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1. 发明授权

US09713723B2 Signal delivery through the right ventricular septum 有权
公开(公告)号：US09713723B2
公开(公告)日：2017-07-25
申请号：US11673812
申请日：2007-02-12
申请人： Itzhak Shemer , Yuval Mika , Benny Rousso
发明人： Itzhak Shemer , Yuval Mika , Benny Rousso
IPC分类号： A61N1/362 , A61N1/368 , A61N1/32 , A61N1/365
CPC分类号： A61N1/3627 , A61N1/32 , A61N1/36542 , A61N1/36557 , A61N1/36564 , A61N1/36585 , A61N1/368
摘要： A method is provided for use with a human subject. The method includes accessing a cardiac site via a vena cava of the subject, and alleviating heart failure of the subject by applying to the cardiac site, during a refractory period of the site, a refractory-period signal that affects the left ventricle of the subject's heart. Other embodiments are also described.

2. 发明授权

US08321013B2 Electrical muscle controller and pacing with hemodynamic enhancement 有权
标题翻译：电子肌肉控制器和起搏与血液动力学增强
公开(公告)号：US08321013B2
公开(公告)日：2012-11-27
申请号：US11933168
申请日：2007-10-31
申请人： Nissim Darvish , Bella Felsen , Itzhak Shemer , Judith Kornfeld , Shlomo Ben-Haim , Maier Fenster , Yuval Mika
发明人： Nissim Darvish , Bella Felsen , Itzhak Shemer , Judith Kornfeld , Shlomo Ben-Haim , Maier Fenster , Yuval Mika
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/05 , A61N1/0587 , A61N1/36514 , A61N1/36564
摘要： A method of modifying the force of contraction of at least a portion of a heart chamber is provided. A non-excitatory electric field of given duration is applied, at a delay after an activation of the heart, which increase the force of contraction by at least 5%. Apparatus is also provided for pacing with hemodynamic improvement. Circuitry applies an extended pacing signal to electrodes to pace the heart, the extended pacing signal having an overall duration greater than 8 ms from a time of initiation of application of that portion of the signal that initiates action potential propagation. The signal includes a train of biphasic pulses having pulse durations of at least 1 ms, and the signal has an amplitude that is at least three times as great as a threshold for pacing the heart and that is sufficient neither for cardioversion nor for defibrillation. Other embodiments are also described.
摘要翻译：提供了改变心室的至少一部分的收缩力的方法。给予持续时间的非兴奋性电场在心脏激活后延迟施加，其将收缩力增加至少5％。还提供了用于具有血液动力学改善的起搏的装置。电路将扩展的起搏信号施加到电极以对心脏进行调节，所述扩展起搏信号的总持续时间大于从启动动作电位传播的信号部分开始施加的时间大于8ms。该信号包括具有至少1ms的脉冲持续时间的两列脉冲，并且该信号具有至少三倍于起搏心脏阈值的幅度，并且既不适用于心脏复律也不适用于除颤。还描述了其它实施例。

3. 发明授权

US07310555B2 Regulation of excitable tissue control of the heart based on physiological input 有权
标题翻译：基于生理投入调节心脏的兴奋性组织控制
公开(公告)号：US07310555B2
公开(公告)日：2007-12-18
申请号：US10800169
申请日：2004-03-10
申请人： Shlomo Ben-Haim , Nissim Darvish , Itzhak Shemer , Yehuda Snir
发明人： Shlomo Ben-Haim , Nissim Darvish , Itzhak Shemer , Yehuda Snir
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/362 , A61N1/36542 , A61N1/36585
摘要： A method and apparatus (30) for modifying contractility of the heart of a patient. The method includes receiving signals from a sensor (22, 23, 46) coupled to the body of the patient indicative of physiological activity. The signals are analyzed to derive a measure of the physiological activity, and excitable tissue control (ETC) stimulation is applied to the heart (20) so as to enhance contractility of the heart muscle responsive to the measure.
摘要翻译：一种用于改变患者心脏的收缩性的方法和装置（30）。该方法包括从耦合到指示生理活动的患者身体的传感器（22,23,46）接收信号。分析信号以产生生理活动的度量，并且将可激发的组织控制（ETC）刺激应用于心脏（20），以便响应于该测量来增强心肌的收缩性。

4. 发明授权

US06725093B1 Regulation of excitable tissue control of the heart based on physiological input 有权
标题翻译：基于生理投入调节心脏的兴奋性组织控制
公开(公告)号：US06725093B1
公开(公告)日：2004-04-20
申请号：US09831100
申请日：2001-09-10
申请人： Shlomo Ben-Haim , Nissim Darvish , Itzhak Shemer , Yehuda Snir
发明人： Shlomo Ben-Haim , Nissim Darvish , Itzhak Shemer , Yehuda Snir
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/362 , A61N1/36542 , A61N1/36585
摘要： A method and apparatus (30) for modifying contractility of the heart of a patient. The method includes receiving signals from a sensor (22, 23, 46) coupled to the body of the patient indicative of physiological activity. The signals are analyzed to derive a measure of the physiological activity, and excitable tissue control (ETC) stimulation is applied to the heart (20) so as to enhance contractility of the heart muscle responsive to the measure.
摘要翻译：一种用于改变患者心脏的收缩性的方法和装置（30）。该方法包括从耦合到指示生理活动的患者身体的传感器（22,23,46）接收信号。分析信号以产生生理活动的度量，并且将可激发的组织控制（ETC）刺激应用于心脏（20），以便响应于该测量来增强心肌的收缩性。

5. 发明授权

US06480737B1 Field delivery safety system using detection of atypical ECG 有权
标题翻译：现场交付安全系统使用非典型心电图检测
公开(公告)号：US06480737B1
公开(公告)日：2002-11-12
申请号：US09914547
申请日：2001-08-28
申请人： Shai Policker , Yuval Mika , David Prutchi , Itzhak Shemer
发明人： Shai Policker , Yuval Mika , David Prutchi , Itzhak Shemer
IPC分类号： A61N100
CPC分类号： A61N1/40 , A61N1/32 , A61N1/3622 , A61N1/368
摘要： Apparatus for applying a non-excitatory signal to a heart, comprising: at least one electrode, a power source, a wide-field ECG sensor that receives a wide-field ECG signal containing contributions from non-local sized portions of the heart, a controller for selectively electrifying said at least one electrode with a non-excitatory signal from said power source, and a safety filter that inhibits said electrifying responsive to said wide-field ECG signal.
摘要翻译：用于向心脏施加非兴奋性信号的装置，包括：至少一个电极，电源，宽场ECG传感器，其接收包含来自心脏的非局部大小部分的贡献的宽视场ECG信号，控制器，用于使用来自所述电源的非兴奋性信号选择性地带电所述至少一个电极;以及安全滤波器，其响应于所述宽场ECG信号禁止所述通电。

6. 发明授权

US07953481B1 Anti-arrhythmic device and a method of delivering anti-arrhythmic cardiac therapy 有权
标题翻译：抗心律失常装置和一种递送抗心律失常心脏治疗的方法
公开(公告)号：US07953481B1
公开(公告)日：2011-05-31
申请号：US10111512
申请日：2000-10-25
申请人： Itzhak Shemer , Shay Policker , Ziv Belsky , Edward Haluska
发明人： Itzhak Shemer , Shay Policker , Ziv Belsky , Edward Haluska
IPC分类号： A61N1/365
CPC分类号： A61N1/39 , A61N1/3621 , A61N1/3627 , A61N1/3956
摘要： A cardiac contractility modulating (CCM) device (30) includes an anti-arrhythmic therapy unit (38) for detecting a cardiac arrhythmia in a heart (2) of a patient based on processing electrical signals related to cardiac activity sensed at the heart, and for delivering anti-arrhythmic therapy to the heart. The device includes a cardiac contractility modulating (CCM) unit (40) capable of delivering cardiac contractility modulating (CCM) signals to the heart for modulating the contractility of a portion of the heart. The device (30) includes a power source (165). The device may be an implantable device or a non-implantable device. A method for delivering anti-arrhythmic therapy to a heart. The method includes applying one or more non-excitatory cardiac contractility modulating electrical signals to said heart.
摘要翻译：心脏收缩力调节（CCM）装置（30）包括抗心律失常治疗单元（38），用于基于处理与心脏感测到的心脏活动相关的电信号来检测患者心脏（2）中的心律不齐，以及用于向心脏递送抗心律失常药物。该装置包括能够向心脏递送心脏收缩调节（CCM）信号以调节一部分心脏的收缩力的心脏收缩力调节（CCM）单元（40）。设备（30）包括电源（165）。该装置可以是可植入装置或非植入装置。一种向心脏递送抗心律失常药物的方法。该方法包括将一个或多个非兴奋性心脏收缩调节电信号应用于所述心脏。

7. 发明授权

US06360123B1 Apparatus and method for determining a mechanical property of an organ or body cavity by impedance determination 有权
标题翻译：用于通过阻抗确定来确定器官或体腔的机械特性的装置和方法
公开(公告)号：US06360123B1
公开(公告)日：2002-03-19
申请号：US09382269
申请日：1999-08-24
申请人： Yoav Kimchi , David Prutchi , Itzhak Shemer
发明人： Yoav Kimchi , David Prutchi , Itzhak Shemer
IPC分类号： A61B505
CPC分类号： A61B5/0215 , A61B5/0031 , A61B5/053 , A61B5/0538 , A61B5/42 , A61N1/36521
摘要： Apparatus and method for determining a mechanical property of an organ or a body part. The method includes positioning an impedance sensor within a blood vessel. The impedance sensor has at least two electrodes disposed within the blood vessel, which is mechanically coupled to the organ or body part. The method further includes determining the electrical impedance between the two electrodes to obtain an impedance signal correlated with the mechanical property of the organ or body part. The organ may be the heart, lungs, uterus, urinary bladder, part of the gastrointestinal tract and the brain. The impedance sensor includes at least two spaced apart electrodes capable of being disposed within a blood vessel. The sensor is operatively connected to an impedance determining unit which determines the impedance between the electrodes. The impedance sensor may be a part of an insertable or implantable lead or catheter like device. Alternatively, the impedance sensor may bea small device adapted to be permanently implanted in a blood vessel and to wirelessly communicate with an external device for transmitting impedance data thereto.
摘要翻译：用于确定器官或身体部位的机械特性的装置和方法。该方法包括将阻抗传感器定位在血管内。阻抗传感器具有设置在血管内的至少两个电极，其被机械联接到器官或身体部分。该方法还包括确定两个电极之间的电阻抗以获得与器官或身体部位的机械特性相关的阻抗信号。器官可能是心脏，肺，子宫，膀胱，胃肠道和脑部分。阻抗传感器包括能够设置在血管内的至少两个间隔开的电极。传感器可操作地连接到确定电极之间的阻抗的阻抗确定单元。阻抗传感器可以是可插入或可植入的引线或类似导管的装置的一部分。或者，阻抗传感器可以是适于永久地植入血管中并且与外部设备进行无线通信以传送阻抗数据的小器件。

8. 发明授权

US06292693B1 Contractility enhancement using excitable tissue control and multi-site pacing 有权
标题翻译：使用可兴奋的组织控制和多部位起搏进行收缩性增强
公开(公告)号：US06292693B1
公开(公告)日：2001-09-18
申请号：US09260769
申请日：1999-03-02
申请人： Nissim Darvish , Itzhak Shemer
发明人： Nissim Darvish , Itzhak Shemer
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/362 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： A method and apparatus for stimulating cardiac tissue. Pacing pulses are applied to the heart at multiple sites in at least two different chambers of the heart; and an Excitable Tissue Control (ETC) signal is applied in a vicinity of one or more of the pacing sites following application of the pacing pulse at the site.
摘要翻译：一种刺激心脏组织的方法和装置。起搏脉冲在心脏的至少两个不同室中的多个部位施加于心脏; 并且在现场施加起搏脉冲之后，在一个或多个起搏部位的附近施加可激励组织控制（ETC）信号。

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