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1. 发明专利

JP2005314382A Azidized aminosugar nucleotide and its application 有权
标题翻译：硫化氨基酸核苷酸及其应用
公开(公告)号：JP2005314382A
公开(公告)日：2005-11-10
申请号：JP2005091056
申请日：2005-03-28
申请人： Shinichiro Nishimura , Yamasa Shoyu Co Ltd , ヤマサ醤油株式会社 , 紳一郎西村
发明人： FURUKAWA JUNICHI , HAMAMOTO TOMOKI , NISHIMURA SHINICHIRO , OKUYAMA KIYOSHI , NOGUCHI TOSHITADA
IPC分类号： C12N9/99 , A61K31/7072 , A61P35/00 , A61P43/00 , C07H19/067 , C12P19/30
CPC分类号： Y02P20/52
摘要： PROBLEM TO BE SOLVED: To provide a non-naturally occurring azidized aminosugar nucleotide. SOLUTION: The azidized aminosugar nucleotide is represented by the formula (wherein B is a nucleobase or its derivative). In a preparation method of an oligosaccharide containing an N-azidoacetyl-α-glucosaminyl group or an N-azidoacetyl-α-D-galactosaminyl, the azidized aminosugar nucleotide is used as a sugar donor, and the N-azidoacetyl-α-glucosaminyl group or the N-azidoacetyl-α-D-galactosaminyl is transferred to a receptor sugar by a glycosyltransferase. An glycosylgransferase inhibitor contains the azidized aminosugar nucleotide or its derivative. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供非天然存在的叠氮化氨基糖苷核苷酸。解决方案：叠氮化氨基糖苷核苷酸由式（其中B是核碱基或其衍生物）表示。在含有N-叠氮基乙酰基-α-葡糖胺基或N-叠氮基乙酰基-α-D-半乳糖胺基的寡糖的制备方法中，叠氮化氨基糖苷核苷酸用作糖供体，N-叠氮基乙酰基-α-葡糖胺基或N-叠氮基乙酰基-α-D-半乳糖胺基被糖基转移酶转移到受体糖中。糖基转移酶抑制剂含有叠氮基氨基糖苷或其衍生物。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2012122073A Polymer particle 审中-公开
标题翻译：聚合物颗粒
公开(公告)号：JP2012122073A
公开(公告)日：2012-06-28
申请号：JP2012006298
申请日：2012-01-16
申请人： Shinichiro Nishimura , Sumitomo Bakelite Co Ltd , 住友ベークライト株式会社 , 紳一郎西村
发明人： NISHIMURA SHINICHIRO , SHIMAOKA HIDEYUKI
IPC分类号： C08F20/60 , C12Q1/04 , G01N33/53 , G01N33/543 , G01N33/547 , G01N37/00
CPC分类号： G01N33/543 , G01N2400/00
摘要： PROBLEM TO BE SOLVED: To provide a means for forming a support useful for research on the participation of sugar chain in biological reaction, and a polymer particle for the separation and purification of merely sugar chains and sugar containing material from a sample that contains inclusions such as living tissue with a simple operation; and to provide a means to fabricate a sugar chain chip that is a device in which sugar chains are fixed on a substrate by a simple and efficient method.SOLUTION: The support supports a functional group that specifically reacts with the aldehyde group of sugar chains, wherein the functional group is at least one selected from an oxylamino group, hydrazide group, and semithiocarbazide group. The polymer particle and the sugar chip are also provide to which the support is applied.
摘要翻译：要解决的问题：提供一种用于形成用于研究糖链参与生物反应的载体的方法，以及用于从样品中仅分离和纯化糖链和含糖材料的聚合物颗粒，含有简单操作的活组织等夹杂物; 并且提供一种制造糖链芯片的方法，该糖链芯片是通过简单有效的方法将糖链固定在基材上的装置。解决方案：载体支持与糖链的醛基特异性反应的官能团，其中官能团为选自氧基氨基，酰肼基和半硫代卡巴肼基中的至少一种。还提供了聚合物颗粒和糖片，其中施加了载体。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2005247907A Chitosan derivative and method for producing the same 审中-公开
标题翻译： CHITOSAN衍生物及其生产方法
公开(公告)号：JP2005247907A
公开(公告)日：2005-09-15
申请号：JP2004056626
申请日：2004-03-01
申请人： Hokkaido Electric Power Co Inc:The , Shinichiro Nishimura , Seibutsu Yuki Kagaku Kenkyusho:Kk , 北海道電力株式会社 , 株式会社生物有機化学研究所 , 紳一郎西村
发明人： NISHIMURA SHINICHIRO , RI GAKUHEI
IPC分类号： C08B37/08
摘要： PROBLEM TO BE SOLVED: To obtain a chitosan derivative having more potent physiological activity.
SOLUTION: The chitosan derivative comprises randomly sequenced structural units represented by formulae (i), (ii), and (iii) (wherein R
1 is a 1 to 20C linear alkylene group; R
2 is a sugar residue in which one or more sugar chains selected from the group consisting of a plurality of sugar chains having various physiological activities are bonded to each other through oxygen atoms on the reducing terminal side in relation to R
1 ; and (x), (y), and (z) are molar ratios, provided that 0≤x
摘要翻译：待解决的问题：获得具有较强生理活性的壳聚糖衍生物。解决方案：壳聚糖衍生物包含由式（i），（ii）和（iii）表示的随机测序的结构单元（其中R 1是1至20C直链亚烷基; SP> 2 是糖残基，其中选自多个具有各种生理活性的糖链的一个或多个糖链通过还原末端侧的氧原子相对于R 1 ;和（x），（y）和（z）是摩尔比，条件是0≤x<1,0

4. 发明专利

JP2005097268A Fluorinated park nucleotide compound, and medicinal application and process thereof 审中-公开
标题翻译：氟化公园核化合物及其药物应用及其过程
公开(公告)号：JP2005097268A
公开(公告)日：2005-04-14
申请号：JP2004233897
申请日：2004-08-10
申请人： Shinichiro Nishimura , Yamasa Shoyu Co Ltd , ヤマサ醤油株式会社 , 紳一郎西村
发明人： SADAMOTO REIKO , HYO HI , UEDA TAICHI , NIIKURA KENICHI , NISHIMURA SHINICHIRO
IPC分类号： A61K38/00 , A61P31/04 , A61P43/00 , C07K1/06 , C07K7/02
CPC分类号： Y02P20/55
摘要： PROBLEM TO BE SOLVED: To provide a compound showing antimicrobial activity by new mechanism of action which does not target enzymes or peptide structure wherein resistant bacteria emerge easily and antibacterial spectrum is apt to be restricted. SOLUTION: The compound or its salt is represented by general formula (I) (wherein R 1 is a nucleic acid base or its derivative, R 2 is a peptide which may have a protecting group, R 3 is a hydrogen atom, a fluorine atom or a hydroxy group which may have a protecting group, wavy line is an α-anomer, a β-anomer or their mixture). COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种通过新的作用机理显示抗微生物活性的化合物，其不涉及容易受到抗菌谱的抗菌谱易于出现的酶或肽结构。解决方案：化合物或其盐由通式（I）表示（其中R 1 是核酸碱基或其衍生物，R SB 2是肽可以具有保护基，R 3是氢原子，氟原子或可以具有保护基的羟基，波浪线是α-端基异构体，β-端基异构体或它们的混合物）。版权所有（C）2005，JPO＆NCIPI

5. 发明授权

US07598372B2 Synthesis of core sugar chain structure of asparagine-linked glycoprotein 失效
标题翻译：天冬酰胺连接糖蛋白核心糖链结构的合成
公开(公告)号：US07598372B2
公开(公告)日：2009-10-06
申请号：US10584065
申请日：2004-12-24
申请人： Shinichiro Nishimura , Yasuhiro Takegawa
发明人： Shinichiro Nishimura , Yasuhiro Takegawa
IPC分类号： C08B37/00 , C07H5/04 , C07H5/06
CPC分类号： C07H13/06 , C07H1/00 , C07H1/08
摘要： It is intended to chemically synthesize the trisaccharide moiety at the reducing end in the core sugar chain structure of an asparagine-linked glycoprotein. By using a highly inexpensive natural polysaccharide having a mannoseβ-1,4-bond as the starting material, a β-1,4-glycoside bond of mannose is formed.
摘要翻译：旨在在天冬酰胺连接的糖蛋白的核心糖链结构的还原端化学合成三糖部分。通过使用具有甘露糖-b-1,4键的高度廉价的天然多糖作为起始原料，形成甘露糖的β-1,4-糖苷键。

6. 发明申请

US20070111951A1 Novel galactosylceramide analogues, and beta-glucocerebrosidase activator, external skin preparations and method of activating beta-glucocerebrosidase using the same 审中-公开
标题翻译：新型半乳糖神经酰胺类似物和β-葡糖脑苷脂酶活化剂，外用皮肤制剂和使用其的β-葡糖脑苷脂酶活化方法
公开(公告)号：US20070111951A1
公开(公告)日：2007-05-17
申请号：US11651978
申请日：2007-01-11
申请人： Rie Uematsu , Fumio Nakajima , Masahiro Yoshida , Kyoko Fukunaga , Mariko Hara , Shintaro Inoue , Shinichiro Nishimura
发明人： Rie Uematsu , Fumio Nakajima , Masahiro Yoshida , Kyoko Fukunaga , Mariko Hara , Shintaro Inoue , Shinichiro Nishimura
IPC分类号： A61K31/70
CPC分类号： C07H15/14 , A61K8/602 , A61Q19/00
摘要： Galactosylceramide analogues represented by the following formula (1) or (2). (wherein X and Y each represent S or O, R1 and R2 each represent an alkyl group or an alkenyl group each having 9 to 35 carbon atoms. R3 represents an alkyl group or an alkenyl group each having 2 to 30 carbon atoms.) It is provided a β-glucocerebrosidase activator which is easily available, and external skin preparations and a method of activating β-glucocerebrosidase, in which improvement in formation of horny layer transmission barrier is expected by activating β-glucocerebrosidase so that an improved effect in rough skin is also expected.
摘要翻译：由下式（1）或（2）表示的半乳糖神经酰胺类似物。（其中X和Y各自表示S或O，R 1和R 2各自表示各自具有9至35个碳原子的烷基或烯基，R SUP > 3 表示各自具有2〜30个碳原子的烷基或烯基。）提供易于获得的β-葡萄糖脑苷脂酶激活剂，以及外用皮肤制剂和β-葡萄糖脑苷脂酶活化方法通过激活β-葡糖脑苷脂酶预期角质层传播屏障形成的改善，从而也预期在粗糙皮肤中的改善效果。

7. 外观设计

USD401592S Antenna radome 失效
公开(公告)号：USD401592S
公开(公告)日：1998-11-24
申请号：US68016
申请日：1997-03-14
申请人： Shinichiro Nishimura , Hideyuki Tsutsui , Hiroyuki Kobayashi , Kazuyuki Oguri
设计人： Shinichiro Nishimura , Hideyuki Tsutsui , Hiroyuki Kobayashi , Kazuyuki Oguri

8. 外观设计

USD394223S Fish finder 失效
公开(公告)号：USD394223S
公开(公告)日：1998-05-12
申请号：US68004
申请日：1997-03-14
申请人： Shinichiro Nishimura , Shigeru Namaizawa , Toshiro Taki , Kiyofumi Ishibashi
设计人： Shinichiro Nishimura , Shigeru Namaizawa , Toshiro Taki , Kiyofumi Ishibashi

9. 发明授权

US07985874B2 Polymer particle 失效
标题翻译：聚合物颗粒
公开(公告)号：US07985874B2
公开(公告)日：2011-07-26
申请号：US10594182
申请日：2005-03-18
申请人： Shinichiro Nishimura , Hideyuki Shimaoka
发明人： Shinichiro Nishimura , Hideyuki Shimaoka
IPC分类号： C01B21/14
CPC分类号： G01N33/543 , G01N2400/00
摘要： A support comprising functional groups supported therein that specifically react with an aldehyde group of a sugar chain, and a polymer particle and a glycochip to which the support is applied, and uses thereof.
摘要翻译：其中包含与糖链的醛基特异性反应的官能团的载体，以及应用了载体的聚合物颗粒和糖芯片及其用途。

10. 发明申请

US20090068752A1 Method for Preparing Analysis Sample, Analysis Sample and Sugar Chain Capture Agent 失效
标题翻译：分析样品，分析样品和糖链捕获剂的制备方法
公开(公告)号：US20090068752A1
公开(公告)日：2009-03-12
申请号：US12224953
申请日：2007-03-13
申请人： Hideyuki Shimaoka , Hiromitsu Kuramoto , Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Jun-ichi Furukawa
发明人： Hideyuki Shimaoka , Hiromitsu Kuramoto , Shinichiro Nishimura , Yasuro Shinohara , Yoshiaki Miura , Jun-ichi Furukawa
IPC分类号： G01N33/50 , C07K2/00
CPC分类号： C07K1/22 , C07B2200/05 , C07B2200/11 , C07C323/60 , C07K5/0806 , Y10T436/143333 , Y10T436/17 , Y10T436/18 , Y10T436/182 , Y10T436/25 , Y10T436/25125
摘要： A method for preparing an analysis sample which involves the sugar chain capture step comprising a reaction of capturing a sugar chain and/or a sugar derivative from a biological sample by using a sugar chain capture agent and the excision step comprising excising a compound containing a moiety capturing the sugar chain and/or the sugar derivative from the sugar chain capture agent after the completion of the sugar chain capture reaction and releasing the compound.
摘要翻译：一种制备包含糖链捕获步骤的分析样品的方法，其包括通过使用糖链捕获剂从生物样品捕获糖链和/或糖衍生物的反应，并且所述切除步骤包括切除含有部分的化合物在糖链捕获反应完成后从糖链捕获剂捕获糖链和/或糖衍生物并释放该化合物。

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