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    • 34. 发明授权
    • Nucleic acid analyzing device and nucleic acid analyzer
    • 核酸分析装置和核酸分析仪
    • US08865403B2
    • 2014-10-21
    • US12997469
    • 2009-05-13
    • Masatoshi NaraharaToshiro SaitoNaoshi ItabashiJiro YamamotoHiroyuki Uchiyama
    • Masatoshi NaraharaToshiro SaitoNaoshi ItabashiJiro YamamotoHiroyuki Uchiyama
    • C12Q1/68C12M1/36G01N21/00G01N21/64
    • G01N21/648
    • An object of the present invention relates to distinguishing, from a fluorophore of an unreacted substrate, a single fluorophore attached to a nucleotide that is incorporated into a probe by a nucleic acid synthesis. The present invention relates to a nucleic acid analyzing device that analyzes a nucleic acid in sample by fluorescence, wherein a localized surface plasmon is generated by illumination, and a probe for analyzing the nucleic acid in the sample is on the site where the surface plasmon is generated. According to the present invention, since it is possible to efficiently produce fluorescence intensifying effects due to the surface plasmon and to immobilize the probe to a region within the reach of the fluorescence intensifying effects, it becomes possible to measure a nucleic acid synthesis without removing unreacted nucleotide to which fluorophores are attached.
    • 本发明的目的在于从未反应的底物的荧光团区分与通过核酸合成并入探针中的核苷酸连接的单个荧光团。 本发明涉及通过荧光分析样品中的核酸的核酸分析装置,其中通过照射产生局部表面等离子体激元,并且用于分析样品中的核酸的探针位于表面等离子体为 生成。 根据本发明,由于可以有效地产生由于表面等离子体激元引起的荧光增强作用并且将探针固定在荧光增强作用范围内的区域,因此可以测量核酸合成而不去除未反应的 附着有荧光团的核苷酸。
    • 37. 发明申请
    • Plasma Processing Apparatus and Plasma Processing Method
    • 等离子体处理装置和等离子体处理方法
    • US20100258529A1
    • 2010-10-14
    • US12496689
    • 2009-07-02
    • Masahito MORITsutomu TetsukaNaoshi Itabashi
    • Masahito MORITsutomu TetsukaNaoshi Itabashi
    • H01L21/306H01L21/02C23C16/513
    • H01J37/32165H01J37/32091H01J37/32155H01J37/32192H01J37/32935H01J37/3299
    • The invention provides a plasma processing apparatus comprising a means for detecting the apparatus condition related to the ion flux quantity of plasma (plasma density) and the distribution thereof for to stabilizing mass production and minimizing apparatus differences. The plasma processing apparatus comprises a vacuum reactor 108, a gas supply means 111, a pressure control means, a plasma source power supply 101, a lower electrode 113 on which an object to be processes 112 is placed within the vacuum reactor, and a high frequency bias power supply 117, further comprising a probe high frequency oscillation means 103 for supplying an oscillation frequency that differs from the plasma source power supply 101 and the high frequency bias power supply 117 into the plasma processing chamber, high frequency receivers 114 through 116 for receiving the high frequency supplied from the probe high frequency oscillation means 603 via a surface coming into contact with plasma, and a high frequency analysis means 110 for measuring the impedance per oscillation frequency within an electric circuit formed by the probe high frequency oscillation means 603 and the receivers 114 through 116, the reflectance and the transmittance, and the variation of harmonic components.
    • 本发明提供一种等离子体处理装置,其包括用于检测与等离子体的离子通量(等离子体密度)相关的装置条件及其分布的装置,用于稳定批量生产并使装置差异最小化。 等离子体处理装置包括真空反应器108,气体供给装置111,压力控制装置,等离子体源电源101,待处理物体112放置在真空反应器内的下部电极113,以及高压 高频偏置电源117,还包括用于将不同于等离子体源电源101和高频偏置电源117的振荡频率提供给等离子体处理室的探头高频振荡装置103,用于 通过与等离子体接触的表面接收从探针高频振荡装置603提供的高频;以及高频分析装置110,用于测量由探针高频振荡装置603形成的电路内的每个振荡频率的阻抗,以及 接收器114至116,反射率和透射率以及谐波分量的变化 s。
    • 39. 发明申请
    • PLASMA PROCESSING APPARATUS AND METHOD FOR DETECTING STATUS OF SAID APPARATUS
    • 等离子体处理装置和检测装置状态的方法
    • US20090105980A1
    • 2009-04-23
    • US12025095
    • 2008-02-04
    • Tsutomu TETSUKANaoshi ItabashiAtsushi Itou
    • Tsutomu TETSUKANaoshi ItabashiAtsushi Itou
    • B05C11/00G06F19/00G01R23/16
    • H01J37/32082H01J37/321H01J37/32174H01J37/32935
    • The invention provides a method for detecting and managing the status of a plasma processing apparatus with high sensitivity so as to enable long-term stable processing. In a plasma processing apparatus comprising a vacuum processing chamber 10, a plasma generating high frequency power supply 16, and a measurement device unit 3 for estimating the status of the apparatus via reflected waves 54 of the incident waves 53 reflected from the processing apparatus including a waveform generator 32, a VCO 33, a directional coupler 34, a detector 35 and a measurement data processing unit 36, frequency-swept high frequency waves 53 for measurement are introduced to the processing chamber where no plasma discharge is performed, so as to monitor the change of absorption spectrum frequency of the reflected waves 54 to thereby monitor the change in status of the processing apparatus.
    • 本发明提供了一种用于检测和管理具有高灵敏度的等离子体处理装置的状态以便能够进行长期稳定处理的方法。 在包括真空处理室10,等离子体产生高频电源16和测量装置单元3的等离子体处理装置中,用于通过从包括a的处理装置反射的入射波53的反射波54估计装置的状态 波形发生器32,VCO33,定向耦合器34,检测器35和测量数据处理单元36,将用于测量的频率扫描高频波53引入到不进行等离子体放电的处理室中,以便监视 反射波54的吸收光谱频率的变化,从而监视处理装置的状态变化。