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1. 发明授权

US09931503B2 Protein activity modification 有权
公开(公告)号：US09931503B2
公开(公告)日：2018-04-03
申请号：US11792811
申请日：2005-12-09
申请人： Benny Rousso , Yuval Mika , Hani N. Sabbah , Shlomo Ben-Haim
发明人： Benny Rousso , Yuval Mika , Hani N. Sabbah , Shlomo Ben-Haim
IPC分类号： A61N1/32 , A61N1/20 , C12N13/00
CPC分类号： A61N1/32 , A61N1/205 , A61N1/326 , C12N13/00
摘要： A method of modifying cardiac tissue behavior, comprising applying a therapeutically effective electric field having an effect of modifying protein activation levels of at least one protein, and repeatedly applying the field at time intervals timed to increase the activation levels of the at least one protein beyond an activation level achieved by natural and/or paced excitation of the muscle without the application, to an extent about at least as high as a decay of the activation between applications of the field.

2. 发明申请

US20100016923A1 Protein activity modification 有权
标题翻译：蛋白活性修饰
公开(公告)号：US20100016923A1
公开(公告)日：2010-01-21
申请号：US11919491
申请日：2006-05-04
申请人： Benny Rousso , Yuval Mika , Shlomo Ben-Haim , Hani N. Sabbah
发明人： Benny Rousso , Yuval Mika , Shlomo Ben-Haim , Hani N. Sabbah
IPC分类号： A61N1/36
CPC分类号： G01N33/6893 , A61N1/205 , A61N1/32 , A61N1/362 , A61N1/3627 , A61N2/004 , C12N13/00 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N2800/325
摘要： A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.
摘要翻译：一种改变组织行为的方法，包括：确定对疾病的治疗，组织行为的短期或长期改变，评估组织状态和评估对刺激的组织反应中的至少一种的组织行为的期望修饰; 选择具有改变至少一种蛋白质的蛋白质活性的预期效果的电场作为组织对场的直接反应，所述预期效果与所述期望的变化相关; 并将所述场应用于所述组织。

3. 发明授权

US08548583B2 Protein activity modification 有权
公开(公告)号：US08548583B2
公开(公告)日：2013-10-01
申请号：US11919491
申请日：2006-05-04
申请人： Benny Rousso , Yuval Mika , Shlomo Ben-Haim , Hani N. Sabbah
发明人： Benny Rousso , Yuval Mika , Shlomo Ben-Haim , Hani N. Sabbah
IPC分类号： A61N1/00
CPC分类号： G01N33/6893 , A61N1/205 , A61N1/32 , A61N1/362 , A61N1/3627 , A61N2/004 , C12N13/00 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N2800/325
摘要： A method of modifying tissue behavior, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and applying said field to said tissue.

4. 发明申请

US20090292324A1 Protein activity modification 有权
标题翻译：蛋白活性修饰
公开(公告)号：US20090292324A1
公开(公告)日：2009-11-26
申请号：US11792811
申请日：2005-12-09
申请人： Benny Rousso , Yuval Mika , Hani N. Sabbah , Shlomo Ben-Haim
发明人： Benny Rousso , Yuval Mika , Hani N. Sabbah , Shlomo Ben-Haim
IPC分类号： A61N1/32
CPC分类号： A61N1/32 , A61N1/205 , A61N1/326 , C12N13/00
摘要： A method of modifying tissue behavior, including cardiac tissue, comprising: determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation; selecting an electric field having a known effect of modifying protein activation levels of at least one protein as an immediate response of a tissue to the field, said known effect correlated with said desired modification; and applying said field to said tissue.
摘要翻译：一种改变组织行为（包括心脏组织）的方法，包括：确定对疾病的治疗，组织行为的短期或长期改变，评估组织状态和评估组织对刺激的反应中的至少一种的组织行为的期望修饰; 选择具有将至少一种蛋白质的蛋白激活水平修饰为具有已知作用的电场作为组织对场的直接反应，所述已知作用与所述期望的修饰相关; 并将所述场应用于所述组织。

5. 发明授权

US07840262B2 Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue 有权
标题翻译：用于传递电信号以修改心脏组织中的基因表达的装置和方法
公开(公告)号：US07840262B2
公开(公告)日：2010-11-23
申请号：US10549216
申请日：2004-03-10
申请人： Yuval Mika , Hani N. Sabbah , Walid Haddad , Benny Rousso
发明人： Yuval Mika , Hani N. Sabbah , Walid Haddad , Benny Rousso
IPC分类号： A61N1/00
CPC分类号： A61N1/0587 , A61N1/326 , A61N1/362 , A61N1/3627 , A61N1/36557
摘要： Method and apparatus (120) for modifying gene expression in cardiac muscle cells (110), by the application of electric fields.
摘要翻译：用于通过施加电场来修饰心肌细胞（110）中的基因表达的方法和装置（120）。

6. 发明申请

US20110093028A1 APPARATUS AND METHOD FOR DELIVERING ELECTRICAL SIGNALS TO MODIFY GENE EXPRESSION IN CARDIAC TISSUE 有权
标题翻译：用于传递电子信号以修改心脏组织中基因表达的装置和方法
公开(公告)号：US20110093028A1
公开(公告)日：2011-04-21
申请号：US12910943
申请日：2010-10-25
申请人： Yuval Mika , Hani N. Sabbah , Walid Haddad , Benny Rousso
发明人： Yuval Mika , Hani N. Sabbah , Walid Haddad , Benny Rousso
IPC分类号： A61N1/362
CPC分类号： A61N1/0587 , A61N1/326 , A61N1/362 , A61N1/3627 , A61N1/36557
摘要： The description above should not be construed as limiting the scope of the invention to the specific embodiments described, which are provided merely as examples or illustrations. The scope of the invention encompasses interchangeable substitutions that are known to or would be appreciated by those skilled in the art. Many other variations are possible. Thus, the scope of the invention should be determined by the appended claims and their legal equivalents, rather than by only the examples given above.
摘要翻译：上述描述不应被理解为将本发明的范围限制于所描述的具体实施例，仅仅作为示例或说明而提供。本发明的范围包括本领域技术人员已知或将要理解的可互换取代。许多其他变化是可能的。因此，本发明的范围应由所附权利要求及其合法等同物而不是仅仅是上面给出的实施例来确定。

7. 发明授权

US08326416B2 Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue 有权
标题翻译：用于传递电信号以修改心脏组织中的基因表达的装置和方法
公开(公告)号：US08326416B2
公开(公告)日：2012-12-04
申请号：US12910943
申请日：2010-10-25
申请人： Yuval Mika , Hani N. Sabbah , Walid Haddad , Benny Rousso
发明人： Yuval Mika , Hani N. Sabbah , Walid Haddad , Benny Rousso
IPC分类号： A61N1/362
CPC分类号： A61N1/0587 , A61N1/326 , A61N1/362 , A61N1/3627 , A61N1/36557
摘要： Method and apparatus for modifying gene expression in cardiac muscle cells, by the application of electric fields. In some embodiments, the modification provides treatment of heart failure. Optionally, the treatment also provides an immediate improvement in cardiac function.
摘要翻译：通过施加电场来改变心肌细胞中基因表达的方法和装置。在一些实施方案中，修饰提供心力衰竭的治疗。任选地，治疗也提供心脏功能的即时改善。

8. 发明授权

US08352031B2 Protein activity modification 有权
标题翻译：蛋白活性修饰
公开(公告)号：US08352031B2
公开(公告)日：2013-01-08
申请号：US11802685
申请日：2007-05-24
申请人： Benny Rousso , Hani N. Sabbah
发明人： Benny Rousso , Hani N. Sabbah
IPC分类号： A61N1/37
CPC分类号： A61N1/3621 , A61N1/3627
摘要： A method of treating a cardiac arrhythmia, comprising: determining a desired arrhythmia control; selecting an electric field having an expected effect of modifying protein activity of at least one protein as a response of a cardiac tissue to the field, said expected effect correlated with said desired arrhythmia control; and applying said field to said cardiac tissue.
摘要翻译：一种治疗心律失常的方法，包括：确定所需的心律失常对照; 选择具有将至少一种蛋白质的蛋白质活性改变为心脏组织的应答的预期效果的电场，所述预期效果与所述期望的心律失常控制相关; 以及将所述场应用于所述心脏组织。

9. 发明申请

US20130211182A1 Cardiac Patterning for Improving Diastolic Function 审中-公开
标题翻译：心脏图案改善舒张功能
公开(公告)号：US20130211182A1
公开(公告)日：2013-08-15
申请号：US13742322
申请日：2013-01-15
申请人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
发明人： Hani N. Sabbah , Randall J. Lee , Andrew G. Hinson
IPC分类号： A61F2/24
CPC分类号： A61F2/2478 , A61B17/00491 , A61B17/12022 , A61B17/12045 , A61B17/12122 , A61B17/12136 , A61B17/12181 , A61B17/12186 , A61B17/1219 , A61B2017/00243 , A61B2017/048 , A61B2017/1205 , A61B2017/12127 , A61F2/2481 , A61F2002/249 , A61F2250/0067 , A61L31/005
摘要： Cardiomyopathy may be treated by distributing a space-occupying diastole-assist agent within the myocardium or within the cardiac venous system in a pattern about one or more chambers of the heart, such that the space-modifying agent integrates into and thickens at least part of the cardiac wall about the chamber so as globally to reduce wall stress, stabilize or even reduce chamber size, and/or improve diastolic function. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function. Patterns of distribution of space-occupying agent within the myocardium for global resizing may also be used or augmented to treat localized conditions such as myocardial infarctions, overt aneurysm of the ventricular wall as typically forms in response to large transmural myocardial infarctions, and mitral regurgitation due to a noncompliant mitral valve. These techniques may also be used to treat localized conditions that may not yet have progressed to cardiomyopathy.
摘要翻译：心肌病可以通过以围绕心脏的一个或多个腔室的模式在心肌内或心脏静脉系统内分布空间占据舒张辅助剂来治疗，使得空间改变剂整合入并增稠至少部分围绕腔室的心脏壁，以便全局地减小壁应力，稳定或甚至减小腔室尺寸，和/或改善舒张功能。一些模式也引起了对室的有益的全局整形。这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。用于全局调整大小的心肌内的空间占位剂的分布模式也可以被使用或增加以治疗局部的情况，例如心肌梗死，通常形成响应于大的透壁性心肌梗死的心室壁的明显的动脉瘤和二尖瓣反流到不合规的二尖瓣。这些技术也可用于治疗可能尚未进展为心肌病的局部病症。

10. 发明授权

US08419711B2 Cardiac repair, resizing and reshaping using the venous system of the heart 有权
标题翻译：心脏修复，使用心脏静脉系统调整大小和整形
公开(公告)号：US08419711B2
公开(公告)日：2013-04-16
申请号：US12972186
申请日：2010-12-17
申请人： Hani N. Sabbah
发明人： Hani N. Sabbah
IPC分类号： A61M31/00
CPC分类号： A61F2/2478 , A61B17/00491 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B2017/00243 , A61B2017/048 , A61B2017/1205 , A61B2017/12127 , A61F2/2451 , A61F2002/30583 , A61F2210/0085
摘要： Structurally supportive material is implanted or injected into cardiac veins as discrete masses at various sites in the cardiac venous system to reinforce the myocardium for the purpose of preventing, moderating, stopping or reversing negative cardiac remodeling due to various adverse cardiac conditions, both acute and chronic, or for the purpose of treating localize anomalies of the heart, or for both purposes. The sites may be arranged in a pattern about one or more chambers of the heart such that the masses cooperatively reduce stress in the chamber wall and reduce chamber size. Some patterns also cause a beneficial global reshaping of the chamber. These changes occur quickly and are sustainable, and have a rapid and sustainable therapeutic effect on cardiac function.
摘要翻译：将结构支持材料植入或注入心静脉中作为心脏静脉系统各个部位的离散质量，以加强心肌，以预防，调节，停止或逆转由于各种不良心脏病，包括急性和慢性心脏重构，或用于治疗心脏的局部异常或两者的目的。这些部位可以以围绕心脏的一个或多个腔室的图案布置，使得该质量协调地减小腔室壁中的应力并减小腔室尺寸。一些模式也引起了对室的有益的全局整形。这些变化迅速发生并且是可持续的，并且对心脏功能具有快速和可持续的治疗作用。

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