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21. 发明授权

US08849373B2 Method and apparatus for real-time 3D target position estimation by combining single x-ray imaging and external respiratory signals 有权
标题翻译：通过组合单个X射线成像和外部呼吸信号实时3D目标位置估计的方法和装置
公开(公告)号：US08849373B2
公开(公告)日：2014-09-30
申请号：US12119464
申请日：2008-05-12
申请人： Paul J. Keall , Amit Sawant , Peter Maxim , Yelin Suh , Lei Xing , Billy W. Loo, Jr. , Byung Chul Cho
发明人： Paul J. Keall , Amit Sawant , Peter Maxim , Yelin Suh , Lei Xing , Billy W. Loo, Jr. , Byung Chul Cho
IPC分类号： A61B5/00 , A61B6/03 , A61B6/12 , A61B6/06 , A61B5/08 , A61B6/00
CPC分类号： A61B6/032 , A61B5/08 , A61B6/06 , A61B6/12 , A61B6/541
摘要： A method and system are disclosed for estimating internal position information of a target in real-time based on a single gantry-mounted x-ray imager and a respiratory signal. The x-ray imaging is done periodically to limit radiation dosage. Initial parameters for the estimation model are determined in a pre-treatment session using four dimensional computed tomography (4D CT) in combination with a respiratory signal acquired from the patient. The model parameters are updated during treatment based on the periodic x-ray image data and the respiratory signal.
摘要翻译：公开了一种用于基于单个机架安装的x射线成像仪和呼吸信号来实时估计目标的内部位置信息的方法和系统。定期进行x射线成像以限制辐射剂量。在使用四维计算机断层摄影（4D CT）与从患者获取的呼吸信号的组合的预处理会话中确定估计模型的初始参数。基于周期性X射线图像数据和呼吸信号在治疗期间更新模型参数。

22. 发明授权

US08229070B2 Intrafraction motion management using a rough to accurate monitoring strategy 有权
$Intrafraction motion management using a rough to accurate monitoring strategy$
标题翻译：使用粗略准确的监控策略进行运动管理
公开(公告)号：US08229070B2
公开(公告)日：2012-07-24
申请号：US12924171
申请日：2010-09-22
申请人： Wu Liu , Lei Xing , Gary Luxton
发明人： Wu Liu , Lei Xing , Gary Luxton
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61N5/1067 , A61N5/107 , A61N2005/1054 , A61N2005/1061
摘要： An adaptive imaging method of monitoring intrafraction target motion during radiation therapy is provided that includes using a simultaneous Mega-Voltage (MV) imaging process and Kilo-Voltage (KV) imaging process to determine an initial 3D target position. 2D target position is monitored using the MV imaging process during a radiation therapy treatment delivery, and is in combination with an online-updated characterization of target motion that are disposed to estimate if the target has moved beyond a 3D threshold distance. The simultaneous MV imaging and KV imaging processes are for accurately determining a new 3D target position for intrafraction motion compensation and for further 2D imaging by the MV imaging process, where another simultaneous MV and KV imaging process is initiated when the target has potentially moved beyond the threshold distance as measured by the MV imaging process. The intrafraction target motion monitoring is achieved at the cost of ultralow patient imaging dose.
摘要翻译：提供了一种在放射治疗期间监测影像内目标运动的自适应成像方法，其包括使用同步的电压（MV）成像过程和基洛电压（KV）成像过程来确定初始3D目标位置。在放射治疗治疗递送期间使用MV成像过程来监测2D目标位置，并且与目标运动的在线更新表征组合，其被设置为估计目标是否已经超过3D阈值距离。同时的MV成像和KV成像过程用于准确地确定用于进帧运动补偿的新的3D目标位置和通过MV成像过程的另外的2D成像，其中当目标可能移动到另外的MV成像过程之后启动另一个同时的MV和KV成像过程通过MV成像过程测量的阈值距离。以超低的患者成像剂量为代价实现了影像内目标运动监测。

23. 发明申请

US20100239066A1 Configurations for integrated MRI-linear accelerators 有权
标题翻译：集成MRI线性加速器的配置
公开(公告)号：US20100239066A1
公开(公告)日：2010-09-23
申请号：US12661303
申请日：2010-03-15
申请人： Rebecca Fahrig , Norbert J. Pelc , Kim Pauly , Greig C. Scott , Amit Sawant , Paul J. Keall , Lei Xing , Steven M. Conolly
发明人： Rebecca Fahrig , Norbert J. Pelc , Kim Pauly , Greig C. Scott , Amit Sawant , Paul J. Keall , Lei Xing , Steven M. Conolly
IPC分类号： A61N5/10 , A61N5/00 , G01R33/44
CPC分类号： G01R33/4808 , A61N5/1049 , A61N5/1067 , A61N2005/1055 , A61N2005/1061 , A61N2005/1087
摘要： The present invention provides a radiotherapy treatment apparatus that includes a treatment beam, a magnetic field disposed parallel collinear to the treatment beam, and a target that is disposed along the treatment beam. The treatment beam can be a charged particle beam, a proton beam, an electron beam, or a linear accelerator (Linac) beam. The magnetic field is from a magnetic resonance imager (MRI), a megavolt x-ray imager, or a kilovolt x-ray imager and is disposed to operate in coordination with operation of the treatment beam and to narrow the beam. The tumor is disposed to rotate with respect to the treatment beam and the magnetic field, or the treatment beam and the magnetic field are disposed to rotate up to 360° with respect to the target when mounted to a ring gantry. The apparatus can include a rotation angle dependent shim disposed to account for Earth's magnetic field.
摘要翻译：本发明提供了一种放射治疗处理装置，其包括处理束，与处理束并行设置的磁场和沿着治疗束设置的靶。处理光束可以是带电粒子束，质子束，电子束或线性加速器（线性加速器）。磁场来自磁共振成像仪（MRI），兆伏X射线成像仪或千伏x射线成像仪，并且被设置成与治疗束的操作协调操作并且使束变窄。肿瘤设置成相对于治疗束和磁场旋转，或者治疗束和磁场被设置为当安装到环形台架时相对于靶旋转高达360度。该装置可以包括设置成考虑地球磁场的旋转角度相关垫片。

24. 发明申请

US20090225932A1 Cone-beam CT imaging scheme 有权
标题翻译：锥束CT成像方案
公开(公告)号：US20090225932A1
公开(公告)日：2009-09-10
申请号：US12380585
申请日：2009-02-27
申请人： Lei Zhu , Lei Xing
发明人： Lei Zhu , Lei Xing
IPC分类号： H05G1/60 , H05G1/42 , H05G1/64
CPC分类号： G21K1/02 , A61B6/032 , A61B6/466 , A61B6/542 , A61N5/103 , G06T11/005
摘要： A general imaging scheme is proposed for applications of CBCT. The approach provides a superior CBCT image quality by effective scatter correction and noise reduction. Specifically, in its implementation of CBCT imaging for radiation therapy, the proposed approach achieves an accurate patient setup using a partially blocked CBCT with a significantly reduced radiation dose. The image quality improvement due to the proposed scatter correction and noise reduction also makes CBCT-based dose calculation a viable solution to adaptive treatment planning.
摘要翻译：提出了CBCT应用的一般成像方案。该方法通过有效的散射校正和降噪来提供卓越的CBCT图像质量。具体来说，在实施用于放射治疗的CBCT成像时，所提出的方法使用部分阻断的CBCT具有显着降低的辐射剂量的精确的患者设置。由于所提出的散射校正和降噪的图像质量改善也使基于CBCT的剂量计算成为适应性治疗计划的可行解决方案。

25. 发明授权

US08331531B2 Configurations for integrated MRI-linear accelerators 有权
标题翻译：集成MRI线性加速器的配置
公开(公告)号：US08331531B2
公开(公告)日：2012-12-11
申请号：US12661303
申请日：2010-03-15
申请人： Rebecca Fahrig , Norbert J. Pelc , Kim Pauly , Greig C. Scott , Amit Sawant , Paul J. Keall , Lei Xing , Steven M. Conolly
发明人： Rebecca Fahrig , Norbert J. Pelc , Kim Pauly , Greig C. Scott , Amit Sawant , Paul J. Keall , Lei Xing , Steven M. Conolly
IPC分类号： A61N5/10 , G01N23/04
CPC分类号： G01R33/4808 , A61N5/1049 , A61N5/1067 , A61N2005/1055 , A61N2005/1061 , A61N2005/1087
摘要： The present invention provides a radiotherapy treatment apparatus that includes a treatment beam, a magnetic field disposed parallel collinear to the treatment beam, and a target that is disposed along the treatment beam. The treatment beam can be a charged particle beam, a proton beam, an electron beam, or a linear accelerator (Linac) beam. The magnetic field is from a magnetic resonance imager (MRI), a megavolt x-ray imager, or a kilovolt x-ray imager and is disposed to operate in coordination with operation of the treatment beam and to narrow the beam. The tumor is disposed to rotate with respect to the treatment beam and the magnetic field, or the treatment beam and the magnetic field are disposed to rotate up to 360° with respect to the target when mounted to a ring gantry. The apparatus can include a rotation angle dependent shim disposed to account for Earth's magnetic field.
摘要翻译：本发明提供了一种放射治疗处理装置，其包括处理束，与处理束并行设置的磁场和沿着治疗束设置的靶。处理光束可以是带电粒子束，质子束，电子束或线性加速器（线性加速器）。磁场来自磁共振成像仪（MRI），兆伏X射线成像仪或千伏X射线成像仪，并且被设置为与治疗束的操作协调操作并且使束变窄。肿瘤设置成相对于治疗束和磁场旋转，或者治疗束和磁场被设置为当安装到环形台架时相对于靶旋转高达360度。该装置可以包括设置成考虑地球磁场的旋转角度相关垫片。

26. 发明申请

US20120292534A1 Multi-phase Gating for Radiation Treatment Delivery and Imaging 审中-公开
标题翻译：用于放射治疗输送和成像的多相门控
公开(公告)号：US20120292534A1
公开(公告)日：2012-11-22
申请号：US13475231
申请日：2012-05-18
申请人： Sarah Geneser , Benjamin Pooya Fahimian , Lei Xing
发明人： Sarah Geneser , Benjamin Pooya Fahimian , Lei Xing
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： A61N5/1069 , A61N5/1042 , A61N2005/1061
摘要： A multi-phase radiation therapy treatment method is provided that includes computational software to simultaneously optimize radiation plans for each phase of delivery. A specific realization of multi-phase therapy, dual gating, is described where the first radiation therapy treatment plan provides treatment during an inhale phase of a patient breathing cycle and the second radiation therapy treatment plan provides treatment during an exhale phase of the patient breathing cycle. Using a radiation therapy machine, the first radiation therapy treatment plan is delivered during the inhale phase and the second radiation therapy treatment plan is delivered during the exhale phase of the patient breathing cycle. An associated imaging method is provided for gated volumetric image guidance at multiple different phases in a single imaging acquisition.
摘要翻译：提供了一种多相放射治疗方法，其包括计算软件，以同时优化每个递送阶段的辐射计划。描述了多相治疗双重选通的具体实现，其中第一放射治疗治疗计划在患者呼吸循环的吸气阶段期间提供治疗，并且第二放射治疗治疗计划在患者呼吸循环的呼气阶段期间提供治疗。使用放射治疗机，在吸气阶段期间输送第一次放射疗法治疗计划，并且在患者呼吸周期的呼气阶段期间传送第二次放射治疗治疗计划。提供了一种相关的成像方法，用于在单个成像采集中的多个不同阶段的门控体积图像引导。

27. 发明授权

US08315357B2 Radiation therapy inverse treatment planning using a regularization of sparse segments 失效
标题翻译：放射治疗逆治疗计划采用正规化稀疏节段
公开(公告)号：US08315357B2
公开(公告)日：2012-11-20
申请号：US12924832
申请日：2010-10-06
申请人： Lei Zhu , Lei Xing
发明人： Lei Zhu , Lei Xing
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1042
摘要： A method of reducing a total number of beam segments in a dose distribution for a radiation therapy field is provided. The method includes providing a multiobjective radiation therapy treatment plan using a suitably programmed computer, where the multiobjective radiation therapy treatment plan includes a radiation beam dose performance objective and a fluence map sparsity objective in a given fluence function domain, and providing a Pareto frontier of tradeoff criteria between the beam dose performance and a total number of radiation segments (or sub-fields) of the multiobjective radiation therapy treatment plan using the suitably programmed computer, where an achieved set of radiation beam dose distributions associated with efficiency points of the Pareto frontier are evaluated using a clinical acceptance criteria, where a clinically acceptable radiation beam dose distribution having a smallest number of the multileaf collimator segments is a final solution for the multiobjective radiation therapy treatment plan.
摘要翻译：提供了一种在放射治疗场的剂量分布中减少光束段的总数的方法。该方法包括使用适当编程的计算机提供多目标放射疗法治疗计划，其中多目标放射疗法治疗计划包括给定注量功能域中的辐射束剂量性能目标和注量点稀疏度目标，并且提供权衡的帕累托前沿光束剂量性能与使用适当编程的计算机的多目标放射治疗计划的辐射段（或子场）的总数之间的标准，其中与帕累托前沿的效率点相关联的实现的辐射束剂量分布的集合是使用临床验收标准进行评估，其中具有最小数目的多叶准直器片段的临床可接受的辐射束剂量分布是多目标放射治疗计划的最终解决方案。

28. 发明申请

US20110085643A1 Radiation therapy inverse treatment planning using a regularization of sparse segments 失效
标题翻译：放射治疗逆治疗计划采用正规化稀疏节段
公开(公告)号：US20110085643A1
公开(公告)日：2011-04-14
申请号：US12924832
申请日：2010-10-06
申请人： Lei Zhu , Lei Xing
发明人： Lei Zhu , Lei Xing
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1042
摘要： A method of reducing a total number of beam segments in a dose distribution for a radiation therapy field is provided. The method includes providing a multiobjective radiation therapy treatment plan using a suitably programmed computer, where the multiobjective radiation therapy treatment plan includes a radiation beam dose performance objective and a fluence map sparsity objective in a given fluence function domain, and providing a Pareto frontier of tradeoff criteria between the beam dose performance and a total number of radiation segments (or sub-fields) of the multiobjective radiation therapy treatment plan using the suitably programmed computer, where an achieved set of radiation beam dose distributions associated with efficiency points of the Pareto frontier are evaluated using a clinical acceptance criteria, where a clinically acceptable radiation beam dose distribution having a smallest number of the multileaf collimator segments is a final solution for the multiobjective radiation therapy treatment plan.
摘要翻译：提供了一种在放射治疗场的剂量分布中减少光束段的总数的方法。该方法包括使用适当编程的计算机提供多目标放射疗法治疗计划，其中多目标放射疗法治疗计划包括给定注量功能域中的辐射束剂量性能目标和注量点稀疏度目标，以及提供权衡的帕累托前沿光束剂量性能与使用适当编程的计算机的多目标放射治疗计划的辐射段（或子场）的总数之间的标准，其中与帕累托前沿的效率点相关联的实现的辐射束剂量分布的集合是使用临床验收标准进行评估，其中具有最小数目的多叶准直器片段的临床可接受的辐射束剂量分布是多目标放射治疗计划的最终解决方案。

29. 发明申请

US20110075911A1 Accurate determination of the shape and localization of metallic object(s) in X-ray CT imaging 失效
标题翻译：准确测定X射线CT成像中金属物体的形状和定位
公开(公告)号：US20110075911A1
公开(公告)日：2011-03-31
申请号：US12924327
申请日：2010-09-23
申请人： Lei Xing , Jing Wang
发明人： Lei Xing , Jing Wang
IPC分类号： G06K9/00
CPC分类号： G06T11/005 , G06T7/12 , G06T7/149 , G06T2207/10081 , G06T2207/30052
摘要： A binary image reconstruction method is provided to identify metal objects in a computer tomography (CT) image. The method includes providing a suitably programmed computer, providing a CT image, where the CT image includes intensity data, and the suitably programmed computer is used to determine a first range of attenuation coefficient values and a second range of attenuation coefficient values in the intensity data, where when a difference between the first range of attenuation coefficient values and the second range of attenuation coefficient values is less than a pre-determined gradient threshold value, a boundary of a metal object in the CT image is determined.
摘要翻译：提供二值图像重建方法来识别计算机断层摄影（CT）图像中的金属物体。该方法包括提供适当编程的计算机，提供CT图像，其中CT图像包括强度数据，并且适当编程的计算机用于确定强度数据中的衰减系数值的第一范围和衰减系数值的第二范围其中，当第一衰减系数值范围和第二衰减系数值范围之间的差小于预定梯度阈值时，确定CT图像中的金属物体的边界。

30. 发明申请

US20110075807A1 Intrafraction motion management using a rough to accurate monitoring strategy 有权
$Intrafraction motion management using a rough to accurate monitoring strategy$
标题翻译：使用粗略准确的监控策略进行运动管理
公开(公告)号：US20110075807A1
公开(公告)日：2011-03-31
申请号：US12924171
申请日：2010-09-22
申请人： Wu Liu , Lei Xing , Gary Luxton
发明人： Wu Liu , Lei Xing , Gary Luxton
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61N5/1067 , A61N5/107 , A61N2005/1054 , A61N2005/1061
摘要： An adaptive imaging method of monitoring intrafraction target motion during radiation therapy is provided that includes using a simultaneous Mega-Voltage (MV) imaging process and Kilo-Voltage (KV) imaging process to determine an initial 3D target position. 2D target position is monitored using the MV imaging process during a radiation therapy treatment delivery, and is in combination with an online-updated characterization of target motion that are disposed to estimate if the target has moved beyond a 3D threshold distance. The simultaneous MV imaging and KV imaging processes are for accurately determining a new 3D target position for intrafraction motion compensation and for further 2D imaging by the MV imaging process, where another simultaneous MV and KV imaging process is initiated when the target has potentially moved beyond the threshold distance as measured by the MV imaging process. The intrafraction target motion monitoring is achieved at the cost of ultralow patient imaging dose.
摘要翻译：提供了一种在放射治疗期间监测影像内目标运动的自适应成像方法，其包括使用同步的电压（MV）成像过程和基洛电压（KV）成像过程来确定初始3D目标位置。在放射治疗治疗递送期间使用MV成像过程来监测2D目标位置，并且与目标运动的在线更新表征组合，其被设置为估计目标是否已经超过3D阈值距离。同时的MV成像和KV成像过程用于准确地确定用于进帧运动补偿的新的3D目标位置和通过MV成像过程的另外的2D成像，其中当目标可能移动到另外的MV成像过程之后启动另一个同时的MV和KV成像过程通过MV成像过程测量的阈值距离。以超低的患者成像剂量为代价实现了影像内目标运动监测。

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