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1. 发明授权

US08340247B2 Method and system for four dimensional intensity modulated radiation therapy for motion compensated treatments 有权
标题翻译：用于运动补偿治疗的四维强度调制放射治疗方法和系统
公开(公告)号：US08340247B2
公开(公告)日：2012-12-25
申请号：US12947643
申请日：2010-11-16
申请人： Paul J. Keall , Yelin Suh , Elisabeth Weiss
发明人： Paul J. Keall , Yelin Suh , Elisabeth Weiss
IPC分类号： A61N5/10 , G21K5/10 , H05G1/08
CPC分类号： A61N5/1042 , A61N5/1036 , A61N5/1037
摘要： A deliverable four dimensional (4D) intensity modulated radiation therapy (IMRT) planning method is disclosed, for delivery using a linear accelerator with a dynamic multi-leaf collimator (DMLC). A 4D computed tomography (CT) scan is used for segmenting tumor anatomy on a reference phase of periodic motion of the tumor. Deformable registration of the 4D CT data is used to generate corresponding anatomical structures on other phases. Preferably, the collimator for each beam position is aligned using the gross tumor volume (GTV) centroid motion corresponding to the periodic motion of the tumor, as determined from the two dimensional (2D) projection of a given beam position. A deliverable IMRT plan is created on the 4D CT image set in which the MLC leaf positions and beam on/off status can vary as a function of respiratory phase by solving a four dimensional optimization problem. The mechanical constraints of the MLC leaves are included in the optimization.
摘要翻译：公开了一种可交付的四维（4D）强度调制放射治疗（IMRT）规划方法，用于使用具有动态多叶准直器（DMLC）的线性加速器的传送。 4D计算机断层扫描（CT）扫描用于在肿瘤周期性运动的参考期分割肿瘤解剖。 4D CT数据的变形注册用于在其他阶段产生相应的解剖结构。优选地，根据给定束位置的二维（2D）投影确定，使用与肿瘤的周期性运动相对应的肿瘤总体积（GTV）质心运动来对准每个束位置的准直器。在4D CT图像集上创建可交付的IMRT计划，其中MLC叶位置和束开/关状态可以通过解决四维优化问题作为呼吸相位的函数而变化。 MLC叶片的机械约束包括在优化中。

2. 发明授权

US08849373B2 Method and apparatus for real-time 3D target position estimation by combining single x-ray imaging and external respiratory signals 有权
标题翻译：通过组合单个X射线成像和外部呼吸信号实时3D目标位置估计的方法和装置
公开(公告)号：US08849373B2
公开(公告)日：2014-09-30
申请号：US12119464
申请日：2008-05-12
申请人： Paul J. Keall , Amit Sawant , Peter Maxim , Yelin Suh , Lei Xing , Billy W. Loo, Jr. , Byung Chul Cho
发明人： Paul J. Keall , Amit Sawant , Peter Maxim , Yelin Suh , Lei Xing , Billy W. Loo, Jr. , Byung Chul Cho
IPC分类号： A61B5/00 , A61B6/03 , A61B6/12 , A61B6/06 , A61B5/08 , A61B6/00
CPC分类号： A61B6/032 , A61B5/08 , A61B6/06 , A61B6/12 , A61B6/541
摘要： A method and system are disclosed for estimating internal position information of a target in real-time based on a single gantry-mounted x-ray imager and a respiratory signal. The x-ray imaging is done periodically to limit radiation dosage. Initial parameters for the estimation model are determined in a pre-treatment session using four dimensional computed tomography (4D CT) in combination with a respiratory signal acquired from the patient. The model parameters are updated during treatment based on the periodic x-ray image data and the respiratory signal.
摘要翻译：公开了一种用于基于单个机架安装的x射线成像仪和呼吸信号来实时估计目标的内部位置信息的方法和系统。定期进行x射线成像以限制辐射剂量。在使用四维计算机断层摄影（4D CT）与从患者获取的呼吸信号的组合的预处理会话中确定估计模型的初始参数。基于周期性X射线图像数据和呼吸信号在治疗期间更新模型参数。

3. 发明申请

US20090041188A1 METHOD AND SYSTEM FOR FOUR DIMENSIONAL INTENSITY MODULATED RADIATION THERAPY FOR MOTION COMPENSATED TREATMENTS 有权
标题翻译：四维强度调制辐射治疗运动补偿治疗方法与系统
公开(公告)号：US20090041188A1
公开(公告)日：2009-02-12
申请号：US12187222
申请日：2008-08-06
申请人： Paul J. Keall , Yelin Suh , Elisabeth Weiss
发明人： Paul J. Keall , Yelin Suh , Elisabeth Weiss
IPC分类号： G21K1/04 , A61N5/10 , G06K9/00
CPC分类号： A61N5/1042 , A61N5/1036 , A61N5/1037
摘要： A deliverable four dimensional (4D) intensity modulated radiation therapy (IMRT) planning method is disclosed, for delivery using a linear accelerator with a dynamic multi-leaf collimator (DMLC). A 4D computed tomography (CT) scan is used for segmenting tumor anatomy on a reference phase of periodic motion of the tumor. Deformable registration of the 4D CT data is used to generate corresponding anatomical structures on other phases. Preferably, the collimator for each beam position is aligned using the gross tumor volume (GTV) centroid motion corresponding to the periodic motion of the tumor, as determined from the two dimensional (2D) projection of a given beam position. A deliverable IMRT plan is created on the 4D CT image set in which the MLC leaf positions and beam on/off status can vary as a function of respiratory phase by solving a four dimensional optimization problem. The mechanical constraints of the MLC leaves are included in the optimization.
摘要翻译：公开了一种可交付的四维（4D）强度调制放射治疗（IMRT）规划方法，用于使用具有动态多叶准直器（DMLC）的线性加速器的传送。 4D计算机断层扫描（CT）扫描用于在肿瘤周期性运动的参考期分割肿瘤解剖。 4D CT数据的变形注册用于在其他阶段产生相应的解剖结构。优选地，根据给定束位置的二维（2D）投影确定，使用与肿瘤的周期性运动相对应的总肿瘤体积（GTV）质心运动来对准每个束位置的准直器。在4D CT图像集上创建可交付的IMRT计划，其中MLC叶位置和束开/关状态可以通过解决四维优化问题作为呼吸相位的函数而变化。 MLC叶片的机械约束包括在优化中。

4. 发明授权

US07469035B2 Method to track three-dimensional target motion with a dynamical multi-leaf collimator 有权
公开(公告)号：US07469035B2
公开(公告)日：2008-12-23
申请号：US12001762
申请日：2007-12-11
申请人： Paul J. Keall , Amit Sawant , Yelin Suh , Sergey Povzner , Herbert Cattell
发明人： Paul J. Keall , Amit Sawant , Yelin Suh , Sergey Povzner , Herbert Cattell
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/1037 , A61N5/1067 , A61N2005/1059 , A61N2005/1061
摘要： A method of continuous real-time monitoring and positioning of multi-leaf collimators during on and off radiation exposure conditions of radiation therapy to account for target motion relative to a radiation beam is provided. A prediction algorithm estimates future positions of a target relative to the radiation source. Target geometry and orientation are determined relative to the radiation source. Target, treatment plan, and leaf width data, and temporal interpolations of radiation doses are sent to the controller. Coordinates having an origin at an isocenter of the isocentric plane establish initial aperture end positions of the leaves that is provided to the controller, where motors to position the MLC midpoint aperture ends according to the position and target information. Each aperture end intersects a single point of a convolution of the target and the isocenter of the isocentric plane. Radiation source hold-conditions are provided according to predetermined undesirable operational and/or treatment states.

5. 发明申请

US20110081002A1 METHOD AND SYSTEM FOR FOUR DIMENSIONAL INTENSITY MODULATED RADIATION THERAPY FOR MOTION COMPENSATED TREATMENTS 有权
标题翻译：四维强度调制辐射治疗运动补偿治疗方法与系统
公开(公告)号：US20110081002A1
公开(公告)日：2011-04-07
申请号：US12947643
申请日：2010-11-16
申请人： Paul J. Keall , Yelin Suh , Elisabeth Weiss
发明人： Paul J. Keall , Yelin Suh , Elisabeth Weiss
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/1036 , A61N5/1037
摘要： A deliverable four dimensional (4D) intensity modulated radiation therapy (IMRT) planning method is disclosed, for delivery using a linear accelerator with a dynamic multi-leaf collimator (DMLC). A 4D computed tomography (CT) scan is used for segmenting tumor anatomy on a reference phase of periodic motion of the tumor. Deformable registration of the 4D CT data is used to generate corresponding anatomical structures on other phases. Preferably, the collimator for each beam position is aligned using the gross tumor volume (GTV) centroid motion corresponding to the periodic motion of the tumor, as determined from the two dimensional (2D) projection of a given beam position. A deliverable IMRT plan is created on the 4D CT image set in which the MLC leaf positions and beam on/off status can vary as a function of respiratory phase by solving a four dimensional optimization problem. The mechanical constraints of the MLC leaves are included in the optimization.
摘要翻译：公开了一种可交付的四维（4D）强度调制放射治疗（IMRT）规划方法，用于使用具有动态多叶准直器（DMLC）的线性加速器的传送。 4D计算机断层扫描（CT）扫描用于在肿瘤周期性运动的参考期分割肿瘤解剖。 4D CT数据的变形注册用于在其他阶段产生相应的解剖结构。优选地，根据给定束位置的二维（2D）投影确定，使用与肿瘤的周期性运动相对应的总肿瘤体积（GTV）质心运动来对准每个束位置的准直器。在4D CT图像集上创建可交付的IMRT计划，其中MLC叶位置和束开/关状态可以通过解决四维优化问题作为呼吸相位的函数而变化。 MLC叶片的机械约束包括在优化中。

6. 发明授权

US07835493B2 Method and system for four dimensional intensity modulated radiation therapy for motion compensated treatments 有权
标题翻译：用于运动补偿治疗的四维强度调制放射治疗方法和系统
公开(公告)号：US07835493B2
公开(公告)日：2010-11-16
申请号：US12187222
申请日：2008-08-06
申请人： Paul J. Keall , Yelin Suh , Elisabeth Weiss
发明人： Paul J. Keall , Yelin Suh , Elisabeth Weiss
IPC分类号： A61N5/10 , H05G1/08
CPC分类号： A61N5/1042 , A61N5/1036 , A61N5/1037
摘要： A deliverable four dimensional (4D) intensity modulated radiation therapy (IMRT) planning method is disclosed, for delivery using a linear accelerator with a dynamic multi-leaf collimator (DMLC). A 4D computed tomography (CT) scan is used for segmenting tumor anatomy on a reference phase of periodic motion of the tumor. Deformable registration of the 4D CT data is used to generate corresponding anatomical structures on other phases. Preferably, the collimator for each beam position is aligned using the gross tumor volume (GTV) centroid motion corresponding to the periodic motion of the tumor, as determined from the two dimensional (2D) projection of a given beam position. A deliverable IMRT plan is created on the 4D CT image set in which the MLC leaf positions and beam on/off status can vary as a function of respiratory phase by solving a four dimensional optimization problem. The mechanical constraints of the MLC leaves are included in the optimization.
摘要翻译：公开了一种可交付的四维（4D）强度调制放射治疗（IMRT）规划方法，用于使用具有动态多叶准直器（DMLC）的线性加速器的传送。 4D计算机断层扫描（CT）扫描用于在肿瘤周期性运动的参考期分割肿瘤解剖。 4D CT数据的变形注册用于在其他阶段产生相应的解剖结构。优选地，根据给定束位置的二维（2D）投影确定，使用与肿瘤的周期性运动相对应的肿瘤总体积（GTV）质心运动来对准每个束位置的准直器。在4D CT图像集上创建可交付的IMRT计划，其中MLC叶位置和束开/关状态可以通过解决四维优化问题作为呼吸相位的函数而变化。 MLC叶片的机械约束包括在优化中。

7. 发明申请

US20080281192A1 METHOD AND APPARATUS FOR REAL-TIME TARGET POSITION ESTIMATION BY COMBINING X-RAY AND EXTERNAL RESPIRATORY SIGNALS 有权
标题翻译：通过组合X射线和外部呼吸信号进行实时目标位置估计的方法和装置
公开(公告)号：US20080281192A1
公开(公告)日：2008-11-13
申请号：US12119464
申请日：2008-05-12
申请人： Paul J. Keall , Amit Sawant , Peter Maxim , Yelin Suh , Lei Xing , Billy W. Loo, JR. , Byung Chul Cho
发明人： Paul J. Keall , Amit Sawant , Peter Maxim , Yelin Suh , Lei Xing , Billy W. Loo, JR. , Byung Chul Cho
IPC分类号： A61B6/00
CPC分类号： A61B6/032 , A61B5/08 , A61B6/06 , A61B6/12 , A61B6/541
摘要： A method and system are disclosed for estimating internal position information of a target in real-time based on a single gantry-mounted x-ray imager and a respiratory signal. The x-ray imaging is done periodically to limit radiation dosage. Initial parameters for the estimation model are determined in a pre-treatment session using four dimensional computed tomography (4D CT) in combination with a respiratory signal acquired from the patient. The model parameters are updated during treatment based on the periodic x-ray image data and the respiratory signal.
摘要翻译：公开了一种用于基于单个机架安装的x射线成像仪和呼吸信号来实时估计目标的内部位置信息的方法和系统。定期进行x射线成像以限制辐射剂量。在使用四维计算机断层摄影（4D CT）与从患者获取的呼吸信号的组合的预处理会话中确定估计模型的初始参数。基于周期性X射线图像数据和呼吸信号在治疗期间更新模型参数。

8. 发明申请

US20080159478A1 Method to track three-dimensional target motion with a dynamical multi-leaf collimator 有权
标题翻译：用动态多叶准直器跟踪三维目标运动的方法
公开(公告)号：US20080159478A1
公开(公告)日：2008-07-03
申请号：US12001762
申请日：2007-12-11
申请人： Paul J. Keall , Amit Sawant , Yelin Suh , Sergey Povzner , Herbert Cattell
发明人： Paul J. Keall , Amit Sawant , Yelin Suh , Sergey Povzner , Herbert Cattell
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/1037 , A61N5/1067 , A61N2005/1059 , A61N2005/1061
摘要： A method of continuous real-time monitoring and positioning of multi-leaf collimators during on and off radiation exposure conditions of radiation therapy to account for target motion relative to a radiation beam is provided. A prediction algorithm estimates future positions of a target relative to the radiation source. Target geometry and orientation are determined relative to the radiation source. Target, treatment plan, and leaf width data, and temporal interpolations of radiation doses are sent to the controller. Coordinates having an origin at an isocenter of the isocentric plane establish initial aperture end positions of the leaves that is provided to the controller, where motors to position the MLC midpoint aperture ends according to the position and target information. Each aperture end intersects a single point of a convolution of the target and the isocenter of the isocentric plane. Radiation source hold-conditions are provided according to predetermined undesirable operational and/or treatment states.
摘要翻译：提供了一种连续实时监测和定位多叶准直器在放射治疗的放射线暴露条件和照射放射治疗期间的辐射照射条件，以解决相对于辐射束的目标运动。预测算法估计目标相对于辐射源的未来位置。目标几何和取向是相对于辐射源确定的。目标，治疗计划和叶宽数据以及辐射剂量的时间插值被发送到控制器。在中心平面的等角点处具有原点的坐标建立了提供给控制器的叶片的初始孔径端部位置，其中定位MLC中点孔径的电机根据位置和目标信息而结束。每个孔径端与目标的卷积和等中心平面的等角点的单个点相交。根据预定的不期望的操作和/或处理状态提供辐射源保持条件。

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