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    • 26. 发明授权
    • Transmucosal drug delivery device and method including chemical permeation enhancers
    • 粘膜下药物递送装置和方法包括化学渗透促进剂
    • US08882748B2
    • 2014-11-11
    • US12576087
    • 2009-10-08
    • Scott UhlandEric PeetersHussain Fatakdawala
    • Scott UhlandEric PeetersHussain Fatakdawala
    • A61K9/22A61M31/00A61K9/00
    • A61M31/002A61K9/0036
    • Devices and methods are provided for transmucosal drug delivery. The transmucosal drug delivery device may include a housing configured for intralumenal deployment, such as intravaginally, into a human or animal subject; a drug-dispensing portion which contains at least one drug, the drug-dispensing portion being configured to dispense the drug from the housing by positive displacement; and a permeability enhancer-dispensing portion configured to release or generate a permeability enhancing substance to disrupt at least one region of a mucosal barrier adjacent to the housing at a selected time while intralumenally deployed in the human or animal subject. The device may be operable to dispense the drug from the housing to a region of the mucosal barrier disrupted by the permeability enhancing substance.
    • 提供了用于经粘膜药物递送的装置和方法。 透粘膜药物递送装置可以包括构造成用于腔内部署的壳体,例如阴道内部分入人或动物受试者; 药物分配部分,其包含至少一种药物,所述药物分配部分构造成通过正位移从所述壳体分配药物; 以及渗透性增强剂分配部分,被配置为释放或产生渗透性增强物质,以在选择的时间在脉管内部署在人或动物受试者中的同时破坏邻近所述壳体的粘膜屏障的至少一个区域。 该装置可操作以将药物从壳体分配到由渗透性增强物质破坏的粘膜屏障的区域。
    • 28. 发明授权
    • Electrostatically addressable microvalves
    • 静电寻址微型阀
    • US08561963B2
    • 2013-10-22
    • US11959778
    • 2007-12-19
    • Ashish PattekarEugene M ChowEric Peeters
    • Ashish PattekarEugene M ChowEric Peeters
    • F16K31/128
    • F16K99/0001B01L3/502738B01L2200/12B01L2300/0819B01L2300/0887B01L2400/0655F16K99/0026Y10T137/0318Y10T137/0391Y10T137/87249
    • An improved microvalve is described. The microvalve includes a corresponding actuation aperture in an actuation aperture layer. A control fluid flows through the actuation aperture. The flow of the control fluid is controlled by an electric field typically applied via a charge distribution near an actuation aperture layer. In one embodiment, the electric field may adjust the opening and closing of the actuation aperture thereby controlling the flow of the control fluid. In a second embodiment, the control fluid is an electrorheological fluid where the electric field controls the viscosity of the ER fluid thereby controlling fluid flow through the actuation aperture. In both embodiments the flow of the control fluid controls stretching of a flexible membrane formed along the wall of a conduit through which a fluid to be controlled flows. The stretching of the flexible membrane controlling the flow of the main fluid to be controlled.
    • 描述了改进的微型阀。 微型阀包括致动孔层中相应的致动孔。 控制流体流过致动孔。 控制流体的流动由通常通过致动孔层附近的电荷分布施加的电场来控制。 在一个实施例中,电场可以调节致动孔的打开和关闭,从而控制控制流体的流动。 在第二实施例中,控制流体是电流变流体,其中电场控制ER流体的粘度,从而控制通过致动孔的流体流动。 在两个实施例中,控制流体的流动控制沿导管的壁形成的柔性膜的拉伸,待控制的流体通过该壁流动。 柔性膜的拉伸控制要控制的主流体的流动。
    • 30. 发明授权
    • Delivery devices and methods with collimated gas stream and particle source
    • 具有准直气流和颗粒源的输送装置和方法
    • US08388569B2
    • 2013-03-05
    • US13089769
    • 2011-04-19
    • Scott UhlandEric Peeters
    • Scott UhlandEric Peeters
    • A61M37/00
    • A61M37/00A61D7/00A61M5/2046A61M5/2053A61M5/3007A61M5/3015
    • Delivery devices, methods and systems are provided for the delivery of particles into a biological tissue. The device includes a gas source comprising a gas or capable of selectively producing a gas; a first particle source comprising a first plurality of particles; a first collimator fluidly connected with the gas source and adapted to form a collimated stream of the first plurality of particles entrained in the gas. The device also includes a tissue-interfacing surface adapted to interface with a surface of the tissue and orient the first collimator with the tissue such that the collimated stream of the first plurality of particles will penetrate the tissue in a direction substantially perpendicular to the surface of the tissue.
    • 提供递送装置,方法和系统用于将颗粒递送到生物组织中。 该装置包括气体源,其包括气体或能选择性地产生气体; 包括第一多个颗粒的第一颗粒源; 第一准直器,其与气体源流体连接并且适于形成夹带在气体中的第一多个颗粒的准直流。 该装置还包括适于与组织的表面相接合并且使第一准直器与组织对准的组织接合表面,使得第一多个颗粒的准直流将沿基本上垂直于组织的表面的方向穿透组织 组织。