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41. 发明申请

US20090204063A1 GI Lead Implantation 有权
标题翻译： GI铅植入
公开(公告)号：US20090204063A1
公开(公告)日：2009-08-13
申请号：US11915647
申请日：2006-06-04
申请人： Shai Policker , David Prutchi , Ophir Bitton , Benny Rousso , Offer Glasberg , Yuval Mika , Tami Harel , Walid Haddad , Lena Milman
发明人： Shai Policker , David Prutchi , Ophir Bitton , Benny Rousso , Offer Glasberg , Yuval Mika , Tami Harel , Walid Haddad , Lena Milman
IPC分类号： A61N1/05 , A61M13/00
CPC分类号： A61N1/36007 , A61B1/00016 , A61B1/00147 , A61B1/2736 , A61B5/073 , A61B5/076 , A61B5/42 , A61B5/6882 , A61B17/3468 , A61B2017/00221 , A61B2017/00292 , A61B2017/00296 , A61B2017/00411 , A61N1/05 , A61N1/0507 , A61N1/37205 , A61N1/37247 , A61N1/37252 , A61N1/375
摘要： A method is provided, including physically contacting a gastric implantation site of a stomach via a transluminal approach, physically contacting the site via a transabdominal approach, stabilizing the site, and implanting an electrode at the site based on the physical contact provided by the transluminal and transabdominal approach. Other embodiments are also described.
摘要翻译：提供了一种方法，包括通过经腔途径物理接触胃的胃注入部位，通过经腹途径物理接触部位，稳定部位，并根据由腔内提供的物理接触在该部位植入电极，以及经腹手术还描述了其它实施例。

42. 发明授权

US08706230B2 Implantable lead connector 有权
标题翻译：可植入导线连接器
公开(公告)号：US08706230B2
公开(公告)日：2014-04-22
申请号：US13265874
申请日：2010-04-23
申请人： Benny Rousso , Yuval Mika , Shlomo Ben-Haim , Daniel Burkhoff , David Prutchi
发明人： Benny Rousso , Yuval Mika , Shlomo Ben-Haim , Daniel Burkhoff , David Prutchi
IPC分类号： A61N1/372 , A61N1/08
CPC分类号： A61N1/025 , A61N1/05 , A61N1/08 , A61N1/362 , A61N1/372 , A61N1/3752 , A61N1/378 , A61N1/3785 , A61N1/3962
摘要： An implantable lead connector configured for long term implantation and to electrically interconnect multiple medical devices and to channel electrical signals between said interconnected devices and a target organ, comprising: a first port adapted to receive a first signal suitable to stimulate a target tissue, a second port adapted to receive a second signal suitable to stimulate a target tissue, and a third port configured to connect to a target organ, wherein at least one of said first and second ports is configured to connect to a signal generator not integrated with said connector.
摘要翻译：一种可植入引线连接器，其被配置为长期植入并且电连接多个医疗装置并且在所述互连装置与目标器官之间引导电信号，包括：第一端口，适于接收适于刺激靶组织的第一信号;第二端适于接收适合于刺激目标组织的第二信号的端口以及被配置为连接到目标器官的第三端口，其中所述第一和第二端口中的至少一个被配置为连接到未与所述连接器集成的信号发生器。

43. 发明申请

US20070156177A1 Blood glucose level control 审中-公开
标题翻译：血糖值控制
公开(公告)号：US20070156177A1
公开(公告)日：2007-07-05
申请号：US10570576
申请日：2006-12-27
申请人： Tami Harel , Shai Policker , Radwan Khawaled , Yuval Mika , Offer Glasberg , Aharon Grossman
发明人： Tami Harel , Shai Policker , Radwan Khawaled , Yuval Mika , Offer Glasberg , Aharon Grossman
IPC分类号： A61N1/39
CPC分类号： A61N1/32 , A61N1/05 , A61N1/36007
摘要： A method of glucose level control comprising, providing at least one electrode adapted to apply an electric field to a pancreas; and applying an electric field to the pancreas using said at least one electrode such that blood glucose levels are significantly reduced and blood insulin levels are not significantly increased compared to a regular insulin response in a same person.
摘要翻译：一种葡萄糖水平控制方法，包括：提供适于向胰腺施加电场的至少一个电极; 以及使用所述至少一个电极向胰腺施加电场，使得相对于同一人中的正常胰岛素反应，血糖水平显着降低，并且血胰岛素水平不显着增加。

44. 发明授权

US07195637B2 Method and device for inserting leads into coronary veins 有权
标题翻译：用于将引线插入冠状静脉的方法和装置
公开(公告)号：US07195637B2
公开(公告)日：2007-03-27
申请号：US10257722
申请日：2001-04-17
申请人： Yuval Mika
发明人： Yuval Mika
IPC分类号： A61B17/00
CPC分类号： A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： A method for inserting a lead into coronary veins of a patient. The method comprises providing a guide sheath that comprises a tube having a proximal portion and a distal portion; a lumen passing through said tube, said lumen is provided with a first opening in said proximal portion and a second opening in said distal portion, said lumen is adapted to allow the lead to pass through it; a balloon provided in said distal portion, said balloon is adapted to be inflated outwardly and circumferentially from said tube; a tubing fluidically connected to said balloon, said tubing extends from said balloon to said proximal portion. The method further comprises inserting the guide sheath into a coronary vein; inflating said balloon so as to prevent retrograde blood flow from the coronary vein; inserting the lead into the coronary vein through said lumen and placing it in a target location. When the balloon is inflated, retrograde blood flow from the coronary veins is prevented, the pressure in the coronary veins is increased and the coronary veins are enlarged allowing the lead to freely advance through them.
摘要翻译：将铅插入患者冠状静脉的方法。该方法包括提供一种引导护套，其包括具有近端部分和远端部分的管子; 通过所述管的内腔，所述内腔在所述近端部分设置有第一开口，在所述远端部分设置有第二开口，所述内腔适于允许引线通过; 设置在所述远端部分中的气囊，所述气囊适于从所述管向外并周向地膨胀; 流体连接到所述气囊的管道，所述管道从所述气囊延伸到所述近端部分。该方法还包括将导向鞘插入冠状静脉中; 充气气球以防止逆行血液从冠状静脉流出; 将引线通过所述内腔插入冠状静脉并将其放置在目标位置。当气囊膨胀时，防止来自冠状静脉的逆行血液流动，冠状静脉中的压力增加，并且冠状静脉扩大，使得引线自由前进通过它们。

45. 发明授权

US06597952B1 Apparatus and method for setting the parameters of an alert window used for timing the delivery of ETC signals to a heart under varying cardiac conditions 有权
标题翻译：用于设置用于在变化的心脏状况下将ETC信号传递到心脏的定时的警报窗口的参数的设备和方法
公开(公告)号：US06597952B1
公开(公告)日：2003-07-22
申请号：US09782347
申请日：2001-02-12
申请人： Yuval Mika , David Prutchi , Ziv Belsky , Andre G. Routh
发明人： Yuval Mika , David Prutchi , Ziv Belsky , Andre G. Routh
IPC分类号： A61N1362
CPC分类号： A61B5/0402 , A61B5/7203 , A61N1/3622 , A61N1/3627 , A61N1/3962 , H01L21/568 , H01L21/6835 , H01L23/3107 , H01L2924/0002 , H01L2924/00
摘要： A method for setting the parameters of an alert time window in an excitable tissue control device operative under a plurality of different cardiac conditions of a heart of a patient. The method includes providing said excitable tissue control device with a set of data including a plurality of sets of alert time window parameters. Each set of window parameters is uniquely associated with a different set of values of a plurality of cardiac condition defining parameters identifying one of the different cardiac conditions. Each set of window parameters includes at least a set of timing parameters usable for obtaining a beginning time point and an ending time point of the alert window. The sets of window parameters are obtained by processing data collected within a data collection session from a plurality of cardiac beats of the same patient under the different cardiac conditions.
摘要翻译：一种用于在可患者组织控制装置中的警报时间窗口的参数设置方法，所述可激发组织控制装置在患者的心脏的多个不同心脏状态下工作。该方法包括向所述可兴奋的组织控制装置提供包括多组警报时间窗参数的一组数据。每套窗口参数与识别不同心脏状况之一的多个心脏病状定义参数的不同的值集合唯一地相关联。每组窗口参数包括至少一组可用于获得警报窗口的开始时间点和结束时间点的定时参数。窗口参数的集合通过在不同的心脏状况下处理来自同一患者的多个心跳的数据收集会话内收集的数据来获得。

46. 发明授权

US09931503B2 Protein activity modification 有权
公开(公告)号：US09931503B2
公开(公告)日：2018-04-03
申请号：US11792811
申请日：2005-12-09
申请人： Benny Rousso , Yuval Mika , Hani N. Sabbah , Shlomo Ben-Haim
发明人： Benny Rousso , Yuval Mika , Hani N. Sabbah , Shlomo Ben-Haim
IPC分类号： A61N1/32 , A61N1/20 , C12N13/00
CPC分类号： A61N1/32 , A61N1/205 , A61N1/326 , C12N13/00
摘要： A method of modifying cardiac tissue behavior, comprising applying a therapeutically effective electric field having an effect of modifying protein activation levels of at least one protein, and repeatedly applying the field at time intervals timed to increase the activation levels of the at least one protein beyond an activation level achieved by natural and/or paced excitation of the muscle without the application, to an extent about at least as high as a decay of the activation between applications of the field.

47. 发明授权

US07187970B2 Excitable tissue control signal delivery to the right ventricular septum 有权
标题翻译：可兴奋的组织控制信号传递到右心室隔膜
公开(公告)号：US07187970B2
公开(公告)日：2007-03-06
申请号：US10672385
申请日：2003-09-26
申请人： Itsik Shemer , Yuval Mika
发明人： Itsik Shemer , Yuval Mika
IPC分类号： A61N1/00 , A61N1/362
CPC分类号： A61N1/36514 , A61B5/0215 , A61B5/029 , A61B5/0422 , A61B5/145 , A61B5/6843 , A61B5/6852 , A61B5/6853 , A61B5/6856 , A61B5/6858 , A61B5/6859 , A61B18/20 , A61B2017/00243 , A61B2017/00247 , A61B2017/0243 , A61B2018/00392 , A61N1/056 , A61N1/3627 , A61N1/3628 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36585 , A61N1/3684
摘要： Apparatus for applying a signal to a heart of a human subject is provided. The apparatus includes a set of one or more electrodes, adapted to be coupled to the right ventricular septum of the heart. A control unit of the apparatus is adapted to drive the electrode set to apply an Excitable-Tissue Control (ETC) signal to the septum. Preferably, the control unit is adapted to configure the signal to be capable of modifying contractility of a portion of the heart.
摘要翻译：提供了将信号施加到人类对象的心脏的装置。该装置包括一组适于与心脏的右心室隔膜联接的一个或多个电极。该装置的控制单元适于驱动电极组以向隔膜施加可激发组织控制（ETC）信号。优选地，控制单元适于将信号配置为能够改变心脏的一部分的收缩性。

48. 发明授权

US06522904B1 Bipolar sensor for muscle tissue action potential duration estimation 有权
标题翻译：用于肌肉组织动作电位持续时间估计的双极传感器
公开(公告)号：US06522904B1
公开(公告)日：2003-02-18
申请号：US09280486
申请日：1999-03-30
申请人： Yuval Mika , David Prutchi
发明人： Yuval Mika , David Prutchi
IPC分类号： A61B504
CPC分类号： A61B5/0492
摘要： A bipolar sensor for muscle tissue action potential duration estimation, in accordance with a preferred embodiment of the present invention, comprising two electrodes exposed at the distal end of an electrode lead. The electrodes at said distal end are kept at a very close proximity, and the sensor is electrically connected to a processing means for processing the signal detected by the sensor. Another prefered embodiment of the bipolar sensor for muscle tissue action potential duration estimation comprises two electrodes positioned at a side wall of an electrode lead, wherein said electrodes are kept at a very close proximity, and wherein said sensor is electrically connected to a processing means for processing the signal detected by the sensor.
摘要翻译：根据本发明的优选实施例的用于肌肉组织动作电位持续时间估计的双极传感器，包括在电极引线的远端处暴露的两个电极。所述远端处的电极保持非常接近，并且传感器电连接到用于处理由传感器检测到的信号的处理装置。用于肌肉组织动作电位持续时间估计的双极传感器的另一个优选实施例包括两个电极位于电极引线的侧壁处，其中所述电极保持非常接近，并且其中所述传感器电连接到用于处理由传感器检测到的信号的处理装置。

49. 发明授权

US06480737B1 Field delivery safety system using detection of atypical ECG 有权
标题翻译：现场交付安全系统使用非典型心电图检测
公开(公告)号：US06480737B1
公开(公告)日：2002-11-12
申请号：US09914547
申请日：2001-08-28
申请人： Shai Policker , Yuval Mika , David Prutchi , Itzhak Shemer
发明人： Shai Policker , Yuval Mika , David Prutchi , Itzhak Shemer
IPC分类号： A61N100
CPC分类号： A61N1/40 , A61N1/32 , A61N1/3622 , A61N1/368
摘要： Apparatus for applying a non-excitatory signal to a heart, comprising: at least one electrode, a power source, a wide-field ECG sensor that receives a wide-field ECG signal containing contributions from non-local sized portions of the heart, a controller for selectively electrifying said at least one electrode with a non-excitatory signal from said power source, and a safety filter that inhibits said electrifying responsive to said wide-field ECG signal.
摘要翻译：用于向心脏施加非兴奋性信号的装置，包括：至少一个电极，电源，宽场ECG传感器，其接收包含来自心脏的非局部大小部分的贡献的宽视场ECG信号，控制器，用于使用来自所述电源的非兴奋性信号选择性地带电所述至少一个电极;以及安全滤波器，其响应于所述宽场ECG信号禁止所述通电。

50. 发明授权

US06370430B1 Apparatus and method for controlling the delivery of non-excitatory cardiac contractility modulating signals to a heart 有权
标题翻译：用于控制向心脏递送非兴奋性心脏收缩调节信号的装置和方法
公开(公告)号：US06370430B1
公开(公告)日：2002-04-09
申请号：US09572482
申请日：2000-05-16
申请人： Yuval Mika , Ziv Belsky
发明人： Yuval Mika , Ziv Belsky
IPC分类号： A61N136
CPC分类号： A61N1/3962 , A61B5/0452 , A61B5/7217 , A61B5/7264 , A61N1/3627 , A61N1/365 , A61N1/368
摘要： A method and device for controlling the delivery of cardiac contractility modulating signals to the heart are disclosed. The method includes applying electrodes to a heart, sensing electrical activity in a first cardiac chamber and in at least a second cardiac chamber to detect events within a cardiac beat cycle and applying a cardiac contractility modulating signal to the heart at or about the first cardiac chamber in response to detecting an event within an alert window time interval. The applying of the cardiac contractility modulating signal is inhibited in response to detecting one or more inhibitory events occurring within specific time intervals defined within a current beat cycle. The method also includes the ignoring of events associated with expected electrical artifact signals if they occur within the duration of specified time intervals, to increase the therapy efficacy. The artifact signals may be associated with pacing of a cardiac chamber or with detected far field sensed electrical artifacts due to intrinsic chamber activation. The timing of the various time intervals and of the cardiac contractility signal may be computed on a beat by beat basis by utilizing a plurality of parameter sets stored in the device and the timing of events detected in each beat cycle. A method for determining and setting the parameter sets in a test session is disclosed.
摘要翻译：公开了一种用于控制心脏收缩力调节信号传送到心脏的方法和装置。该方法包括将电极施加到心脏，感测第一心室和第二心室中的电活动，以检测心搏周期内的事件，并将心脏收缩调节信号施加于第一心室或其周围的心脏响应于检测到警报窗口时间间隔内的事件。响应于检测在当前搏动周期内定义的特定时间间隔内发生的一个或多个抑制事件，抑制心肌收缩调节信号的应用。该方法还包括忽略与预期的电假象信号相关联的事件，如果它们在指定时间间隔的持续时间内发生，以增加治疗功效。神经信号可能与心室的起搏相关联，或与由于内腔活化而被检测到的远场感测到的电假象有关。可以通过利用存储在设备中的多个参数集和在每个拍子周期中检测到的事件的定时，以搏动为基础计算各种时间间隔和心脏收缩信号的定时。公开了一种在测试会话中确定和设置参数集的方法。

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