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31. 发明授权

US08048992B2 Anti-IgSF4 antibody and utilization of the same 失效
标题翻译：抗IgSF4抗体与利用相同
公开(公告)号：US08048992B2
公开(公告)日：2011-11-01
申请号：US11885245
申请日：2006-02-22
申请人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
发明人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
IPC分类号： C07K16/00
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/00 , G01N33/57426 , G01N33/57438
摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.
摘要翻译：旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。

32. 发明申请

US20090053243A1 Anti-IgSF4 Antibody and Utilization of the Same 失效
标题翻译：抗IgSF4抗体及其利用
公开(公告)号：US20090053243A1
公开(公告)日：2009-02-26
申请号：US11885245
申请日：2006-02-22
申请人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
发明人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , A61P31/00 , C12N5/06 , G01N33/574
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/00 , G01N33/57426 , G01N33/57438
摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.
摘要翻译：旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。

33. 发明申请

US20050177683A1 Method for managing disk drives of different types in disk array device 失效
公开(公告)号：US20050177683A1
公开(公告)日：2005-08-11
申请号：US10808364
申请日：2004-03-25
申请人： Daisuke Isobe , Azuma Kano , Akihisa Hirasawa , Shingo Itagaki , Kenichi Tateyama , Yoshinori Nagaiwa , Nobuhiro Takahashi
发明人： Daisuke Isobe , Azuma Kano , Akihisa Hirasawa , Shingo Itagaki , Kenichi Tateyama , Yoshinori Nagaiwa , Nobuhiro Takahashi
IPC分类号： G06F3/06 , G06F12/00 , G11B33/12
CPC分类号： G06F3/0661 , G06F3/0607 , G06F3/0658 , G06F3/0689 , G11B33/12
摘要： The present invention manages disk-drive types in a storage device in which a mixture of disk drives of a plurality of types with different interfaces is stored. The storage device enclosure stores a mixture of an FC disk drive 220F with a fiber channel interface and a SATA disk drive with a serial interface. The SATA disk drive is connected to a fiber channel via an FC/SATA interface connection device 233 that performs interface conversion. At startup and so forth, the controller 310 issues an inquiry to the enclosure management unit or to each of the disk drives and, based on the address allocated to each of the disk drives, or similar, automatically confirms the type of each disk drive and manages the confirmation results.

34. 发明授权

US5416015A Isolated genes encoding peptidyl prolyl-cis.trans-isomerase and plasmids comprising said genes 失效
标题翻译：编码肽基脯氨酰基 - 顺反异构酶的分离基因和包含所述基因的质粒
公开(公告)号：US5416015A
公开(公告)日：1995-05-16
申请号：US89850
申请日：1993-07-09
申请人： Toshiya Hayano , Setsuko Katou , Noboru Maki , Nobuhiro Takahashi , Masanori Suzuki
发明人： Toshiya Hayano , Setsuko Katou , Noboru Maki , Nobuhiro Takahashi , Masanori Suzuki
IPC分类号： C12N9/90 , C12N15/61 , C12N15/63 , C12N15/70
CPC分类号： C12N9/90
摘要： A yeast PPIase characterized by possessing following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro stands for L-proline), (2) exhibiting a single molecular weight of about 17,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 6.2 in the isoelectric focusing, and (4) inhibited by CsA;an E. coli PPIase-.beta. characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro for L-proline), (2) exhibiting a single molecular weight of about 20,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 5.0 in the isoelectric focusing, and (4) no being inhibited by CsA;an E. coli PPIase-.alpha. characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro for L-proline), (2) exhibiting a single molecular weight of about 22,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 9.7 in the isoelectric focusing, and (4) not being inhibited by CsA.
摘要翻译：特征在于具有以下性质的酵母PPI酶：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro代表L-脯氨酸），（2）表现出约17,000道尔顿单分子量在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中，（3）在等电聚焦中表现出约6.2的单一等电点，（4）被CsA抑制; 特征在于具有以下性质的大肠杆菌PPI酶-β：（1）作用于Xaa-Pro（Xaa代表任何氨基酸，Pro-L-脯氨酸，Xaa代表任意氨基酸，Pro表示单分子量）在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中为约20,000道尔顿，（3）在等电聚焦中呈现约5.0的单等电点，（4）不被CsA抑制; 其特征在于具有以下性质：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro为L-脯氨酸），（2）表现出单分子量在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中约为22,000道尔顿，（3）在等电聚焦中显示出约9.7的单一等电点，（4）不被CsA抑制。

35. 发明授权

US4993892A Thread cutting throw-away tip 失效
标题翻译：螺纹切削扔掉尖端
公开(公告)号：US4993892A
公开(公告)日：1991-02-19
申请号：US396663
申请日：1989-08-22
申请人： Nobuhiro Takahashi
发明人： Nobuhiro Takahashi
IPC分类号： B23B27/06
CPC分类号： B23B27/065 , Y10T407/235 , Y10T407/24 , Y10T407/245
摘要： A throw-away thread cutting insert having a cutting tip at a corner part thereof corresponding to a shape of a thread groove, a lead groove formed in an upper surface of the insert and disposed adjacent to and inwardly of said cutting tip, and a curl recess formed in an upper wall of the insert in continuous relation to one side wall of the insert and disposed inwardly of said lead groove.

36. 发明申请

US20120046451A1 ANTI-lgSF4 ANTIBODY AND UTILIZATION OF THE SAME 审中-公开
标题翻译：抗-IgSF4抗体及其应用
公开(公告)号：US20120046451A1
公开(公告)日：2012-02-23
申请号：US13238096
申请日：2011-09-21
申请人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsutsumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
发明人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsutsumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
IPC分类号： C07K16/42
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/00 , G01N33/57426 , G01N33/57438
摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.
摘要翻译：旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。

37. 发明授权

US08021623B2 Examination method and examination assistant device for quartz product of semiconductor processing apparatus 有权
标题翻译：半导体加工设备石英制品检验方法及检验辅助装置
公开(公告)号：US08021623B2
公开(公告)日：2011-09-20
申请号：US10574286
申请日：2004-09-06
申请人： Masayuki Oikawa , Katsuhiko Anbai , Nobuhiro Takahashi , Teruyuki Hayashi
发明人： Masayuki Oikawa , Katsuhiko Anbai , Nobuhiro Takahashi , Teruyuki Hayashi
IPC分类号： G01N1/32 , H01L21/00
CPC分类号： H01L21/67253 , G01N1/32 , H01L21/67288 , H01L21/67303 , H01L21/67326
摘要： An examination assistant device (3) is used for examination in which a process solution containing an etching solution is held in contact with an examination objective portion of a quartz pole member (21) of a semiconductor processing apparatus, and then the process solution is analyzed to identify a metal impurity contained in the examination objective portion. The pole member (21) includes a pair of concave portions (22) disposed one on either side of the examination objective portion. The examination assistant device (3) includes a pair of end plates (32) configured to engage with the pair of concave portions, a frame (30) connecting the pair of end plates, and a solution receiver (31) disposed between the pair of end plates. The solution receiver (31) has dimensions to store the process solution and hold the process solution in contact with the examination objective portion.
摘要翻译：使用检查辅助装置（3），其中含有蚀刻液的处理液与半导体处理装置的石英杆部件（21）的检查对象部分保持接触，然后分析处理液以识别包含在检查对象部分中的金属杂质。极构件（21）包括一对设置在检查对象部分两侧的凹部（22）。检查辅助装置（3）包括一对端板（32），其构造成与所述一对凹部接合，连接所述一对端板的框架（30）和设置在所述一对端板之间的溶液接收器（31）端板。解决方案接收器（31）具有存储处理溶液并保持处理溶液与检查对象部分接触的尺寸。

38. 发明授权

US06778076B2 Oil pressure switch failure detection system for outboard motor 有权
标题翻译：舷外马达油压开关故障检测系统
公开(公告)号：US06778076B2
公开(公告)日：2004-08-17
申请号：US10028360
申请日：2001-12-28
申请人： Sadafumi Shidara , Nobuhiro Takahashi
发明人： Sadafumi Shidara , Nobuhiro Takahashi
IPC分类号： B60Q100
CPC分类号： F01M1/16 , F01M1/20
摘要： An oil pressure switch failure detection system for an outboard motor, having a first oil pressure switch which generates an ON signal indicating that the oil pressure is less than or equal to a first predetermined oil pressure and a second oil pressure switch which generates an ON signal indicating that the oil pressure is less than or equal to a second predetermined oil pressure which is set higher than the first predetermined oil pressure. In the system, by discriminating whether the generated signals of the first and second oil pressure switches are equal to be expected signals expected under operating conditions of the engine, it is determined whether at least one of the first and second oil pressure switches fails. With this, it become possible to detect failure of the first and second oil pressure switches, accurately.
摘要翻译：一种用于舷外马达的油压开关故障检测系统，具有产生指示油压小于或等于第一预定油压的ON信号的第一油压开关和产生ON信号的第二油压开关指示油压小于或等于设定为高于第一预定油压的第二预定油压。在该系统中，通过判断第一和第二油压开关的产生的信号是否等于在发动机的运行条件下预期的预期信号，确定第一和第二油压开关中的至少一个是否失效。由此，可以准确地检测第一和第二油压开关的故障。

39. 发明授权

US06353455B1 Method of evaluating characteristics of a light beam, apparatus for evaluating the characteristics, and apparatus for adjusting a write unit by employing the evaluating method 失效
标题翻译：评价光源的特性的评价方法，评价特性的装置以及采用该评价方法的写入装置的调整装置
公开(公告)号：US06353455B1
公开(公告)日：2002-03-05
申请号：US09398761
申请日：1999-09-17
申请人： Shinichi Ozaki , Katsushi Abe , Nobuhiro Takahashi
发明人： Shinichi Ozaki , Katsushi Abe , Nobuhiro Takahashi
IPC分类号： B41J2435
CPC分类号： H04N1/00015 , B41J2/471 , G02B26/127 , H04N1/00002 , H04N1/00018 , H04N1/00031 , H04N1/00053 , H04N1/00082 , H04N1/1135
摘要： At least two light beam detection units are spaced at a predetermined distance and provided in the scanning direction of a surface to be scanned. A light beam is emitted to the light beam detection unit provided on a scanning start side, by lighting a light beam source which is employed to scan the surface linearly during a scanning period equivalent to 1 dot during scanning. A light beam is emitted to the light beam detection unit provided on a scanning end side, by lighting the light beam source during the scanning period after elapse of a light-off period computed from a previously designed scanning speed and the predetermined distance. Based on a detection result of the light beam detection unit provided on the scanning start side and a detection result of the light beam detection unit provided on the scanning end side, scanning characteristics required of the light beam are evaluated.
摘要翻译：至少两个光束检测单元以预定距离隔开并且设置在待扫描表面的扫描方向上。通过点亮在扫描期间相当于1点的扫描周期中线性地扫描表面的光束源，将光束发射到设置在扫描开始侧的光束检测单元。通过在从先前设计的扫描速度和预定距离计算出的熄灭时段之后的扫描期间点亮光束源，向设置在扫描端侧的光束检测单元发射光束。基于扫描开始侧设置的光束检测单元的检测结果和设置在扫描端侧的光束检测单元的检测结果，评价光束所需的扫描特性。

40. 发明授权

US5284762A Peptidyl prolyl-cis.trans-isomerase 失效
标题翻译：肽基脯氨酰 - 顺反异构酶
公开(公告)号：US5284762A
公开(公告)日：1994-02-08
申请号：US555944
申请日：1990-07-19
申请人： Toshiya Hayano , Setsuko Katou , Noboru Maki , Nobuhiro Takahashi , Masanori Suzuki
发明人： Toshiya Hayano , Setsuko Katou , Noboru Maki , Nobuhiro Takahashi , Masanori Suzuki
IPC分类号： C12N9/90 , C12N15/61 , C12N15/70
CPC分类号： C12N9/90
摘要： A yeast PPIase characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro stands for L-proline), (2) exhibiting a single molecular weight of about 17,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 6.2 in the isoelectric focusing, and (4) inhibited by CsA;an E. coli PPIase-.beta. characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro for L-proline), (2) exhibiting a single molecular weight of about 20,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 5.0 in the isoelectric focusing, and (4) no being inhibited by CsA;an E. coli PPIase-.alpha. characterized by possessing the following properties: (1) acting on and isomerizing the bond X.sub.aa -Pro (wherein X.sub.aa stands for any amino acid and Pro for L-proline), (2) exhibiting a single molecular weight of about 22,000 daltons in the sodium dodecyl sulfate-polyacrylamide concentration gradient gel electrophoresis, (3) exhibiting a single isoelectric point of about 9.7 in the isoelectric focusing, and (4) not being inhibited by CsA.
摘要翻译：特征在于具有以下特性的酵母PPI酶：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro代表L-脯氨酸），（2）表现出单一分子量约17,000 十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中的道尔顿，（3）在等电聚焦中显示约6.2的单一等电点，和（4）被CsA抑制; 特征在于具有以下特性的大肠杆菌PPIase-（β）：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro代表L-脯氨酸），（2）表现出单一的在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中分子量约20,000道尔顿，（3）在等电聚焦中呈现约5.0的单一等电点，（4）不被CsA抑制; 特征在于具有以下性质的大肠杆菌PPIase-（α）：（1）作用于Xaa-Pro键（Xaa代表任何氨基酸，Pro代表L-脯氨酸），（2）表现出单一的在十二烷基硫酸钠 - 聚丙烯酰胺浓度梯度凝胶电泳中分子量约22,000道尔顿，（3）在等电聚焦中显示约9.7的单一等电点，（4）不被CsA抑制。

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