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1. 发明授权

US09090569B2 Triazone compounds that modulate HSP90 activity 有权
标题翻译：调节HSP90活性的三嗪类化合物
公开(公告)号：US09090569B2
公开(公告)日：2015-07-28
申请号：US12604970
申请日：2009-10-23
申请人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
发明人： Weiwen Ying , David James , Shijie Zhang , Teresa Przewloka , Junghyun Chae , Dinesh U. Chimmanamada , Chi-Wan Lee , Elena Kostik , Howard P. Ng , Kevin Foley , Zhenjian Du , James Barsoum
IPC分类号： A61K31/4196 , C07D249/08 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
CPC分类号： C07D249/08 , A61K31/4196 , C07D249/12 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D473/00 , C07D473/34
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及在有需要的受试者中抑制Hsp90的活性的方法和在有需要的受试者中预防或治疗过度增殖性疾病如癌症的方法，其包括向受试者施用本发明的取代的三唑化合物，或包含这种化合物的组合物。

2. 发明申请

US20130296378A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY 有权
公开(公告)号：US20130296378A1
公开(公告)日：2013-11-07
申请号：US13857665
申请日：2013-04-05
申请人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Prezewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
发明人： Lijun Sun , Weiwen Ying , Junghyun Chae , Teresa Prezewloka , Shijie Zhang , Dinesh U. Chimmanamada , Kevin Paul Foley , Zhenjian Du , Hao Li , David James , Howard P. Ng , Zachary Demko , Dan Zhou , Shuzhen Qin
IPC分类号： C07D401/04 , A61K45/06 , A61K31/4439 , C07D401/14
CPC分类号： C07D403/04 , A61K31/4196 , A61K31/422 , A61K31/4439 , A61K31/475 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D249/12 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/14 , C07D413/14 , C07D487/04
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.

3. 发明申请

US20130169234A1 METHOD AND SYSTEM FOR CONTROLLING ENERGY STORAGE DEVICE 有权
标题翻译：控制能量储存装置的方法和系统
公开(公告)号：US20130169234A1
公开(公告)日：2013-07-04
申请号：US13338380
申请日：2011-12-28
申请人： Christopher James Chuah , Roger Bull , James Sudworth , Vincent Boccanfuso , David James
发明人： Christopher James Chuah , Roger Bull , James Sudworth , Vincent Boccanfuso , David James
IPC分类号： H02J7/00
CPC分类号： H01M10/44 , G01R31/3624 , G01R31/3679 , H01M10/443 , H01M10/448 , H01M10/48 , H01M10/486
摘要： A system and method of use including a controller responsive to a deviation in absolute value or relative slope and operable to terminate a discharge operation in an energy storage device is provided. The absolute value or relative slope is determined at sampling frequency based upon a combination of measured operating parameters, for example, potential and current. Any deviation in the absolute value or relative slope indicates that a threshold limit in the available energy of the system has been reached, for example when active materials in the device are at a point of depletion, indicating a need to cease the discharge operation. The system and method operate on a real-time basis, providing instantaneous SOH information with regard to the device.
摘要翻译：提供了一种系统和使用方法，其包括响应于绝对值或相对斜率的偏差并可操作以终止能量存储装置中的放电操作的控制器。基于测量的操作参数（例如电位和电流）的组合，以采样频率确定绝对值或相对斜率。绝对值或相对斜率的任何偏差表示已经达到系统可用能量的阈限，例如当器件中的活性材料处于耗尽点时，表示需要停止放电操作。该系统和方法在实时的基础上运行，提供关于设备的即时SOH信息。

4. 发明授权

US08299107B2 Triazole compounds that modulate HSP90 activity 有权
标题翻译：调节HSP90活性的三唑化合物
公开(公告)号：US08299107B2
公开(公告)日：2012-10-30
申请号：US12526491
申请日：2008-02-08
申请人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa K. Przewloka
发明人： Dinesh U. Chimmanamada , Joseph A. Burlison , Weiwen Ying , Lijun Sun , Stefan Michael Schweizer , Shijie Zhang , Zachary Demko , David James , Teresa K. Przewloka
IPC分类号： A61K31/41 , C07D249/00
CPC分类号： C07D417/14 , C07D249/08 , C07D249/10 , C07D249/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/12
摘要： The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to the use of a substituted triazole compound of the invention, or a composition comprising such a compound in the preparation of a medicament for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof.
摘要翻译：本发明涉及取代的三唑化合物和包含取代的三唑化合物的组合物。本发明还涉及本发明的取代的三唑化合物或包含这种化合物的组合物在制备用于预防或治疗有需要的受试者中的过度增殖性疾病如癌症的药物中的用途。

5. 发明授权

US07919487B2 Heteroaryl compounds 有权
标题翻译：杂芳基化合物
公开(公告)号：US07919487B2
公开(公告)日：2011-04-05
申请号：US11271704
申请日：2005-11-10
申请人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
发明人： Lijun Sun , Shijie Zhang , Keizo Koya , Dinesh Chimmanamada , Hao Li , David James , Elena Kostik
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/50 , A61K31/53 , A61K31/505 , C07D413/14 , C07D251/02 , C07D401/14
CPC分类号： C07D213/75 , C07D213/77 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/56 , C07D251/42 , C07D251/52 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07D491/10
摘要： This invention relates to compounds of formula (I): their compositions and methods of use thereof. The compounds (and compositions) are useful in modulating IL-12 production and processes mediated by IL-12.
摘要翻译：本发明涉及式（I）化合物：它们的组成及其使用方法。化合物（和组合物）可用于调节由IL-12介导的IL-12产生和过程。

6. 发明申请

US20100222448A1 AQUEOUS POLYURETHANE DISPERSION 有权
标题翻译：水性聚氨酯分散体
公开(公告)号：US20100222448A1
公开(公告)日：2010-09-02
申请号：US11909606
申请日：2006-03-16
申请人： Göran Ziegler , David James , Kent Sörensen
发明人： Göran Ziegler , David James , Kent Sörensen
IPC分类号： C08F2/46 , C08L75/04
CPC分类号： C08G18/672 , C08G18/0823 , C08G18/12 , C08G18/44 , C09D175/16 , C08G18/3228 , C08G18/6659
摘要： Disclosed is an aqueous polyurethane dispersion obtained by dispersing in water a reaction product obtained by reacting a reaction mixture comprising at least one organic, aliphatic, cycloaliphatic or aromatic di, tri or poryisocyanate, at least one isocyanate reactive polycarbonate diol, triol or polyol, at least one compound comprising at least one isocyanate reactive group and at least one free radically polymerisable unsaturated group, and at least one compound comprising at least one isocyanate reactive group and at least one at least dispersing active group, and optionally at least one compound comprising at least two isocyanate reactive groups and having a molecular weight of less than 1000 g/mol.
摘要翻译：公开了一种水性聚氨酯分散体，其通过将包含至少一种有机，脂族，脂环族或芳族二，三或异氰酸酯的反应混合物，至少一种异氰酸酯反应性聚碳酸酯二醇，三醇或多元醇的反应混合物分散在水中而得到的反应产物，至少一种包含至少一种异氰酸酯反应性基团和至少一种可自由基聚合的不饱和基团的化合物和至少一种包含至少一种异氰酸酯反应性基团和至少一种至少分散的活性基团的化合物，以及任选的至少一种包含至少两个异氰酸酯反应性基团，分子量小于1000g / mol。

7. 发明授权

US07532923B1 Apparatus and method for detecting a fetal heart rate 有权
标题翻译：用于检测胎儿心率的装置和方法
公开(公告)号：US07532923B1
公开(公告)日：2009-05-12
申请号：US10089997
申请日：2000-10-06
申请人： Barrie Hayes-Gill , David James , John Crowe , Jean-Francois Pieri
发明人： Barrie Hayes-Gill , David James , John Crowe , Jean-Francois Pieri
IPC分类号： A61B5/0444
CPC分类号： A61B5/4362 , A61B5/02411 , A61B5/0444
摘要： The present invention relates to apparatus for detecting the heart rate of a fetus. The apparatus includes at least two detectors for detecting heart beats of the fetus, each detector comprising at least two electrodes for detecting ECG signals. A processor, which is coupled to the detectors, is used to process the ECG signals received from each detector and determine the heart rate of the fetus.
摘要翻译：本发明涉及用于检测胎儿心率的装置。该装置包括用于检测胎儿心跳的至少两个检测器，每个检测器包括用于检测ECG信号的至少两个电极。耦合到检测器的处理器用于处理从每个检测器接收的ECG信号并确定胎儿的心率。

8. 发明申请

US20090100057A1 Organization System for Distributed Items 有权
标题翻译：分布式项目组织系统
公开(公告)号：US20090100057A1
公开(公告)日：2009-04-16
申请号：US11870805
申请日：2007-10-11
申请人： Peter Francis Martone , Gaurav Dhawan , David James , Jeff Liu , Richard Xia , Jun Wang , Joshua Pointer , Sobia Tariq
发明人： Peter Francis Martone , Gaurav Dhawan , David James , Jeff Liu , Richard Xia , Jun Wang , Joshua Pointer , Sobia Tariq
IPC分类号： G06F17/30
CPC分类号： G06F17/30212 , G06F17/30176
摘要： An item grouping mechanism may be applied to files or other computer objects to allow the files or objects to be accessed according to the group definition. The group definition may be defined in a table with other group definitions and distributed across an organization so that each device using the group definition may have files or other items presented in a consistent manner. The group definition may be distributed through a different mechanism than for the files or other items. If a device determines that a file defined in the group definition is missing from a local store, the device may retrieve the file from a distribution server.
摘要翻译：项目分组机制可以应用于文件或其他计算机对象，以允许根据组定义来访问文件或对象。组定义可以在具有其他组定义的表中定义并且分布在组织中，使得使用组定义的每个设备可以具有以一致方式呈现的文件或其他项目。组定义可以通过与文件或其他项目不同的机制来分发。如果设备确定在本地存储中缺少组定义中定义的文件，则设备可以从分发服务器检索该文件。

9. 发明申请

US20070249661A1 Compounds for inflammation and immune-related uses 失效
标题翻译：用于炎症和免疫相关用途的化合物
公开(公告)号：US20070249661A1
公开(公告)日：2007-10-25
申请号：US11233224
申请日：2005-09-21
申请人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Xia
发明人： Shoujun Chen , Jun Jiang , Hao Li , David James , Dinesh Chimmanamada , Christopher Borella , Lijun Sun , Yu Xie , Mats Holmqvist , Jerome Mahiou , Zhi Xia
IPC分类号： A61K31/44 , A61K31/40 , A61K31/415 , A61P19/02 , A61P5/00 , C07D235/28 , C07D471/02 , C07D455/02 , C07D235/00 , A61P3/10 , A61P17/00 , A61K31/437
CPC分类号： A61K31/437 , A61K31/403 , A61K31/4184 , A61K31/4439 , A61K31/444 , A61K31/537 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/24 , C07D235/28 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , Y02A50/422
摘要： The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof wherein X, Y, A, Z, L and n are defined herein. These compounds are useful as immunosuppressive agents and for treating and preventing inflammatory conditions and immune disorders.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，包合物或前药，其中X，Y，A，Z，L和n如本文所定义。这些化合物可用作免疫抑制剂并用于治疗和预防炎性病症和免疫疾病。

10. 发明授权

US07186771B2 Air drying waterborne resin composition 有权
标题翻译：空气干燥水性树脂组合物
公开(公告)号：US07186771B2
公开(公告)日：2007-03-06
申请号：US10532058
申请日：2003-10-16
申请人： Bo Haggman , Hakan Bjornberg , Birger Midelf , David James
发明人： Bo Haggman , Hakan Bjornberg , Birger Midelf , David James
IPC分类号： C08J3/00 , C08K5/00 , C08L67/00 , C08L75/00 , C08G18/42
CPC分类号： C08L101/005 , C09D201/005 , C08L2666/14
摘要： An air drying waterborne resin composition is disclosed. Said resin composition comprises at least one amphiphlic air drying dendritic polymer, at least one non-amphiphilic air drying alkyd resin, at least one drier initiating and/or promoting autoxidation, and water, and optionally at least one anionic and/or nonionic surfactant, and/or at least one coalescent agent. Said at least one amphiphilic air drying dendritic polymer is built up from a polyhydric dendritic core polymer having terminal hydroxyl groups and at least one unsaturated carboxylic acid and at least one adduct, obtainable by addition of a monoalkylated polyethylene glycol to a dicarboxylic acid or anhydride and/or a diisocyanate, each bonded to at least one terminal hydroxyl group in said polyhydric dendritic core polymer.
摘要翻译：公开了一种空气干燥水性树脂组合物。所述树脂组合物包含至少一种两亲空气干燥树枝状聚合物，至少一种非两亲空气干燥醇酸树脂，至少一种引发和/或促进自动氧化的干燥剂，以及任选至少一种阴离子和/或非离子表面活性剂，和/或至少一种聚结剂。所述至少一种两亲空气干燥树枝状聚合物由具有末端羟基和至少一种不饱和羧酸的多元树枝状核聚合物和至少一种加合物构成，所述加成物可通过将二烷基化聚乙二醇加入到二羧酸或酸酐中而得到， /或二异氰酸酯，各自与所述多羟基树枝状核聚合物中的至少一个末端羟基键合。

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