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1. 发明授权

US08331531B2 Configurations for integrated MRI-linear accelerators 有权
标题翻译：集成MRI线性加速器的配置
公开(公告)号：US08331531B2
公开(公告)日：2012-12-11
申请号：US12661303
申请日：2010-03-15
申请人： Rebecca Fahrig , Norbert J. Pelc , Kim Pauly , Greig C. Scott , Amit Sawant , Paul J. Keall , Lei Xing , Steven M. Conolly
发明人： Rebecca Fahrig , Norbert J. Pelc , Kim Pauly , Greig C. Scott , Amit Sawant , Paul J. Keall , Lei Xing , Steven M. Conolly
IPC分类号： A61N5/10 , G01N23/04
CPC分类号： G01R33/4808 , A61N5/1049 , A61N5/1067 , A61N2005/1055 , A61N2005/1061 , A61N2005/1087
摘要： The present invention provides a radiotherapy treatment apparatus that includes a treatment beam, a magnetic field disposed parallel collinear to the treatment beam, and a target that is disposed along the treatment beam. The treatment beam can be a charged particle beam, a proton beam, an electron beam, or a linear accelerator (Linac) beam. The magnetic field is from a magnetic resonance imager (MRI), a megavolt x-ray imager, or a kilovolt x-ray imager and is disposed to operate in coordination with operation of the treatment beam and to narrow the beam. The tumor is disposed to rotate with respect to the treatment beam and the magnetic field, or the treatment beam and the magnetic field are disposed to rotate up to 360° with respect to the target when mounted to a ring gantry. The apparatus can include a rotation angle dependent shim disposed to account for Earth's magnetic field.
摘要翻译：本发明提供了一种放射治疗处理装置，其包括处理束，与处理束并行设置的磁场和沿着治疗束设置的靶。处理光束可以是带电粒子束，质子束，电子束或线性加速器（线性加速器）。磁场来自磁共振成像仪（MRI），兆伏X射线成像仪或千伏X射线成像仪，并且被设置为与治疗束的操作协调操作并且使束变窄。肿瘤设置成相对于治疗束和磁场旋转，或者治疗束和磁场被设置为当安装到环形台架时相对于靶旋转高达360度。该装置可以包括设置成考虑地球磁场的旋转角度相关垫片。

2. 发明申请

US20080281192A1 METHOD AND APPARATUS FOR REAL-TIME TARGET POSITION ESTIMATION BY COMBINING X-RAY AND EXTERNAL RESPIRATORY SIGNALS 有权
标题翻译：通过组合X射线和外部呼吸信号进行实时目标位置估计的方法和装置
公开(公告)号：US20080281192A1
公开(公告)日：2008-11-13
申请号：US12119464
申请日：2008-05-12
申请人： Paul J. Keall , Amit Sawant , Peter Maxim , Yelin Suh , Lei Xing , Billy W. Loo, JR. , Byung Chul Cho
发明人： Paul J. Keall , Amit Sawant , Peter Maxim , Yelin Suh , Lei Xing , Billy W. Loo, JR. , Byung Chul Cho
IPC分类号： A61B6/00
CPC分类号： A61B6/032 , A61B5/08 , A61B6/06 , A61B6/12 , A61B6/541
摘要： A method and system are disclosed for estimating internal position information of a target in real-time based on a single gantry-mounted x-ray imager and a respiratory signal. The x-ray imaging is done periodically to limit radiation dosage. Initial parameters for the estimation model are determined in a pre-treatment session using four dimensional computed tomography (4D CT) in combination with a respiratory signal acquired from the patient. The model parameters are updated during treatment based on the periodic x-ray image data and the respiratory signal.
摘要翻译：公开了一种用于基于单个机架安装的x射线成像仪和呼吸信号来实时估计目标的内部位置信息的方法和系统。定期进行x射线成像以限制辐射剂量。在使用四维计算机断层摄影（4D CT）与从患者获取的呼吸信号的组合的预处理会话中确定估计模型的初始参数。基于周期性X射线图像数据和呼吸信号在治疗期间更新模型参数。

3. 发明申请

US20080159478A1 Method to track three-dimensional target motion with a dynamical multi-leaf collimator 有权
标题翻译：用动态多叶准直器跟踪三维目标运动的方法
公开(公告)号：US20080159478A1
公开(公告)日：2008-07-03
申请号：US12001762
申请日：2007-12-11
申请人： Paul J. Keall , Amit Sawant , Yelin Suh , Sergey Povzner , Herbert Cattell
发明人： Paul J. Keall , Amit Sawant , Yelin Suh , Sergey Povzner , Herbert Cattell
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/1037 , A61N5/1067 , A61N2005/1059 , A61N2005/1061
摘要： A method of continuous real-time monitoring and positioning of multi-leaf collimators during on and off radiation exposure conditions of radiation therapy to account for target motion relative to a radiation beam is provided. A prediction algorithm estimates future positions of a target relative to the radiation source. Target geometry and orientation are determined relative to the radiation source. Target, treatment plan, and leaf width data, and temporal interpolations of radiation doses are sent to the controller. Coordinates having an origin at an isocenter of the isocentric plane establish initial aperture end positions of the leaves that is provided to the controller, where motors to position the MLC midpoint aperture ends according to the position and target information. Each aperture end intersects a single point of a convolution of the target and the isocenter of the isocentric plane. Radiation source hold-conditions are provided according to predetermined undesirable operational and/or treatment states.
摘要翻译：提供了一种连续实时监测和定位多叶准直器在放射治疗的放射线暴露条件和照射放射治疗期间的辐射照射条件，以解决相对于辐射束的目标运动。预测算法估计目标相对于辐射源的未来位置。目标几何和取向是相对于辐射源确定的。目标，治疗计划和叶宽数据以及辐射剂量的时间插值被发送到控制器。在中心平面的等角点处具有原点的坐标建立了提供给控制器的叶片的初始孔径端部位置，其中定位MLC中点孔径的电机根据位置和目标信息而结束。每个孔径端与目标的卷积和等中心平面的等角点的单个点相交。根据预定的不期望的操作和/或处理状态提供辐射源保持条件。

4. 发明授权

US08971489B2 Method and system for real-time DMLC-based target tracking with optimal motion compensating leaf adaptation 有权
标题翻译：用于实时基于DMLC的目标跟踪的优化运动补偿叶适应的方法和系统
公开(公告)号：US08971489B2
公开(公告)日：2015-03-03
申请号：US13261121
申请日：2010-07-09
申请人： Dan Ruan , Paul J. Keall , Amit Sawant
发明人： Dan Ruan , Paul J. Keall , Amit Sawant
IPC分类号： A61N5/10 , G21K1/04 , H05G1/28 , A61B6/06 , G21K1/02
CPC分类号： G21K1/025 , A61N5/1031 , A61N5/1036 , A61N5/1037 , A61N5/1038 , A61N5/1045 , A61N5/1067 , G21K1/04
摘要： A method of multileaf collimator (MLC) leaf positioning in tracking-based adaptive radiotherapy is provided. The method includes determining a radiotherapy beam pattern by transforming a treatment beam plan into radiotherapy beam coordinates, determining a dose discrepancy between the radiotherapy beam pattern and a deliverable MLC aperture, where the dose discrepancy includes a sum of an overdose cost and an underdose cost to a treatment volume, and minimizing the dose discrepancy, where the dose discrepancy minimization provides a determined deliverable MLC aperture for the radiotherapy beam.
摘要翻译：提供了一种基于跟踪的自适应放疗的多叶准直器（MLC）叶定位方法。该方法包括通过将治疗束计划转换为放射治疗束坐标来确定放射治疗束图案，确定放射治疗束图案与可递送MLC孔径之间的剂量差异，其中剂量差异包括过量成本和剂量过低的总和治疗体积和最小化剂量差异，其中剂量差异最小化为放射治疗束提供确定的可递送MLC孔。

5. 发明申请

US20120099704A1 METHOD AND SYSTEM FOR REAL-TIME DMLC-BASED TARGET TRACKING WITH OPTIMAL MOTION COMPENSATING LEAF ADAPTATION 有权
标题翻译：用于实时基于DMLC的目标跟踪与最佳运动补偿叶适应的方法和系统
公开(公告)号：US20120099704A1
公开(公告)日：2012-04-26
申请号：US13261121
申请日：2010-07-09
申请人： Dan Ruan , Paul J. Keall , Amit Sawant
发明人： Dan Ruan , Paul J. Keall , Amit Sawant
IPC分类号： A61N5/10
CPC分类号： G21K1/025 , A61N5/1031 , A61N5/1036 , A61N5/1037 , A61N5/1038 , A61N5/1045 , A61N5/1067 , G21K1/04
摘要： A method of multileaf collimator (MLC) leaf positioning in tracking-based adaptive radiotherapy is provided. The method includes determining a radiotherapy beam pattern by transforming a treatment beam plan into radiotherapy beam coordinates, determining a dose discrepancy between the radiotherapy beam pattern and a deliverable MLC aperture, where the dose discrepancy includes a sum of an overdose cost and an underdose cost to a treatment volume, and minimizing the dose discrepancy, where the dose discrepancy minimization provides a determined deliverable MLC aperture for the radiotherapy beam.
摘要翻译：提供了一种基于跟踪的自适应放疗的多叶准直器（MLC）叶定位方法。该方法包括通过将治疗束计划转换为放射治疗束坐标来确定放射治疗束图案，确定放射治疗束图案与可递送MLC孔径之间的剂量差异，其中剂量差异包括过量成本和剂量过低的总和治疗体积和最小化剂量差异，其中剂量差异最小化为放射治疗束提供确定的可递送MLC孔。

6. 发明授权

US07469035B2 Method to track three-dimensional target motion with a dynamical multi-leaf collimator 有权
公开(公告)号：US07469035B2
公开(公告)日：2008-12-23
申请号：US12001762
申请日：2007-12-11
申请人： Paul J. Keall , Amit Sawant , Yelin Suh , Sergey Povzner , Herbert Cattell
发明人： Paul J. Keall , Amit Sawant , Yelin Suh , Sergey Povzner , Herbert Cattell
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/1037 , A61N5/1067 , A61N2005/1059 , A61N2005/1061
摘要： A method of continuous real-time monitoring and positioning of multi-leaf collimators during on and off radiation exposure conditions of radiation therapy to account for target motion relative to a radiation beam is provided. A prediction algorithm estimates future positions of a target relative to the radiation source. Target geometry and orientation are determined relative to the radiation source. Target, treatment plan, and leaf width data, and temporal interpolations of radiation doses are sent to the controller. Coordinates having an origin at an isocenter of the isocentric plane establish initial aperture end positions of the leaves that is provided to the controller, where motors to position the MLC midpoint aperture ends according to the position and target information. Each aperture end intersects a single point of a convolution of the target and the isocenter of the isocentric plane. Radiation source hold-conditions are provided according to predetermined undesirable operational and/or treatment states.

7. 发明授权

US08849373B2 Method and apparatus for real-time 3D target position estimation by combining single x-ray imaging and external respiratory signals 有权
标题翻译：通过组合单个X射线成像和外部呼吸信号实时3D目标位置估计的方法和装置
公开(公告)号：US08849373B2
公开(公告)日：2014-09-30
申请号：US12119464
申请日：2008-05-12
申请人： Paul J. Keall , Amit Sawant , Peter Maxim , Yelin Suh , Lei Xing , Billy W. Loo, Jr. , Byung Chul Cho
发明人： Paul J. Keall , Amit Sawant , Peter Maxim , Yelin Suh , Lei Xing , Billy W. Loo, Jr. , Byung Chul Cho
IPC分类号： A61B5/00 , A61B6/03 , A61B6/12 , A61B6/06 , A61B5/08 , A61B6/00
CPC分类号： A61B6/032 , A61B5/08 , A61B6/06 , A61B6/12 , A61B6/541
摘要： A method and system are disclosed for estimating internal position information of a target in real-time based on a single gantry-mounted x-ray imager and a respiratory signal. The x-ray imaging is done periodically to limit radiation dosage. Initial parameters for the estimation model are determined in a pre-treatment session using four dimensional computed tomography (4D CT) in combination with a respiratory signal acquired from the patient. The model parameters are updated during treatment based on the periodic x-ray image data and the respiratory signal.
摘要翻译：公开了一种用于基于单个机架安装的x射线成像仪和呼吸信号来实时估计目标的内部位置信息的方法和系统。定期进行x射线成像以限制辐射剂量。在使用四维计算机断层摄影（4D CT）与从患者获取的呼吸信号的组合的预处理会话中确定估计模型的初始参数。基于周期性X射线图像数据和呼吸信号在治疗期间更新模型参数。

8. 发明申请

US20100239066A1 Configurations for integrated MRI-linear accelerators 有权
标题翻译：集成MRI线性加速器的配置
公开(公告)号：US20100239066A1
公开(公告)日：2010-09-23
申请号：US12661303
申请日：2010-03-15
申请人： Rebecca Fahrig , Norbert J. Pelc , Kim Pauly , Greig C. Scott , Amit Sawant , Paul J. Keall , Lei Xing , Steven M. Conolly
发明人： Rebecca Fahrig , Norbert J. Pelc , Kim Pauly , Greig C. Scott , Amit Sawant , Paul J. Keall , Lei Xing , Steven M. Conolly
IPC分类号： A61N5/10 , A61N5/00 , G01R33/44
CPC分类号： G01R33/4808 , A61N5/1049 , A61N5/1067 , A61N2005/1055 , A61N2005/1061 , A61N2005/1087
摘要： The present invention provides a radiotherapy treatment apparatus that includes a treatment beam, a magnetic field disposed parallel collinear to the treatment beam, and a target that is disposed along the treatment beam. The treatment beam can be a charged particle beam, a proton beam, an electron beam, or a linear accelerator (Linac) beam. The magnetic field is from a magnetic resonance imager (MRI), a megavolt x-ray imager, or a kilovolt x-ray imager and is disposed to operate in coordination with operation of the treatment beam and to narrow the beam. The tumor is disposed to rotate with respect to the treatment beam and the magnetic field, or the treatment beam and the magnetic field are disposed to rotate up to 360° with respect to the target when mounted to a ring gantry. The apparatus can include a rotation angle dependent shim disposed to account for Earth's magnetic field.
摘要翻译：本发明提供了一种放射治疗处理装置，其包括处理束，与处理束并行设置的磁场和沿着治疗束设置的靶。处理光束可以是带电粒子束，质子束，电子束或线性加速器（线性加速器）。磁场来自磁共振成像仪（MRI），兆伏X射线成像仪或千伏x射线成像仪，并且被设置成与治疗束的操作协调操作并且使束变窄。肿瘤设置成相对于治疗束和磁场旋转，或者治疗束和磁场被设置为当安装到环形台架时相对于靶旋转高达360度。该装置可以包括设置成考虑地球磁场的旋转角度相关垫片。

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