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1. 发明授权

US08301256B2 GI lead implantation 有权
标题翻译： GI导联植入
公开(公告)号：US08301256B2
公开(公告)日：2012-10-30
申请号：US11915647
申请日：2006-06-04
申请人： Shai Policker , David Prutchi , Ophir Bitton , Benny Rousso , Offer Glasberg , Yuval Mika , Tami Harel , Walid Haddad , Lena Milman
发明人： Shai Policker , David Prutchi , Ophir Bitton , Benny Rousso , Offer Glasberg , Yuval Mika , Tami Harel , Walid Haddad , Lena Milman
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61B1/00016 , A61B1/00147 , A61B1/2736 , A61B5/073 , A61B5/076 , A61B5/42 , A61B5/6882 , A61B17/3468 , A61B2017/00221 , A61B2017/00292 , A61B2017/00296 , A61B2017/00411 , A61N1/05 , A61N1/0507 , A61N1/37205 , A61N1/37247 , A61N1/37252 , A61N1/375
摘要： A method is provided, including physically contacting a gastric implantation site of a stomach via a transluminal approach, physically contacting the site via a transabdominal approach, stabilizing the site, and implanting an electrode at the site based on the physical contact provided by the transluminal and transabdominal approach. Other embodiments are also described.
摘要翻译：提供了一种方法，包括通过经腔途径物理接触胃的胃注入部位，通过经腹途径物理接触部位，稳定部位，并根据由腔内提供的物理接触在该部位植入电极，以及经腹手术还描述了其它实施例。

2. 发明授权

US08406864B2 Assessing cardiac activity 有权
标题翻译：评估心脏活动
公开(公告)号：US08406864B2
公开(公告)日：2013-03-26
申请号：US12223651
申请日：2007-02-04
申请人： Benny Rousso , Eyal Lebanony , David Prutchi , Ophir Bitton
发明人： Benny Rousso , Eyal Lebanony , David Prutchi , Ophir Bitton
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/3625 , A61N1/36514 , A61N1/36521 , A61N1/36564
摘要： A method of assessing contractility of a cardiac muscle which has at least one activation parameter, the method comprising: (a) utilizing time correlated data pertaining to at least one activation parameter to produce a profile of said parameter; (b) identifying from measurement of said at least one parameter a time interval during which interference from an artificial signal occurs; (c) ameliorating effects of said interference; and (d) analyzing changes in said profile to generate an indication of contractility, as a function of time to generate a cardiac activation profile.
摘要翻译：一种评估具有至少一个激活参数的心肌的收缩力的方法，所述方法包括：（a）利用与至少一个激活参数相关的时间相关数据以产生所述参数的轮廓; （b）从所述至少一个参数的测量中识别发生来自人造信号的干扰的时间间隔; （c）改善所述干扰的影响; 以及（d）分析所述轮廓中的变化以产生收缩性的指示，作为产生心脏激活曲线的时间的函数。

3. 发明申请

US20090204063A1 GI Lead Implantation 有权
标题翻译： GI铅植入
公开(公告)号：US20090204063A1
公开(公告)日：2009-08-13
申请号：US11915647
申请日：2006-06-04
申请人： Shai Policker , David Prutchi , Ophir Bitton , Benny Rousso , Offer Glasberg , Yuval Mika , Tami Harel , Walid Haddad , Lena Milman
发明人： Shai Policker , David Prutchi , Ophir Bitton , Benny Rousso , Offer Glasberg , Yuval Mika , Tami Harel , Walid Haddad , Lena Milman
IPC分类号： A61N1/05 , A61M13/00
CPC分类号： A61N1/36007 , A61B1/00016 , A61B1/00147 , A61B1/2736 , A61B5/073 , A61B5/076 , A61B5/42 , A61B5/6882 , A61B17/3468 , A61B2017/00221 , A61B2017/00292 , A61B2017/00296 , A61B2017/00411 , A61N1/05 , A61N1/0507 , A61N1/37205 , A61N1/37247 , A61N1/37252 , A61N1/375
摘要： A method is provided, including physically contacting a gastric implantation site of a stomach via a transluminal approach, physically contacting the site via a transabdominal approach, stabilizing the site, and implanting an electrode at the site based on the physical contact provided by the transluminal and transabdominal approach. Other embodiments are also described.
摘要翻译：提供了一种方法，包括通过经腔途径物理接触胃的胃注入部位，通过经腹途径物理接触部位，稳定部位，并根据由腔内提供的物理接触在该部位植入电极，以及经腹手术还描述了其它实施例。

4. 发明申请

US20090030471A1 Assessing Cardiac Activity 有权
标题翻译：评估心脏活动
公开(公告)号：US20090030471A1
公开(公告)日：2009-01-29
申请号：US12223651
申请日：2007-02-04
申请人： Benny Rousso , Eyal Lebanony , David Prutchi , Ophir Bitton
发明人： Benny Rousso , Eyal Lebanony , David Prutchi , Ophir Bitton
IPC分类号： A61N1/08
CPC分类号： A61N1/3627 , A61N1/3625 , A61N1/36514 , A61N1/36521 , A61N1/36564
摘要： A method of assessing contractility of a cardiac muscle which has an activation parameter, the method comprising: (a) utilizing time correlated data pertaining to an activation parameter to produce a profile of said parameter; and (b) analyzing changes in said profile to generate an indication of contractility.
摘要翻译：一种评估具有激活参数的心肌的收缩力的方法，所述方法包括：（a）利用与激活参数有关的时间相关数据以产生所述参数的轮廓; 和（b）分析所述简档中的变化以产生收缩性的指示。

5. 发明申请

US20080065168A1 Ingestible Capsule For Appetite Regulation 有权
标题翻译：食欲调节胶囊
公开(公告)号：US20080065168A1
公开(公告)日：2008-03-13
申请号：US11566775
申请日：2006-12-05
申请人： Ophir Bitton , Shai Policker , Benny Rousso
发明人： Ophir Bitton , Shai Policker , Benny Rousso
IPC分类号： A61N1/05
CPC分类号： A61N1/36007 , A61N1/00 , A61N1/36082
摘要： A method is provided for treating a subject. The method includes administering to the subject an ingestible capsule containing one or more flexible support elements adapted to expand while in a stomach of the subject, thereby bringing a plurality of electrodes into contact with a wall of the stomach. The method also includes driving the electrodes to apply an electrical signal to the stomach wall at first and second times, the second time at last 24 hours after the first time. Other embodiments are also described.
摘要翻译：提供了一种治疗受试者的方法。该方法包括向受试者施用含有适于在受试者的胃中膨胀的一种或多种柔性支撑元件的可摄取胶囊，从而使多个电极与胃壁接触。该方法还包括驱动电极，以在第一次和第二次施加电信号到胃壁，第一次第二次最后24小时。还描述了其它实施例。

6. 发明授权

US07437195B2 Regulation of eating habits 有权
标题翻译：调节饮食习惯
公开(公告)号：US07437195B2
公开(公告)日：2008-10-14
申请号：US10250714
申请日：2002-01-03
申请人： Shai Policker , Ricardo Aviv , Ophir Bitton
发明人： Shai Policker , Ricardo Aviv , Ophir Bitton
IPC分类号： A61N1/00
CPC分类号： A61K49/0004 , A61N1/36007
摘要： A method for treating a subject is provided, including receiving a sensor signal responsive to the subject eating, analyzing the sensor signal, and driving a current into tissue of the subject responsive to analyzing the signal. The current is typically driven into muscle tissue of the subject's stomach (20). Preferably, receiving the sensor signal includes sensing electrical potential change generated responsive to contraction of a muscle such as a stomach muscle of the subject. In a preferred embodiment, the sensor signal is analyzed with respect to the timing of ingestion, and a level of compliance of the subject with a desired ingestion schedule is determined. As appropriate, a parameter of the current driven into the tissue may be configured such that the application of the current to the tissue induces in the subject a sensation of satiation, discomfort, nausea, or vertigo.
摘要翻译：提供了一种用于治疗受试者的方法，包括响应于所述受试者进食，分析所述传感器信号，并且响应于所述信号的分析而将电流驱动到所述对象的组织中。电流通常被驱动到受试者的胃的肌肉组织（20）中。优选地，接收传感器信号包括响应于诸如受试者的胃肌的肌肉收缩而产生的电位变化。在优选实施例中，相对于摄取的时间来分析传感器信号，并且确定受试者与期望摄取时间表的顺应性水平。适当地，驱动到组织中的电流的参数可以被配置为使得电流施加到组织会在受试者中引起饱腹感，不适感，恶心或眩晕感。

7. 发明授权

US08295932B2 Ingestible capsule for appetite regulation 有权
标题翻译：食欲调节胶囊
公开(公告)号：US08295932B2
公开(公告)日：2012-10-23
申请号：US11566775
申请日：2006-12-05
申请人： Ophir Bitton , Shai Policker , Benny Rousso
发明人： Ophir Bitton , Shai Policker , Benny Rousso
IPC分类号： A61N1/18
CPC分类号： A61N1/36007 , A61N1/00 , A61N1/36082
摘要： A method is provided for treating a subject. The method includes administering to the subject an ingestible capsule containing one or more flexible support elements adapted to expand while in a stomach of the subject, thereby bringing a plurality of electrodes into contact with a wall of the stomach. The method also includes driving the electrodes to apply an electrical signal to the stomach wall at first and second times, the second time at last 24 hours after the first time. Other embodiments are also described.
摘要翻译：提供了一种治疗受试者的方法。该方法包括向受试者施用含有适于在受试者的胃中膨胀的一种或多种柔性支撑元件的可摄取胶囊，从而使多个电极与胃壁接触。该方法还包括驱动电极，以在第一次和第二次施加电信号到胃壁，第一次第二次最后24小时。还描述了其它实施例。

8. 发明授权

US08265758B2 Wireless leads for gastrointestinal tract applications 有权
标题翻译：无线线路用于胃肠道应用
公开(公告)号：US08265758B2
公开(公告)日：2012-09-11
申请号：US11909501
申请日：2006-03-24
申请人： Shai Policker , David Prutchi , Ophir Bitton , Benny Rousso , Offer Glasberg
发明人： Shai Policker , David Prutchi , Ophir Bitton , Benny Rousso , Offer Glasberg
IPC分类号： A61N1/375
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/04884 , A61B5/053 , A61B5/0538 , A61B5/1107 , A61B5/14532 , A61B5/14539 , A61B5/42 , A61B5/6882 , A61B2560/0456 , A61N1/05 , A61N1/36007 , A61N1/37205 , A61N1/37247 , A61N1/37252 , A61N1/375 , A61N1/3756
摘要： Apparatus is provided, including a control unit (310), adapted to be implanted within a patient (324), and a corkscrew-shaped electrode mount (400), adapted to be implanted in a wall of a stomach of the patient. The corkscrew-shaped electrode mount includes first (404) and second (424) electrodes, at respective sites of the electrode mount, and a controller (420), wirelessly coupled to the control unit. Other embodiments are also described.
摘要翻译：提供了一种装置，包括适于植入患者体内的控制单元（310），以及适于植入患者胃的壁的开塞式电极座（400）。螺旋形电极安装件包括在电极安装件的相应位置处的第一（404）和第二（424）电极，以及无线地耦合到控制单元的控制器（420）。还描述了其它实施例。

9. 发明申请

US20100228105A1 Wireless Leads For Gastrointestinal Tract Applications 有权
标题翻译：无线线路用于胃肠道应用
公开(公告)号：US20100228105A1
公开(公告)日：2010-09-09
申请号：US11909501
申请日：2006-03-24
申请人： Shai Policker , David Prutchi , Ophir Bitton , Benny Rousso , Offer Glasberg
发明人： Shai Policker , David Prutchi , Ophir Bitton , Benny Rousso , Offer Glasberg
IPC分类号： A61B5/04 , A61B5/07 , A61B17/00
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/04884 , A61B5/053 , A61B5/0538 , A61B5/1107 , A61B5/14532 , A61B5/14539 , A61B5/42 , A61B5/6882 , A61B2560/0456 , A61N1/05 , A61N1/36007 , A61N1/37205 , A61N1/37247 , A61N1/37252 , A61N1/375 , A61N1/3756
摘要： Apparatus is provided, including a control unit (310), adapted to be implanted within a patient (324), and a corkscrew-shaped electrode mount (400), adapted to be implanted in a wall of a stomach of the patient. The corkscrew-shaped electrode mount includes first (404) and second (424) electrodes, at respective sites of the electrode mount, and a controller (420), wirelessly coupled to the control unit. Other embodiments are also described.
摘要翻译：提供了一种装置，包括适于植入患者体内的控制单元（310），以及适于植入患者胃的壁的开塞式电极座（400）。螺旋形电极安装件包括在电极安装件的相应位置处的第一（404）和第二（424）电极，以及无线地耦合到控制单元的控制器（420）。还描述了其它实施例。

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