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41. 发明授权

US08901308B2 Triazole compounds that modulate Hsp90 activity 有权
标题翻译：调节Hsp90活性的三唑化合物
公开(公告)号：US08901308B2
公开(公告)日：2014-12-02
申请号：US13550324
申请日：2012-07-16
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： C07D401/04 , C07D405/04 , C07D417/04 , C07D413/04 , C07D403/04 , C07D403/10 , C07D249/08 , C07D473/00 , C07D249/12 , C07D409/04 , C07D473/34
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

42. 发明授权

US08478802B2 Organization system for distributed items 有权
标题翻译：分散项目组织制度
公开(公告)号：US08478802B2
公开(公告)日：2013-07-02
申请号：US11870805
申请日：2007-10-11
申请人： Peter Francis Martone , Gaurav Dhawan , David James , Jeff Liu , Richard Xia , Jun Wang , Joshua Pointer , Sobia Tariq
发明人： Peter Francis Martone , Gaurav Dhawan , David James , Jeff Liu , Richard Xia , Jun Wang , Joshua Pointer , Sobia Tariq
IPC分类号： G06F17/30
CPC分类号： G06F17/30212 , G06F17/30176
摘要： An item grouping mechanism may be applied to files or other computer objects to allow the files or objects to be accessed according to the group definition. The group definition may be defined in a table with other group definitions and distributed across an organization so that each device using the group definition may have files or other items presented in a consistent manner. The group definition may be distributed through a different mechanism than for the files or other items. If a device determines that a file defined in the group definition is missing from a local store, the device may retrieve the file from a distribution server.
摘要翻译：项目分组机制可以应用于文件或其他计算机对象，以允许根据组定义来访问文件或对象。组定义可以在具有其他组定义的表中定义并且分布在组织中，使得使用组定义的每个设备可以具有以一致方式呈现的文件或其他项目。组定义可以通过与文件或其他项目不同的机制来分发。如果设备确定在本地存储中缺少组定义中定义的文件，则设备可以从分发服务器检索该文件。

43. 发明申请

US20120324780A1 Insect Monitoring System 审中-公开
标题翻译：昆虫监测系统
公开(公告)号：US20120324780A1
公开(公告)日：2012-12-27
申请号：US13582406
申请日：2011-03-04
申请人： David James
发明人： David James
IPC分类号： A01M1/10 , A01M1/00
CPC分类号： A01M1/026 , A01M1/103
摘要： Generally, an insect monitor which delivers an insect attractant in the form of one or more gases proximate an enclosure in concentration effective to attract insects to an insect trap within the enclosure to monitor an area for insects. Specifically, an insect monitor which delivers a mixture of gases produced from a fermentation broth in a vessel proximate an enclosure to attract insects to an insect trap within the enclosure to monitor an area for insects.
摘要翻译：通常，昆虫监测器以浓度有效的一种或多种气体的形式递送昆虫引诱剂，以有效地吸引昆虫到壳体内的昆虫陷阱以监测昆虫的区域。具体地说，一种昆虫监测器，其将靠近外壳的容器中的发酵液产生的气体混合物吸引到外壳内的昆虫陷阱以监测昆虫的区域。

44. 发明授权

US08318790B2 Triazole compounds that modulate HSP90 activity 有权
公开(公告)号：US08318790B2
公开(公告)日：2012-11-27
申请号：US11807201
申请日：2007-05-25
申请人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
发明人： Weiwen Ying , David James , Shijie Zhang , Junghyun Chae , Teresa Przewloka , Howard P. Ng , Hao Li , Zachary Demko , Dinesh U. Chimmanamada , Chi-wan Lee , Zhenjian Du , Kevin Foley , Minghu Song , Lijun Sun , Keizo Koya , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4196 , A61P35/00 , C07D249/12
CPC分类号： C07D417/04 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D409/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

45. 发明授权

US08314134B2 Compounds for inflammation and immune-related uses 失效
标题翻译：用于炎症和免疫相关用途的化合物
公开(公告)号：US08314134B2
公开(公告)日：2012-11-20
申请号：US12718366
申请日：2010-03-05
申请人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhiqiang Xia
发明人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhiqiang Xia
IPC分类号： C07D235/00 , A01N43/52 , A61K31/415
CPC分类号： A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。

46. 发明申请

US20120046288A1 Hydrazonamide Compounds That Modulate Hsp90 Activity 有权
标题翻译：调节Hsp90活性的肼腙化合物
公开(公告)号：US20120046288A1
公开(公告)日：2012-02-23
申请号：US13001255
申请日：2009-06-26
申请人： Joseph A. Burlison , Dinesh U. Chimmanamada , Weiwen Ying , Shijie Zhang , David James
发明人： Joseph A. Burlison , Dinesh U. Chimmanamada , Weiwen Ying , Shijie Zhang , David James
IPC分类号： A61K31/5377 , C07D295/155 , C07D317/66 , A61P35/00 , C07D405/12 , A61K31/535 , A61K31/36 , A61K31/4525 , C07D413/04 , C07D317/58
CPC分类号： C07C257/22 , C07D213/74 , C07D317/58 , C07D317/66
摘要： The present invention relates to substituted hydrazonamide compounds. The invention further relates to methods of inhibiting the activity of Hsρ90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted hydrazonamide compound of the invention, or a pharmaceutical composition comprising such a compound.
摘要翻译：本发明涉及取代的酰胺化合物。本发明还涉及在有需要的受试者中抑制Hs＆gt; 90的活性的方法以及在有需要的受试者中治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的酰胺化合物，或包含这种化合物的药物组合物。

47. 发明申请

US20110319447A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
公开(公告)号：US20110319447A1
公开(公告)日：2011-12-29
申请号：US13229178
申请日：2011-09-09
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Przewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： A61K31/4709 , C07D413/14 , A61P35/00 , A61K31/4196 , A61K31/422 , C07D403/12 , C07D403/14
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

48. 发明申请

US20110289825A1 PEST ERADICATION DEVICE 审中-公开
标题翻译： PEST排除装置
公开(公告)号：US20110289825A1
公开(公告)日：2011-12-01
申请号：US12998620
申请日：2010-02-19
申请人： David James
发明人： David James
IPC分类号： A01M1/20 , A01M1/00
摘要： Generally, a structure for eradication of insects and method of treating materials infested with insects. Specifically, a support structure which engages a flexible enclosure to define an enclosed space in which heat can be controlled over a period of time to eradicate insects inside of the enclosed space.
摘要翻译：通常，用于消灭昆虫的结构和用昆虫侵染的物质的处理方法。具体地说，一种支撑结构，其与柔性外壳接合以限定封闭空间，在该空间中可以在一段时间内控制热量以消除封闭空间内的昆虫。

49. 发明授权

US07872057B2 Dual cure composition 有权
标题翻译：双重治疗组合物
公开(公告)号：US07872057B2
公开(公告)日：2011-01-18
申请号：US12090824
申请日：2006-10-02
申请人： David James , Kent Sörensen , Henrik Bernquist
发明人： David James , Kent Sörensen , Henrik Bernquist
IPC分类号： C09D4/00 , C08G18/04 , C08G69/00 , C08G73/00
CPC分类号： C09D175/16 , C08G18/68 , C08J3/243 , C08L2312/06
摘要： A liquid radiation and thermally curing composition characterized in, that said composition comprises at least one ester between at least one tri or polyalcohol and acrylic and/or methacrylic acid, which ester has at least two hydroxyl groups, at least one acrylic or methacrylic double bond, a hydroxyl value of 50-500 mg KOH/g and a double bond concentration of 1-10 mmoles/g, at least one crosslinking agent for hydroxyl functional compounds, which crosslinking agent optionally has at least one olefinic double bond, and an additive package comprising at least one photoinitiator, radical scavenger, light stabilizer, wetting agent and/or leveling agent, and optionally at least one monomeric or oligomeric reactive diluent.
摘要翻译：一种液体辐射和热固化组合物，其特征在于，所述组合物包含至少一种三醇或多元醇与丙烯酸和/或甲基丙烯酸之间的酯，该酯具有至少两个羟基，至少一个丙烯酸或甲基丙烯酸双键，羟基值为50-500mg KOH / g，双键浓度为1-10mmoles / g，至少一种用于羟基官能化合物的交联剂，该交联剂任选具有至少一个烯属双键，以及添加剂包含至少一种光引发剂，自由基清除剂，光稳定剂，润湿剂和/或流平剂，以及任选的至少一种单体或低聚反应性稀释剂。

50. 外观设计

USD614725S1 Pest eradication device 有权
标题翻译：害虫根除装置
公开(公告)号：USD614725S1
公开(公告)日：2010-04-27
申请号：US29341672
申请日：2009-08-11
申请人： David James
设计人： David James

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