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1. 发明申请

WO1996000240A1 NOVEL PROTEIN AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：新型蛋白质及其生产方法
公开(公告)号：WO1996000240A1
公开(公告)日：1996-01-04
申请号：PCT/JP1995001270
申请日：1995-06-26
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , GOTO, Masaaki , TSUDA, Eisuke , YANO, Kazuki , KOBAYASHI, Fumie , YAMAGUCHI, Kyoji , WASHIDA, Naohiro , SATAKE, Toshiko , MORINAGA, Tomonori , UEDA, Masatsugu , HIGASHIO, Kanji
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K14/51
CPC分类号： C07K14/51 , A61K38/00 , Y02A50/473
摘要： A protein having an osteoblast proliferating activity, originating in human fibroblasts, and having the amino acid sequence represented by SEQ ID No: 1 in the Sequence Listing as the N-terminal amino acid sequence thereof and a molecular weight of about 15kD as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis under both reducing and non-reducing conditions; a protein having an osteoblast proliferating activity and the amino acid sequence represented by SEQ ID No: 9 in the Sequence Listing; and a process for producing the proteins by culturing human fibroblasts and purifying the culture medium by adsorption on a cation exchanger and heparin. The proteins can be produced also by genetic engineering techniques. They are used for treating bone weight reducing diseases such as osteoporosis and as an antigen for the immunological diagnosis of these diseases.
摘要翻译：具有成骨细胞增殖活性的蛋白质，源于人成纤维细胞，并且具有序列表中SEQ ID No：1所示的氨基酸序列作为其N-末端氨基酸序列，分子量约为15kD，由钠还原和非还原条件下的十二烷基硫酸盐 - 聚丙烯酰胺凝胶电泳; 具有成骨细胞增殖活性的蛋白质和序列表中SEQ ID No：9所示的氨基酸序列; 以及通过培养人成纤维细胞并通过在阳离子交换剂和肝素上吸附来纯化培养基来生产蛋白质的方法。蛋白质也可以通过基因工程技术生产。它们用于治疗骨量减少疾病如骨质疏松症和作为这些疾病免疫诊断的抗原。

2. 发明申请

WO1994014845A1 MODIFIED TCF 审中-公开
标题翻译：修改TCF
公开(公告)号：WO1994014845A1
公开(公告)日：1994-07-07
申请号：PCT/JP1993001905
申请日：1993-12-27
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , YAMAGUCHI, Kyoji , SHIMA, Nobuyuki , MURAKAMI, Akihiko , GOTO, Masaaki , TSUDA, Eisuke , MASUNAGA, Hiroaki , TAKAHIRA, Reiko , OOGAKI, Fumiko , UEDA, Masatsugu , HIGASHIO, Kanji
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K15/00
CPC分类号： C07K14/4753 , A61K38/00
摘要： Modified TCF in which amino-acid residue(s) of the wild-type TCF responsible for glycosylation is (are) substituted or deleted so that at least one N-linked oligosaccharide chain is removed. The modified TCF have longer biological half-lives without loss of its biological activities. The modified TCFs are therapeutically important as agents for liver diseases or as anti-cancer drugs.
摘要翻译：修饰的TCF，其中负责糖基化的野生型TCF的氨基酸残基被取代或缺失，使得至少一个N-连接的糖链被除去。改良型TCF具有较长的生物半衰期，不丧失生物活性。修饰的TCF作为肝脏疾病或抗癌药物具有治疗作用。

3. 发明申请

WO1996020214A1 TCF MUTANT 审中-公开
公开(公告)号：WO1996020214A1
公开(公告)日：1996-07-04
申请号：PCT/JP1995002708
申请日：1995-12-27
申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , KINOSAKI, Masahiko , YAMAGUCHI, Kyoji , KOBAYASHI, Fumie , GOTO, Masaaki , MURAKAMI, Akihiko , UEDA, Masatsugu , HIGASHIO, Kanji , YAMASHITA, Yasushi
发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
IPC分类号： C07K14/52
CPC分类号： C07K14/4753 , A61K38/00
摘要： A TCF mutant having a novel amino acid sequence which is obtained by mutagenizing one or more amino acids contained in a domain ranging from the N-terminal to the first kringle of the amino acid sequence of natural TCF and has a depressed affinity for heparin and/or an elevated biological activity. The TCF mutant, which is prepared by gene manipulations with the use of TCF, has the activity of proliferating liver parenchymatous cells and/or promoting the proliferation of the same and is useful as a remedy for various liver diseases and an antitumor agent.
摘要翻译：具有新的氨基酸序列的TCF突变体，其通过诱变在天然TCF的氨基酸序列的N末端到第一个三环的范围内包含的一个或多个氨基酸而获得，并且对肝素和/ 或升高的生物活性。通过使用TCF的基因操作制备的TCF突变体具有增殖肝实质细胞和/或促进其增殖的活性，并且可用作各种肝脏疾病和抗肿瘤剂的补救剂。

4. 发明专利

JPH0257248A ARTIFICIAL TOOTH 失效
公开(公告)号：JPH0257248A
公开(公告)日：1990-02-27
申请号：JP21008988
申请日：1988-08-23
申请人： YAMAGUCHI KYOJI
发明人： YAMAGUCHI KYOJI
IPC分类号： A61C13/09
摘要： PURPOSE:To keep initial effect for a long time and to obtain balance and the stability of a denture over a long period of time by integrally fixing a metal blade having a U-shape or a shape wherein U-shapes are continued and also having an edge at the leading end thereof to a region becoming the occlusal surface of a denture body. CONSTITUTION:A denture body 20 is made of a synthetic resin and a metal blade body 21 is mounted to a region 20a becoming an occlusal surface by an adhesive 23 or implantation. The blade body 21 has a U-shape or a shape wherein U-shapes are continued, for example, an S-shape and integrally formed so as to protrude on a base 22. Further, the blade body 21 has an edge 21a forming a flat surface and is formed so as to have a certain height (h) from the surface of the base 2 so as to be same to the width W of the blade body. By this constitution, three elements of cutting, crushing and grinding necessary for the chewing operation of food can be effectively performed and an initial state can be ensured for a long time without lowering crushing action.

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