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1. 发明授权

US07402253B2 Controlled bypass flow and ozone proportion method and system 有权
标题翻译：控制旁路流量和臭氧比例法和系统
公开(公告)号：US07402253B2
公开(公告)日：2008-07-22
申请号：US11226359
申请日：2005-09-15
申请人： Johannes van Leeuwen , Michael D. Jennings , Richard A Mueller , Jack H. Robinson
发明人： Johannes van Leeuwen , Michael D. Jennings , Richard A Mueller , Jack H. Robinson
IPC分类号： C02F1/78 , B63B39/03
CPC分类号： C02F1/78 , C02F2103/008 , C02F2209/006 , C02F2301/043 , Y10S210/931
摘要： A method and system of ozone treatment diverts a portion of water from a flow of water in a conduit; injects an ozone-containing gas into the portion to provide an ozonated portion; recombines the ozonated portion with the flow of water in the conduit; and controls and regulates the diverted portion to provide a minimum diverted portion flow rate according to flow in the conduit and proportion of ozone in the injected gas.
摘要翻译：臭氧处理的方法和系统将一部分水从导管中的水流中分离出来; 在该部分中注入含臭氧气体以提供臭氧化部分; 将臭氧化部分与管道中的水流重新组合; 并且控制和调节转向部分以根据管道中的流动和注入气体中的臭氧比例来提供最小转向部分流量。

2. 发明授权

US07199158B2 Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效
标题翻译：用作逆转录病毒蛋白酶抑制剂的琥珀酰氨基羟基氨基磺酰脲衍生物
公开(公告)号：US07199158B2
公开(公告)日：2007-04-03
申请号：US11183230
申请日：2005-07-18
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号： C07C311/00 , A61K31/18
CPC分类号： C07D213/42 , C07C307/06 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/088 , C07D295/13 , C07D295/185 , C07D303/36
摘要： Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R1–R6, R7, R7′, R8, R30–R34, X′, Y, Y′, t, x, and n are as defined herein, are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译：下式的琥珀酰氨基羟基氨基磺酰脲衍生物：

3. 发明授权

US07038084B2 Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 失效
公开(公告)号：US07038084B2
公开(公告)日：2006-05-02
申请号：US10784916
申请日：2004-02-24
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
IPC分类号： C07C311/03 , C07C311/07 , C07C311/08 , C07D295/04 , C07D333/10
CPC分类号： C07C311/05 , C07C311/18 , C07C311/29
摘要： Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

4. 发明授权

US06951886B2 Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors 失效
标题翻译：用作逆转录病毒蛋白酶抑制剂的琥珀酰氨基羟基氨基磺酰脲衍生物
公开(公告)号：US06951886B2
公开(公告)日：2005-10-04
申请号：US10315254
申请日：2002-12-10
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , Eric T. Sun
IPC分类号： C07C307/06 , C07D207/16 , C07D213/42 , C07D295/088 , C07D295/13 , C07D295/185 , C07D521/00 , C07C311/00 , A61K31/18
CPC分类号： C07D213/42 , C07C307/06 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/088 , C07D295/13 , C07D295/185 , C07D303/36
摘要： Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein the substituents are as defined in the specification, are effective as retroviral protease inhibitors and in particular as inhibitors of HIV protease.
摘要翻译：下式的琥珀酰氨基羟基氨基磺酰脲衍生物：其中取代基如说明书中所定义，作为逆转录病毒蛋白酶抑制剂，特别是作为HIV蛋白酶的抑制剂是有效的。

5. 发明授权

US06743929B1 Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 失效
标题翻译：用作逆转录病毒蛋白酶抑制剂的磺酰基烷酰氨基羟乙基氨基磺酰胺
公开(公告)号：US06743929B1
公开(公告)日：2004-06-01
申请号：US09655844
申请日：2000-09-06
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
IPC分类号： C07D30346
CPC分类号： A61K31/63 , A61K31/18 , C07C317/44
摘要： Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译：含磺酰胺的羟乙胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。

6. 发明授权

US06570027B2 Method of preparing intermediates useful in synthesis of retroviral protease inhibitors 失效
公开(公告)号：US06570027B2
公开(公告)日：2003-05-27
申请号：US10114313
申请日：2002-04-03
申请人： John S Ng , Claire A. Przybyla , Richard A Mueller , Michael L Vazquez , Daniel P Getman
发明人： John S Ng , Claire A. Przybyla , Richard A Mueller , Michael L Vazquez , Daniel P Getman
IPC分类号： C07D30102
CPC分类号： C07K5/06191 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/216 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C04B35/632 , C07B2200/07 , C07C213/00 , C07C213/02 , C07C213/08 , C07C269/06 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/22 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C329/06 , C07C335/08 , C07C335/12 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D303/36 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/021 , C07K5/06026 , C07K5/06139 , C07C215/08 , C07C215/28 , C07C271/16
摘要： A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

7. 发明授权

US06534493B1 &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 失效
公开(公告)号：US06534493B1
公开(公告)日：2003-03-18
申请号：US09694785
申请日：2000-10-24
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
IPC分类号： A61K3800
CPC分类号： C07C311/05 , A61K38/00 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/18 , C07C311/20 , C07C311/24 , C07C311/29 , C07C311/32 , C07C311/41 , C07C311/46 , C07C317/04 , C07C317/10 , C07C317/14 , C07C317/28 , C07C317/44 , C07C323/49 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D213/30 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D233/64 , C07D239/26 , C07D277/24 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/79 , C07D317/62 , C07D333/34 , C07D405/12 , C07D417/12 , C07K5/06026 , C07K5/06139
摘要： &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

8. 发明授权

US06472407B1 &agr; and &bgr;-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 失效
标题翻译：可用作逆转录病毒蛋白酶抑制剂的α和β-氨基酸羟乙基氨基磺酰胺
公开(公告)号：US06472407B1
公开(公告)日：2002-10-29
申请号：US09511005
申请日：2000-02-22
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel Getman , Gary A. DeCrescenzo , John N. Freskos
IPC分类号： A61K3147
CPC分类号： C07C311/05 , A61K38/00 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/18 , C07C311/20 , C07C311/24 , C07C311/29 , C07C311/32 , C07C311/41 , C07C311/46 , C07C317/04 , C07C317/10 , C07C317/14 , C07C317/28 , C07C317/44 , C07C323/49 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D213/30 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D233/64 , C07D239/26 , C07D277/24 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/79 , C07D317/62 , C07D333/34 , C07D405/12 , C07D417/12 , C07K5/06026 , C07K5/06139
摘要： &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译： α-和β-氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。

9. 发明授权

US06444248B1 Apparatus and method for forming casingless sausages 失效
标题翻译：无菌香肠成型装置及方法
公开(公告)号：US06444248B1
公开(公告)日：2002-09-03
申请号：US09690358
申请日：2000-10-17
申请人： Rodney L. Franklin , Marvin J. Mentjes , Richard A. Mueller , Charles A. Triplett
发明人： Rodney L. Franklin , Marvin J. Mentjes , Richard A. Mueller , Charles A. Triplett
IPC分类号： A22C700
CPC分类号： A23B4/005 , A22C11/001
摘要： The present invention relates to apparatus and method for forming a proteinaceous emulsion or batter into shaped food products such as sausages without the use of a casing. A supply of suitable proteinaceous emulsion is provided and such emulsion is conveyed under pressure into an elongated hollow stuffing tube to form a continuous length of shaped emulsion. Thereafter the shaped emulsion is directed into a molding tube which is slideably mounted about the stuffing tube. As the emulsion enters the molding tube, the pressure of the emulsion causes the molding tube to move away from the stuffing tube. A treating fluid, such as a diluted food grade acid, is directed to the interior surface of the molding tube at about the point where the emulsion first enters the molding tube. The treating fluid is directed to the interior of the molding tube in such a manner that the interior of the molding tube is continuously wetted by the treating fluid as the molding tube moves relative to the stuffing tube. This ensures that the entire surface of the shaped emulsion is contacted by the treating fluid, thereby forming a proteinaceous skin about the shaped emulsion. After the molding tube is filled with the emulsion, it is separated from the stuffing tube, subjected to a heat treatment, and a length of formed sausage is removed from the molding tube and subjected to further processing.
摘要翻译：本发明涉及将蛋白质乳液或面糊形成成型食品如香肠而不使用套管的装置和方法。提供合适的蛋白质乳液的供应，并且将这种乳液在压力下输送到细长的中空填充管中以形成连续长度的成型乳液。此后，成型的乳液被引导到成型管中，该成型管可滑动地安装在填充管周围。当乳液进入成型管时，乳液的压力使成型管远离填料管移动。处理液，例如稀释的食品级酸，在乳液首先进入成型管的位置处被引导到成型管的内表面。处理流体以这样的方式被引导到模制管的内部，使得当模制管相对于填充管移动时，模制管的内部被处理流体连续地润湿。这确保了成形乳液的整个表面被处理流体接触，从而在成形乳液周围形成蛋白质皮肤。在成型管充满乳液之后，将其与填料管分离，进行热处理，并从成形管中取出长度形成的香肠，并进行进一步处理。

10. 发明授权

US06417387B1 &agr;-and &bgr;-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors 失效
标题翻译：可用作逆转录病毒蛋白酶抑制剂的α-和β-氨基酸羟乙基氨基磺酰胺
公开(公告)号：US06417387B1
公开(公告)日：2002-07-09
申请号：US09798255
申请日：2001-03-05
申请人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Deborah E. Bertenshaw , Robert M. Heintz
发明人： Michael L. Vazquez , Richard A. Mueller , John J. Talley , Daniel P. Getman , Gary A. DeCrescenzo , John N. Freskos , Deborah E. Bertenshaw , Robert M. Heintz
IPC分类号： C07C30300
CPC分类号： C07C311/05 , A61K38/00 , C07C311/11 , C07C311/13 , C07C311/14 , C07C311/18 , C07C311/20 , C07C311/24 , C07C311/29 , C07C311/32 , C07C311/41 , C07C311/46 , C07C317/04 , C07C317/10 , C07C317/14 , C07C317/28 , C07C317/44 , C07C323/49 , C07C323/67 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07D209/08 , C07D213/30 , C07D213/42 , C07D213/64 , C07D213/73 , C07D213/81 , C07D213/82 , C07D213/89 , C07D215/48 , C07D217/26 , C07D233/64 , C07D239/26 , C07D241/18 , C07D241/44 , C07D263/34 , C07D277/24 , C07D277/62 , C07D277/82 , C07D307/20 , C07D307/42 , C07D307/79 , C07D307/85 , C07D317/62 , C07D333/32 , C07D333/34 , C07D333/48 , C07D405/12 , C07D417/12 , C07D493/04 , C07K5/06026 , C07K5/06139
摘要： &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译： α-和β-氨基酸羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。

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