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1. 发明授权

US06656493B2 Edible film formulations containing maltodextrin 有权
标题翻译：含麦芽糊精的食用薄膜配方
公开(公告)号：US06656493B2
公开(公告)日：2003-12-02
申请号：US09682164
申请日：2001-07-30
申请人： Michael R. Dzija , David G. Barkalow , Albert H. Chapdelaine , Daniel J. Zyck
发明人： Michael R. Dzija , David G. Barkalow , Albert H. Chapdelaine , Daniel J. Zyck
IPC分类号： A61K4736
CPC分类号： A61K8/733 , A61K8/19 , A61K8/73 , A61K8/731 , A61K8/732 , A61K8/97 , A61K9/0056 , A61K9/7007 , A61K2800/594 , A61Q11/00
摘要： Improved edible films for mucoadhesion are provided. The films include at least three types film forming agents other than pullulan, such as maltodextrins, hydrocolloids and fillers. Medicaments and other additive agents can also be incorporated into the edible films. In this regard, the edible films can be utilized to deliver or release the medicaments into an oral cavity, thereby providing effective oral treatment with respect to, for example, oral cleansing and breath freshening.
摘要翻译：提供改进的用于粘膜粘附的可食用膜。膜包括除支链淀粉以外的至少三种成膜剂，例如麦芽糖糊精，水胶体和填料。药剂和其他添加剂也可以并入可食用膜中。在这方面，可以使用可食用的膜来将药物输送或释放到口腔中，从而为例如口腔清洁和呼吸清新提供有效的口服治疗。

2. 发明授权

US06576251B1 Carbohydrate mixture 有权
标题翻译：碳水化合物混合物
公开(公告)号：US06576251B1
公开(公告)日：2003-06-10
申请号：US09341775
申请日：1999-11-09
申请人： Bernd Stahl , Gunther Sawatzki
发明人： Bernd Stahl , Gunther Sawatzki
IPC分类号： A61K4736
CPC分类号： A61K31/702 , A23L29/30 , A23L33/125
摘要： The invention relates to a carbohydrate mixture for dietetic foods administered by the enteral or parenteral route and pharmaceuticals, characterized in that said mixture consists of (a) monosaccharide(s), (b) oligosaccharide(s) (at most hexasaccharides) and (c) polysaccharide(s) (at least heptasaccharides), where the mixing ratio a, b, c, in respect of weight, is: &agr;=1, b=40 to 1000, and c=1 to 50, and in that it contains at least 1 weight percent of fucose occurring either freely and/or bound to an oligosaccharide and/or a polysaccharide. According to the invention, the carbohydrate mixture has both a nutritional and a biological effect which is considerably greater than the corresponding action of the individual constituents.
摘要翻译：本发明涉及通过肠内或肠胃外途径和药物施用的饮食食品的碳水化合物混合物，其特征在于所述混合物由（a）单糖，（b）寡糖（至多六糖）和（c ）多糖（至少七糖），其中混合比a，b，c在重量方面为：α= 1，b = 40至1000，c = 1至50，并且其含有至少1重量％的岩藻糖自由地和/或与寡糖和/或多糖结合。根据本发明，碳水化合物混合物具有营养和生物效应，其显着大于各个成分的相应作用。

3. 发明授权

US06309646B1 Protein-polysaccharide conjugate vaccines and other immunological reagents prepared using homobifunctional and heterobifunctional vinylsulfones, and processes for preparing the conjugates 失效
标题翻译：蛋白质 - 多糖结合疫苗和使用同双功能和异双功能乙烯砜制备的其他免疫试剂，以及制备共轭物的方法
公开(公告)号：US06309646B1
公开(公告)日：2001-10-30
申请号：US08852733
申请日：1997-05-07
申请人： Andrew Lees
发明人： Andrew Lees
IPC分类号： A61K4736
CPC分类号： C07K1/1077 , A61K39/385 , A61K47/61 , A61K47/646 , A61K2039/6081 , A61K2039/627 , Y10S436/822 , Y10S436/823 , Y10S436/828
摘要： A method is disclosed for producing a soluble conjugate vaccine, and preferably protein/polysaccharide conjugates. In this process, the polysaccharide is reacted with a reagent so as to provide a functional group on the polysaccharide molecule. Once the functional group is in place, the polysaccharide is reacted with a homobifunctional or heterobifunctional vinylsulfone to produce a vinylsulfone derivatized polysaccharide. Thereafter, the vinylsulfone derivatized polysaccharide is reacted with a protein to produce the conjugate. If desired, the protein may be derivatized with a functional group prior to the conjugation reaction step. In an alternative embodiment, the protein may be functionalized with a reactive group and then derivatized with the vinylsulfone group to produce a vinylsulfone derivatized protein. This protein may then be reacted with a polysaccharide to produce the conjugate. Optionally, the polysaccharide may be functionalized with a reactive group prior to the conjugation reaction. As another alternative, the polysaccharide may be derivatized directly with a pendant vinylsulfone of the crosslinking agent. The vinylsulfone derivatized polysaccharide may then be coupled to the protein (which may or may not be functionalized). In a similar manner, the protein may be derivatized directly with a pendant vinylsulfone of the crosslinking agent and then coupled to a polysaccharide molecule (which may or may not be functionalized).
摘要翻译：公开了用于生产可溶性缀合疫苗，优选蛋白质/多糖缀合物的方法。在该方法中，多糖与试剂反应，以便在多糖分子上提供官能团。一旦官能团就位，多糖与同双功能或异双功能的乙烯砜反应生成乙烯基砜衍生的多糖。此后，乙烯基砜衍生的多糖与蛋白质反应以产生缀合物。如果需要，蛋白质可以在共轭反应步骤之前用官能团衍生化。在替代实施方案中，蛋白质可以用反应性基团官能化，然后用乙烯基砜基团衍生化以产生乙烯基砜衍生化的蛋白质。然后可以将该蛋白质与多糖反应以产生缀合物。任选地，多糖可以在共轭反应之前用反应性基团官能化。作为另一种选择，多糖可以直接用交联剂的侧链乙烯基砜衍生化。乙烯基砜衍生的多糖然后可以与蛋白质偶联（其可以或可以不被官能化）。以类似的方式，蛋白质可以直接用交联剂的侧链乙烯基砜衍生化，然后与多糖分子（其可以或可以不被官能化）偶联。

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