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1. 发明申请

US20130035584A1 Robotic Linac Adaptation (RLA) for the in-line MRI-linac Configuration 有权
标题翻译：机器人线性适配（RLA）用于在线MRI-linacac配置
公开(公告)号：US20130035584A1
公开(公告)日：2013-02-07
申请号：US13565343
申请日：2012-08-02
申请人： Rebecca Fahrig , Dragos E. Constantin
发明人： Rebecca Fahrig , Dragos E. Constantin
IPC分类号： A61N5/01 , A61B5/055
CPC分类号： A61N5/1083 , A61B5/055 , A61N5/1067 , A61N2005/1055
摘要： An in-line MRI-linac apparatus is provided that includes an MRI magnet of an MRI scanner, where the MRI magnetic includes a magnetic field, where the magnetic field has a quasi-uniform fringe field, where the fringe field is proximal to an axis of symmetry of the MRI magnet, and a magnetically unshielded dynamically moveable linac that includes a treatment beam that is aligned with field lines of the fringe field in a quasi axial symmetric configuration, where a position of the linac in the fringe field continuously adapts according to a target position to enable continuous dose delivery to the target.
摘要翻译：提供了一种在线MRI线性加速器装置，其包括MRI扫描仪的MRI磁体，其中MRI磁性包括磁场，其中磁场具有准均匀的边缘场，其中边缘场靠近轴线 MRI磁体的对称性以及磁性非屏蔽动态可动线性加速器，其包括与准轴对称配置中的边缘场的场线对准的处理束，其中沿着线性场的直线加速器的位置根据目标位置，以实现目标的连续剂量输送。

2. 发明申请

US20060088140A1 System and method for performing scatter measurement in volumetric CT 审中-公开
标题翻译：在体积CT中进行散射测量的系统和方法
公开(公告)号：US20060088140A1
公开(公告)日：2006-04-27
申请号：US11240233
申请日：2005-09-30
申请人： Rebecca Fahrig , Norbert Strobel , Lei Zhu
发明人： Rebecca Fahrig , Norbert Strobel , Lei Zhu
IPC分类号： G21K1/00
CPC分类号： A61B6/06 , A61B6/583
摘要： The invention provides a system and method for reducing the affects of scattering in an image. The system and method comprises providing at least one blocker array between an x-ray source and an object, obtaining a first image of the via a detector and a first signal, rotationally displacing the at least one blocker array, wherein primary radiation is disrupted at different locations in each projection image, obtaining a second image of the object via the detector and a second signal, estimating the scatter based on a comparison of the first signal and the second signal, and reconstructing a final image by accounting for scatter.
摘要翻译：本发明提供了减少图像中散射影响的系统和方法。该系统和方法包括在x射线源和物体之间提供至少一个阻塞阵列，获得经由检测器的第一图像和第一信号，旋转移位所述至少一个阻断阵列，其中主辐射被破坏在每个投影图像中的不同位置，经由检测器获得对象的第二图像和第二信号，基于第一信号和第二信号的比较来估计散射，以及通过考虑散射来重构最终图像。

3. 发明授权

US06975895B1 Modified X-ray tube for use in the presence of magnetic fields 有权
标题翻译：用于存在磁场的改进的X射线管
公开(公告)号：US06975895B1
公开(公告)日：2005-12-13
申请号：US09823889
申请日：2001-03-30
申请人： Norbert J. Pelc , Rebecca Fahrig , Marcus T. Alley , Zhifei Wen
发明人： Norbert J. Pelc , Rebecca Fahrig , Marcus T. Alley , Zhifei Wen
IPC分类号： H01J35/14 , H01J35/16 , H05C1/02 , H01J35/30 , A61B5/05
CPC分类号： H05C1/02 , G01R33/4812 , H01J35/14 , H01J35/16
摘要： An imaging system and method combines a magnetic resonance imaging (MRI) system and an x-ray fluoroscopy system such that the two systems have coincident fields of view. X-rays are generated by a stationary anode x-ray tube in which an electron beam is accelerated from a cathode to an anode. In the presence of the static magnetic field of the MRI system, the electron beam is deflected unless it is parallel to the static magnetic field. The x-ray source of the invention contains elements used to steer the electron beam and increase its focusing on the anode. The beam can be steered electrostatically, electromagnetically, or by adding magnetic material to the x-ray source. In the resulting system, MR and x-ray images are acquired without moving the object, which is particularly useful for image-guided medical intervention procedures.
摘要翻译：成像系统和方法结合磁共振成像（MRI）系统和x射线透视系统，使得两个系统具有重合的视场。 X射线由固定的阳极x射线管产生，其中电子束从阴极加速到阳极。在MRI系统的静磁场的存在下，电子束被偏转，除非它与静磁场平行。本发明的X射线源包含用于引导电子束并增加其在阳极上聚焦的元件。光束可以静电，电磁学或通过向x射线源添加磁性材料。在所得到的系统中，获取MR和X射线图像而不移动物体，这对于图像引导的医疗干预程序特别有用。

4. 发明授权

US09125570B2 Real-time tomosynthesis guidance for radiation therapy 有权
标题翻译：放射治疗的实时体层合成指导
公开(公告)号：US09125570B2
公开(公告)日：2015-09-08
申请号：US13184482
申请日：2011-07-15
申请人： Norbert Joseph Pelc , Rebecca Fahrig , Joseph Anthony Heanue , Edward Gerald Solomon , Brian Patrick Wilfley
发明人： Norbert Joseph Pelc , Rebecca Fahrig , Joseph Anthony Heanue , Edward Gerald Solomon , Brian Patrick Wilfley
IPC分类号： A61B6/02 , G06T11/00 , A61N5/10 , G06T7/00 , A61B6/12 , A61B6/03 , A61B6/00
CPC分类号： A61B6/025 , A61B6/032 , A61B6/12 , A61B6/4007 , A61B6/4014 , A61B6/4028 , A61B6/4241 , A61N5/1049 , A61N5/1065 , A61N5/1067 , A61N5/1069 , A61N5/1071 , A61N2005/1061 , G06T7/0012 , G06T11/003
摘要： The present invention pertains to an apparatus and method for delivering radiation to a human patient or other mammal. A scanning electron beam x-ray source is used and the detector can be a photon counting detector. The area of the detector is less than the area of field of view in the patient. Tomosynthesis can be used to generate images and images can be produced rapidly in real time.
摘要翻译：本发明涉及用于将辐射递送给人类患者或其他哺乳动物的装置和方法。使用扫描电子束x射线源，检测器可以是光子计数检测器。检测器的面积小于患者视野的面积。可以使用Tomosynthesis来生成图像，并且可以实时快速生成图像。

5. 发明授权

US08331531B2 Configurations for integrated MRI-linear accelerators 有权
标题翻译：集成MRI线性加速器的配置
公开(公告)号：US08331531B2
公开(公告)日：2012-12-11
申请号：US12661303
申请日：2010-03-15
申请人： Rebecca Fahrig , Norbert J. Pelc , Kim Pauly , Greig C. Scott , Amit Sawant , Paul J. Keall , Lei Xing , Steven M. Conolly
发明人： Rebecca Fahrig , Norbert J. Pelc , Kim Pauly , Greig C. Scott , Amit Sawant , Paul J. Keall , Lei Xing , Steven M. Conolly
IPC分类号： A61N5/10 , G01N23/04
CPC分类号： G01R33/4808 , A61N5/1049 , A61N5/1067 , A61N2005/1055 , A61N2005/1061 , A61N2005/1087
摘要： The present invention provides a radiotherapy treatment apparatus that includes a treatment beam, a magnetic field disposed parallel collinear to the treatment beam, and a target that is disposed along the treatment beam. The treatment beam can be a charged particle beam, a proton beam, an electron beam, or a linear accelerator (Linac) beam. The magnetic field is from a magnetic resonance imager (MRI), a megavolt x-ray imager, or a kilovolt x-ray imager and is disposed to operate in coordination with operation of the treatment beam and to narrow the beam. The tumor is disposed to rotate with respect to the treatment beam and the magnetic field, or the treatment beam and the magnetic field are disposed to rotate up to 360° with respect to the target when mounted to a ring gantry. The apparatus can include a rotation angle dependent shim disposed to account for Earth's magnetic field.
摘要翻译：本发明提供了一种放射治疗处理装置，其包括处理束，与处理束并行设置的磁场和沿着治疗束设置的靶。处理光束可以是带电粒子束，质子束，电子束或线性加速器（线性加速器）。磁场来自磁共振成像仪（MRI），兆伏X射线成像仪或千伏X射线成像仪，并且被设置为与治疗束的操作协调操作并且使束变窄。肿瘤设置成相对于治疗束和磁场旋转，或者治疗束和磁场被设置为当安装到环形台架时相对于靶旋转高达360度。该装置可以包括设置成考虑地球磁场的旋转角度相关垫片。

6. 发明申请

US20080194945A1 Apparatus and Method for Aligning a Light Pointer With a Medical Interventional Device Trajectory 失效
标题翻译：用于将光指针与医疗介入装置轨迹对准的装置和方法
公开(公告)号：US20080194945A1
公开(公告)日：2008-08-14
申请号：US11970707
申请日：2008-01-08
申请人： Markus Kukuk , Norbert Strobel , Sandy Napel , Rebecca Fahrig
发明人： Markus Kukuk , Norbert Strobel , Sandy Napel , Rebecca Fahrig
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B6/08 , A61B6/4476 , A61B6/463 , A61B34/10 , A61B2090/376
摘要： A pointing light device includes a light pointer, such as a laser pointer; and an elongated pointing member detachably associated with the light pointer. The pointing member contains at least two bead-like members. Also, a method for aligning a light pointer with a predetermined medical interventional device trajectory. The method includes attaching a pointing member to an output end the light pointer to form a movable pointing light device; imaging two or more bead-like members of the pointing member to create live projection images or shadows in the live projection image; projecting at least first and second points associated with the predetermined medical interventional device trajectory onto the live projection image; and moving the pointing light device until the live projection images of the two members are aligned with corresponding ones of the projected first and second points in the live projection image.
摘要翻译：指示灯装置包括诸如激光指示器的光指示器; 以及可拆卸地与光指示器相关联的细长指向构件。指向构件包含至少两个珠状构件。而且，一种用于将光指示器与预定医疗介入装置轨迹对准的方法。该方法包括将指示构件附接到输出端光指示器以形成可移动指示灯装置; 对指向构件的两个或更多个珠状构件进行成像，以在实时投影图像中创建实时投影图像或阴影; 将与预定医疗介入装置轨迹相关联的至少第一和第二点投影到实时投影图像上; 并且移动指示灯装置，直到两个部件的实时投影图像与投影图像中的投影的第一和第二点中的相应投影图像对准。

7. 发明申请

US20060210015A1 Computed tomography with increased field of view 审中-公开
公开(公告)号：US20060210015A1
公开(公告)日：2006-09-21
申请号：US11438053
申请日：2006-05-18
申请人： Norbert Pelc , Rebecca Fahrig , Edward Solomon
发明人： Norbert Pelc , Rebecca Fahrig , Edward Solomon
IPC分类号： A61B6/00 , G01N23/00 , G21K1/12 , H05G1/60
CPC分类号： G01N23/046 , A61B6/032 , A61B6/4014 , G01N2223/419 , G01T1/2985
摘要： A volumetric computed tomography system with a large field of view has, in a forward geometry implementation, multiple x-ray point sources emitting corresponding fan beams at a single detector array. The central ray of at least one of the fan beams is radially offset from the axis of rotation of the system by an offset distance D. Consequently, the diameter of the in-plane field of view provided by the fan beams may be larger than in a conventional CT scanner. Any number of point sources may be used. Analogous systems may be implemented with an inverse geometry so that a single source array emits multiple fan beams that converge upon corresponding detectors.

8. 发明申请

US20120014501A1 REAL-TIME TOMOSYNTHESIS GUIDANCE FOR RADIATION THERAPY 有权
标题翻译：实时放射治疗的药物治疗指南
公开(公告)号：US20120014501A1
公开(公告)日：2012-01-19
申请号：US13184482
申请日：2011-07-15
申请人： Norbert Joseph Pelc , Rebecca Fahrig , Joseph Anthony Heanue , Edward Gerald Solomon , Brian Patrick Wilfley
发明人： Norbert Joseph Pelc , Rebecca Fahrig , Joseph Anthony Heanue , Edward Gerald Solomon , Brian Patrick Wilfley
IPC分类号： A61B6/03 , A61N5/10
CPC分类号： A61B6/025 , A61B6/032 , A61B6/12 , A61B6/4007 , A61B6/4014 , A61B6/4028 , A61B6/4241 , A61N5/1049 , A61N5/1065 , A61N5/1067 , A61N5/1069 , A61N5/1071 , A61N2005/1061 , G06T7/0012 , G06T11/003
摘要： The present invention pertains to an apparatus and method for delivering radiation to a human patient or other mammal. A scanning electron beam x-ray source is used and the detector can be a photon counting detector. The area of the detector is less than the area of field of view in the patient. Tomosynthesis can be used to generate images and images can be produced rapidly in real time.
摘要翻译：本发明涉及用于将辐射递送给人类患者或其他哺乳动物的装置和方法。使用扫描电子束x射线源，检测器可以是光子计数检测器。检测器的面积小于患者视野的面积。可以使用Tomosynthesis来生成图像，并且可以实时快速生成图像。

9. 发明授权

US07656990B2 Adaptive anisotropic filtering of projection data for computed tomography 有权
标题翻译：计算机断层扫描投影数据的自适应各向异性滤波
公开(公告)号：US07656990B2
公开(公告)日：2010-02-02
申请号：US11533289
申请日：2006-09-19
申请人： Lars Wigstrom , Rebecca Fahrig
发明人： Lars Wigstrom , Rebecca Fahrig
IPC分类号： A61B6/00
CPC分类号： A61B6/032 , G06T5/002 , G06T5/20 , G06T11/005 , G06T2207/10081 , G06T2207/20012 , G06T2207/20192 , G06T2207/30004
摘要： CT imaging is enhanced by adaptively filtering x-ray attenuation data prior to image reconstruction. Detected x-ray projection data are adaptively and anisotropically filtered based on the locally estimated orientation of structures within the projection data from an object being imaged at a plurality of rotation positions. The detected x-ray data are uniformly low pass filtered to preserve the local mean values in the data, while the high pass filtering is controlled based on the estimated orientations. The resulting filtered data provide projection data with smoothing along the structures while maintaining sharpness along edges. Image noise and noise induced streak artifacts are reduced without increased blurring along edges in the reconstructed images. The enhanced image allows reduced x-ray dose while maintaining image quality.
摘要翻译：通过在图像重建之前自适应地过滤x射线衰减数据来增强CT成像。基于在多个旋转位置处成像的物体的投影数据内的结构的局部估计取向，自适应地和各向异性地过滤检测到的X射线投影数据。检测到的x射线数据被均匀地低通滤波以保留数据中的局部平均值，而基于估计的取向控制高通滤波。所得到的滤波数据提供具有沿结构平滑的投影数据，同时沿着边缘保持锐度。图像噪声和噪声引起的条纹伪影减少，而不会在重建图像中沿边缘增加模糊。增强的图像允许减少X射线剂量同时保持图像质量。

10. 发明授权

US07463712B2 Scatter correction for x-ray imaging using modulation of primary x-ray spatial spectrum 有权
标题翻译：使用原始X射线空间光谱调制进行X射线成像的散射校正
公开(公告)号：US07463712B2
公开(公告)日：2008-12-09
申请号：US11557440
申请日：2006-11-07
申请人： Lei Zhu , Rebecca Fahrig
发明人： Lei Zhu , Rebecca Fahrig
IPC分类号： G01N23/00
CPC分类号： A61B6/5282 , A61B6/4291 , A61B6/583
摘要： Scatter radiation in an x-ray imaging system including an x-ray source and an x-ray detector is separated by using amplitude modulation to translate the spatial frequency of a detected x-ray beam to a higher frequency and provide separation from low frequency scatter signal. The low frequency content of the detected x-ray beam is then obtained by demodulating the detected modulated signal.
摘要翻译：通过使用幅度调制来分离包括X射线源和X射线检测器的X射线成像系统中的散射辐射，以将检测到的X射线束的空间频率转换到更高的频率，并提供与低频散射的分离信号。然后通过解调检测到的调制信号来获得检测到的X射线束的低频内容。

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