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1. 发明授权

US07306827B2 Method and machine for replicating holographic gratings on a substrate 有权
标题翻译：用于在基板上复制全息光栅的方法和机器
公开(公告)号：US07306827B2
公开(公告)日：2007-12-11
申请号：US10201818
申请日：2002-07-23
申请人： Peter Y. Li , Jean Qiu , Alex Borsody
发明人： Peter Y. Li , Jean Qiu , Alex Borsody
IPC分类号： B05D3/06 , B05D3/12
CPC分类号： G01N21/253 , B01L3/5085 , G01N21/4788 , G01N21/7743 , G01N33/54373 , G02B5/1809
摘要： A machine and process for a pattern, such as a submicron grating pattern onto a substrate.
摘要翻译：用于图案的机器和工艺，例如在基底上的亚微米光栅图案。

2. 发明授权

US07863052B2 Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor 有权
公开(公告)号：US07863052B2
公开(公告)日：2011-01-04
申请号：US11490556
申请日：2006-07-20
申请人： Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
发明人： Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
IPC分类号： G01N33/551
CPC分类号： G01N21/648 , G01N21/552 , G01N21/6428 , G01N21/7743 , Y10S435/808 , Y10S436/805 , Y10T436/143333
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.

3. 发明授权

US07960170B2 Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor 有权
标题翻译：光栅传感器结合无标签结合检测和荧光放大和传感器读出系统
公开(公告)号：US07960170B2
公开(公告)日：2011-06-14
申请号：US12387391
申请日：2009-04-30
申请人： Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
发明人： Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
IPC分类号： C12M1/34
CPC分类号： G01N21/648 , G01N21/552 , G01N21/6428 , G01N21/7743 , Y10S435/808 , Y10S436/805 , Y10T436/143333
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.
摘要翻译：公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。公开了一些实施例，其被优化用于空气模式中的ER检测，其中样品是干的。其他实施方案针对液体模式中的ER检测进行了优化，其中将样品悬浮在诸如水的液体介质中。还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。还公开了一种用于这种传感器的读出系统。一个实施例包括优化用于收集无标记检测数据的第一光源，为采集ER荧光放大数据而优化的第二光源和至少一个检测器。在一个实施例中，检测器是成像系统，并且包括用于收集ER和无标签数据的CCD照相机。在其他实施例中，至少一个检测器采用用于收集无标记数据的光谱仪的形式和用于收集ER数据的光电倍增管。在其他实施例中，使用诸如可调激光器或宽带光源的单个光源。

4. 发明申请

US20100329933A1 Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor 审中-公开
标题翻译：光栅传感器结合无标签结合检测和荧光放大和传感器读出系统
公开(公告)号：US20100329933A1
公开(公告)日：2010-12-30
申请号：US12804525
申请日：2010-07-22
申请人： Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
发明人： Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
IPC分类号： G01N21/00
CPC分类号： G01N21/648 , G01N21/552 , G01N21/6428 , G01N21/7743 , Y10S435/808 , Y10S436/805 , Y10T436/143333
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is in the form of an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.
摘要翻译：公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。公开了一些实施例，其被优化用于空气模式中的ER检测，其中样品是干的。其他实施方案针对液体模式中的ER检测进行了优化，其中将样品悬浮在诸如水的液体介质中。还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。还公开了一种用于这种传感器的读出系统。一个实施例包括优化用于收集无标记检测数据的第一光源，为采集ER荧光放大数据而优化的第二光源和至少一个检测器。在一个实施例中，检测器是成像系统的形式，并且包括用于收集ER和无标签数据的CCD照相机。在其他实施例中，至少一个检测器采用用于收集无标签数据的光谱仪的形式和用于收集ER数据的光电倍增管。在其他实施例中，使用诸如可调激光器或宽带光源的单个光源。

5. 发明申请

US20100227769A1 GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR 有权
标题翻译：基于GRATING的传感器组合无标签绑定检测和荧光放大和读取传感器系统
公开(公告)号：US20100227769A1
公开(公告)日：2010-09-09
申请号：US11490556
申请日：2006-07-20
申请人： Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
发明人： Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
IPC分类号： C40B30/04 , G01N30/00 , C12M1/34 , C40B60/12 , G01N21/00 , G01N33/00 , C12Q1/70 , G01N33/48 , G01N33/543 , C12Q1/02 , G01N33/567 , G01N33/554 , G01N21/55 , G01J3/28
CPC分类号： G01N21/648 , G01N21/552 , G01N21/6428 , G01N21/7743 , Y10S435/808 , Y10S436/805 , Y10T436/143333
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.
摘要翻译：公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。公开了一些实施例，其被优化用于空气模式中的ER检测，其中样品是干的。其他实施方案针对液体模式中的ER检测进行了优化，其中将样品悬浮在诸如水的液体介质中。还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。还公开了一种用于这种传感器的读出系统。一个实施例包括优化用于收集无标记检测数据的第一光源，为采集ER荧光放大数据而优化的第二光源和至少一个检测器。在一个实施例中，检测器是成像系统，并且包括用于收集ER和无标签数据的CCD照相机。在其他实施例中，至少一个检测器采用用于收集无标签数据的光谱仪的形式和用于收集ER数据的光电倍增管。在其他实施例中，使用诸如可调激光器或宽带光源的单个光源。

6. 发明申请

US20100003743A1 Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor 有权
标题翻译：光栅传感器结合无标签结合检测和荧光放大和传感器读出系统
公开(公告)号：US20100003743A1
公开(公告)日：2010-01-07
申请号：US12387391
申请日：2009-04-30
申请人： Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
发明人： Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
IPC分类号： C12M1/34
CPC分类号： G01N21/648 , G01N21/552 , G01N21/6428 , G01N21/7743 , Y10S435/808 , Y10S436/805 , Y10T436/143333
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.
摘要翻译：公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。公开了一些实施例，其被优化用于空气模式中的ER检测，其中样品是干的。其他实施方案针对液体模式中的ER检测进行了优化，其中将样品悬浮在诸如水的液体介质中。还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。还公开了一种用于这种传感器的读出系统。一个实施例包括优化用于收集无标记检测数据的第一光源，为采集ER荧光放大数据而优化的第二光源和至少一个检测器。在一个实施例中，检测器是成像系统，并且包括用于收集ER和无标签数据的CCD照相机。在其他实施例中，至少一个检测器采用用于收集无标签数据的光谱仪的形式和用于收集ER数据的光电倍增管。在其他实施例中，使用诸如可调激光器或宽带光源的单个光源。

7. 发明申请

US20080240543A1 Calibration and normalization method for biosensors 审中-公开
标题翻译：生物传感器的校正和归一化方法
公开(公告)号：US20080240543A1
公开(公告)日：2008-10-02
申请号：US12077809
申请日：2008-03-20
申请人： Wolfgang Ernst Gustav Budach , Dieter Neuschafer , Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
发明人： Wolfgang Ernst Gustav Budach , Dieter Neuschafer , Stephen C. Schulz , Brian T. Cunningham , Lance G. Laing , Peter Y. Li , Brant Binder , Gangadhar Jogikalmath , Alex Borsody
IPC分类号： G06K9/00
CPC分类号： G01N33/54373 , B01L3/5085 , G01N21/4788 , G01N21/552 , G01N21/554 , G01N21/6428 , G01N21/645 , G01N21/648 , G01N21/7743
摘要： Calibration and normalization methods for a grating-based sensor design are disclosed. The sensor may be constructed in a manner optimized for both label-free and luminescence, e.g. fluorescence, amplification detection in a single device. Such a sensor, based on grating or another periodical structure with appropriate coating, dramatically increases the diversity of applications and allows realizing novel concepts that provide qualitative and quantitative information/data for each location or capture element in the sensor surface. The invention takes advantage of these different modes to carry out a quality control (QC) step and a calibration of each individual location of the sensor. Thus, the assay data can be flagged according to their quality and local density variations, batch variations and variations in the printed deposition of probes or the materials to the surface can be compensated.
摘要翻译：公开了基于光栅的传感器设计的校准和归一化方法。传感器可以以针对无标记和发光两者而优化的方式来构造。荧光，放大检测在单个器件中。这种基于光栅或具有适当涂层的周期性结构的传感器显着地增加了应用的多样性，并且实现了为传感器表面中的每个位置或捕获元件提供定性和定量的信息/数据的新概念。本发明利用这些不同的模式来执行传感器的每个单独位置的质量控制（QC）步骤和校准。因此，可以根据其质量和局部密度变化标记测定数据，可以补偿探针的印刷沉积或表面的材料的批量变化和变化。

8. 发明申请

US20100189338A1 SYSTEMS AND METHODS FOR COUNTING CELLS AND BIOMOLECULES 审中-公开
标题翻译：用于计数细胞和生物分子的系统和方法
公开(公告)号：US20100189338A1
公开(公告)日：2010-07-29
申请号：US12404803
申请日：2009-03-16
申请人： Bo Lin , Peter Y. Li , Jean Qiu , Timothy Smith , Todd Sobolewski , Alnoor Pirani
发明人： Bo Lin , Peter Y. Li , Jean Qiu , Timothy Smith , Todd Sobolewski , Alnoor Pirani
IPC分类号： G06K9/00
CPC分类号： G01N15/1475 , G01N2015/1006 , G01N2015/1486
摘要： The present invention generally relates to systems and methods for counting biomolecules or cells. In certain embodiments, the invention provides a cell counting or biomolecule counting system including: a covered chamber having a known height and configured to hold a suspension of biomolecules or cells in a sample; at least one fluorescent light source connected to at least one fluorescent light beam narrowing device; a bright-field light source connected to a bright-field light beam narrowing device; a microscope objective; a detection device; a fluorescent filter assembly to allow only excitation light to illuminate the sample and allow only emission light from the sample to be imaged by the detection device; and a movable light shutter to block bright-field light during fluorescent detection.
摘要翻译：本发明一般涉及计数生物分子或细胞的系统和方法。在某些实施方案中，本发明提供细胞计数或生物分子计数系统，其包括：具有已知高度并被构造成保持样品中生物分子或细胞悬浮液的被覆室; 至少一个荧光光源连接到至少一个荧光光束变窄装置; 连接到明场光束变窄装置的亮场光源; 显微镜目标; 检测装置; 荧光过滤器组件，仅允许激发光照射样品并且仅允许来自样品的发射光被检测装置成像; 以及可动光闸以在荧光检测期间阻挡亮场光。

9. 发明授权

US08883491B2 Systems and methods for counting cells and biomolecules 有权
标题翻译：用于计数细胞和生物分子的系统和方法
公开(公告)号：US08883491B2
公开(公告)日：2014-11-11
申请号：US12935973
申请日：2009-04-08
申请人： Bo Lin , Peter Y. Li , Jean Qiu , Timothy Smith , Todd Sobolewski , Alnoor Pirani
发明人： Bo Lin , Peter Y. Li , Jean Qiu , Timothy Smith , Todd Sobolewski , Alnoor Pirani
IPC分类号： G01N21/00 , C12M1/34 , G01N21/76 , G01N15/14 , G01N21/64 , G01N15/10
CPC分类号： G06K9/00134 , G01N15/1475 , G01N21/64 , G01N21/6458 , G01N33/487 , G01N2015/1006 , G01N2015/1486 , G01N2015/1493 , G01N2021/6439 , G01N2201/062 , G02B21/06 , G02B21/16 , G02B21/365 , Y10T436/101666 , Y10T436/143333
摘要： The present invention generally relates to systems and methods for counting biomolecules or cells. In certain embodiments, the invention provides a cell counting or biomolecule counting system including: a covered chamber having a known height and configured to hold a suspension of biomolecules or cells in a sample; at least one fluorescent light source connected to at least one fluorescent light beam narrowing device; a bright-field light source connected to a bright-field light beam narrowing device; a microscope objective; a detection device; a fluorescent filter assembly to allow only excitation light to illuminate the sample and allow only emission light from the sample to be imaged by the detection device; and a movable light shutter to block bright-field light during fluorescent detection.
摘要翻译：本发明一般涉及计数生物分子或细胞的系统和方法。在某些实施方案中，本发明提供细胞计数或生物分子计数系统，其包括：具有已知高度并被构造成保持样品中生物分子或细胞悬浮液的被覆室; 至少一个荧光光源连接到至少一个荧光光束变窄装置; 连接到明场光束变窄装置的亮场光源; 显微镜目标; 检测装置; 荧光过滤器组件，其仅允许激发光照射样品并且仅允许来自样品的发射光被检测装置成像; 以及可动光闸以在荧光检测期间阻挡亮场光。

10. 发明申请

US20110136152A1 SYSTEMS AND METHODS FOR COUNTING CELLS AND BIOMOLECULES 有权
标题翻译：用于计数细胞和生物分子的系统和方法
公开(公告)号：US20110136152A1
公开(公告)日：2011-06-09
申请号：US12935973
申请日：2009-04-08
申请人： Bo Lin , Peter Y. Li , Jean Qiu , Timothy Smith , Todd Sobolewski , Alnoor Pirani
发明人： Bo Lin , Peter Y. Li , Jean Qiu , Timothy Smith , Todd Sobolewski , Alnoor Pirani
IPC分类号： G01N33/53 , C12M1/34 , C12Q1/06 , C12Q1/68 , G01N21/64
CPC分类号： G06K9/00134 , G01N15/1475 , G01N21/64 , G01N21/6458 , G01N33/487 , G01N2015/1006 , G01N2015/1486 , G01N2015/1493 , G01N2021/6439 , G01N2201/062 , G02B21/06 , G02B21/16 , G02B21/365 , Y10T436/101666 , Y10T436/143333
摘要： The present invention generally relates to systems and methods for counting biomolecules or cells. In certain embodiments, the invention provides a cell counting or biomolecule counting system including: a covered chamber having a known height and configured to hold a suspension of biomolecules or cells in a sample; at least one fluorescent light source connected to at least one fluorescent light beam narrowing device; a bright-field light source connected to a bright-field light beam narrowing device; a microscope objective; a detection device; a fluorescent filter assembly to allow only excitation light to illuminate the sample and allow only emission light from the sample to be imaged by the detection device; and a movable light shutter to block bright-field light during fluorescent detection.
摘要翻译：本发明一般涉及计数生物分子或细胞的系统和方法。在某些实施方案中，本发明提供细胞计数或生物分子计数系统，其包括：具有已知高度并被构造成保持样品中生物分子或细胞悬浮液的被覆室; 至少一个荧光光源连接到至少一个荧光光束变窄装置; 连接到明场光束变窄装置的亮场光源; 显微镜目标; 检测装置; 荧光过滤器组件，仅允许激发光照射样品并且仅允许来自样品的发射光被检测装置成像; 以及可动光闸以在荧光检测期间阻挡亮场光。

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