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31. 发明申请

US20130120747A1 CELL COUNTING AND SAMPLE CHAMBER AND METHODS OF FABRICATION 有权
公开(公告)号：US20130120747A1
公开(公告)日：2013-05-16
申请号：US13519283
申请日：2011-01-19
申请人： Leo L. Chan , Jean Qiu
发明人： Leo L. Chan , Jean Qiu
IPC分类号： G01N21/03
CPC分类号： B29C59/021 , B01L3/502707 , B01L2200/0689 , B01L2300/0877 , B01L2300/0887 , B29C65/4825 , B29C65/4835 , B29C65/5021 , B29C65/5057 , B29C66/1122 , B29C66/53461 , B29C66/71 , B29K2033/08 , B29K2063/00 , B29K2075/00 , B29L2031/756 , G01N15/14 , G01N15/1463 , G01N15/1484 , G01N21/03 , G01N21/6458 , G01N2015/1486 , G01N2201/02 , Y10T29/49826 , B29K2067/00 , B29K2069/00 , B29K2033/12 , B29K2025/06 , B29K2023/38
摘要： The invention generally relates to analytical and monitoring systems useful for analyzing and measuring cells and biological sample. More particularly, the invention relates to a unique cell counting chamber, e.g., a thin gap fluidic cell chamber for both bright field and fluorescent imaging of bacteria or parasites, and methods for making the same.

32. 发明申请

US20060286663A1 Method for producing a colorimetric resonant reflection biosensor on rigid surfaces 失效
公开(公告)号：US20060286663A1
公开(公告)日：2006-12-21
申请号：US11485867
申请日：2006-07-13
申请人： Brian Cunningham , Jean Qiu
发明人： Brian Cunningham , Jean Qiu
IPC分类号： C12M1/34 , B29D11/00
CPC分类号： B01L3/5085 , G01N21/253 , G01N21/4788 , G01N33/54373 , G02B5/1809 , Y10S435/808
摘要： The invention provides methods for fabricating calorimetric resonant reflection biosensors.

33. 发明授权

US06696286B1 Method and devices for detecting and enumerating microorganisms 失效
标题翻译：用于检测和列举微生物的方法和装置
公开(公告)号：US06696286B1
公开(公告)日：2004-02-24
申请号：US09495092
申请日：2000-02-01
申请人： Kurt J. Halverson , Ai-Ping Wei , Jean Qiu , Clyde D. Calhoun , James G. Berg , James G. Bentsen , Raymond P. Johnston
发明人： Kurt J. Halverson , Ai-Ping Wei , Jean Qiu , Clyde D. Calhoun , James G. Berg , James G. Bentsen , Raymond P. Johnston
IPC分类号： C12M134
CPC分类号： C12Q1/02
摘要： A method for detecting a microorganism in a test sample is described. The method involves distributing microvolumes of a sample to a plurality of microcompartments of a culture device, incubating for a time sufficient to permit at least one cell division cycle of the microorganism, then detecting the presence or absence of the microorganism in the microcompartments. Also disclosed are devices for carrying out these methods.
摘要翻译：描述了测试样品中微生物检测方法。该方法包括将样品的微量体积分配到培养装置的多个微室中，孵育足以允许微生物的至少一个细胞分裂周期的时间，然后检测微室中的微生物的存在或不存在。还公开了用于执行这些方法的装置。

34. 发明授权

US07306827B2 Method and machine for replicating holographic gratings on a substrate 有权
标题翻译：用于在基板上复制全息光栅的方法和机器
公开(公告)号：US07306827B2
公开(公告)日：2007-12-11
申请号：US10201818
申请日：2002-07-23
申请人： Peter Y. Li , Jean Qiu , Alex Borsody
发明人： Peter Y. Li , Jean Qiu , Alex Borsody
IPC分类号： B05D3/06 , B05D3/12
CPC分类号： G01N21/253 , B01L3/5085 , G01N21/4788 , G01N21/7743 , G01N33/54373 , G02B5/1809
摘要： A machine and process for a pattern, such as a submicron grating pattern onto a substrate.
摘要翻译：用于图案的机器和工艺，例如在基底上的亚微米光栅图案。

35. 发明授权

US06391578B2 Method and devices for partitioning biological sample liquids into microvolumes 有权
标题翻译：将生物样品液体分解成微量体积的方法和装置
公开(公告)号：US06391578B2
公开(公告)日：2002-05-21
申请号：US09824160
申请日：2001-04-02
申请人： Michael G. Williams , Kurt J. Halverson , Gary E. Krejcarek , Ai-Ping Wei , James G. Berg , Peter D. Wickert , Clyde D. Calhoun , Mark K. Debe , Jean Qiu
发明人： Michael G. Williams , Kurt J. Halverson , Gary E. Krejcarek , Ai-Ping Wei , James G. Berg , Peter D. Wickert , Clyde D. Calhoun , Mark K. Debe , Jean Qiu
IPC分类号： C12Q106
CPC分类号： B01L3/5085 , C12M23/12 , C12M23/20 , C12M23/44 , C12M25/04 , C12M41/36
摘要： A method for partitioning an aqueous biological liquid sample into discrete microvolumes for detection and enumeration of microorganisms is described. The method involves distributing microvolumes of a sample to a plurality of hydrophilic liquid-retaining zones of a culture device, where each liquid-retaining zone is surrounded by a portion of a hydrophobic “land” area. Also disclosed are devices for carrying out these methods.
摘要翻译：描述了将水性生物液体样品分成用于微生物检测和计数的离散微量体积的方法。该方法包括将样品的微量体积分配到培养装置的多个亲水性液体保持区，其中每个液体保持区被疏水性“陆地”区域的一部分包围。还公开了用于执行这些方法的装置。

36. 发明授权

US07329537B2 Micro-pattern embedded plastic optical film device for cell-based assays 有权
标题翻译：用于基于细胞的测定的微图案嵌入式塑料光学膜装置
公开(公告)号：US07329537B2
公开(公告)日：2008-02-12
申请号：US10825883
申请日：2004-04-17
申请人： Jean Qiu
发明人： Jean Qiu
IPC分类号： C12M1/34
CPC分类号： B01L3/5085 , B01L9/50 , B01L2200/12 , B01L2300/0819 , B01L2300/163 , C12M25/02 , C12M41/36
摘要： In the present invention, a micro-pattern embedded optical film for cell-based assays is described. The optical film contains micro-patterns in the form of geometric shapes, such as lines and curves, and numbers and letters. Furthermore, the optical film contains a coordinate system that allows identification of each location on the optical film for cell-based assays, including cell growth, identification, and measurements under an optical microscope. Furthermore, an apparatus with the micro-pattern embedded optical film and a supporting part is described. Methods for making the optical film and apparatus are disclosed. A method for performing cell-based assays using the optical film or apparatus is shown.
摘要翻译：在本发明中，描述了用于基于细胞的测定的微图案嵌入式光学膜。光学膜包含几何形状的微图案，例如线条和曲线以及数字和字母。此外，光学膜包含坐标系，其允许在光学膜上识别每个位置用于基于细胞的测定，包括细胞生长，鉴定和光学显微镜下的测量。此外，描述了具有微图案嵌入式光学膜和支撑部件的装置。公开了制造光学膜和装置的方法。示出了使用光学膜或装置进行基于细胞的测定的方法。

37. 发明申请

US20050208467A1 Micro-pattern embedded plastic optical film device for cell-based assays 有权
标题翻译：用于基于细胞的测定的微图案嵌入式塑料光学膜装置
公开(公告)号：US20050208467A1
公开(公告)日：2005-09-22
申请号：US10825883
申请日：2004-04-17
申请人： Jean Qiu
发明人： Jean Qiu
IPC分类号： B01L3/00 , C12M1/34 , C12Q1/00
CPC分类号： B01L3/5085 , B01L9/50 , B01L2200/12 , B01L2300/0819 , B01L2300/163 , C12M25/02 , C12M41/36
摘要： In the present invention, a micro-pattern embedded optical film for cell-based assays is described. The optical film contains micro-patterns in the form of geometric shapes, such as lines and curves, and numbers and letters. Furthermore, the optical film contains a coordinate system that allows identification of each location on the optical film for cell-based assays, including cell growth, identification, and measurements under an optical microscope. Furthermore, an apparatus with the micro-pattern embedded optical film and a supporting part is described. Methods for making the optical film and apparatus are disclosed. A method for performing cell-based assays using the optical film or apparatus is shown.
摘要翻译：在本发明中，描述了用于基于细胞的测定的微图案嵌入式光学膜。光学膜包含几何形状的微图案，例如线条和曲线以及数字和字母。此外，光学膜包含坐标系，其允许在光学膜上识别每个位置用于基于细胞的测定，包括细胞生长，鉴定和光学显微镜下的测量。此外，描述了具有微图案嵌入式光学膜和支撑部件的装置。公开了制造光学膜和装置的方法。示出了使用光学膜或装置进行基于细胞的测定的方法。

38. 发明授权

US06244208B1 Time-temperature integrating indicator device with barrier material 失效
标题翻译：具有阻隔材料的时间积分指示装置
公开(公告)号：US06244208B1
公开(公告)日：2001-06-12
申请号：US09069576
申请日：1998-04-29
申请人： Jean Qiu , Joan M. Noyola , David J. Yarusso
发明人： Jean Qiu , Joan M. Noyola , David J. Yarusso
IPC分类号： G01K300
CPC分类号： G01K3/04
摘要： A time-temperature indicator device provides a visually observable indication of the cumulative thermal exposure of an object. The device includes a substrate having a diffusely light-reflective porous matrix and a backing. The backing includes on its surface a viscoelastic indicator material for contacting the substrate and a barrier material for substantially inhibiting the lateral flow of viscoelastic indicator material between the substrate and the backing.
摘要翻译：时间 - 温度指示器装置提供对物体的累积热暴露的视觉可见的指示。该装置包括具有漫反射多孔基体和背衬的基底。背衬在其表面上包括用于接触基底的粘弹性指示剂材料和用于基本上抑制基底和背衬之间的粘弹性指示剂材料的侧向流动的阻挡材料。

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