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21. 发明授权

US07498318B1 Food for diabetics 失效
标题翻译：糖尿病食物
公开(公告)号：US07498318B1
公开(公告)日：2009-03-03
申请号：US10129095
申请日：2000-11-10
申请人： Bernd Stahl , Michael Kliem , Sandra Farwer , Gunther Sawatzki , Gunther Boehm
发明人： Bernd Stahl , Michael Kliem , Sandra Farwer , Gunther Sawatzki , Gunther Boehm
IPC分类号： A61K31/718
CPC分类号： C12Y204/01019 , A23L5/00 , A23L29/30 , A23L33/125 , A23L33/20 , A23L33/21 , C12P19/14 , C12P19/18 , C12Y204/01024
摘要： Provided is a carbohydrate mixture comprising at least one modified carbohydrate from a base body and a carbohydrate residue coupled therewith. The base body concerned is either a digestible glucose-containing carbohydrate in the form of a digestible glucan or a non-digestible reserve carbohydrate, skeletal carbohydrate or a low-molecular component thereof. By coupling the base body with a carbohydrate residue, the glucose release from the inventive carbohydrate mixture is reduced by at least 10%, determined in an in-vivo digestion system on the basis of pancreatine and compared with a carbohydrate mixture containing the same amount by weight of non-modified carbohydrates. By means of the inventive carbohydrate mixture, the postprandial blood glucose concentration after eating can be moderated. The glucose can thus be metabolized by diabetics in spite of the existing lack of insulin. The inventive carbohydrate mixtures can be used in food for diabetics and in pharmaceuticals.
摘要翻译：提供了包含至少一种来自碱体的修饰的碳水化合物和与其偶联的碳水化合物残基的碳水化合物混合物。所涉及的基体是可消化葡萄糖或不可消化的储备碳水化合物，骨骼碳水化合物或其低分子组分形式的可消化的含葡萄糖的碳水化合物。通过将基体与碳水化合物残基偶联，将本发明的碳水化合物混合物的葡萄糖释放量减少至少10％，在基于胰腺的体内消化系统中测定，并与含有相同量的碳水化合物混合物非改性碳水化合物的重量。通过本发明的碳水化合物混合物，饮食后餐后血糖浓度可以缓和。糖可以由糖尿病代谢，尽管目前缺乏胰岛素。本发明的碳水化合物混合物可用于糖尿病患者和药物中。

22. 发明授权

US06576251B1 Carbohydrate mixture 有权
标题翻译：碳水化合物混合物
公开(公告)号：US06576251B1
公开(公告)日：2003-06-10
申请号：US09341775
申请日：1999-11-09
申请人： Bernd Stahl , Gunther Sawatzki
发明人： Bernd Stahl , Gunther Sawatzki
IPC分类号： A61K4736
CPC分类号： A61K31/702 , A23L29/30 , A23L33/125
摘要： The invention relates to a carbohydrate mixture for dietetic foods administered by the enteral or parenteral route and pharmaceuticals, characterized in that said mixture consists of (a) monosaccharide(s), (b) oligosaccharide(s) (at most hexasaccharides) and (c) polysaccharide(s) (at least heptasaccharides), where the mixing ratio a, b, c, in respect of weight, is: &agr;=1, b=40 to 1000, and c=1 to 50, and in that it contains at least 1 weight percent of fucose occurring either freely and/or bound to an oligosaccharide and/or a polysaccharide. According to the invention, the carbohydrate mixture has both a nutritional and a biological effect which is considerably greater than the corresponding action of the individual constituents.
摘要翻译：本发明涉及通过肠内或肠胃外途径和药物施用的饮食食品的碳水化合物混合物，其特征在于所述混合物由（a）单糖，（b）寡糖（至多六糖）和（c ）多糖（至少七糖），其中混合比a，b，c在重量方面为：α= 1，b = 40至1000，c = 1至50，并且其含有至少1重量％的岩藻糖自由地和/或与寡糖和/或多糖结合。根据本发明，碳水化合物混合物具有营养和生物效应，其显着大于各个成分的相应作用。

23. 发明授权

US09566291B2 Nutritional composition comprising indigestible oligosaccharides 有权
标题翻译：包含难消化的寡糖的营养组合物
公开(公告)号：US09566291B2
公开(公告)日：2017-02-14
申请号：US11574180
申请日：2005-08-24
申请人： Günther Boehm , Laura M'Rabet , Bernd Stahl , Johan Garssen
发明人： Günther Boehm , Laura M'Rabet , Bernd Stahl , Johan Garssen
IPC分类号： A61K31/715 , A61K31/733 , A61K39/42 , A61K45/00 , A61P11/00 , A61K31/702 , A61K31/202 , A61K35/741
CPC分类号： A61K31/702 , A23L33/12 , A23L33/21 , A23L33/40 , A23V2002/00 , A23Y2300/29 , A61K31/202 , A61K31/733 , A61K35/741 , A61K39/42 , A61K2300/00 , A23V2200/324 , A23V2250/28 , A23V2250/608 , A23V2250/304 , A23V2250/1642 , A23V2250/1882 , A23V2200/3202 , A23V2200/3204
摘要： The present invention provides a method and composition for the treatment and/or prevention of respiratory tract infection and/or respiratory tract infection disease, said method comprising orally administering a composition to a mammal, said composition comprising a galactose containing indigestible oligosaccharide and at least 5 wt. % digestible galactose saccharide.
摘要翻译：本发明提供了用于治疗和/或预防呼吸道感染和/或呼吸道感染疾病的方法和组合物，所述方法包括向哺乳动物口服施用组合物，所述组合物包含含有不可消化的寡糖的半乳糖和至少5 重量％消化半乳糖。

24. 发明授权

US09084433B2 Intestinal barrier integrity 有权
标题翻译：肠屏障完整性
公开(公告)号：US09084433B2
公开(公告)日：2015-07-21
申请号：US13594147
申请日：2012-08-24
申请人： Eric Alexander Franciscus Van Tol , Linette Eustachia Maria Willemsen , Marleen Antoinette Koetsier , Christopher Beermann , Bernd Stahl
发明人： Eric Alexander Franciscus Van Tol , Linette Eustachia Maria Willemsen , Marleen Antoinette Koetsier , Christopher Beermann , Bernd Stahl
IPC分类号： A61K31/733 , A61P1/00 , A61P1/12 , A61P37/08 , A23L1/29 , A23L1/30
CPC分类号： A23L29/04 , A23L29/30 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K31/202 , A61K31/702 , A23V2200/32 , A23V2200/304 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/28 , A23V2250/5062
摘要： The invention concerns a method for stimulating barrier integrity in a mammal by administering to a mammal a composition comprising: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (ARA), and at least two distinct oligosaccharides.
摘要翻译：本发明涉及通过向哺乳动物施用包含二十碳五烯酸（EPA），二十二碳六烯酸（DHA）和花生四烯酸（ARA）以及至少两种不同的低聚糖的组合物来刺激哺乳动物的屏障完整性的方法。

25. 发明授权

US08680239B2 Use of RGM and its modulators 有权
标题翻译：使用RGM及其调制器
公开(公告)号：US08680239B2
公开(公告)日：2014-03-25
申请号：US13493005
申请日：2012-06-11
申请人： Bernhard K. Mueller , Paolo Macchi , Friedrich Bonhoeffer , Bernd Stahl , Matthias Mann , Jens S. Andersen , Philippe P. Monnier
发明人： Bernhard K. Mueller , Paolo Macchi , Friedrich Bonhoeffer , Bernd Stahl , Matthias Mann , Jens S. Andersen , Philippe P. Monnier
IPC分类号： C07K14/705 , C07K14/46 , C07K14/465 , C07K14/435
CPC分类号： C07K14/47 , A61K38/1709 , A61K2039/505 , C07K14/465 , C07K14/4702 , C07K16/28
摘要： The present invention relates to the use of a modulator of a polypeptide having or comprising an amino acid sequence as disclosed herein or of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with seizures or associated with angiogenic disorders or disorders of the cardio-vascular system.
摘要翻译：本发明涉及具有或包含本文公开的氨基酸序列或其功能片段或衍生物或编码所述多肽或片段或衍生物的多核苷酸的调节剂用于制备药物组合物的用途预防，减轻或治疗与癫痫相关的脊椎动物神经组织的退化或损伤相关的疾病或病症或与心血管系统的血管生成障碍或病症有关。

26. 发明授权

US08580316B2 Immune stimulatory infant nutrition 有权
标题翻译：免疫刺激婴儿营养
公开(公告)号：US08580316B2
公开(公告)日：2013-11-12
申请号：US13360508
申请日：2012-01-27
申请人： Günther Boehm , Christopher Beermann , Bernd Stahl , Laura M'Rabet , Johan Garssen
发明人： Günther Boehm , Christopher Beermann , Bernd Stahl , Laura M'Rabet , Johan Garssen
IPC分类号： A61K38/16 , A61K33/30 , A61P17/00 , A61P37/08 , A61P29/00 , A61P1/12
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： A nutritional or pharmaceutical composition comprising fat, protein, carbohydrate, whey and casein is provided. The composition has a weight ratio of casein to whey between 1:1 to 1:2.4 and comprises: a) at least 3 grams arginine per 100 grams protein; b) at least 10 wt. % linoleic acid based on total fatty acids; c) at least 1 wt. % alpha linolenic acid based on total fatty acids; d) at least one long chain-polyunsaturated fatty acid in an amount exceeding 0.1 wt. % based on total fatty acids selected from docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid; e) 5 to 25 wt. % of at least one polyunsaturated fatty acid based on total fatty acids; and 2 to 12 grams indigestible oligosaccharides having a degree of polymerisation of 2 to 100 per 100 gram dry weight of the composition. Methods of treatment by administering the composition are also provided.
摘要翻译：提供了包含脂肪，蛋白质，碳水化合物，乳清和酪蛋白的营养或药物组合物。该组合物的酪蛋白与乳清的重量比在1:1至1:2.4之间，包括：a）每100克蛋白质至少3克精氨酸; b）至少10wt。％亚油酸基于总脂肪酸; c）至少1wt。基于总脂肪酸的％α亚麻酸; d）至少一种超过0.1重量％的长链多不饱和脂肪酸。基于选自二十二碳六烯酸，花生四烯酸和二十碳五烯酸的总脂肪酸的％; e）5至25wt。至少一种基于总脂肪酸的多不饱和脂肪酸的％; 和2至12克不可消化的寡糖，其组合物的每100克干重具有聚合度为2至100。还提供了施用组合物的治疗方法。

27. 发明授权

US08557794B2 Immunemodulating oligosaccharides 失效
标题翻译：免疫调节寡糖
公开(公告)号：US08557794B2
公开(公告)日：2013-10-15
申请号：US10576834
申请日：2004-10-25
申请人： Bernd Stahl , Laura M'Rabet , Arjan Paul Vos , Johan Garssen , Günther Boehm
发明人： Bernd Stahl , Laura M'Rabet , Arjan Paul Vos , Johan Garssen , Günther Boehm
IPC分类号： A61K31/715
CPC分类号： A61K31/732 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/40 , A23V2002/00 , A61K31/70 , A61K31/702 , A23V2200/324 , A23V2250/28
摘要： The present invention relates to a method for enhancing the immune system and the treatment and/or prevention of immune system related disorders in a mammal, particularly newborns, said method comprising the administration of acid oligosaccharide and neutral oligosaccharide. Food compositions suitable for use in the above method are also provided.
摘要翻译：本发明涉及增强哺乳动物，特别是新生儿免疫系统和治疗和/或预防免疫系统相关疾病的方法，所述方法包括施用酸性寡糖和中性寡糖。还提供了适用于上述方法的食品组合物。

28. 发明申请

US20130102560A1 NUTRITIONAL COMPOSITION COMPRISING IMMUNOGLOBULINS AND OLIGOSACCHARIDES 审中-公开
标题翻译：包含免疫球蛋白和低聚糖的营养组合物
公开(公告)号：US20130102560A1
公开(公告)日：2013-04-25
申请号：US13620216
申请日：2012-09-14
申请人： Günther Boehm , Laura M'Rabet , Bernd Stahl , Johan Garssen , Antony William Scammell , Raymonde Peter Peeters
发明人： Günther Boehm , Laura M'Rabet , Bernd Stahl , Johan Garssen , Antony William Scammell , Raymonde Peter Peeters
IPC分类号： A61K31/702 , A61K31/202 , A61K31/733
摘要： The present invention provides a method and composition for the treatment and/or prevention of infection, said method comprising orally administering a composition to a mammal, said composition comprising a galactose containing indigestible oligosaccharide and immunoglobulin from the milk or colostrum of hyperimmunized cows.
摘要翻译：本发明提供了用于治疗和/或预防感染的方法和组合物，所述方法包括向哺乳动物口服施用组合物，所述组合物包含含有不可消化的寡糖的半乳糖和来自超免疫母牛的乳或初乳的免疫球蛋白。

29. 发明申请

US20120141541A1 SYNERGISTIC MIXTURE OF BETA-GALACTO-OLIGOSACCHARIDES WITH BETA-1,3 AND BETA-1,4/1,6 LINKAGES 有权
标题翻译：具有BETA-1,3和BETA-1,4 / 1,6链接的BETA-GALACTO-OLIGOSACCHARIDES的协同混合物
公开(公告)号：US20120141541A1
公开(公告)日：2012-06-07
申请号：US13377464
申请日：2010-06-14
申请人： Bernd Stahl , Alma Jildou Nauta
发明人： Bernd Stahl , Alma Jildou Nauta
IPC分类号： A61K31/702 , A61P11/06 , A61P37/08 , A61P17/00 , A61K31/7016 , A61P1/12 , A61P1/00 , A61P29/00 , A61P37/04 , A61K31/715 , A61K35/74 , A61P31/00
CPC分类号： A61K31/702 , A23L33/135 , A23L33/21 , A23L33/40 , A61K35/745
摘要： The present invention relates to a nutritional composition comprising at least two different beta-galacto-oligosaccharides (BGOS) A and B wherein the majority of linkages between two galactose residues in BGOS A are beta 1,4 and/or beta 1,6, and the majority of linkages between two galactose residues in BGOS B are beta 1,3. Such mixtures show superior effects on the immune system and are particularly suitable for infant nutrition.
摘要翻译：本发明涉及包含至少两种不同的β-半乳寡聚糖（BGOS）A和B的营养组合物，其中BGOS A中两个半乳糖残基之间的大部分连接是β1,4和/或β1,6，以及 BGOS B中两个半乳糖残基之间的大部分连接是β1,3。这样的混合物对免疫系统表现出优异的效果，并且特别适用于婴儿营养。

30. 发明授权

US07981420B2 Therapeutic use of antibodies directed against repulsive guidance molecule (RGM) 有权
标题翻译：针对排斥指导分子（RGM）的抗体的治疗用途
公开(公告)号：US07981420B2
公开(公告)日：2011-07-19
申请号：US10451586
申请日：2001-12-21
申请人： Bernhard K. Mueller , Philippe P. Monnier , Paolo Macchi , Friedrich Bonhoeffer , Bernd Stahl , Matthias Mann , Jens S. Anderson
发明人： Bernhard K. Mueller , Philippe P. Monnier , Paolo Macchi , Friedrich Bonhoeffer , Bernd Stahl , Matthias Mann , Jens S. Anderson
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K14/47 , A61K38/1709 , A61K2039/505 , C07K14/465 , C07K14/4702 , C07K16/28
摘要： The present invention relates to the use of a modulator of a polypeptide having or comprising an amino acid sequence as disclosed herein or of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with seizures or associated with angiogenic disorders or disorders of the cardio-vascular system. Furthermore, the invention provides for the use of a modulator of a polypeptide having or comprising said amino acid sequence of a functional fragment or derivative thereof or of a polynucleotide encoding said polypeptide or fragment or derivative for the preparation of a pharmaceutical composition for preventing, alleviating or treating diseases or conditions associated with the degeneration or injury of vertebrate nervous tissue, associated with angiogenic disorders or disorders of the cardio-vascular system. In addition the invention provides for the use of said polypeptide or said functional fragment or derivative thereof for the preparation of a pharmaceutical composition for preventing or treating tumor growth or formation of tumor metastases or as a marker of stem cells.
摘要翻译：本发明涉及具有或包含本文公开的氨基酸序列或其功能片段或衍生物或编码所述多肽或片段或衍生物的多核苷酸的调节剂用于制备药物组合物的用途预防，减轻或治疗与癫痫相关的脊椎动物神经组织的退化或损伤相关的疾病或病症或与心血管系统的血管生成障碍或病症有关。此外，本发明提供了具有或包含其功能片段或其衍生物的所述氨基酸序列或编码所述多肽或片段或衍生物的多核苷酸的多肽的调节剂用于制备用于预防，缓解的药物组合物或治疗与脊髓动物神经组织的变性或损伤相关的疾病或病症，与血管生成障碍或心血管系统的病症有关。此外，本发明提供了所述多肽或其功能片段或其衍生物用于制备用于预防或治疗肿瘤生长或肿瘤转移形成或作为干细胞标记的药物组合物的用途。

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