIMADA, Shinichi , SEYA, Motohide , OKUE, Masayuki , YAGI, Yuzo , OGANE, Nobuo , SAITOU, Yasunari
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07D217/02
CPC分类号： C07D231/12 , C07D217/02 , C07D233/56 , C07D249/08 , C07D401/12 , C07D413/12 , C07D417/12
摘要： Novel isoquinoline derivatives represented by general formula (I) or pharmaceutically acceptable acid-addition salts thereof, prepared by aiming at providing novel compounds which have an inhibitory activity on nerve cell death of the apoptosis type, wherein Ar represents an optionally substituted aromatic ring; and n is 0, 1 or 2. Because of the inhibitory effect on cell death, these compounds are useful as preventives and remedies for neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's chorea and amyotrophic lateral sclerosis, ischemic cerebral diseases such as cerebral stroke, and peripheral nerve disorders observed in diabetes, etc.
摘要翻译：通过旨在提供对细胞凋亡类型的神经细胞死亡具有抑制活性的新化合物而制备的由通式（I）表示的新型异喹啉衍生物或其药学上可接受的酸加成盐，其中Ar表示任选取代的芳环; n为0,1或2.由于对细胞死亡的抑制作用，这些化合物可用作神经变性疾病如阿尔茨海默病，帕金森病，亨廷顿氏舞蹈病和肌萎缩性侧索硬化症，脑缺血性脑疾病中风和周围神经功能障碍等。

2. 发明申请

WO1997043434A1 NOVEL PHYSIOLOGICALLY ACTIVE SUBSTANCE AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：新的生理活性物质及其生产方法
公开(公告)号：WO1997043434A1
公开(公告)日：1997-11-20
申请号：PCT/JP1997001612
申请日：1997-05-14
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , KUROSAWA, Kazuhiko , TAKAHASHI, Kousaku , MATSUBARA, Kyouko , OKUE, Masayuki , WASHIDA, Naohiro , HIGASHIO, Kanji
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C12P17/16
CPC分类号： C07D407/04 , C12P17/162
摘要： A novel physiologically active substance; a microorganism to be used for producing the same; and medicines containing the same as the active ingredient. A novel physiologically active substance SNF4435 represented by formula (I); a strain Streptomyces spectabilis SNF4435 isolated from the soil in the main island of Okinawa; a process comprising culturing the microorganism in a medium and separating the substance from the culture; and a process for producing the substance via chemical synthesis from its analog produced in the culture. The above substance is usable as medicines such as an immunosuppressant, an antibacterial agent for autoimmune diseases, allergic diseases and infectious diseases, and an antagonist against tolerance to anticancer drugs.
摘要翻译：一种新的生理活性物质; 用于制造它的微生物; 和含有与活性成分相同的药物。由式（I）表示的新型生理活性物质SNF4435; 从冲绳主岛土壤中分离出的菌株Streptomyces spectabilis SNF4435; 一种方法，包括在培养基中培养微生物并将该物质与培养物分离; 以及通过化学合成从其在培养物中产生的类似物生产物质的方法。上述物质可用作免疫抑制剂，自身免疫性疾病的抗菌剂，过敏性疾病和感染性疾病等药物，以及抗癌药耐受性的拮抗剂。

3. 发明申请

WO1998042745A1 IRON-CASEIN COMPLEX AND PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：铁 - 壳复合物及其制备方法
公开(公告)号：WO1998042745A1
公开(公告)日：1998-10-01
申请号：PCT/JP1997000963
申请日：1997-03-24
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , SAKURAI, Toshio , UCHIDA, Toshiaki , HAMASHITA, Kazumasa , TOMIZAWA, Akira
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K14/47
CPC分类号： C07K14/4732 , A61K38/1709 , A61K47/62 , Y10S530/832 , A61K2300/00
摘要： An iron-casein complex which does not give an astringent taste peculiar to iron even upon heat sterilization and has a high iron-replenishing effect. It can be prepared by mixing three solutions, that is, a solution (A) containing carbonic acid, bicarbonic acid, or a mixture of them, a solution (B1) containing iron, and a solution (B2) containing a casein, in a suitable order. In this case, however, the coexistence of carbonic acid, bicarbonic acid and iron only should be avoided. The iron-casein complex contains 1 to 1,000 atoms of iron and at least one molecule of each of carbonic and bicarbonic acids per molecule of the casein, and does not give an astringent taste even upon heat sterilization. It has a higher antianemic effect than inorganic iron salts.
摘要翻译：铁 - 酪蛋白复合物即使在加热灭菌时也不会产生铁特有的涩味，并且具有高的铁补充效果。可以通过混合三种溶液，即含有碳酸，碳酸或它们的混合物的溶液（A），含铁溶液（B1）和含有酪蛋白的溶液（B2），在合适的订单。但在这种情况下，应避免碳酸，碳酸氢和铁的共存。铁酪蛋白复合物每分子酪蛋白含有1至1,000个铁原子和至少一个碳酸和碳酸氢根分子，即使加热灭菌也不会产生涩味。它比无机铁盐具有更高的抗血吸虫作用。

4. 发明申请

WO1996029859A1 PROCESS FOR PREPARING PRECUT FAT OR OIL FOOD IN WATER-IN-OIL TYPE EMULSION FORM AND APPARATUS THEREFOR 审中-公开
标题翻译：油脂类型乳液形式的预处理油脂的制备方法及其设备
公开(公告)号：WO1996029859A1
公开(公告)日：1996-10-03
申请号：PCT/JP1996000607
申请日：1996-03-12
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , OKAMOTO, Kiyotaka , HONDA, Yoshihiko , MURAKAMI, Motoi , ONIKI, Shigeru , SUZUKI, Koji
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： A01J23/00
CPC分类号： A23D7/04 , A01J21/00 , A01J23/00 , A23P30/10
摘要： Conventional fat or oil foods in water-in-oil type emulsion form are fluid immediately after the preparation, but become very hard upon cooling. This necessitates preheating before the division of the foods, resulting in poor working efficiency and, even when the remaining portion is again cooled and stored, the deterioration in quality is unavoidable because the surface and the other portion have been melted. All the above problems have now been solved by filling a fat or oil food in fluid water-in-oil type emulsion form into a mold with a partitioning frame consisting of a plurality of partitioning plates provided therein, moving the filled food from a filling position to a discharging position, and extruding and discharging the food from the mold by means of an extruding die which has been partitioned into the same configuration as the partitioning frame and has grooves for entrance of the partitioning plates, thereby precutting the food.
摘要翻译：油包水型乳液形式的常规脂肪或油性食品在制备后立即是流体，但在冷却时变得非常困难。这在食品分配之前需要预热，导致差的工作效率，并且即使剩余部分再次被冷却和储存，质量的劣化也是不可避免的，因为表面和其它部分已经熔化。所有上述问题现在已经通过将脂肪或油性食品以流体油包水型乳液形式填充到具有由设置在其中的多个分隔板组成的分隔框架的模具中来解决，将填充的食物从填充位置移动到达排出位置，并且通过已经被分隔成与分隔框架相同的构造的挤压模具从模具中挤出和排出食物，并具有用于分隔板的入口的槽，从而预先切割食物。

5. 发明申请

WO1996000240A1 NOVEL PROTEIN AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：新型蛋白质及其生产方法
公开(公告)号：WO1996000240A1
公开(公告)日：1996-01-04
申请号：PCT/JP1995001270
申请日：1995-06-26
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , GOTO, Masaaki , TSUDA, Eisuke , YANO, Kazuki , KOBAYASHI, Fumie , YAMAGUCHI, Kyoji , WASHIDA, Naohiro , SATAKE, Toshiko , MORINAGA, Tomonori , UEDA, Masatsugu , HIGASHIO, Kanji
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K14/51
CPC分类号： C07K14/51 , A61K38/00 , Y02A50/473
摘要： A protein having an osteoblast proliferating activity, originating in human fibroblasts, and having the amino acid sequence represented by SEQ ID No: 1 in the Sequence Listing as the N-terminal amino acid sequence thereof and a molecular weight of about 15kD as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under both reducing and non-reducing conditions; a protein having an osteoblast proliferating activity and the amino acid sequence represented by SEQ ID No: 9 in the Sequence Listing; and a process for producing the proteins by culturing human fibroblasts and purifying the culture medium by adsorption on a cation exchanger and heparin. The proteins can be produced also by genetic engineering techniques. They are used for treating bone weight reducing diseases such as osteoporosis and as an antigen for the immunological diagnosis of these diseases.
摘要翻译：具有成骨细胞增殖活性的蛋白质，源于人成纤维细胞，并且具有序列表中SEQ ID No：1所示的氨基酸序列作为其N-末端氨基酸序列，分子量约为15kD，由钠还原和非还原条件下的十二烷基硫酸盐 - 聚丙烯酰胺凝胶电泳; 具有成骨细胞增殖活性的蛋白质和序列表中SEQ ID No：9所示的氨基酸序列; 以及通过培养人成纤维细胞并通过在阳离子交换剂和肝素上吸附来纯化培养基来生产蛋白质的方法。蛋白质也可以通过基因工程技术生产。它们用于治疗骨量减少疾病如骨质疏松症和作为这些疾病免疫诊断的抗原。

6. 发明申请

WO1991017036A1 CONTAINER SUBJECTED TO IN-MOLD LABELING AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：容纳在模具标签上的容器及其制造方法
公开(公告)号：WO1991017036A1
公开(公告)日：1991-11-14
申请号：PCT/JP1991000596
申请日：1991-05-01
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , NIPPLA CO., LTD. , HIRATA, Masanori , MAEKAWA, Koji , KATAYAMA, Ken , MIZUKOSHI, Kohbu
发明人： SNOW BRAND MILK PRODUCTS CO., LTD. , NIPPLA CO., LTD.
IPC分类号： B29C45/26
CPC分类号： B65D25/36 , B29C45/0046 , B29C45/14 , B29C45/14475 , B29C2045/14918 , B29C2045/14934 , B65D2203/02
摘要： Cut-ins are formed in extensions of an edge of a bottom surface portion on the side of a side wall surface portion of a label consisting of the bottom surface portion and the side wall surface portion. A bent line or a cut-away portion is formed in a direction perpendicular to the forward ends of the cut-ins of the side wall surface portion and the side wall surface portion is bend from the bottom surface portion, whereby the bottom end of the label is positioned below the inner bottom surface of a container at the outer surface of a corner portion of a curved surface. This label is loaded into a mold consisting of a core and a cavity and subjected to in-mold labeling by injected resin. Furthermore, a thick wall portion may be formed on the bent portion of the label with grooves for introducing the injected resin and so forth of the core on the bottom surface portion of the container, or grooves for directing the flows of the injected resin may be provided in the bottom surface portion of the container on the mold's core side.

7. 发明申请

WO1990010651A1 GLYCOPROTEIN OF HUMAN ORIGIN, PHYSIOLOGICALLY ACTIVE FACTOR COMPRISING THE SAME, AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译：人造血液蛋白酶，包含其的生理活性因子和含有该成分的药物制剂作为活性成分
公开(公告)号：WO1990010651A1
公开(公告)日：1990-09-20
申请号：PCT/JP1990000314
申请日：1990-03-09
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , HIGASHIO, Kanji , MITSUDA, Shinjiro , SHIMA, Nobuyuki , ITAGAKI, Yasuharu , NAGAO, Masaya
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K15/14
CPC分类号： C07K14/4753 , A61K38/00 , C07K14/475
摘要： A glycoprotein is obtained from a supernatant of a culture medium of the fibroblasts of human origin. It has an antitumor activity and activities of inducing the differentiation of leukemia cells, enhancing cell-mediated immunity, accelerating the proliferation of endothelial cells of human blood vessel, and proliferating hepatic parenchymal cells.

8. 发明申请

WO1997004669A1 PROCESS FOR PRODUCING LOW FAT SAUSAGE 审中-公开
标题翻译：生产低脂肪酱的方法
公开(公告)号：WO1997004669A1
公开(公告)日：1997-02-13
申请号：PCT/JP1996001546
申请日：1996-06-07
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , SNOW BRAND FOOD CO., LTD. , ATSUTA, Eiji , MAEDA, Maki , SATO, Kaoru , KAWANARI, Masami
发明人： SNOW BRAND MILK PRODUCTS CO., LTD. , SNOW BRAND FOOD CO., LTD.
IPC分类号： A23L01/315
CPC分类号： A23L13/65 , A23L13/424 , A23L13/43 , Y10S426/804
摘要： A process for producing a low fat sausage with juiciness which comprises adding thermally denatured whey protein and an emulsion composition prepared by emulsifying thermally denatured whey protein with an edible fat to the meat employed as the raw sausage material; and the low fat sausage thus obtained. The low fat sausage is comparable to the conventional sausages containing animal fats (lard, etc.) in texture and juiciness and useful as a health food.
摘要翻译：一种生产具有多汁性的低脂香肠的方法，其包括加入热变性乳清蛋白和通过将热变性乳清蛋白与食用脂肪乳化而制成的乳液组合物作为原料香肠材料使用的肉; 和由此获得的低脂香肠。低脂香肠与传统的包含动物脂肪（猪油等）的香肠相当，具有质地和多汁性，并且可用作保健食品。

9. 发明申请

WO1996028037A1 WATER-IN-OIL TYPE EMULSIFYING FATS AND OILS FOOD HAVING SPLIT SECTION LAYERS AND METHOD OF MANUFACTURING SAME 审中-公开
标题翻译：油包水型脂肪和具有分割部分层的油类食品及其制造方法
公开(公告)号：WO1996028037A1
公开(公告)日：1996-09-19
申请号：PCT/JP1995001918
申请日：1995-09-22
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , OKAMOTO, Kiyotaka , HONDA, Yoshihiko , MURAKAMI, Motoi
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： A23D07/00
CPC分类号： A23C15/12 , A01J21/00 , A01J21/02 , A23C15/02 , A23D7/00 , A23D7/04
摘要： A conventional water-in-oil type emulsifying fats and oils food is extruded from a nozzle at a particular shear rate to provide therein split section layers composed of thin water film layers and the like. Accordingly, the food can be readily split even when it is taken out from a refrigerator immediately before use, and prevention of deterioration in quality and improvement of productivity are attained.
摘要翻译：常规的油包水型乳化油脂食品以特定的剪切速率从喷嘴挤出，从而在其中提供由薄水膜层等构成的分割部分层。因此，即使在使用前立即从冰箱中取出食品也容易分散，可以防止质量下降，生产率提高。

10. 发明申请

WO1996020214A1 TCF MUTANT 审中-公开
公开(公告)号：WO1996020214A1
公开(公告)日：1996-07-04
申请号：PCT/JP1995002708
申请日：1995-12-27
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , KINOSAKI, Masahiko , YAMAGUCHI, Kyoji , KOBAYASHI, Fumie , GOTO, Masaaki , MURAKAMI, Akihiko , UEDA, Masatsugu , HIGASHIO, Kanji , YAMASHITA, Yasushi
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K14/52
CPC分类号： C07K14/4753 , A61K38/00
摘要： A TCF mutant having a novel amino acid sequence which is obtained by mutagenizing one or more amino acids contained in a domain ranging from the N-terminal to the first kringle of the amino acid sequence of natural TCF and has a depressed affinity for heparin and/or an elevated biological activity. The TCF mutant, which is prepared by gene manipulations with the use of TCF, has the activity of proliferating liver parenchymatous cells and/or promoting the proliferation of the same and is useful as a remedy for various liver diseases and an antitumor agent.
摘要翻译：具有新的氨基酸序列的TCF突变体，其通过诱变在天然TCF的氨基酸序列的N末端到第一个三环的范围内包含的一个或多个氨基酸而获得，并且对肝素和/ 或升高的生物活性。通过使用TCF的基因操作制备的TCF突变体具有增殖肝实质细胞和/或促进其增殖的活性，并且可用作各种肝脏疾病和抗肿瘤剂的补救剂。

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