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41. 发明申请

US20070020689A1 Label-free high throughput biomolecular screening system and method 审中-公开
标题翻译：无标记的高通量生物分子筛选系统和方法
公开(公告)号：US20070020689A1
公开(公告)日：2007-01-25
申请号：US11489173
申请日：2006-07-19
申请人： Stephen Caracci , Volker Eckelt , Anthony Frutos , Mark Krol , Thomas Moore , David Pastel , Gordon Shedd
发明人： Stephen Caracci , Volker Eckelt , Anthony Frutos , Mark Krol , Thomas Moore , David Pastel , Gordon Shedd
IPC分类号： C40B30/06 , G01N33/53 , G06F19/00 , C12M1/34
CPC分类号： G01N35/028 , G01N2035/00158 , G01N2035/00356 , G01N2035/0097
摘要： A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occurr in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.
摘要翻译：本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。

42. 发明申请

US20060210140A1 Apparatus and method for automated stress testing of flip-chip packages 失效
标题翻译：倒装芯片封装自动应力测试的装置和方法
公开(公告)号：US20060210140A1
公开(公告)日：2006-09-21
申请号：US11367562
申请日：2006-03-03
申请人： Lyudmila Zaykova-Feldman , Thomas Moore
发明人： Lyudmila Zaykova-Feldman , Thomas Moore
IPC分类号： G06K9/00
CPC分类号： G01R31/2881 , G01M7/08 , G01N3/00 , G01N3/307 , G01N3/313 , G01N2203/0044 , G01N2203/005 , G01N2203/0057 , G01N2203/0296 , G01N2203/0676 , G01R31/2868 , H01L21/67011
摘要： An apparatus for testing flip-chip packages has a programmed computer, a test-engine stage for applying an impact to at least one package under test, and a monitoring stage. The test-engine stage causes an impact on the package on the side opposite its ball-grid array. The test-engine stage has actuators connected to the test-engine stage and the computer, for moving and aligning the test-engine stage. The monitoring stage has a digital camera connected to the computer for transmitting digital images from the ball-grid array side of the package to the computer. A microscope is preferably connected to the digital camera. A sample stage located between the test-engine stage and the monitoring stage holds the package under test. The sample stage has an acoustic transducer capable of being removably connected to the package under test. The acoustic transducer is connected to the computer for transmitting signals from the acoustic transducer to the computer.
摘要翻译：用于测试倒装芯片封装的装置具有编程的计算机，用于对至少一个待测试包进行冲击的测试引擎阶段和监视阶段。测试引擎级在与球栅阵列相反的一侧对包装产生影响。测试发动机级具有连接到测试发动机级和计算机的致动器，用于移动和对准测试引擎级。监控级具有连接到计算机的数字照相机，用于将数字图像从包装的球栅阵列侧传输到计算机。显微镜优选地连接到数码相机。位于测试引擎级和监控级之间的样品台保持被测试的包装。样品台具有能够可拆卸地连接到被测试包装的声学换能器。声学换能器连接到计算机，用于将信号从声学传感器传输到计算机。

43. 发明申请

US20060113478A1 Kit for preparing a TEM sample holder 失效
标题翻译：用于制备TEM样品架的试剂盒
公开(公告)号：US20060113478A1
公开(公告)日：2006-06-01
申请号：US11335415
申请日：2006-01-19
申请人： Thomas Moore
发明人： Thomas Moore
IPC分类号： G21K7/00
CPC分类号： H01J37/20 , H01J37/26 , H01J2237/31745 , Y10T29/49915 , Y10T29/49922 , Y10T29/5147
摘要： A kit for preparing TEM sample holders includes at least one TEM coupon made of a sheet of material and having one or more paths from its edge to a TEM sample holder form embodied in the TEM coupon. There is at least one hole in the coupon defining the outer boundary of the TEM sample holder form. This hole has a mouth that defines a land of material. This land connects the TEM sample holder form to the edge of the sheet. The kit preferably includes at least one probe tip, where the probe tip has a probe-tip point, and finally, a press. The press has inner and outer dies and a former rod opposing the inner and outer dies. A shear punch is situated coaxially with the former rod. Thus, when an actuator drives the shear punch toward the inner and outer dies, the shear punch severs the land and cuts an opening in the TEM sample holder form, and simultaneously the former rod presses the probe tip point or points into the sheet of material. The result is a TEM sample holder with probe-tip points embedded in it, ready for inspection in a TEM of samples attached to the probe-tip points.
摘要翻译：用于制备TEM样品保持器的试剂盒包括至少一种由一片材料制成的TEM试片，并且具有从其边缘到TEM样品保持器形式的一个或多个路径，其体现在TEM试片中。试样中至少有一个孔限定了TEM样品保持器形式的外边界。这个洞有一个口，定义了一块土地。该土地将TEM样品架形式连接到片材的边缘。套件优选地包括至少一个探针尖端，其中探针尖端具有探针尖端点，最后包括压力机。压机具有内模和外模以及与内模和外模对置的前杆。剪切冲头与前一个杆同轴设置。因此，当致动器向内模和外模驱动剪切冲头时，剪切冲压器切割焊盘并切割TEM样品保持器形式的开口，同时前者杆将探针尖端点或点压入材料片。结果是具有探针尖点的TEM样品架，嵌入其中，准备在附着于探针尖端的样品的TEM中进行检查。

44. 发明申请

US20060113475A1 TEM sample holder 有权
标题翻译： TEM样品架
公开(公告)号：US20060113475A1
公开(公告)日：2006-06-01
申请号：US11334927
申请日：2006-01-19
申请人： Thomas Moore
发明人： Thomas Moore
IPC分类号： G21K7/00
CPC分类号： H01J37/20 , H01J37/26 , H01J2237/31745 , Y10T29/49915 , Y10T29/49922 , Y10T29/5147
摘要： A TEM sample holder is formed by cutting the TEM sample holder form from a coupon in a press. The cutting at the same time joins the tip point of a nano-manipulator probe tip with the formed TEM sample holder. The tip point of the probe has a sample attached for inspection in a TEM. The cutting process also creates a gap in the sample holder to allow for FIB milling of the specimen.
摘要翻译：通过在压机中从试样中切割TEM样品保持器形式形成TEM样品保持器。同时切割将纳米机械手探针尖端的尖端与形成的TEM样品架连接。探针的尖端具有附着在TEM中检查的样品。切割过程也在样品架上产生间隙，以允许样品的FIB铣削。

45. 发明申请

US20060091325A1 Method and apparatus for the automated process of in-situ lift-out 有权
标题翻译：用于现场提升自动化过程的方法和装置
公开(公告)号：US20060091325A1
公开(公告)日：2006-05-04
申请号：US11265934
申请日：2005-11-03
申请人： Thomas Moore , Lyudmila Zaykova-Feldman
发明人： Thomas Moore , Lyudmila Zaykova-Feldman
IPC分类号： H01J37/08
CPC分类号： H01J37/302 , B82Y15/00 , G01N1/32 , H01J37/20 , H01J37/22 , H01J37/3056 , H01J2237/20 , H01J2237/202 , H01J2237/204 , H01J2237/206 , H01J2237/208 , H01J2237/2482 , H01J2237/28 , H01J2237/30411 , H01J2237/30472 , H01J2237/31745
摘要： An apparatus for performing automated in-situ lift-out of a sample from a specimen includes a computer having a memory with computer-readable instructions, a stage for a specimen and a nano-manipulator. The stage and the nano-manipulator are controlled by motion controllers connected to the computer. The nano-manipulator has a probe tip for attachment to samples excised from the specimen. The computer-readable instructions include instructions to cause the stage motion controllers and the nano-manipulator motion controllers, as well as an ion-beam source, to automatically perform in-situ lift-out of a sample from the specimen.
摘要翻译：用于从样本进行样品的自动原位提取的装置包括具有具有计算机可读指令的存储器的计算机，用于样本的台和纳米操纵器。舞台和纳米操纵器由连接到计算机的运动控制器控制。纳米操纵器具有用于附着到从样品切除的样品的探针尖端。计算机可读指令包括使载物台运动控制器和纳米操纵器运动控制器以及离子束源自动执行样品从样本的原位提取的指令。

46. 发明申请

US20060084911A1 Driveable catheter systems and methods 有权
标题翻译：可驱动的导管系统和方法
公开(公告)号：US20060084911A1
公开(公告)日：2006-04-20
申请号：US11254234
申请日：2005-10-18
申请人： W. Belef , John Ream , Thomas Moore , Steven Roe , Jeffrey Jones , Niyazi Beyhan , Arcadi Elbert
发明人： W. Belef , John Ream , Thomas Moore , Steven Roe , Jeffrey Jones , Niyazi Beyhan , Arcadi Elbert
IPC分类号： A61M31/00
CPC分类号： A61B8/12 , A61B1/0016 , A61B8/4209 , A61B8/4461 , A61B46/10 , A61M25/0113 , A61M2025/0008
摘要： The system (2) includes a catheter drive unit (22) and a catheter (24) extending therefrom movably mounted to a catheter drive sled (26). The catheter drive unit rotates and translates the catheter core (34) within the catheter sheath (36). The sled has a serrated, conical drive unit interface (82), with a bag-piercing tip (86) mateable with a translator drive output (92) so that a sterile drape (112) enclosing the catheter drive unit is automatically pierced when the catheter drive unit is mounted to the sled. A control unit (6) is spaced apart from the catheter drive unit and provides power and commands to the catheter drive unit and receives information and data from the catheter drive unit. The rotator and translator drive motors (54, 90) are operated from both the control unit and the catheter drive unit. Both the control unit and catheter drive unit have translation displacement displays (10, 30).
摘要翻译：系统（2）包括导管驱动单元（22）和从其可移动地安装到导管驱动滑架（26）上的导管（24）。导管驱动单元旋转并平移导管芯（34）在导管套（36）内。滑板具有锯齿状的锥形驱动单元接口（82），具有与翻译器驱动输出（92）配合的穿刺尖端（86），使得当包括导管驱动单元的无菌悬垂（112）自动穿透时导管驱动单元安装在滑轨上。控制单元（6）与导管驱动单元间隔开，并向导管驱动单元提供电力和命令，并从导管驱动单元接收信息和数据。旋转器和转换器驱动马达（54,90）从控制单元和导管驱动单元两者操作。控制单元和导管驱动单元都具有平移位移显示器（10,30）。

47. 发明申请

US20060022136A1 Multiple gas injection system for charged particle beam instruments 审中-公开
标题翻译：多重气体注入系统用于带电粒子束仪器
公开(公告)号：US20060022136A1
公开(公告)日：2006-02-02
申请号：US11186706
申请日：2005-07-21
申请人： Thomas Moore
发明人： Thomas Moore
IPC分类号： G21K7/00
CPC分类号： H01J37/3178 , G21K7/00 , H01J37/3056 , H01J2237/006 , H01J2237/30411 , H01J2237/30455 , H01J2237/31 , H01J2237/31744
摘要： We disclose a gas injection system having at least one crucible, each crucible holding at least one deposition constituent; at least one transfer tube, the number of transfer tubes corresponding to the number of crucibles, each transfer tube being connected to a corresponding crucible. There is at least one metering valve, the number of metering valves corresponding to the number of transfer tubes, each metering valve being connected to a corresponding transfer tube so that the metering valve can measure and adjust vapor flow in the corresponding transfer tube. A sensor is provided capable of sensing reactions between deposition constituents and a focused ion beam A computer is connected to receive the output of the sensor; the computer is also connected to each metering valve to control the operation of the valve, and the computer is programmed to send control signals to each metering valve to control the operation of the valve; the control signals being computed responsive to feedback from the output of the sensor.
摘要翻译：我们公开了具有至少一个坩埚的气体注入系统，每个坩埚保持至少一个沉积成分; 至少一个传送管，传送管的数量对应于坩埚的数量，每个传送管连接到相应的坩埚。存在至少一个计量阀，计量阀的数量对应于转移管的数量，每个计量阀连接到相应的转移管，使得计量阀可以测量和调节相应的转移管中的蒸气流。提供能够感测沉积成分和聚焦离子束之间的反应的传感器。计算机被连接以接收传感器的输出; 计算机还连接到每个计量阀以控制阀的操作，并且计算机被编程为向每个计量阀发送控制信号以控制阀的操作; 响应于来自传感器的输出的反馈来计算控制信号。

48. 发明申请

US20050029830A1 Flip seat arrangement having upper seat back pivot 有权
标题翻译：翻转座椅布置具有上座椅靠背枢轴
公开(公告)号：US20050029830A1
公开(公告)日：2005-02-10
申请号：US10942241
申请日：2004-09-16
申请人： Kenneth Mack , Thomas Moore , Russell Fielding
发明人： Kenneth Mack , Thomas Moore , Russell Fielding
IPC分类号： B60J7/16 , B60N2/30 , B60N2/36 , B60P3/42 , B60R3/02 , B62D33/00
CPC分类号： B60R3/02 , B60N2/3015 , B60N2/305 , B60N2/36 , B60P3/423
摘要： A rear seat assembly of a passenger cabin of a pick-up truck includes a rear seat cushion and a rear seat back, each rotatable such that a bottom surface of the rotated rear seat back can rest upon a rear end of the rotated seat cushion to provide a storage space beneath the rotated seat back and between the rotated seat cushion and a rear wall of the passenger cabin. The cargo bed of the truck may be extended into the storage space by providing an access door thereto in a front wall of the cargo bed in communication with a corresponding opening in the rear wall of the passenger cabin.
摘要翻译：拾起车的客舱的后排座椅组件包括后座垫和后座椅靠背，每个后座椅靠背可旋转，使得旋转的后座椅靠背的底面能够靠在旋转的座垫的后端，在旋转的座椅靠背之下和旋转的座垫与客舱的后壁之间提供储存空间。叉车的货物床可以通过在货舱的前壁中提供通道门而与客舱的后壁中相应的开口连通地延伸到储存空间中。

49. 发明申请

US20050029829A1 Convertible cover arrangement for vehicle cargo area 有权
标题翻译：车辆货物区可转换盖板布置
公开(公告)号：US20050029829A1
公开(公告)日：2005-02-10
申请号：US10942261
申请日：2004-09-16
申请人： Kenneth Mack , Thomas Moore , Russell Fielding
发明人： Kenneth Mack , Thomas Moore , Russell Fielding
IPC分类号： B60J7/16 , B60N2/30 , B60N2/36 , B60P3/42 , B60R3/02 , B62D33/04
CPC分类号： B60J7/1621 , B60J7/1614 , B60N2/3015 , B60N2/36 , B60P3/423 , B60R3/02
摘要： A convertible cargo bed cover can function as both a tonneau cover and a cargo bed cap. The cover is raised by motorized elements to be substantially aligned with a roof of a passenger cabin of the vehicle. Side and rear window panels stored inside the cover can be installed to transform the cover to a cap to enlarge available enclosed cargo space. Rear pillars are installed at the rear corners of the tonneau cover in its raised position to complete the installation.
摘要翻译：可转换的货物舱盖可用作吨位盖和货舱盖。盖子被电动元件抬起以与车辆的客舱的车顶大致对准。可以安装储存在盖子内的侧面和后部窗户面板，以将盖子转换成盖子，以扩大可用的封闭货物空间。后柱安装在吨位盖的后角处于升高位置，以完成安装。

50. 发明授权

US06698470B1 Method and device for collecting fractions after material separation 失效
$Method and device for collecting fractions after material separation$
标题翻译：材料分离后收集馏分的方法和装置
公开(公告)号：US06698470B1
公开(公告)日：2004-03-02
申请号：US10169449
申请日：2002-07-01
申请人： Anton Horn , Stefan Kreusch , Thomas Moore , Guenther Sammler , Guenter Ditze
发明人： Anton Horn , Stefan Kreusch , Thomas Moore , Guenther Sammler , Guenter Ditze
IPC分类号： G01N100
CPC分类号： G01N35/1079 , B01L3/50853
摘要： An airbag cover is defined by a predetermined breaking line which is introduced into a shaped flat material in a recessed manner. The recesses are achieved by removing material by means of laser radiation. According to the invention, the flat material is provided with a barrier layer. The barrier layer, by reason of its material properties, has greater resistance to removal of material by laser action than the material of the rest of the flat material. The recesses made by removing material extend along the predetermined breaking line in the flat material up to the barrier layer. The barrier layer makes it possible to produce a predetermined breaking line by means of laser machining which allows an exact residual wall thickness of the airbag cover in the area of the predetermined breaking line, so that the tearing strength can be adjusted very accurately, which is critically important for a reliable deployment of an airbag. Further, a method for the efficient production of an airbag cover of this type is indicated.
摘要翻译：安全气囊盖由预定的断裂线限定，其以凹进的方式被引入成形的平坦材料中。通过用激光辐射去除材料来实现凹陷。根据本发明，扁平材料设置有阻挡层。阻挡层由于其材料性质而具有比平坦材料的其余部分的材料更大的抗激光作用的材料去除。通过去除材料制成的凹槽沿着平坦材料中的预定断裂线延伸直到阻挡层。阻挡层可以通过激光加工来制造预定的断裂线，这允许安全气囊盖在预定断裂区域的区域中的准确的残留壁厚，从而可以非常精确地调节撕裂强度，即对于安全气囊的可靠部署至关重要。此外，示出了用于有效地生产这种类型的安全气囊盖的方法。

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