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1. 发明授权

US08277835B2 Nutritional composition comprising immunoglobulins and oligosaccharides 有权
标题翻译：包含免疫球蛋白和寡糖的营养组合物
公开(公告)号：US08277835B2
公开(公告)日：2012-10-02
申请号：US11574123
申请日：2005-08-24
申请人： Günther Boehm , Laura M'Rabet , Bernd Stahl , Johan Garssen , Antony William Scammell , Raymonde Peter Peeters
发明人： Günther Boehm , Laura M'Rabet , Bernd Stahl , Johan Garssen , Antony William Scammell , Raymonde Peter Peeters
IPC分类号： A61K47/00 , A01N43/04 , A23D9/00 , A23C9/154 , A23J1/00 , A23G3/00
CPC分类号： A61K31/702 , A23L33/12 , A23L33/21 , A23L33/40 , A23V2002/00 , A23Y2300/29 , A61K31/202 , A61K31/733 , A61K35/741 , A61K39/42 , A61K2300/00 , A23V2200/324 , A23V2250/28 , A23V2250/608 , A23V2250/304 , A23V2250/1642 , A23V2250/1882 , A23V2200/3202 , A23V2200/3204
摘要： The present invention provides a method and composition for the treatment and/or prevention of infection, said method comprising orally administering a composition to a mammal, said composition comprising a galactose containing indigestible oligosaccharide and immunoglobulin from the milk or colostrum of hyperimmunized cows.
摘要翻译：本发明提供了用于治疗和/或预防感染的方法和组合物，所述方法包括向哺乳动物口服施用组合物，所述组合物包含含有不可消化的寡糖的半乳糖和来自超免疫母牛的乳或初乳的免疫球蛋白。

2. 发明申请

US20060204549A1 Method of improving nutrient utilisation by a mammal and a composition for use therein 审中-公开
标题翻译：改善哺乳动物营养利用的方法及其中使用的组合物
公开(公告)号：US20060204549A1
公开(公告)日：2006-09-14
申请号：US10541566
申请日：2004-01-07
申请人： Laura M'Rabet , Belinda Potappel-Van'Tland
发明人： Laura M'Rabet , Belinda Potappel-Van'Tland
IPC分类号： A61K47/00 , A61K38/40
CPC分类号： A61K38/40 , A23L33/12 , A23L33/175 , A23L33/19 , A23L33/40 , A23V2002/00 , A23V2250/54248 , A23V2250/0612 , A23V2250/1882
摘要： The invention relates to a method of stimulating nutrient utilization, especially through improved gastric emptying, comprising oral administration of a nutritional composition. The invention is concerned with a method of improving nutrient utilization by a mammal comprising orally administering a lactoferrin-containing nutritional composition to the mammal in an amount effective to reduce the residence time of nutrients in the stomach of the mammal, said composition exhibiting a weight ratio of lactoferrin to β-lactoglobulin that exceeds 1 to 15. The invention also relates to a pourable nutritional composition having a caloric content of at least 1.0 kcal/ml, a viscosity of 100 mPa.s or less at 21° C. and comprising: 50-79.6 wt. % water; at least 0.4 wt. % lactoferrin; 1-30 wt. % proteinaceous matter other than lactoferrin; 0.1-20 wt. % lipids; and 10-30 wt. % carbohydrates; wherein the combination of these components constitutes at least 80 wt. % of the composition and wherein the proteinaceous matter, lipids and/or carbohydrates together constitute at least 20 wt. % of the composition.
摘要翻译：本发明涉及一种刺激营养利用的方法，特别是通过改善胃排空，包括口服施用营养组合物。本发明涉及一种改善哺乳动物营养利用的方法，其包括以有效减少哺乳动物胃中营养物停留时间的量向哺乳动物口服施用含有乳铁蛋白的营养组合物，所述组合物显示重量比的乳铁蛋白至超过1至15的β-乳球蛋白。本发明还涉及具有至少1.0kcal / ml的热量含量，在21℃下粘度为100mPa.s或更低的可倾倒营养组合物，其包含： 50-79.6wt。％水; 至少0.4wt。％乳铁蛋白 1-30重量％除乳铁蛋白以外的％蛋白质物质; 0.1-20重量％％脂质和10-30重量％％碳水化合物; 其中这些组分的组合构成至少80wt。％的组合物，其中蛋白质物质，脂质和/或碳水化合物一起构成至少20重量％％的组成。

3. 发明申请

US20100136134A1 Immune stimulatory infant nutrition 有权
标题翻译：免疫刺激婴儿营养
公开(公告)号：US20100136134A1
公开(公告)日：2010-06-03
申请号：US11660594
申请日：2005-08-19
申请人： Günther Boehm , Christopher Beermann , Bernd Stahl , Laura M'rabet , Johan Garssen
发明人： Günther Boehm , Christopher Beermann , Bernd Stahl , Laura M'rabet , Johan Garssen
IPC分类号： A61K38/02 , A23C11/04 , A61K33/30 , A61P17/00 , A61P29/00 , A61P1/00
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： A nutritional or pharmaceutical composition containing a fat component, a protein component and a carbohydrate component and comprising whey and casein. The composition has a weight ratio of casein to whey is 1:1 to 1:2.4 and that the composition contains: a) at least 3 grams arginine per 100 grams protein; b) at least 10 wt. % linoleic acid based on total fatty acids; c) at least 1 wt. % alpha linolenic acid based on total fatty acids; d) at least one long chain-polyunsaturated fatty acid in an amount exceeding 0.1 wt. % based on total fatty acids. The long chain polyunsaturated fatty acid being docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid; e) 5 to 25 wt. % of at least one polyunsaturated fatty acid based on total fatty acids; and f) 2 to 12 grams indigestible oligosaccharides having a degree of polymerisation of 2 to 100 per 100 gram dry weight of the composition. The composition reduces—among others—the risks attached to feeding whey dominant infant formula.
摘要翻译：一种含有脂肪组分，蛋白质组分和碳水化合物组分并包含乳清和酪蛋白的营养或药物组合物。该组合物的酪蛋白与乳清的重量比为1:1至1:2.4，组合物含有：a）每100克蛋白质至少3克精氨酸; b）至少10wt。％亚油酸基于总脂肪酸; c）至少1wt。基于总脂肪酸的％α亚麻酸; d）至少一种超过0.1重量％的长链多不饱和脂肪酸。基于总脂肪酸的％。长链多不饱和脂肪酸是二十二碳六烯酸，花生四烯酸和二十碳五烯酸; e）5至25wt。至少一种基于总脂肪酸的多不饱和脂肪酸的％; 和f）2至12克不可消化的低聚糖，其聚合度为每100克组合物干重2至100。组合物减少 - 其中包括喂食乳清主要婴儿配方奶粉的风险。

4. 发明申请

US20080124323A1 Nutritional Composition Comprising Indigestible Oligosaccharides 有权
标题翻译：营养组合物包含难消化的寡糖
公开(公告)号：US20080124323A1
公开(公告)日：2008-05-29
申请号：US11574180
申请日：2005-08-24
申请人： Gunther Boehm , Laura M'Rabet , Bernd Stahl , Johan Garssen
发明人： Gunther Boehm , Laura M'Rabet , Bernd Stahl , Johan Garssen
IPC分类号： A61K31/733 , A61K31/715 , A61K45/00 , A61K39/42 , A61P11/00
CPC分类号： A61K31/702 , A23L33/12 , A23L33/21 , A23L33/40 , A23V2002/00 , A23Y2300/29 , A61K31/202 , A61K31/733 , A61K35/741 , A61K39/42 , A61K2300/00 , A23V2200/324 , A23V2250/28 , A23V2250/608 , A23V2250/304 , A23V2250/1642 , A23V2250/1882 , A23V2200/3202 , A23V2200/3204
摘要： The present invention provides a method and composition for the treatment and/or prevention of respiratory tract infection and/or respiratory tract infection disease, said method comprising orally administering a composition to a mammal, said composition comprising a galactose containing indigestible oligosaccharide and at least 5 wt. % digestible galactose saccharide.
摘要翻译：本发明提供了一种用于治疗和/或预防呼吸道感染和/或呼吸道感染疾病的方法和组合物，所述方法包括向哺乳动物口服施用组合物，所述组合物包含含有不可消化的寡糖的半乳糖和至少5 重量％消化半乳糖。

5. 发明申请

US20120195975A1 IMMUNE STIMULATORY INFANT NUTRITION 有权
标题翻译：免疫刺激性哺乳动物营养
公开(公告)号：US20120195975A1
公开(公告)日：2012-08-02
申请号：US13360508
申请日：2012-01-27
申请人： Günther Boehm , Christopher Beermann , Bernd Stahl , Laura M'Rabet , Johan Garssen
发明人： Günther Boehm , Christopher Beermann , Bernd Stahl , Laura M'Rabet , Johan Garssen
IPC分类号： A61K38/16 , A61K33/30 , A61P17/00 , A61P37/08 , A61P29/00 , A61P1/12
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： A nutritional or pharmaceutical composition comprising fat, protein, carbohydrate, whey and casein is provided. The composition has a weight ratio of casein to whey between 1:1 to 1:2.4 and comprises: a) at least 3 grams arginine per 100 grams protein; b) at least 10 wt. % linoleic acid based on total fatty acids; c) at least 1 wt. % alpha linolenic acid based on total fatty acids; d) at least one long chain-polyunsaturated fatty acid in an amount exceeding 0.1 wt. % based on total fatty acids selected from docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid; e) 5 to 25 wt. % of at least one polyunsaturated fatty acid based on total fatty acids; and f) 2 to 12 grams indigestible oligosaccharides having a degree of polymerisation of 2 to 100 per 100 gram dry weight of the composition. Methods of treatment by administering the composition are also provided.
摘要翻译：提供了包含脂肪，蛋白质，碳水化合物，乳清和酪蛋白的营养或药物组合物。该组合物的酪蛋白与乳清的重量比在1:1至1:2.4之间，包括：a）每100克蛋白质至少3克精氨酸; b）至少10wt。％亚油酸基于总脂肪酸; c）至少1wt。基于总脂肪酸的％α亚麻酸; d）至少一种超过0.1重量％的长链多不饱和脂肪酸。基于选自二十二碳六烯酸，花生四烯酸和二十碳五烯酸的总脂肪酸的％; e）5至25wt。至少一种基于总脂肪酸的多不饱和脂肪酸的％; 和f）2至12克不可消化的低聚糖，其聚合度为每100克组合物干重2至100。还提供了施用该组合物的治疗方法。

6. 发明申请

US20090257993A1 Lactic Acid Producing Bacteria and Lung Function 审中-公开
标题翻译：乳酸生产细菌和肺功能
公开(公告)号：US20090257993A1
公开(公告)日：2009-10-15
申请号：US10583171
申请日：2004-12-16
申请人： Laura M'Rabet , Gelske Speelmans , Adrianus Johannes Maria Vriesema , Johan Garssen , Jan Knol
发明人： Laura M'Rabet , Gelske Speelmans , Adrianus Johannes Maria Vriesema , Johan Garssen , Jan Knol
IPC分类号： A61K35/74 , A61P11/00 , C12N1/20
CPC分类号： C12N1/20 , A23L33/135 , A23V2002/00 , A23Y2220/77 , A61K35/745 , A61K35/747 , C12R1/46 , A23V2200/3204 , A23V2200/314
摘要： The present invention provides novel use for live (probiotic) lactic acid producing bacteria, dead or non-viable bacteria thereof, as well as food supplements, nutritive compositions and/or pharmaceutical compositions comprising these, for the treatment or prophylaxis of lung dysfunction in a subject. A suitable lactic acid producing bacterium has a significant beneficial effect on airway narrowing determined by measuring the enhanced pause value (Penti) of a test animal.
摘要翻译：本发明提供了用于活的（益生菌）乳酸生产细菌，其死或不存活的细菌以及包含这些细菌的食品添加剂，营养组合物和/或药物组合物用于治疗或预防学科。合适的乳酸生产细菌通过测量测试动物的增强的暂停值（Penti）来确定对气道变窄有显着的有益效果。

7. 发明授权

US08754064B2 Milk oligosaccharide for stimulating the immune system 失效
标题翻译：乳寡糖用于刺激免疫系统
公开(公告)号：US08754064B2
公开(公告)日：2014-06-17
申请号：US12294768
申请日：2007-03-21
申请人： Laura M'Rabet , Antonie Van Baalen , Bernd Stahl , Arjan Paul Vos , Thomas Hubertus Martinus Snoeren
发明人： Laura M'Rabet , Antonie Van Baalen , Bernd Stahl , Arjan Paul Vos , Thomas Hubertus Martinus Snoeren
IPC分类号： C07H3/00 , A61K31/702
CPC分类号： C07H3/00 , A23L33/10 , A23L33/12 , A23L33/185 , A23L33/19 , A23L33/21 , A23L33/40 , A61K31/702 , A61K35/20
摘要： The present invention relates to methods and nutritional compositions for stimulating the immune system, particularly in subjects with an impaired immune system such as 5 infants, said method comprising administering a composition comprising sheep milk and/or short chain oligosaccharides.
摘要翻译：本发明涉及用于刺激免疫系统的方法和营养组合物，特别是在诸如5名婴儿的免疫系统受损的受试者中，所述方法包括施用包含绵羊乳和/或短链寡糖的组合物。

8. 发明授权

US08114441B2 Immune stimulatory infant nutrition 有权
标题翻译：免疫刺激婴儿营养
公开(公告)号：US08114441B2
公开(公告)日：2012-02-14
申请号：US11660594
申请日：2005-08-19
申请人： Günther Boehm , Christopher Beermann , Bernd Stahl , Laura M'rabet , Johan Garssen
发明人： Günther Boehm , Christopher Beermann , Bernd Stahl , Laura M'rabet , Johan Garssen
IPC分类号： A61K38/02 , A61K33/30 , A23C11/04 , A61P17/00 , A61P29/00 , A61P1/00
CPC分类号： A61K31/201 , A23L33/12 , A23L33/19 , A23L33/22 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K31/7052 , A61K31/715 , A23V2250/28 , A23V2250/5046 , A23V2250/1872 , A23V2250/1874 , A23V2250/187 , A23V2250/1868 , A23V2250/1862 , A23V2250/5072
摘要： A nutritional or pharmaceutical composition containing a fat component, a protein component and a carbohydrate component and comprising whey and casein. The composition has a weight ratio of casein to whey is 1:1 to 1:2.4 and that the composition contains: a) at least 3 grams arginine per 100 grams protein; b) at least 10 wt. % linoleic acid based on total fatty acids; c) at least 1 wt. % alpha linolenic acid based on total fatty acids; d) at least one long chain-polyunsaturated fatty acid in an amount exceeding 0.1 wt. % based on total fatty acids. The long chain polyunsaturated fatty acid being docosahexaenoic acid, arachidonic acid and eicosapentaenoic acid; e) 5 to 25 wt. % of at least one polyunsaturated fatty acid based on total fatty acids; and f) 2 to 12 grams indigestible oligosaccharides having a degree of polymerization of 2 to 100 per 100 gram dry weight of the composition. The composition reduces—among others—the risks attached to feeding whey dominant infant formula.
摘要翻译：一种含有脂肪组分，蛋白质组分和碳水化合物组分并包含乳清和酪蛋白的营养或药物组合物。该组合物的酪蛋白与乳清的重量比为1:1至1:2.4，组合物含有：a）每100克蛋白质至少3克精氨酸; b）至少10wt。％亚油酸基于总脂肪酸; c）至少1wt。基于总脂肪酸的％α亚麻酸; d）至少一种超过0.1重量％的长链多不饱和脂肪酸。基于总脂肪酸的％。长链多不饱和脂肪酸是二十二碳六烯酸，花生四烯酸和二十碳五烯酸; e）5至25wt。至少一种基于总脂肪酸的多不饱和脂肪酸的％; 和f）2至12克不可消化的低聚糖，其聚合度为组合物每100克干重2至100。组合物减少 - 其中包括喂食乳清主要婴儿配方奶粉的风险。

9. 发明申请

US20070098762A1 Immunemodulating oligosaccharides 失效
标题翻译：免疫调节寡糖
公开(公告)号：US20070098762A1
公开(公告)日：2007-05-03
申请号：US10576834
申请日：2004-10-25
申请人： Bernd Stahl , Laura M'Rabet , Arjan Vos , Johan Garssen , Gunther Boehm
发明人： Bernd Stahl , Laura M'Rabet , Arjan Vos , Johan Garssen , Gunther Boehm
IPC分类号： A61K31/715 , A61K47/00
CPC分类号： A61K31/732 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/40 , A23V2002/00 , A61K31/70 , A61K31/702 , A23V2200/324 , A23V2250/28
摘要： The present invention relates to a method for enhancing the immune system and the treatment and/or prevention of immune system related disorders in a mammal, particularly newborns, said method comprising the administration of acid oligosaccharide and neutral oligosaccharide. Food compositions suitable for use in the above method are also provided.
摘要翻译：本发明涉及增强哺乳动物，特别是新生儿免疫系统和治疗和/或预防免疫系统相关疾病的方法，所述方法包括施用酸性寡糖和中性寡糖。还提供了适用于上述方法的食品组合物。

10. 发明授权

US09566291B2 Nutritional composition comprising indigestible oligosaccharides 有权
标题翻译：包含难消化的寡糖的营养组合物
公开(公告)号：US09566291B2
公开(公告)日：2017-02-14
申请号：US11574180
申请日：2005-08-24
申请人： Günther Boehm , Laura M'Rabet , Bernd Stahl , Johan Garssen
发明人： Günther Boehm , Laura M'Rabet , Bernd Stahl , Johan Garssen
IPC分类号： A61K31/715 , A61K31/733 , A61K39/42 , A61K45/00 , A61P11/00 , A61K31/702 , A61K31/202 , A61K35/741
CPC分类号： A61K31/702 , A23L33/12 , A23L33/21 , A23L33/40 , A23V2002/00 , A23Y2300/29 , A61K31/202 , A61K31/733 , A61K35/741 , A61K39/42 , A61K2300/00 , A23V2200/324 , A23V2250/28 , A23V2250/608 , A23V2250/304 , A23V2250/1642 , A23V2250/1882 , A23V2200/3202 , A23V2200/3204
摘要： The present invention provides a method and composition for the treatment and/or prevention of respiratory tract infection and/or respiratory tract infection disease, said method comprising orally administering a composition to a mammal, said composition comprising a galactose containing indigestible oligosaccharide and at least 5 wt. % digestible galactose saccharide.
摘要翻译：本发明提供了用于治疗和/或预防呼吸道感染和/或呼吸道感染疾病的方法和组合物，所述方法包括向哺乳动物口服施用组合物，所述组合物包含含有不可消化的寡糖的半乳糖和至少5 重量％消化半乳糖。

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