专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

US20060135861A1 Apparatus and method for blood analysis 审中-公开
标题翻译：血液分析仪器及方法
公开(公告)号：US20060135861A1
公开(公告)日：2006-06-22
申请号：US10544293
申请日：2004-01-19
申请人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort , Rolf Wolthuis
发明人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort , Rolf Wolthuis
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0066 , G01N21/65 , G01N2021/656
摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for blood analysis on vessels. An excitation system (exs) emits an excitation beam to excite a target region. A detection system (dsy) is provided for detecting and analyzing scattered radiation from the target region. Those areas are selected or predetermined so that only scattered radiation from blood in capillaries having a diameter below a predetermined diameter value and/or including an amount of red blood cells below a predetermined cell amount is analyzed. Thus, in contrast to analysis on whole blood or large amounts of blood cells less reabsorption and scattering of Raman light due to red blood cells is obtained. Further, the possibility to directly measure in the blood plasma without interference of the red blood cells, thereby yielding a higher signal-to-noise ratio, is given.
摘要翻译：本发明涉及用于血管分析的分析装置，特别是光谱分析装置。激发系统（exs）发射激发光束以激发目标区域。提供了一种用于检测和分析来自目标区域的散射辐射的检测系统（dsy）。选择或预定那些区域，以便仅分析具有低于预定直径值的直径的毛细血管和/或包括低于预定细胞量的红细胞量的来自血液的散射辐射。因此，与全血或大量血细胞的分析相反，获得了由于红细胞引起的拉曼光的再吸收和散射较少。此外，给出了在血浆中直接测量而不干扰红细胞，从而产生更高的信噪比的可能性。

22. 发明申请

US20060100524A1 Analysis apparatus and method 审中-公开
标题翻译：分析装置和方法
公开(公告)号：US20060100524A1
公开(公告)日：2006-05-11
申请号：US10541176
申请日：2003-12-04
申请人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort
发明人： Gerhardus Lucassen , Gerwin Puppels , Marjolein Van Der Voort
IPC分类号： A61B6/00
CPC分类号： G01J3/44 , A61B5/0059 , A61B5/0068 , G01N21/65 , G01N2021/656
摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for analysing an object, such as the blood of a patient, and a corresponding analysis method. An excitation system (exs) emits an excitation beam (exb) to excite a target region and a beam separation unit (hm) separates at least part of elastically scattered radiation from inelastically scattered radiation, said scattered radiation being generated by the excitation beam (exb) at the target region. A monitoring system (lso) generates an image of the target region using the elastically scattered or the inelastically scattered radiation and defines a region of interest in said image. To increase efficiency of the recording of Raman spectra, a control unit (ctrl) is provided for controlling the excitation system (exs) such that the defined region of interest of the target region is excited and/or for controlling the detection system (dsy) such that only signals from the defined region of interest are detected, and a detection system (dsy) is provided for detecting scattered radiation from the defined region of interest generated by the excitation beam. Preferably the signal from the defined region of interest is averaged by distributing the laser excitation power over the defined region of interest area.
摘要翻译：本发明涉及一种用于分析诸如患者血液的物体的分析装置，特别是光谱分析装置和相应的分析方法。激发系统（exs）发射激发光束（exb）以激发目标区域，光束分离单元（hm）将弹性散射辐射的至少一部分与非弹性散射辐射分离，所述散射辐射由激发光束（exb ）在目标区域。监测系统（lso）使用弹性散射或非弹性散射的辐射产生目标区域的图像，并且定义所述图像中的感兴趣区域。为了提高拉曼光谱记录的效率，提供控制单元（ctrl）以控制激励系统（exs），使得目标区域的限定的目标区域被激发和/或用于控制检测系统（dsy）使得仅检测到来自限定的感兴趣区域的信号，并且提供检测系统（dsy），用于检测来自由激发光束产生的所定义的感兴趣区域的散射辐射。优选地，通过在所定义的感兴趣区域区域上分布激光激发功率来平均来自限定的感兴趣区域的信号。

23. 发明授权

US08812080B2 Algorithm for photonic needle console 有权
标题翻译：光子针控制器算法
公开(公告)号：US08812080B2
公开(公告)日：2014-08-19
申请号：US13376702
申请日：2010-06-07
申请人： Rami Nachabe , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Marjolein Van Der Voort , Adrien Desjardins , Drazenko Babic , Nenad Mihajlovic
发明人： Rami Nachabe , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Marjolein Van Der Voort , Adrien Desjardins , Drazenko Babic , Nenad Mihajlovic
IPC分类号： A61B5/05
CPC分类号： G06F19/321 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/14503 , A61B5/6848 , A61B5/7435 , A61B5/7475 , A61B6/467 , A61B6/469 , A61B6/545 , A61B8/0833 , A61B8/461 , A61B8/467 , A61B8/469 , A61B8/585 , A61B17/3401 , A61B17/3403 , A61B34/20 , A61B90/92 , A61B90/96 , A61B90/98 , A61B2017/00199 , A61B2017/00225 , A61B2034/2055 , A61B2090/376 , A61B2090/3908 , A61B2090/3945 , A61B2562/08 , G06F19/00 , G16H40/63
摘要： Needles are widely used in interventional radiology. Each medical application requires a specific needle type. The same holds for the photonic needles which analysis depends on the type of application the clinician aims for. Therefore, it is relevant to have the X-ray machine recognize the type of needle that is being used and to load the required software for the tissue analysis. It is therefore proposed to have a data link established between the imaging modality used for the acquisition of the patient anatomy (X-ray, CT, MR or US) and the system that processes optical data from the needle, so that the information from this imaging modality can be used to guide the processing. In a preferred embodiment the selection is made by reading out the code present in the disposable needle when it is connected to the console.
摘要翻译：针头广泛用于介入放射学。每个医疗应用都需要特殊的针型。同样适用于光子针，分析取决于临床医生的应用类型。因此，使X射线机器识别正在使用的针的类型并加载组织分析所需的软件是相关的。因此，建议在用于获取患者解剖结构（X射线，CT，MR或US）的成像模式和处理来自针的光学数据的系统之间建立数据链路，使得来自该信息的信息成像模式可用于指导处理。在优选实施例中，通过在连接到控制台时读出一次性针头中存在的代码来进行选择。

24. 发明申请

US20120093378A1 VISUALIZATION OF PHYSIOLOGICAL PARAMETERS 审中-公开
标题翻译：生理参数的可视化
公开(公告)号：US20120093378A1
公开(公告)日：2012-04-19
申请号：US13379668
申请日：2010-06-29
申请人： Rami Nachabé , Bernardus Hendrikus Wilhelmus Hendriks , Drazenko Babic , Augustinus Laurentius Braun , Marjolein Van Der Voort , Adrien Emmanuel Desjardins , Nenad Mihajlovic , Rik Harbers
发明人： Rami Nachabé , Bernardus Hendrikus Wilhelmus Hendriks , Drazenko Babic , Augustinus Laurentius Braun , Marjolein Van Der Voort , Adrien Emmanuel Desjardins , Nenad Mihajlovic , Rik Harbers
IPC分类号： G06K9/00 , H04N7/18
CPC分类号： A61B6/12 , A61B1/00147 , A61B5/065 , A61B6/463 , A61B6/5247 , A61B8/463 , A61B34/20 , A61B2034/256 , A61B2090/365
摘要： The invention relates to a medical imaging apparatus for providing information about an object. The invention further relates to a method for providing information about an object. In order to improve the preparation and the visual reception of information relating to an object during medical interventions, a medical imaging apparatus for providing information about an object is provided that comprises an image acquisition device an interventional device, a processing device and a display device. The image acquisition device detects object data from at least one region of interest of an object and provides the object data to the processing device. The interventional device detects physiological parameters of the object depending on the position of a predetermined area of the interventional device in relation to the object and provides the physiological parameters to the processing device. Further, the processing device transforms at least a part of the object data into image data and converts the physiological parameters into physiological data. The processing device then modifies at least one image parameter of the image data depending on the physiological data and thereby transforms the image data into modified live image data which is provided to the display device displaying a modified live image.
摘要翻译：本发明涉及一种用于提供关于物体的信息的医学成像设备。本发明还涉及一种用于提供关于对象的信息的方法。为了改善在医疗干预期间与物体有关的信息的准备和视觉接收，提供了一种用于提供关于物体的信息的医学成像装置，其包括图像获取装置，介入装置，处理装置和显示装置。图像获取装置从对象的至少一个感兴趣区域检测对象数据，并将对象数据提供给处理装置。介入装置根据介入装置相对于物体的预定区域的位置来检测物体的生理参数，并将生理参数提供给处理装置。此外，处理装置将至少一部分对象数据变换为图像数据，并将生理参数转换为生理数据。处理装置然后根据生理数据修改图像数据的至少一个图像参数，从而将图像数据变换为提供给显示修改的实时图像的显示装置的修改的实况图像数据。

25. 发明申请

US20120088991A1 ALGORITHM FOR PHOTONIC NEEDLE CONSOLE 有权
标题翻译： PHOTONIC NEEDLE CONSOLE算法
公开(公告)号：US20120088991A1
公开(公告)日：2012-04-12
申请号：US13376702
申请日：2010-06-07
申请人： Rami Nachabe , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Marjolein Van Der Voort , Adrien Desjardins , Drazenko Babic , Nenad Mihajlovic
发明人： Rami Nachabe , Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Marjolein Van Der Voort , Adrien Desjardins , Drazenko Babic , Nenad Mihajlovic
IPC分类号： A61B5/1455 , A61B5/055 , A61B5/05
CPC分类号： G06F19/321 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0091 , A61B5/14503 , A61B5/6848 , A61B5/7435 , A61B5/7475 , A61B6/467 , A61B6/469 , A61B6/545 , A61B8/0833 , A61B8/461 , A61B8/467 , A61B8/469 , A61B8/585 , A61B17/3401 , A61B17/3403 , A61B34/20 , A61B90/92 , A61B90/96 , A61B90/98 , A61B2017/00199 , A61B2017/00225 , A61B2034/2055 , A61B2090/376 , A61B2090/3908 , A61B2090/3945 , A61B2562/08 , G06F19/00 , G16H40/63
摘要： Needles are widely used in interventional radiology. Each medical application requires a specific needle type. The same holds for the photonic needles which analysis depends on the type of application the clinician aims for. Therefore, it is relevant to have the X-ray machine recognize the type of needle that is being used and to load the required software for the tissue analysis. It is therefore proposed to have a data link established between the imaging modality used for the acquisition of the patient anatomy (X-ray, CT, MR or US) and the system that processes optical data from the needle, so that the information from this imaging modality can be used to guide the processing. In a preferred embodiment the selection is made by reading out the code present in the disposable needle when it is connected to the console.
摘要翻译：针头广泛用于介入放射学。每个医疗应用都需要特殊的针型。同样适用于光子针，分析取决于临床医生的应用类型。因此，使X射线机器识别正在使用的针的类型并加载组织分析所需的软件是相关的。因此，建议在用于获取患者解剖结构（X射线，CT，MR或US）的成像模式和处理来自针的光学数据的系统之间建立数据链路，使得来自该信息的信息成像模式可用于指导处理。在优选实施例中，通过在连接到控制台时读出一次性针头中存在的代码来进行选择。

26. 发明授权

US07761129B2 Measurement head for non-invasive blood analysis 失效
标题翻译：非侵入性血液分析测量头
公开(公告)号：US07761129B2
公开(公告)日：2010-07-20
申请号：US11568743
申请日：2005-05-03
申请人： Marjolein Van Der Voort , Bernardus Leonardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
发明人： Marjolein Van Der Voort , Bernardus Leonardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
IPC分类号： A61B5/145
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/68 , A61B5/6843
摘要： A measurement head has an objective for imaging of a target area such as including a capillary vessel in the skin. The measurement head does not require a lateral shifting of the optical axis of the objective. Transverse relative movements between the objective and a capillary vessel in the skin are performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors for measuring the contact pressure between the measurement head and the skin. Pressure information may be exploited in order to calibrate a spectroscopic analyzer, and/or to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.
摘要翻译：测量头具有用于对目标区域进行成像的目的，例如在皮肤中包括毛细血管。测量头不需要物镜光轴的横向偏移。通过相对于测量头的目标机械地移动皮肤来执行物体和皮肤中的毛细血管之间的横向相对运动。此外，测量头适于承载用于测量测量头与皮肤之间的接触压力的一个或多个压力传感器。可以利用压力信息来校准光谱分析仪，和/或调节预定边界内的接触压力，指定用于毛细血管的光谱检查的最佳接触压力范围。

27. 发明授权

US07511812B2 Aberration correction for spectroscopic analysis 有权
标题翻译：光谱分析的畸变校正
公开(公告)号：US07511812B2
公开(公告)日：2009-03-31
申请号：US11570133
申请日：2005-06-13
申请人： Michael Cornelis Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker
发明人： Michael Cornelis Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Gerardus Bakker
IPC分类号： G01J3/30
CPC分类号： G02B27/0025 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/28
摘要： A spectroscopic system which determines a property of a biological structure in a volume of interest of a person includes a low cost objective lens for directing an excitation beam into a volume of interest and for collecting return radiation from the volume of interest. After detection of the return radiation and generation of spectroscopic signals, a correction unit performs a compensation for aberrations of the spectroscopic signals introduced by the low cost objective lens. Since the aberrations of the objective lens strongly depend on the lateral distance of the volume of interest from the optical axis of the objective lens, the correction unit uses a correction table providing an assignment between correction values and various lateral positions of the volume of interest.
摘要翻译：确定人的感兴趣体积的生物结构的性质的光谱系统包括用于将激发光束引导到感兴趣体积中并用于从感兴趣体积收集返回辐射的低成本物镜。在检测到返回辐射和产生分光信号之后，校正单元对由低成本物镜引入的分光信号的像差进行补偿。由于物镜的像差强烈地取决于物镜的光轴的感兴趣的体积的横向距离，所以校正单元使用校正表，该校正表提供校正值与感兴趣体积的各个横向位置之间的分配。

28. 发明申请

US20070252978A1 Method and Apparatus for Optical Spectroscopy 审中-公开
标题翻译：光谱学方法与装置
公开(公告)号：US20070252978A1
公开(公告)日：2007-11-01
申请号：US10596501
申请日：2004-12-13
申请人： Marjolein Van Der Voort , Gerhardus Lucassen , Gerwin Puppels , Michael Van Beek , Coen Theodorus Hubertus Liedenbaum
发明人： Marjolein Van Der Voort , Gerhardus Lucassen , Gerwin Puppels , Michael Van Beek , Coen Theodorus Hubertus Liedenbaum
IPC分类号： G01J3/44 , G01J3/00
CPC分类号： G01N21/65 , G01J3/44 , G01J2003/4424
摘要： The present invention provides for a method of optical spectroscopy, in particular Raman spectroscopy for performing invasive or non-invasive blood analysis. The fluorescence component of return radiation which is received from a detection volume is eliminated which is enabled by the usage of a pulsed excitation light source. The pulse length is substantially shorter than the fluorescence life time Hence, the elimination of the fluorescence composent can be performed by time gating or by other electronics or optical means.
摘要翻译：本发明提供一种用于进行侵入性或非侵入性血液分析的光谱学方法，特别是拉曼光谱法。消除了从检测体积接收的返回辐射的荧光分量，其通过使用脉冲激发光源来实现。脉冲长度明显短于荧光寿命。因此，荧光成分的消除可以通过时间选通或其他电子学或光学方法进行。

29. 发明申请

US20070070328A1 Method of determining a property of a fluid and spectroscopic system 失效
标题翻译：确定流体和光谱系统性质的方法
公开(公告)号：US20070070328A1
公开(公告)日：2007-03-29
申请号：US10595358
申请日：2004-10-15
申请人： Wouter Rensen , Michael Van Beek , Marjolein Van Der Voort , Bernardus Bakker , Gerhardus Lucassen , Teunis Tukker
发明人： Wouter Rensen , Michael Van Beek , Marjolein Van Der Voort , Bernardus Bakker , Gerhardus Lucassen , Teunis Tukker
IPC分类号： G01N33/48 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/0068 , A61B5/489
摘要： The present invention enables to determine the property of a fluid, such as for the purposes of in vivo blood analysis. First the position of a volume of interest through which the fluid flows is determined by means of an optical detection step by making use of an objective. Preferably the optical detection step is an imaging step. Next the objective is moved to bring the focal point of the objective to the volume of interest. In this position an optical spectroscopic step is performed. This has the advantage that the measurement beam for performing the optical spectroscopy travels along the optical axis for optimum efficiency.
摘要翻译：本发明能够确定流体的性质，例如用于体内血液分析的目的。首先，通过利用目标的光学检测步骤来确定流体流过的感兴趣体积的位置。优选地，光学检测步骤是成像步骤。接下来，将目标转移到目标的焦点。在该位置，进行光学分光步骤。这具有以下优点：用于执行光学光谱的测量光束沿着光轴行进以获得最佳效率。

30. 发明申请

US20120029360A1 NEEDLE WITH INTEGRATED FIBERS IN THE CUTTING FACETS OF THE BEVEL 审中-公开
标题翻译：带有整体纤维的针在水平切割面上
公开(公告)号：US20120029360A1
公开(公告)日：2012-02-02
申请号：US13264388
申请日：2010-04-12
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Rik Habers , Marjolein Van Der Voort , Adrien Desjardins , Rami Nachabe
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Augustinus Laurentius Braun , Rik Habers , Marjolein Van Der Voort , Adrien Desjardins , Rami Nachabe
IPC分类号： A61B6/00
CPC分类号： A61B5/0084 , A61B5/0075 , A61B5/6848
摘要： A needle comprises a tip part, a holder part, a shaft, and fibers capable of transmitting light, wherein the shaft comprises a distal end connected to the tip part, and a proximal end connected to the holder part, wherein the tip part comprises a bevel, cutting facets, and at least one channel for accommodating a fiber, and wherein an end section of the fiber is located in the channel and an end surface of the fiber is located at one of the cutting facets. By way of the facets an introduction of the needle into tissue may be facilitated. A further aspect of the invention is a method for producing such a needle.
摘要翻译：针包括尖端部分，保持器部分，轴和能够透射光的光纤，其中所述轴包括连接到所述尖端部分的远端以及连接到所述保持器部分的近端，其中所述尖端部分包括斜面，切割面和用于容纳纤维的至少一个通道，并且其中光纤的端部位于通道中，并且光纤的端表面位于一个切割平面上。通过这些方面，可以促进将针引入组织中。本发明的另一方面是制造这种针的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式