基本信息:
- 专利标题： NOVEL PROTEIN AND METHODS FOR THE PRODUCTION OF THE SAME
- 专利标题（中）：新型蛋白质及其生产方法
- 申请号：PCT/JP1996000374 申请日：1996-02-20
- 公开(公告)号：WO1996026217A1 公开(公告)日：1996-08-29
- 发明人： SNOW BRAND MILK PRODUCTS CO., LTD.
- 申请人： SNOW BRAND MILK PRODUCTS CO., LTD. , GOTO, Masaaki , TSUDA, Eisuke , MOCHIZUKI, Shin' ichi , YANO, Kazuki , KOBAYASHI, Fumie , SHIMA, Nobuyuki , YASUDA, Hisataka , NAKAGAWA, Nobuaki , MORINAGA, Tomonori , UEDA, Masatsugu , HIGASHIO, Kanji
- 专利权人： SNOW BRAND MILK PRODUCTS CO., LTD.,GOTO, Masaaki,TSUDA, Eisuke,MOCHIZUKI, Shin' ichi,YANO, Kazuki,KOBAYASHI, Fumie,SHIMA, Nobuyuki,YASUDA, Hisataka,NAKAGAWA, Nobuaki,MORINAGA, Tomonori,UEDA, Masatsugu,HIGASHIO, Kanji
- 当前专利权人： SNOW BRAND MILK PRODUCTS CO., LTD.,GOTO, Masaaki,TSUDA, Eisuke,MOCHIZUKI, Shin' ichi,YANO, Kazuki,KOBAYASHI, Fumie,SHIMA, Nobuyuki,YASUDA, Hisataka,NAKAGAWA, Nobuaki,MORINAGA, Tomonori,UEDA, Masatsugu,HIGASHIO, Kanji
- 优先权： JP7/54977 19950220; JP7/207508 19950721
- 主分类号： C07K14/52
- IPC分类号： C07K14/52
摘要：
A novel protein having the activity of suppressing the differentiation and/or maturation of osteoclasts and methods of the production of the same. This protein is produced from human fetal pulmonary fibroblasts and has a molecular weight of about 60 KD under reductive conditions or about 120 KD under nonreductive conditions. It can be isolated and purified from the culture medium of the above-mentioned cells. Alternatively, it can be produced by genetic engineering techniques. The invention also provides a cDNA for the genetic engineering production of the protein, an antibody showing an affinity specifically for the protein, and a method for assaying the protein with the use of this antibody.
摘要（中）：
具有抑制破骨细胞的分化和/或成熟的活性的新型蛋白质及其制造方法。 该蛋白质由人胎儿肺成纤维细胞产生，在还原条件下分子量为约60KD，在非还原条件下为约120KD。 可以从上述细胞的培养基中分离纯化。 或者，它可以通过基因工程技术生产。 本发明还提供了用于蛋白质的遗传工程生产的cDNA，显示出对蛋白质的亲和力的抗体，以及使用该抗体测定蛋白质的方法。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07K | 肽 |
| ------C07K14/00 | 具有多于20个氨基酸的肽；促胃液素；生长激素释放抑制因子；促黑激素；其衍生物 |
| --------C07K14/415 | .来自植物 |
| ----------C07K14/52 | ..细胞激活素；淋巴激活素；干扰素 |