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1. 发明授权

US08048992B2 Anti-IgSF4 antibody and utilization of the same 失效
标题翻译：抗IgSF4抗体与利用相同
公开(公告)号：US08048992B2
公开(公告)日：2011-11-01
申请号：US11885245
申请日：2006-02-22
申请人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
发明人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
IPC分类号： C07K16/00
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/00 , G01N33/57426 , G01N33/57438
摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.
摘要翻译：旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。

2. 发明申请

US20090053243A1 Anti-IgSF4 Antibody and Utilization of the Same 失效
标题翻译：抗IgSF4抗体及其利用
公开(公告)号：US20090053243A1
公开(公告)日：2009-02-26
申请号：US11885245
申请日：2006-02-22
申请人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
发明人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , A61P31/00 , C12N5/06 , G01N33/574
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/00 , G01N33/57426 , G01N33/57438
摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.
摘要翻译：旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。

3. 发明申请

US20120046451A1 ANTI-lgSF4 ANTIBODY AND UTILIZATION OF THE SAME 审中-公开
标题翻译：抗-IgSF4抗体及其应用
公开(公告)号：US20120046451A1
公开(公告)日：2012-02-23
申请号：US13238096
申请日：2011-09-21
申请人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsutsumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
发明人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsutsumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
IPC分类号： C07K16/42
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/00 , G01N33/57426 , G01N33/57438
摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.
摘要翻译：旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。

4. 发明申请

US20090203538A1 Method of classifying antibody, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same 审中-公开
公开(公告)号：US20090203538A1
公开(公告)日：2009-08-13
申请号：US12318829
申请日：2009-01-09
申请人： Atsushi Sugioka , Mototaka Sugiura , Yasushi Akahori , Nobuhiro Hayashi , Akihiko Takasaki , Miwa Morita , Gene Kurosawa , Mariko Sumitomo , Susumu Tsutsumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Noriko Satou , Masachika Azuma , Yoshinori Ukai , Kazuhiro Suzuki , Yoshikazu Kurosawa , Miho Tanaka , Mamoru Shiraishi
发明人： Atsushi Sugioka , Mototaka Sugiura , Yasushi Akahori , Nobuhiro Hayashi , Akihiko Takasaki , Miwa Morita , Gene Kurosawa , Mariko Sumitomo , Susumu Tsutsumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Noriko Satou , Masachika Azuma , Yoshinori Ukai , Kazuhiro Suzuki , Yoshikazu Kurosawa , Miho Tanaka , Mamoru Shiraishi
IPC分类号： C40B30/04 , G01N33/567 , G01N33/574 , C07K16/00 , C40B40/10 , C40B60/10
CPC分类号： C07K16/30 , C07K16/005 , C07K16/28 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/303 , C07K16/32 , C07K16/40 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C12N15/1138 , C12N2310/14 , G01N33/57492 , G01N33/6854
摘要： It is intended to provide a method whereby a plural number of antibodies against cell surface antigens are quickly classified and to provide a method whereby antigens of the thus classified antibodies are quickly identified. Further, it is intended to provide a method of promoting the utilization of the useful data obtained by the above methods. Furthermore, it is intended to provide an antibody which is effective in treating or diagnosing cancer. Namely, a method of classifying antibodies which comprises: (1) the step of preparing a plural number of antibodies respectively recognizing cell surface antigens; (2) the step of bringing each of these antibodies into contact with a cell of the same species; (3) the step of analyzing each of the cells having been treated in the step (2) by flow cytometry and thus obtaining data indicating the reactivity of each antibody with its cell surface antigen; and (4) the step of comparing the thus obtained data and classifying the individual antibodies depending on the similarity. A method of identifying antigens which further comprises: (5) the step of selecting one to several antibodies from each antibody group formed in the step (4) and identifying antigens thereof; and (6) on the assumption that antigens of the antibodies belonging to a single antibody group are the same or highly related to one another, making relations between the antigens having been identified in the step (5) and the antibody groups to thereby identify the antigens. An antibody against HER1, an antibody against HER2, an antibody against CD46, an antibody against ITGA3, an antibody against ICAM1, an antibody against ALCAM, an antibody against CD147, an antibody against C1qR, an antibody against CD44, an antibody against CD73, an antibody against EpCAM and an antibody against HGFR, each obtained by using the above methods.

5. 发明授权

US08370630B2 Client device, mail system, program, and recording medium 有权
标题翻译：客户端设备，邮件系统，程序和记录介质
公开(公告)号：US08370630B2
公开(公告)日：2013-02-05
申请号：US12302621
申请日：2006-07-31
申请人： Keiko Ogawa
发明人： Keiko Ogawa
IPC分类号： H04L29/06
CPC分类号： H04L9/00 , H04L51/00 , H04L63/0428 , H04L63/061
摘要： A mail system having high security is realized by mounting TCP2 for mail communication between client apparatuses. The present invention relates to a mail communication system which is connected to a network and exchanges mails between client apparatuses provided with the existing mailers, and each client apparatus is mounted with a TCP2 driver. A TCP2 driver 34 includes a TCP2 core 36 and a mail system core 37 and an e-mail received via the network is processed in this TCP2 driver 34 and thereafter, is supplied to an existing mailer 31 of the client apparatus. In the mail system core 37 of the TCP2 driver 34, control of mail encryption and decryption, deletion of an unnecessary mail and the like is carried out.
摘要翻译：具有高安全性的邮件系统通过在客户端设备之间安装用于邮件通信的TCP2来实现。邮件通信系统技术领域本发明涉及一种邮件通信系统，其连接到网络并且在提供有现有邮件的客户端设备之间交换邮件，并且每个客户端装置都安装有TCP2驱动程序。 TCP2驱动器34包括TCP2核心36和邮件系统核心37，并且在该TCP2驱动器34中处理经由网络接收的电子邮件，然后提供给客户端装置的现有邮件程序31。在TCP2驱动器34的邮件系统核心37中，执行邮件加密和解密的控制，删除不必要的邮件等。

6. 发明申请

US20100077203A1 RELAY DEVICE 审中-公开
标题翻译：继电器
公开(公告)号：US20100077203A1
公开(公告)日：2010-03-25
申请号：US12373370
申请日：2006-07-13
申请人： Keiko Ogawa , Hirotsugu Ozaki
发明人： Keiko Ogawa , Hirotsugu Ozaki
IPC分类号： H04L29/06 , H04L12/22 , H04L12/66
CPC分类号： H04L69/16 , H04L12/66 , H04L63/1441 , H04L69/03 , H04L69/161 , H04L69/32
摘要： “Leakage”, “falsifying”, “masquerading”, “approach”, or “attack” of data on the Internet are prevented in a communication between a personal computer and the outside thereof without installing software or hardware in the personal computer. An intermediary apparatus includes NIC (Network Interface Card) drivers connected to networks respectively and a network layer and a transport layer which include “TCP/IP” defining a communication method for communicating while carrying out routing (ROUTING) between any two nodes and is provided for a physical layer and a data-link layer including the NIC drivers. Between the data-link layer and network layer, the function of “TCP2” can be provided.
摘要翻译：在个人计算机之间的个人计算机与其外部的通信中，在不安装软件或硬件的情况下，防止因特网上数据的“泄漏”，“伪造”，“伪装”，“接近”或“攻击”数据。中间装置包括分别连接到网络的NIC（网络接口卡）驱动器和网络层和传输层，其包括定义用于在任何两个节点之间进行路由（ROUTING）的通信的通信方法的“TCP / IP”，并且被提供用于物理层和包括NIC驱动程序的数据链路层。在数据链路层和网络层之间，可以提供“TCP2”功能。

7. 发明授权

US5576134A Two-component type developer and image forming process 失效
标题翻译：双组分型显影剂和成像方法
公开(公告)号：US5576134A
公开(公告)日：1996-11-19
申请号：US346015
申请日：1994-11-29
申请人： Keiko Ogawa , Michiaki Ishikawa , Meizo Shirose
发明人： Keiko Ogawa , Michiaki Ishikawa , Meizo Shirose
IPC分类号： G03G9/107 , G03G9/113 , G03G13/09
CPC分类号： G03G9/1075 , G03G13/09 , G03G9/1139
摘要： Disclosed is a two component type developer for negatively chargeable developer use, comprising a carrier and a colored toner particle comprising a binder resin and a colorant, wherein said carrier comprises a magnetic particle having thereon a resin coated layer containing a resin and a magnesium compound.
摘要翻译：公开了一种用于负电荷显影剂用途的双组分型显影剂，其包含载体和包含粘合剂树脂和着色剂的着色调色剂颗粒，其中所述载体包含其上含有树脂和镁化合物的树脂涂层的磁性颗粒。

8. 发明授权

US5441839A Negatively chargeable developer with carrier containing magnesium oxide 失效
标题翻译：带负电荷的负极显影剂含有氧化镁
公开(公告)号：US5441839A
公开(公告)日：1995-08-15
申请号：US222933
申请日：1994-04-05
申请人： Michiaki Ishikawa , Keiko Ogawa , Meizo Shirose , Hiroyuki Takagiwa
发明人： Michiaki Ishikawa , Keiko Ogawa , Meizo Shirose , Hiroyuki Takagiwa
IPC分类号： G03G9/097 , G03G9/107 , G03G9/113
CPC分类号： G03G9/09716 , G03G9/1075 , G03G9/1132 , G03G9/1139 , Y10T428/2998
摘要： A negative charge developer for electrophotography comprises a toner and a carrier having a core coated with a resin which contains at least one magnesium compound of a magnesium oxide, a magnesium hydroxide or a magnesium carbonate, wherein the magnesium compound has a single crystal structure.
摘要翻译：用于电子照相术的负电荷显影剂包括调色剂和具有包覆有至少一种镁化合物的氢氧化镁或碳酸镁的树脂的核的载体，其中所述镁化合物具有单晶结构。

9. 发明授权

US08195961B2 Removable storage device and associated methodology of data encryption 有权
标题翻译：可移动存储设备和相关联的数据加密方法
公开(公告)号：US08195961B2
公开(公告)日：2012-06-05
申请号：US12351050
申请日：2009-01-09
申请人： Keiko Ogawa
发明人： Keiko Ogawa
IPC分类号： G06F11/30
CPC分类号： H04L9/0844 , H04L9/0866 , H04L9/0897 , H04L63/0435 , H04L63/0464 , H04L2209/80
摘要： A data encryption transmission system and associated methodology is provided including a data input site that compresses and encrypts data based on a shared encryption key and then transmits the compressed and encrypted data to an external network. A database server which is operably linked to the external network and stores, manages, transmits, and receives data. A removable storage stores an identification code, and a client site which is configured to receive the removable storage generates an encryption key based on the identification code, receives encrypted data from the external network, decrypts and expands the received data based on the shared encryption key, encrypts the data based on the encryption key and saves the encrypted data, and finally decrypts the encrypted data and outputs the data using the encryption key.
摘要翻译：提供了数据加密传输系统和相关联的方法，包括基于共享加密密钥压缩和加密数据的数据输入站点，然后将压缩和加密的数据传输到外部网络。可操作地链接到外部网络并存储，管理，发送和接收数据的数据库服务器。可拆卸存储器存储识别码，并且被配置为接收可移动存储器的客户端站点基于识别码生成加密密钥，从外部网络接收加密数据，基于共享加密密钥解密和扩展接收到的数据，根据加密密钥加密数据，并保存加密数据，最后解密加密数据，并使用加密密钥输出数据。

10. 发明申请

US20110293673A1 ORAL FILM-FORM BASE AND ORAL FILM-FORM PREPARATION 有权
标题翻译：口腔膜形式和口腔膜形成准备
公开(公告)号：US20110293673A1
公开(公告)日：2011-12-01
申请号：US13146829
申请日：2009-03-06
申请人： Daisuke Asari , Mitsuhiko Hori , Keiko Ogawa
发明人： Daisuke Asari , Mitsuhiko Hori , Keiko Ogawa
IPC分类号： A61K9/00 , A61P25/06 , A61K31/135 , A61P37/08 , A61K31/18 , A61P13/08 , A61P1/08 , A61K31/437 , A61K31/426 , A61P1/04 , A61K31/4184 , A61P9/12 , A61K31/4439 , A61P3/10 , A61K31/4418 , A61K31/445 , A61K31/422
CPC分类号： A61K9/0056 , A61K9/7007 , A61K47/26 , A61K47/38
摘要： The present invention provides a film-form base having one or more sugars or sugar alcohols dispersed as fine particles therein, and also provides a film-form preparation containing the base and a drug. The base is produced by dispersing, in an organic solvent having a solubility parameter of 9.7 or higher, an edible polymer soluble in water and the organic solvent, and particles of one or two or more compounds selected from the group consisting of mono- to hexasaccharide sugars and sugar alcohols thereof which have an average particle size of 0.1 μm to 60 μm and are insoluble in an organic solvent. The present invention can therefore provide oral film-form base and preparation which have a rapid dissolution profile in the mouth and sufficient film strength, and provide a reduced sticky sensation attributed to the water-soluble polymer in the mouth and an improved feel when handled with the fingers.
摘要翻译：本发明提供一种具有分散为细颗粒的一种或多种糖或糖醇的薄膜形式的底物，并且还提供含有该基质和药物的薄膜形式的制剂。该碱是通过在溶解度参数为9.7以上的有机溶剂中分散可溶于水和有机溶剂的可食性聚合物，以及一种或两种以上选自单 - 六糖和糖醇，其平均粒度为0.1〜60μm，不溶于有机溶剂。因此，本发明可以提供在口腔中具有快速溶出曲线并具有足够的膜强度的口腔膜形式的基质和制剂，并且在口腔中提供归因于水溶性聚合物的降低的粘稠感和当用手指。

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