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52. 发明授权

US06809083B1 Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections 有权
标题翻译：使用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物治疗肝炎病毒感染
公开(公告)号：US06809083B1
公开(公告)日：2004-10-26
申请号：US09249220
申请日：1999-02-12
申请人： Richard A. Mueller , Martin L. Bryant , Richard A. Partis , Gary S. Jacob , Timothy M. Block , Raymond A. Dwek
发明人： Richard A. Mueller , Martin L. Bryant , Richard A. Partis , Gary S. Jacob , Timothy M. Block , Raymond A. Dwek
IPC分类号： A01N4304
CPC分类号： C07D211/46 , A61K31/445 , A61K45/06
摘要： Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, mixtures thereof, or immunomodulating/immunostimulating agents, or (2) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds alone or in combination with nucleoside antiviral agents, nucleotide antiviral agents, or mixtures thereof, and immunomodulating/immuno-stimulating agents.
摘要翻译：提供用于治疗哺乳动物，特别是人类的肝炎病毒感染的方法和组合物。方法包括（1）单独或与核苷抗病毒剂，核苷酸抗病毒剂，其混合物或免疫调节/免疫刺激剂单独或组合施用N-取代的-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物，或（2）单独或与核苷抗病毒剂，核苷酸抗病毒剂或其混合物以及免疫调节/免疫刺激剂组合施用N-取代-1,5-二脱氧-1,5-亚氨基-D-葡萄糖醇化合物。

53. 发明授权

US06733812B2 Apparatus and method for forming casingless sausages 有权
标题翻译：无菌香肠成型装置及方法
公开(公告)号：US06733812B2
公开(公告)日：2004-05-11
申请号：US10234648
申请日：2002-09-03
申请人： Rodney L. Franklin , Marvin J. Mentjes , Richard A. Mueller , Charles A. Triplett
发明人： Rodney L. Franklin , Marvin J. Mentjes , Richard A. Mueller , Charles A. Triplett
IPC分类号： A22C700
CPC分类号： A23B4/005 , A22C11/001
摘要： An apparatus and method is disclosed for forming an emulsion or batter into shaped food products without the use of a casing. The apparatus includes a hollow stuffing tube connected to a source of suitable proteinaceous emulsion, and a molding tube mounted about the stuffing tube, the molding tube having an open end and a closed end. A supply of emulsion is conveyed under pressure into the stuffing tube to form a continuous length of shaped emulsion. Then, the shaped emulsion is directed into the molding tube, where the pressure of the emulsion bears against the closed end of the molding tube and causes the molding tube to move relative the stuffing tube. A treating fluid is directed to the interior surface of the molding tube, such that the interior surface is continuously wetted and evenly coated by the treating fluid, thereby forming a proteinaceous skin about the shaped emulsion.
摘要翻译：公开了一种用于在不使用壳体的情况下将乳液或面糊形成成型食品的装置和方法。该装置包括连接到合适的蛋白质乳液源的中空填料管和围绕填料管安装的成型管，该成型管具有开口端和封闭端。在压力下将乳液供给到填料管中以形成连续长度的成型乳液。然后，将成形乳液引导到成型管中，其中乳液的压力抵靠成型管的封闭端，并使成型管相对于填充管移动。将处理流体引导到模制管的内表面，使得内表面被处理流体连续润湿并均匀地涂覆，从而在成形乳液周围形成蛋白质皮肤。

54. 发明授权

US06683648B2 &agr;- and &bgr;-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效
标题翻译：可用作逆转录病毒蛋白酶抑制剂的α-和β-氨基酸羟乙基氨基磺酰脲衍生物
公开(公告)号：US06683648B2
公开(公告)日：2004-01-27
申请号：US10138534
申请日：2002-05-06
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号： C07D40302
CPC分类号： C07D213/42 , C07C307/06 , C07D215/48 , C07D215/50 , C07D215/54 , C07D235/06 , C07D239/38 , C07D307/85 , C07K5/06026 , C07K5/06139 , C07K5/06191
摘要： &agr;-and &bgr;-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译： α-和β-氨基酸羟乙基氨基磺酰脲衍生物化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。

55. 发明授权

US06538006B1 Retroviral protease inhibitors 失效
标题翻译：逆转录病毒蛋白酶抑制剂
公开(公告)号：US06538006B1
公开(公告)日：2003-03-25
申请号：US09743460
申请日：2001-08-20
申请人： Richard A. Mueller , Daniel P. Getman
发明人： Richard A. Mueller , Daniel P. Getman
IPC分类号： A61K3144
CPC分类号： C07D401/12 , C07D217/26
摘要： N-heterocyclic moiety-containing hydroxyethylamine protease inhibitor compounds, methods for making the compounds, and intermediates useful in the method. Also, a method for inhibiting retroviral proteases and for treatment or prophylaxis of a retroviral infection.
摘要翻译：含有N-杂环部分的羟乙基胺蛋白酶抑制剂化合物，制备该化合物的方法和可用于该方法的中间体。另外，用于抑制逆转录病毒蛋白酶和治疗或预防逆转录病毒感染的方法。

56. 发明授权

US06515024B2 Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效
公开(公告)号：US06515024B2
公开(公告)日：2003-02-04
申请号：US10011778
申请日：2001-12-11
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号： A61K3118
CPC分类号： C07D213/42 , C07C307/06 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/088 , C07D295/13 , C07D295/185 , C07D303/36
摘要： Succinoylamino hydroxyethylamino sulfonyl urea derivatives are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

57. 发明授权

US5981580A Fatty acid analogs and prodrugs 失效
标题翻译：脂肪酸类似物和前药
公开(公告)号：US5981580A
公开(公告)日：1999-11-09
申请号：US175634
申请日：1998-10-20
申请人： Sean T. Nugent , Richard A. Mueller
发明人： Sean T. Nugent , Richard A. Mueller
IPC分类号： C07C45/00 , C07C59/135 , C07C229/18 , C07C235/06 , C07C235/12 , C07C235/16 , C07C237/22 , C07C255/13 , C07C255/16 , C07C271/22 , C07D209/20 , C07D257/04 , A61K31/16 , A61K31/21 , C07D209/04
CPC分类号： C07D257/04 , C07C229/18 , C07C235/06 , C07C235/12 , C07C235/16 , C07C237/22 , C07C255/13 , C07C255/16 , C07C271/22 , C07C45/004 , C07C59/135 , C07D209/20 , C07B2200/07
摘要： Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcohols, alcohol esters and nitrites thereof, and are useful as substrates for N-myristoyltransferase (NMT) and/or its acyl coenzyme, as anti-viral and anti-fungal agents or pro-drugs of such agents.
摘要翻译：公开了脂肪酸部分中具有1至3个可以是氧，硫或氮的杂原子的脂肪酸类似物的新型衍生物，其中羧基末端已被修饰以形成各种酰胺，酯，酮，醇，醇酯和亚硝酸盐，并且可用作N-肉豆蔻酰转移酶（NMT）和/或其酰基辅酶的底物，作为这些药物的抗病毒和抗真菌剂或前药。

59. 发明授权

US5965588A Sulfonylalkanoylamino hydroxyethylamimo sulfonamides useful as retroviral protease inhibitors 失效
标题翻译：用作逆转录病毒蛋白酶抑制剂的磺酰基烷酰氨基羟乙基咪唑磺酰胺
公开(公告)号：US5965588A
公开(公告)日：1999-10-12
申请号：US48034
申请日：1998-03-26
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
IPC分类号： A61K31/225 , A61K31/18 , A61K31/63 , A61P31/12 , C07C311/18 , C07C317/44 , C07C327/38 , C07D307/79 , C07D319/16 , A61K31/38 , A61K31/44
CPC分类号： A61K31/63 , A61K31/18 , C07C317/44
摘要： Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译：含磺酰胺的羟乙基胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。

60. 发明授权

US5952377A Fatty acid analogs and prodrugs 失效
标题翻译：脂肪酸类似物和前药
公开(公告)号：US5952377A
公开(公告)日：1999-09-14
申请号：US175740
申请日：1998-10-20
申请人： Sean T. Nugent , Richard A. Mueller
发明人： Sean T. Nugent , Richard A. Mueller
IPC分类号： C07C45/00 , C07C59/135 , C07C229/18 , C07C235/06 , C07C235/12 , C07C235/16 , C07C237/22 , C07C255/13 , C07C255/16 , C07C271/22 , C07D209/20 , C07D257/04 , A61K31/16 , C07D233/04
CPC分类号： C07D257/04 , C07C229/18 , C07C235/06 , C07C235/12 , C07C235/16 , C07C237/22 , C07C255/13 , C07C255/16 , C07C271/22 , C07C45/004 , C07C59/135 , C07D209/20 , C07B2200/07
摘要： Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcohols, alcohol esters and nitriles thereof, and are useful as substrates for N-myristoyltransferase (NMT) and/or its acyl coenzyme, as anti-viral and anti-fungal agents or pro-drugs of such agents.
摘要翻译：公开了脂肪酸部分中具有1至3个可以是氧，硫或氮的杂原子的脂肪酸类似物的新型衍生物，其中羧基末端已被修饰以形成各种酰胺，酯，酮，醇，醇酯和腈，可用作N-肉豆蔻酰转移酶（NMT）和/或其酰基辅酶的底物，作为抗病毒和抗真菌剂或这些药剂的前药。

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