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1. 发明授权

US07761129B2 Measurement head for non-invasive blood analysis 失效
标题翻译：非侵入性血液分析测量头
公开(公告)号：US07761129B2
公开(公告)日：2010-07-20
申请号：US11568743
申请日：2005-05-03
申请人： Marjolein Van Der Voort , Bernardus Leonardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
发明人： Marjolein Van Der Voort , Bernardus Leonardus Bakker , Gerald Lucassen , Hendrikus Antonius Cornelus Maria Compen , Michael Cornelis Van Beek , Wouter Harry Jacinth Rensen
IPC分类号： A61B5/145
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/68 , A61B5/6843
摘要： A measurement head has an objective for imaging of a target area such as including a capillary vessel in the skin. The measurement head does not require a lateral shifting of the optical axis of the objective. Transverse relative movements between the objective and a capillary vessel in the skin are performed by mechanically shifting the skin with respect to the objective of the measurement head. Moreover, the measurement head is adapted to host one or more pressure sensors for measuring the contact pressure between the measurement head and the skin. Pressure information may be exploited in order to calibrate a spectroscopic analyzer, and/or to regulate the contact pressure within predefined margins specifying an optimum range of contact pressure for spectroscopic examination of capillary vessels.
摘要翻译：测量头具有用于对目标区域进行成像的目的，例如在皮肤中包括毛细血管。测量头不需要物镜光轴的横向偏移。通过相对于测量头的目标机械地移动皮肤来执行物体和皮肤中的毛细血管之间的横向相对运动。此外，测量头适于承载用于测量测量头与皮肤之间的接触压力的一个或多个压力传感器。可以利用压力信息来校准光谱分析仪，和/或调节预定边界内的接触压力，指定用于毛细血管的光谱检查的最佳接触压力范围。

2. 发明申请

US20090015819A1 OPTICAL ANALYSIS SYSTEM, BLOOD ANALYSIS SYSTEM AND METHOD OF DETERMINING AN AMPLITUDE OF A PRINCIPAL COMPONENT 审中-公开
标题翻译：光学分析系统，血液分析系统和确定主成分的幅度的方法
公开(公告)号：US20090015819A1
公开(公告)日：2009-01-15
申请号：US10596563
申请日：2004-12-13
申请人： Michael Cornelis Van Beek , Bernardus Leonardus Bakker , Wouter Harry Jacinth Rensen , Frank Jeroen Pieter Schuurmans
发明人： Michael Cornelis Van Beek , Bernardus Leonardus Bakker , Wouter Harry Jacinth Rensen , Frank Jeroen Pieter Schuurmans
IPC分类号： G01N33/48
CPC分类号： G01N21/31 , G01J3/28 , G01N21/274 , G01N21/64 , G01N21/6445 , G01N21/65 , G01N2021/3196 , G01N2021/6417 , G01N2021/655
摘要： The optical analysis system (20) is arranged to determine an amplitude of a principal component of an optical signal. The optical analysis system (20) comprises a multivariate optical element (5, 6) for weighing the optical signal by a spectral weighing function and a detector (7, 8) for detecting the weighed optical signal. The optical signal comprises the principal component and a further component which was not accounted for when designing the spectral weighing function. Therefore, the detected weighed optical signal comprises a part relating to the amplitude of the principal component and a further part relating to a further amplitude of the further component. The optical analysis system (20) further comprises a modulator element (13) for modulating the detected weighed optical signal. The difference between the modulated detected weighed optical signal and the detected weighed optical signal relates to the amplitude of the principal component and thus allows for determining the amplitude of the principal component in an accurate way. The blood analysis system (40) comprises such an optical analysis system (20). The method of determining an amplitude of an principal component makes use of the optical analysis system (20).
摘要翻译：光学分析系统（20）被布置成确定光信号的主分量的幅度。光学分析系统（20）包括用于通过光谱称重功能称量光信号的多元光学元件（5,6）和用于检测加权光信号的检测器（7,8）。光信号包括主分量和另外的分量，在设计光谱称重功能时不考虑。因此，检测到的加权光信号包括与主分量的振幅有关的部分，以及与另一分量的另一幅度相关的另一部分。光学分析系统（20）还包括用于调制检测到的称重光信号的调制器元件（13）。调制检测到的称重光信号与检测到的称重光信号之间的差异与主分量的振幅有关，因此允许以准确的方式确定主分量的振幅。血液分析系统（40）包括这样的光学分析系统（20）。确定主成分的振幅的方法利用光学分析系统（20）。

3. 发明授权

US07453564B2 Method of determining a property of a fluid and spectroscopic system 失效
标题翻译：确定流体和光谱系统性质的方法
公开(公告)号：US07453564B2
公开(公告)日：2008-11-18
申请号：US10595358
申请日：2004-10-15
申请人： Wouter Harry Rensen , Michael Cornelis Van Beek , Marjolein Van Der Voort , Bernardus Leonardus Bakker , Gerhardus Wilhelmus Lucassen , Teunis Willem Tukker
发明人： Wouter Harry Rensen , Michael Cornelis Van Beek , Marjolein Van Der Voort , Bernardus Leonardus Bakker , Gerhardus Wilhelmus Lucassen , Teunis Willem Tukker
IPC分类号： G01J3/00
CPC分类号： A61B5/0059 , A61B5/0068 , A61B5/489
摘要： A property of a fluid is determined spectroscopically, such as for the purposes of in vivo blood analysis. First the position of a volume of interest through which the fluid flows is determined by an optical detection step by making use of an objective. Preferably the optical detection step is an imaging step. Next the objective is moved to bring the focal point of the objective into coincidence with the volume of interest. In this position an optical spectroscopic step is performed. This has the advantage that the measurement beam for performing the optical spectroscopy travels along the optical axis for optimum efficiency.
摘要翻译：光谱性质确定流体的性质，例如用于体内血液分析的目的。首先，通过利用目标的光学检测步骤来确定流体流过的感兴趣体积的位置。优选地，光学检测步骤是成像步骤。接下来的目标是使目标的焦点与感兴趣的数量相吻合。在该位置，进行光学分光步骤。这具有以下优点：用于执行光学光谱的测量光束沿着光轴行进以获得最佳效率。

4. 发明申请

US20080002199A1 Aberration Correction for Spectroscopic Analysis 有权
标题翻译：光谱分析的畸变校正
公开(公告)号：US20080002199A1
公开(公告)日：2008-01-03
申请号：US11570133
申请日：2005-06-13
申请人： Michael Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Bakker
发明人： Michael Van Beek , Wouter Rensen , Gerald Lucassen , Marjolein Van Der Voort , Bernardus Leonardus Bakker
IPC分类号： G01J3/30 , G06F19/00
CPC分类号： G02B27/0025 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/28
摘要： The present invention provides a spectroscopic system (100) for determining of a property of a biological structure in a volume of interest (120) of a person. The spectroscopic system (100) comprises a low cost objective lens (118) for directing an excitation beam into a volume of interest (120) and for collecting return radiation (124) from the volume of interest (120). After detection of the return radiation (124), i.e. the spectroscopic signals, a correction unit (106) performs the compensation of the aberrations of the spectroscopic signals introduced by the low cost objective lens (118). Since the aberrations of the objective lens (118) strongly depend on the lateral distance (122) of the volume of interest (120) from the optical axis (116) of the objective lens (118), the correction unit (106) makes effective use of a correction table (110) providing an assignment between correction values and various lateral positions (122) of the volume of interest (120).
摘要翻译：本发明提供一种用于确定人的感兴趣体积（120）中的生物结构的性质的光谱系统（100）。分光系统（100）包括用于将激发光束引导到感兴趣体积（120）中并用于从感兴趣体积（120）收集返回辐射（124）的低成本物镜（118）。在检测到返回辐射（124）即分光信号之后，校正单元（106）执行由低成本物镜（118）引入的分光信号的像差的补偿。由于物镜（118）的像差强烈地取决于物镜（118）的光轴（116）的感兴趣体积（120）的横向距离（122），所以校正单元（106）有效使用校正表（110）提供校正值与感兴趣体积（120）的各种侧向位置（122）之间的分配。

5. 发明申请

US20070291251A1 Optical Analysis System With Background Signal Compensation 审中-公开
标题翻译：具有背景信号补偿的光学分析系统
公开(公告)号：US20070291251A1
公开(公告)日：2007-12-20
申请号：US11574181
申请日：2005-08-24
申请人： Wouter Rensen , Bernardus Leonardus Bakker , Michael Van Beek
发明人： Wouter Rensen , Bernardus Leonardus Bakker , Michael Van Beek
IPC分类号： G01N33/48 , G01N21/00 , G06F19/00
CPC分类号： G01J3/30 , G01J3/02 , G01J3/0229 , G01J3/32 , G01J3/44
摘要： The invention provides an optical analysis system for efficient compensation of spectroscopic broadband back-ground, such as spectroscopic fluorescence background or background signals that are due to the dark current of a detector. The optical analysis system effectively provides multivariate optical analysis of a spectroscopic signal. It provides wavelength selective detection of various spectral components that are indicative of a superposition of spectroscopic peaks or bands and their broadband background. Additionally, the optical analysis system is adapted to acquire spectral components that predominantly correspond to the broadband background of the spectroscopic peaks or bands. Wavelength selective selection of various spectral components is performed on the basis of reconfigurable multivariate optical elements or on the basis of a position displacement of a spatial optical transmission mask.
摘要翻译：本发明提供了一种用于有效补偿光谱宽带背景的光学分析系统，例如由于检测器的暗电流引起的分光荧光背景或背景信号。光学分析系统有效地提供了光谱信号的多变量光学分析。它提供各种光谱分量的波长选择性检测，这些光谱分量指示光谱峰或带的叠加及其宽带背景。此外，光学分析系统适于获取主要对应于光谱峰或带的宽带背景的光谱分量。基于可重构多变量光学元件或者基于空间光学透射掩模的位置位移来执行各种光谱分量的波长选择性选择。

6. 发明申请

US20060015091A1 Device for treating human skin by means of radiation 有权
标题翻译：用于通过辐射处理人体皮肤的装置
公开(公告)号：US20060015091A1
公开(公告)日：2006-01-19
申请号：US10536242
申请日：2003-10-31
申请人： Robbert Van Hal , Bernardus Leonardus Bakker , Paul Ackermans
发明人： Robbert Van Hal , Bernardus Leonardus Bakker , Paul Ackermans
IPC分类号： A61B18/20 , A61N5/06
CPC分类号： A61B18/203 , A61B2018/00005 , A61B2018/00452 , A61B2018/1807
摘要： The invention relates to a device (1) for treating human skin by means of radiation. The device comprises a housing (3) with a radiation exit opening (13). A radiation source (9) is accommodated in the housing. Radiation generated by the radiation source propagates from the radiation source towards the radiation exit opening via a radiation path (15) comprising a radiation filter having a predetermined transmission spectrum. According to the invention the radiation filter comprises a reflecting surface (23) via which the radiation propagating along the radiation path (15) is reflected. The reflecting surface has a coating which provides the reflecting surface with a reflection spectrum substantially matching the predetermined transmission spectrum. An advantage is that the reflection surface can be optimally and uniformly cooled, so that the heat generated as a result of the absorption of part of the radiation by the radiation filter can be effectively transmitted to a cooling system (25) of the device (1). In a particular embodiment the device (1) is an epilator for removing hairs from the human skin and the radiation source (9) is a flash lamp. The radiation path (15) is enclosed by a channel (17) having a bend (19) and having an inner wall (21) on which the reflecting surface (23) is provided.
摘要翻译：本发明涉及一种用于通过辐射处理人体皮肤的装置（1）。该装置包括具有辐射出口（13）的壳体（3）。辐射源（9）容纳在壳体中。由辐射源产生的辐射经由包括具有预定透射光谱的辐射滤光片的辐射路径（15）从辐射源向辐射出口开口传播。根据本发明，辐射过滤器包括反射表面（23），沿着辐射路径（15）传播的辐射被反射。反射面具有使反射面具有基本上与预定透射光谱相一致的反射光谱的涂层。优点在于反射面可以被最佳和均匀地冷却，使得由辐射过滤器吸收一部分辐射而产生的热能被有效地传递到装置（1）的冷却系统（25））。在特定实施例中，装置（1）是用于从人体皮肤去除头发的脱毛器，并且辐射源（9）是闪光灯。辐射路径（15）由具有弯曲部（19）的通道（17）包围，并具有设置有反射面（23）的内壁（21）。

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