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111. 发明授权

US07920913B1 Systems and methods for increasing implantable sensor accuracy 有权
标题翻译：增加植入式传感器精度的系统和方法
公开(公告)号：US07920913B1
公开(公告)日：2011-04-05
申请号：US11771514
申请日：2007-06-29
申请人： Yelena Nabutovsky , Gene A. Bornzin , Kyungmoo Ryu , Taraneh Ghaffari Farazi
发明人： Yelena Nabutovsky , Gene A. Bornzin , Kyungmoo Ryu , Taraneh Ghaffari Farazi
IPC分类号： A61B5/04
CPC分类号： A61B5/14551 , A61B2560/02
摘要： Provided herein are implantable systems, and methods for use therewith, that increase the accuracy of measurements produced using an implanted sensor, where the measurements are affected by cycles of a cyclical body function (e.g., heart beat and/or respiration). In accordance with specific embodiments of system, a measurement that is presumed to be accurate is obtained. The measurement can be of a physiologic property, such as, but not limited to, blood oxygen saturation, hematocrit, or blood glucose concentration. Additionally, the implanted is used to produce a plurality of measurements of the physiologic property. Such measurements, produced using the implanted sensor, are compared to the measurement presumed to be accurate to thereby identify when the measurements produced using the implanted sensor are most accurate. Thereafter, the implanted system is configured to use the implanted sensor to produce measurements when the measurements produced using the implanted sensor are most accurate.
摘要翻译：本文提供了可植入系统及其使用的方法，其增加使用植入式传感器产生的测量的精度，其中测量受周期性身体功能（例如心跳和/或呼吸）的周期的影响。根据系统的具体实施例，获得推测为准确的测量值。测量可以具有生理特性，例如但不限于血氧饱和度，血细胞比容或血糖浓度。另外，植入用于产生生理特性的多个测量。将使用植入的传感器产生的这种测量与推定为准确的测量进行比较，从而识别何时使用植入的传感器产生的测量是最准确的。此后，当使用植入的传感器产生的测量最准确时，植入系统被配置为使用植入的传感器来产生测量。

112. 发明授权

US07877141B1 PAC therapy 有权
标题翻译： PAC疗法
公开(公告)号：US07877141B1
公开(公告)日：2011-01-25
申请号：US11349497
申请日：2006-02-06
申请人： Gene A. Bornzin , Peter Boileau
发明人： Gene A. Bornzin , Peter Boileau
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61N1/3624 , A61N1/3712 , A61N1/3714
摘要： An exemplary method includes detecting a first atrial event, initiating a detection window after detecting the first atrial event, detecting a second atrial event during the detection window, classifying the second atrial event as a premature atrial contraction and calling for delivery of an atrial extrastimulus in response to the premature atrial contraction. Various other exemplary technologies are also disclosed.
摘要翻译：一种示例性方法包括检测第一心房事件，在检测到第一心房事件之后启动检测窗口，在检测窗口期间检测第二心房事件，将第二心房事件分类为过早心房收缩并呼吁将房性过度激发递送至对早产性心房收缩的反应。还公开了各种其它示例性技术。

113. 发明申请

US20100298670A1 ELECTROLYTE MONITORING USING IMPLANTED CARDIAC RHYTHM MANAGEMENT DEVICE 审中-公开
标题翻译：使用植入式牙科管理装置进行电解质监测
公开(公告)号：US20100298670A1
公开(公告)日：2010-11-25
申请号：US12469564
申请日：2009-05-20
申请人： Rupinder Bharmi , Gene A. Bornzin
发明人： Rupinder Bharmi , Gene A. Bornzin
IPC分类号： A61B5/145
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/042 , A61B5/14546 , A61N1/36557 , A61N1/368 , A61N1/37211
摘要： A method for diagnosing an electrolyte level with a cardiac rhythm management device includes recording intra-cardiac electrograms from multiple sites. The method determines the electrolyte level based upon a comparative analysis of intra-cardiac electrograms recorded from at least two of the sites. The electrolyte level can be quantified based upon a general model, or a patient specific model.
摘要翻译：用心律管理装置诊断电解质水平的方法包括记录多个部位的心脏内电图。该方法基于从至少两个位点记录的心脏内电图的比较分析来确定电解质水平。可以基于一般模型或患者特异性模型量化电解质水平。

114. 发明授权

US07801607B1 PAC therapy 有权
标题翻译： PAC疗法
公开(公告)号：US07801607B1
公开(公告)日：2010-09-21
申请号：US11735872
申请日：2007-04-16
申请人： Gene A. Bornzin , Peter Boileau
发明人： Gene A. Bornzin , Peter Boileau
IPC分类号： A61N1/37
CPC分类号： A61N1/3627 , A61N1/3624 , A61N1/3712 , A61N1/3714
摘要： An implantable cardiac device is programmed to detect and classify premature atrial contractions (PACs) and administer responsive pacing therapy. The responsive pacing therapy is in the form of an atrial extrastimulus, which is intended to preempt initiation of a reentrant tachycardia. The atrial extrastimulus is timed to occur late enough after a PAC to ensure atrial capture, but early enough that the resulting atrial depolarization does not conduct through the AV node to the ventricles if the PAC has already done so. If both of these criteria cannot be met, the device may be configured to inhibit the atrial extrastimulus.
摘要翻译：可植入心脏装置被编程以检测和分类早产性心房收缩（PAC）并进行响应性起搏治疗。响应性起搏治疗是以心房超激发的形式，其旨在抢先引发折返性心动过速。房间超激发定时发生在PAC后足够晚，以确保心房捕获，但足够早，如果PAC已经这样做，所产生的心房去极化不会通过AV节点进入心室。如果这两个标准都不能满足，则可以将该装置配置成抑制心房再刺激。

115. 发明申请

US20100121395A1 System and Method for Setting Atrioventricular Pacing Delays Based on Far-Field Atrial Signals 有权
标题翻译：基于远场心房信号设置房室起搏延迟的系统和方法
公开(公告)号：US20100121395A1
公开(公告)日：2010-05-13
申请号：US12267483
申请日：2008-11-07
申请人： Jong Gill , Gene A. Bornzin
发明人： Jong Gill , Gene A. Bornzin
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61B5/0452 , A61N1/3704
摘要： An intrinsic inter-atrial conduction delay is determined by a pacemaker or implantable cardioverter-defibrillator based, at least in part, on far-field atrial events sensed using ventricular pacing/sensing leads. An atrioventricular pacing delay is then set based on the inter-atrial conduction delay. By detecting atrial events using ventricular leads, rather than using atrial leads, a more useful measurement of the intrinsic inter-atrial conduction delay can be obtained. In this regard, since atrial electrodes detect atrial activity locally around the electrodes, a near-field atrial event sensed using an atrial electrode might not properly represent the actual timing of the atrial event across both the right and left atria. Far-field atrial events sensed using ventricular leads thus allow for a more useful measurement of inter-atrial conduction delays for use in setting atrioventricular pacing delays. The delivery of individual V-pulses to the heart of the patient may be timed relative to the ends of individual far-field atrial events.
摘要翻译：至少部分地基于使用心室起搏/感测引线感测的远场心房事件，起搏器或植入式心律转复除颤器确定内在的心房间传导延迟。然后基于心房间传导延迟来设置房室起搏延迟。通过使用心室导联检测心房事件，而不是使用心房线，可以获得更有用的内在心房传导延迟的测量。在这方面，由于心房电极在电极周围局部地检测心房活动，使用心房电极感测到的近场心房事件可能不能正确地表示在右心房和左心房两侧的心房事件的实际时间。使用心室引线检测的远场心房事件因此允许更有用的测量心房间传导延迟，用于设置房室起搏延迟。单个V脉冲到患者心脏的传送可以相对于单个远场心房事件的结束而定时。

116. 发明申请

US20100114236A1 HYBRID BATTERY SYSTEM WITH BIOELECTRIC CELL FOR IMPLANTABLE CARDIAC THERAPY DEVICE 审中-公开
标题翻译：具有用于可植入心脏治疗装置的生物电池的混合电池系统
公开(公告)号：US20100114236A1
公开(公告)日：2010-05-06
申请号：US12263348
申请日：2008-10-31
申请人： Naixiong Jiang , Gene A. Bornzin , John W. Poore
发明人： Naixiong Jiang , Gene A. Bornzin , John W. Poore
IPC分类号： A61N1/362 , H01M10/36
CPC分类号： A61N1/378 , A61N1/3956 , A61N1/3981 , H01M8/16 , H01M10/0525 , H01M10/425 , H01M10/44 , H01M16/006 , H02J7/0054 , H02J7/0063 , Y02E60/527
摘要： A system and method for powering an implantable cardiac therapy device (ICTD) via a hybrid battery system. The hybrid battery is comprised of a low voltage and low current bioelectric cell, a high voltage and high current rechargeable cell, and a charging means. Via the charging means, the bioelectric cell maintains the rechargeable cell at or near full power. The rechargeable cell is configured to power some or all operations of the ICTD. Some ICTD operations may be powered directly by the bioelectric cell. The rechargeable cell is further configured to be charged via a continuous charging process, reducing the complexity of the charging circuitry. In an embodiment, at least the bioelectric cell is external to the ICTD, enabling easy replacement of this power source. In an embodiment, a consumable anode of the bioelectric cell is external to the ICTD, enabling replacement of the power source by replacing only the anode.
摘要翻译：通过混合电池系统为植入式心脏治疗装置（ICTD）供电的系统和方法。混合电池包括低电压和低电流生物电池，高电压和高电流可再充电电池以及充电装置。通过充电装置，生物电池将可再充电电池维持在或接近全功率。可充电电池被配置为为ICTD的一些或所有操作供电。一些ICTD操作可以由生物电池直接供电。可再充电电池还被配置为经由连续充电过程进行充电，从而降低充电电路的复杂性。在一个实施例中，至少生物电池在ICTD的外部，使得能够容易地更换该电源。在一个实施例中，生物电池的消耗性阳极在ICTD的外部，能够通过仅替换阳极来替换电源。

117. 发明授权

US07630078B1 Calibrating implantable optical sensors 失效
标题翻译：校准植入光学传感器
公开(公告)号：US07630078B1
公开(公告)日：2009-12-08
申请号：US11683521
申请日：2007-03-08
申请人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
发明人： Yelena Nabutovsky , Gene A. Bornzin , Taraneh Ghaffari Farazi , John W. Poore
IPC分类号： G01B9/08
CPC分类号： A61B5/14542 , A61B5/02028 , A61B5/14535 , A61B5/1459 , A61B2560/0223 , A61N1/36557
摘要： A measurement light detector detects light transmitted by a light source of an implantable system that is scattered back into an implantable housing, and produces a measurement signal indicative of the intensity of the light detected by the measurement light detector. A calibration light detector detects a portion of the transmitted light that has not exited the housing, and produces a calibration signal that is indicative of the intensity of the light detected by the calibration light detector, which is indicative of the intensity of the light transmitted by the light source. Changes in the intensity of the transmitted light are compensated for based on the calibration signal produced by the calibration light detector. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.
摘要翻译：测量光检测器检测由可植入系统的光源透射的光，其被散射回到可植入的壳体中，并且产生指示由测量光检测器检测到的光的强度的测量信号。校准光检测器检测未离开壳体的透射光的一部分，并且产生指示由校准光检测器检测的光的强度的校准信号，该校准信号指示由光学器件发射的光的强度光源。基于由校准光检测器产生的校准信号来补偿透射光强度的变化。本说明书不是对本发明的完整描述或限制本发明的范围。本发明的其它特征，方面和目的可以通过对说明书，附图和权利要求的评述来获得。

118. 发明授权

US07613508B2 Implantable cardiac stimulation device, system and method which provides an electrogram signal facilitating measurement of slow-changing electrogram features 有权
标题翻译：可植入的心脏刺激装置，系统和方法，其提供便于测量慢变化电描记图特征的电描记图信号
公开(公告)号：US07613508B2
公开(公告)日：2009-11-03
申请号：US11871873
申请日：2007-10-12
申请人： Peter Boileau , Gene A. Bornzin , Jong Gill
发明人： Peter Boileau , Gene A. Bornzin , Jong Gill
IPC分类号： A61B5/042
CPC分类号： A61N1/3702 , A61B5/04018 , A61B5/042 , A61B5/0452 , A61N1/368
摘要： An implantable cardiac system including an implantable cardiac stimulation device provides a heart activity signal of a heart facilitating measurement of slowly changing electrogram features. The system comprises at least one implantable electrode arrangement that senses cardiac electrical activity and provides an intracardiac electrogram signal, a first high pass filter that filters the electrogram and an equalizer that filters the filtered electrogram signal. The equalizer has a transfer function that is non-decreasing for frequencies up to a lower frequency breakpoint that is less than the upper frequency breakpoint, decreasing for frequencies between the lower frequency breakpoint and the upper frequency breakpoint, and generally flat for frequencies above the upper frequency breakpoint through a bandpass region of interest.
摘要翻译：包括可植入心脏刺激装置的可植入心脏系统提供心脏的心脏活动信号，便于测量缓慢变化的电描绘图特征。该系统包括感测心脏电活动并提供心内电描记图信号的至少一个可植入电极装置，对电描记图进行滤波的第一高通滤波器和对经滤波的电描记图信号进行滤波的均衡器。均衡器具有对于低于较高频率断点的频率的频率不降低的传递函数，对于较低频率断点和较高频率断点之间的频率而言降低，并且对于高于上限频率的频率，通常平坦频率断点通过感兴趣的带通区域。

119. 发明授权

US07590446B1 Methods for ventricular pacing 有权
标题翻译：心室起搏方法
公开(公告)号：US07590446B1
公开(公告)日：2009-09-15
申请号：US10986273
申请日：2004-11-10
申请人： Xiaoyi Min , Gene A. Bornzin
发明人： Xiaoyi Min , Gene A. Bornzin
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/368
摘要： An exemplary method includes determining an atrial to ventricular activation time for a right ventricle; determining an atrial to ventricular activation time for a left ventricle; and determining a pacing sequence that paces the right ventricle prior to activation of the left ventricle if the time for the right ventricle exceeds the time for the left ventricle or that paces the left ventricle prior to activation of the right ventricle if the time for the left ventricle exceeds the time for the right ventricle, wherein, in the pacing sequence, pacing of the prior, paced ventricle occurs at a time based at least in part on a difference between the time for the right ventricle and the time for the left ventricle and an atrio-ventricular delay limit. Various other exemplary methods, devices and/or systems are also disclosed.
摘要翻译：示例性方法包括确定右心室的心室至心室激活时间; 确定左心室的心室至心室激活时间; 并且如果右心室的时间超过左心室的时间或在右心室的激活之前步行左心室，则确定在左心室激活之前步行右心室的起搏序列，如果左侧时间心室超过右心室的时间，其中，在起搏序列中，先前起搏的心室的起搏至少部分地基于右心室的时间与左心室的时间之间的差异发生，以及房室延迟限制。还公开了各种其它示例性方法，装置和/或系统。

120. 发明授权

US07529580B2 Detection of renal failure by cardiac implantable medical device 有权
标题翻译：通过心脏植入式医疗器械检测肾功能衰竭
公开(公告)号：US07529580B2
公开(公告)日：2009-05-05
申请号：US11202534
申请日：2005-08-11
申请人： Jong Gill , Gene A. Bornzin
发明人： Jong Gill , Gene A. Bornzin
IPC分类号： A61B5/02
CPC分类号： A61B5/0452 , A61B5/201 , A61N1/3702
摘要： Morphological features within electrical cardiac signals are tracked and feature changes are monitored to detect renal failure. The morphological feature may be an interval between corresponding polarization events such as the interval between QRS-complexes and peaks of corresponding T-waves (QTmax interval); the interval between QRS-complexes and ends of corresponding T-waves (QTend interval); or the interval between P-waves and corresponding QRS-complexes (PR interval). The feature may also be the elevation of a cardiac signal segment between corresponding polarization events, such as QRS-complexes and corresponding T-waves (ST segment); a duration of a polarization event, such as a QRS-complex (QRS width); or an amplitude of a polarization event, such as a T-wave (T-wave amplitude). The change in the feature may comprise a decrease in QTmax intervals, a decrease in QTend intervals, a deviation in ST segment elevation, an increase in QRS width, an increase in PR interval or a deviation in T-wave amplitude.
摘要翻译：跟踪电心脏信号中的形态特征，并监测特征变化以检测肾衰竭。形态特征可以是相应的极化事件之间的间隔，例如QRS-复合物之间的间隔和对应的T波的峰值（QTmax间隔）; QRS复合体与相应T波结束之间的间隔（QTend间隔）; 或P波与相应的QRS复合体之间的间隔（PR间隔）。该特征还可以是对应的极化事件之间的心脏信号段的升高，例如QRS复合物和相应的T波（ST段）; 极化事件的持续时间，例如QRS复合（QRS宽度）; 或极化事件的振幅，例如T波（T波振幅）。特征的变化可以包括QTmax间隔的减小，QTend间隔的减小，ST段抬高的偏差，QRS宽度的增加，PR间期的增加或T波幅度的偏差。

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