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11. 发明申请

US20060058350A1 Alkynyl-substituted azasugar derivative and drug containing the same as the active ingredient 审中-公开
标题翻译：炔基取代的十八烷基衍生物和含有与活性成分相同的药物
公开(公告)号：US20060058350A1
公开(公告)日：2006-03-16
申请号：US10540485
申请日：2003-08-01
申请人： Takahiro Tsukida , Hideki Moriyama , Shinichiro Nishimura , Yoshimasa Inoue
发明人： Takahiro Tsukida , Hideki Moriyama , Shinichiro Nishimura , Yoshimasa Inoue
IPC分类号： A61K31/445 , C07D211/54
CPC分类号： C07D211/96
摘要： An alkynyl-substituted azasugar derivative and a drug containing the same as an active ingredient are disclosed. This drug is useful as a preventive or remedy for insulin-independent diabetes, rheumatoid arthritis, osteoarthritis, sepsis, acquired immune deficiency syndrome (AIDS), graft-versus-host disease (GVHD), asthma, atopic dermatitis, and ulcerative colitis.
摘要翻译：公开了炔基取代的十八烷基衍生物和含有它们的活性成分的药物。这种药物可用作胰岛素不依赖性糖尿病，类风湿性关节炎，骨关节炎，败血症，获得性免疫缺陷综合征（AIDS），移植物抗宿主病（GVHD），哮喘，特应性皮炎和溃疡性结肠炎的预防或补救。

12. 发明申请

US20050154017A1 Novel azasugar derivative and drug containing the same as the active ingredient 失效
公开(公告)号：US20050154017A1
公开(公告)日：2005-07-14
申请号：US10504777
申请日：2003-06-26
申请人： Takahiro Tsukida , Hideki Moriyama , Koichi Yokota , Mariko Hatakeyama , Shinichiro Nishimura
发明人： Takahiro Tsukida , Hideki Moriyama , Koichi Yokota , Mariko Hatakeyama , Shinichiro Nishimura
IPC分类号： A61K31/445 , A61P17/00 , A61P43/00 , C07D211/96 , C07D491/04 , C07D491/056 , C07D211/40
CPC分类号： C07D491/04 , A61K31/445 , C07D211/96
摘要： A novel azasugar derivative, and a drug containing the same as an active ingredient are disclosed. The drug is useful for treatment of keratinocyte-proliferative diseases.

13. 外观设计

USD398546S Fish finder 失效
公开(公告)号：USD398546S
公开(公告)日：1998-09-22
申请号：US68005
申请日：1997-03-14
申请人： Shinichiro Nishimura , Toshiro Taki , Shigeru Namaizawa , Shinichi Kato
设计人： Shinichiro Nishimura , Toshiro Taki , Shigeru Namaizawa , Shinichi Kato

14. 发明授权

US08877454B2 Apparatus for auto-pretreating sugar chain 有权
标题翻译：用于自动预处理糖链的装置
公开(公告)号：US08877454B2
公开(公告)日：2014-11-04
申请号：US12681573
申请日：2008-10-03
申请人： Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Hiroshi Yamazaki , Michio Horiuchi , Hiroaki Motoki , Toshiharu Kuroda , Yoko Kita , Mika Nakano
发明人： Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Hiroshi Yamazaki , Michio Horiuchi , Hiroaki Motoki , Toshiharu Kuroda , Yoko Kita , Mika Nakano
IPC分类号： C12Q1/37 , G01N33/68 , G01N30/72 , H01J49/00
CPC分类号： G01N33/6848 , G01N30/7233 , G01N2400/00 , H01J49/00
摘要： To provide an autoanalyzer for analyzing a sugar chain contained in a biological sample, in particular, serum. Namely, it is intended to provide a method of analyzing a sugar chain in a sample, which comprises the following steps: A) the sugar chain-releasing step of releasing the sugar chain in the sample; B) the detection sample-preparing step of preparing the released sugar chain for detection; and, in the case of conducting mass spectrometry using a plate, C) the step of forming a plate for the mass spectrometry having the captured sugar chain dotted thereon which comprises the step of providing the tagged sugar chain sample solution obtained in the step B) on a collection plate; and, if required, the step of conducting an operation in a solid phase support-enclosed plate to form the plate for mass spectrometry; and D) the step of analyzing the sugar chain to be assayed.
摘要翻译：提供一种用于分析生物样品，特别是血清中所含的糖链的自动分析仪。即，提供一种分析样品中的糖链的方法，其包括以下步骤：A）释放样品中的糖链的糖链释放步骤; B）制备释放的糖链进行检测的检测样品制备步骤; 并且在使用板进行质谱分析的情况下，C）形成具有点状捕获的糖链的用于质谱的板的步骤，其包括提供步骤B）中获得的标记的糖链样品溶液的步骤，在收集板上; 如果需要，在固相支持封闭板中进行操作以形成质谱板的步骤; 和D）分析要测定的糖链的步骤。

15. 发明授权

US08232079B2 Oligosaccharide synthesizer 失效
标题翻译：寡糖合成仪
公开(公告)号：US08232079B2
公开(公告)日：2012-07-31
申请号：US11197335
申请日：2005-08-05
申请人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
发明人： Kisaburo Deguchi , Genzou Hirata , Masahito Ito , Hiroaki Nakagawa , Shinichiro Nishimura
IPC分类号： C12M1/00 , C12P19/18
CPC分类号： C12P19/30
摘要： After various sugar nucleotide solutions and glycosyltransferases (or primers) have been mixed, they are introduced into a reaction tank (column) with primers (or glycosyltransferases) immobilized thereon. Then solutions coming out of the reaction tank are led to an ultrafiltration column. The oligosaccharide synthesizer according to the present invention is equipped with a flow path for ensuring that glycosyltransferases or primers separated by the ultrafiltration column are returned into a container for storing each solution in a sample injector.
摘要翻译：在各种糖核苷酸溶液和糖基转移酶（或引物）已被混合之后，将它们引入固定在其上的引物（或糖基转移酶）的反应罐（柱）中。然后将从反应槽出来的溶液引入超滤柱。根据本发明的寡糖合成仪配备有用于确保由超滤塔分离的糖基转移酶或引物返回到用于将每种溶液存储在样品注射器中的容器中的流动路径。

16. 发明授权

US07964687B2 Oxylamino group-containing compound and polymer 有权
标题翻译：含氧基氨基的化合物和聚合物
公开(公告)号：US07964687B2
公开(公告)日：2011-06-21
申请号：US11660985
申请日：2005-07-07
申请人： Shinichiro Nishimura , Hideyuki Shimaoka
发明人： Shinichiro Nishimura , Hideyuki Shimaoka
IPC分类号： C08F120/58
CPC分类号： C08F220/60 , C07C291/04 , C08F222/1006
摘要： An oxylamino group-containing compound represented by the following formula: R1—B-A-B—R2, wherein R1 represents a polymerizable group, R2 represents an oxylamino group-containing group or an oxylamino derivative-containing group, B represents an ester linkage or an amide linkage, and A represents an optionally substituted alkylene group having 2 to 12 carbon atoms.
摘要翻译：由下式表示的含氧基氨基的化合物：R1-BAB-R2，其中R1表示可聚合基团，R2表示含氧基氨基的基团或含氧基氨基衍生物的基团，B表示酯键或酰胺键 A表示任选取代的碳原子数2〜12的亚烷基。

17. 发明授权

US07964410B2 Method for preparing analysis sample, analysis sample and sugar chain capture agent 失效
标题翻译：分析样品，分析样品和糖链捕获剂的制备方法
公开(公告)号：US07964410B2
公开(公告)日：2011-06-21
申请号：US12224953
申请日：2007-03-13
申请人： Hideyuki Shimaoka , Hiromitsu Kuramoto , Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Jun-ichi Furukawa
发明人： Hideyuki Shimaoka , Hiromitsu Kuramoto , Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Jun-ichi Furukawa
IPC分类号： G01N33/00
CPC分类号： C07K1/22 , C07B2200/05 , C07B2200/11 , C07C323/60 , C07K5/0806 , Y10T436/143333 , Y10T436/17 , Y10T436/18 , Y10T436/182 , Y10T436/25 , Y10T436/25125
摘要： A method for preparing an analysis sample which involves the sugar chain capture step comprising a reaction of capturing a sugar chain and/or a sugar derivative from a biological sample by using a sugar chain capture agent and the excision step comprising excising a compound containing a moiety capturing the sugar chain and/or the sugar derivative from the sugar chain capture agent after the completion of the sugar chain capture reaction and releasing the compound.
摘要翻译：一种制备包含糖链捕获步骤的分析样品的方法，其包括通过使用糖链捕获剂从生物样品捕获糖链和/或糖衍生物的反应，并且所述切除步骤包括切除含有部分的化合物在糖链捕获反应完成后从糖链捕获剂捕获糖链和/或糖衍生物并释放该化合物。

18. 发明申请

US20110111443A1 APPARATUS FOR AUTO-PRETREATING SUGAR CHAIN 有权
标题翻译：用于自动预处理糖链的装置
公开(公告)号：US20110111443A1
公开(公告)日：2011-05-12
申请号：US12681573
申请日：2008-10-03
申请人： Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Hiroshi Yamazaki , Michio Horiuchi , Hiroaki Motoki , Toshiharu Kuroda , Yoko Kita , Mika Nakano
发明人： Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Hiroshi Yamazaki , Michio Horiuchi , Hiroaki Motoki , Toshiharu Kuroda , Yoko Kita , Mika Nakano
IPC分类号： C12Q1/37 , C12M1/34 , C12P19/00 , C40B60/14
CPC分类号： G01N33/6848 , G01N30/7233 , G01N2400/00 , H01J49/00
摘要： To provide an autoanalyzer for analyzing a sugar chain contained in a biological sample, in particular, serum. Namely, it is intended to provide a method of analyzing a sugar chain in a sample, which comprises the following steps: A) the sugar chain-releasing step of releasing the sugar chain in the sample; B) the detection sample-preparing step of preparing the released sugar chain for detection; and, in the case of conducting mass spectrometry using a plate, C) the step of forming a plate for the mass spectrometry having the captured sugar chain dotted thereon which comprises the step of providing the tagged sugar chain sample solution obtained in the step B) on a collection plate; and, if required, the step of conducting an operation in a solid phase support-enclosed plate to form the plate for mass spectrometry; and D) the step of analyzing the sugar chain to be assayed.
摘要翻译：提供一种用于分析生物样品，特别是血清中所含的糖链的自动分析仪。即，提供一种分析样品中的糖链的方法，其包括以下步骤：A）释放样品中的糖链的糖链释放步骤; B）制备释放的糖链进行检测的检测样品制备步骤; 并且在使用板进行质谱分析的情况下，C）形成具有点状捕获的糖链的用于质谱的板的步骤，其包括提供步骤B）中获得的标记的糖链样品溶液的步骤，在收集板上; 如果需要，在固相支持封闭板中进行操作以形成质谱板的步骤; 和D）分析要测定的糖链的步骤。

19. 发明授权

US07883873B2 Saccharide composition synthesizer 有权
标题翻译：糖组成合成仪
公开(公告)号：US07883873B2
公开(公告)日：2011-02-08
申请号：US11060810
申请日：2005-02-18
申请人： Masanori Takaki , Kuriko Yamada , Kisaburo Deguchi , Hiroaki Nakagawa , Shinichiro Nishimura
发明人： Masanori Takaki , Kuriko Yamada , Kisaburo Deguchi , Hiroaki Nakagawa , Shinichiro Nishimura
IPC分类号： C12P19/18 , C12P19/16 , B01J19/00
CPC分类号： C12P19/18
摘要： The present invention provides a sugar chain synthesizer capable of continuously reacting sugar chains when a plurality of sugar chains are successively reacted. The sugar chain synthesizer of the present invention includes a plurality of vessels containing respective sugar nucleotide solutions, a plurality of vessels containing respective glycosyltransferases, and a reactor containing a primer that is a water-soluble polymer, into which the above described sugar nucleotide solution and glycosyltransferase are introduced. In the present invention, components in a reaction solution obtained in the reactor are separated through an ultrafiltration column, and a reaction product is then returned to the above described reactor, so as to continuously synthesize sugar chains. Although it is a complicated synthesis of sugar chains, it becomes possible to carry out such synthesis continuously and automatically.
摘要翻译：本发明提供了当多个糖链连续反应时能够连续反应糖链的糖链合成器。本发明的糖链合成装置包括含有各糖苷溶液的多个容器，含有各糖基转移酶的多个容器，以及含有水溶性聚合物的底物的反应器，上述糖核苷酸溶液和糖基转移酶。在本发明中，通过超滤塔将反应器中得到的反应溶液中的成分分离，然后将反应产物返回到上述反应器中，以连续合成糖链。糖链的合成虽然复杂，但可以连续自动进行合成。

20. 发明申请

US20080113924A1 Neuramindase Inhibitor 审中-公开
标题翻译：神经酰胺糖苷酶抑制剂
公开(公告)号：US20080113924A1
公开(公告)日：2008-05-15
申请号：US11721581
申请日：2005-12-16
申请人： Shinichiro Nishimura , Hiroshi Hinou , Hirosato Kondo , Kazuhiko Fujiwara
发明人： Shinichiro Nishimura , Hiroshi Hinou , Hirosato Kondo , Kazuhiko Fujiwara
IPC分类号： A61K31/7048 , A61K31/366 , A61K31/35 , C07D311/02
CPC分类号： C07H15/203 , C07H15/26 , C07H17/075 , C12Q1/04 , C12Q1/34 , G01N2333/924 , G01N2800/26
摘要： There are provided a novel compound having irreversible inhibitory activity against neuraminidase, a therapeutic agent and a detection agent for a disease involving neuraminidase. A compound represented by the following formula (I) and a salt thereof, a production method thereof, and an application method thereof, wherein: A1 represents an aryl group optionally having a substituent group or a heteroaryl group optionally having a substituent group; A2 represents —CX2R6 or —CHXR6 wherein X represents —F, —Cl, —Br, or —I; R1 represents a hydrogen atom or an alkyl group optionally having a substituent group; R2, R3, R4, and R5 represent each independently —OC(═O)R6, —OR6, —N(R6)2, —N3, —NHC(═NH)NHR6, —NHCOR6, —OSO3R6, —OPO3(R6)2, F, Cl, Br, or I; and R6 represents each independently a hydrogen atom, an alkyl group optionally having a substituent group, an aryl group optionally having a substituent group, or an optionally substituted heteroaryl group.
摘要翻译：提供了对神经氨酸酶具有不可逆抑制活性的新型化合物，治疗剂和涉及神经氨酸酶的疾病检测剂。由下式（I）表示的化合物及其盐，其制备方法及其施加方法，其中：A 1表示任选具有取代基的芳基或杂芳基任选具有取代基; 其中X代表-F，-Cl， - ， - ， - Br或-I; R 1表示氢原子或任选具有取代基的烷基; R 2，R 3，R 4和R 5各自独立地表示-OC（-O）R 6， - 6， - （R 6）2 - ， - N 3 - ，-NHC（-NH）NHR 6，-NHCOR 6，-OSO 3，＆lt; 6＆lt; 6＆gt; -OPO 3（R 6）2，F，Cl，Br或I; 和R 6各自独立地表示氢原子，任选具有取代基的烷基，任选具有取代基的芳基或任选取代的杂芳基。

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