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1. 发明授权

US08170664B1 Monitoring heart disease using implantable sensors and slopes determined therefrom 有权
标题翻译：使用由其确定的可植入传感器和斜坡来监测心脏病
公开(公告)号：US08170664B1
公开(公告)日：2012-05-01
申请号：US11931165
申请日：2007-10-31
申请人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61N1/37 , A61N1/08
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36557 , A61N1/36564 , A61N1/36578 , A61N1/3702
摘要： Specific embodiments of the present invention use an implanted sensor, during a period of time, to measure a physiologic property when the patient's heart is not stressed, and when the patient's heart is stressed. A slope is determined, where the slope is indicative of a change in the physiologic property during the period of time. Heart disease is monitored based on a magnitude of the slope. In further embodiments of the present invention, a slope indicative of a change in a physiologic property during a period of time is determined, for each of a plurality of periods of time. Changes in the patient's heart disease are monitored based on changes in the slope.
摘要翻译：本发明的具体实施例在一段时间内使用植入式传感器来测量当患者的心脏没有受到压力时以及当患者的心脏被压力时的生理特性。确定斜率，其中斜率表示在一段时间内生理特性的变化。基于斜率的大小来监测心脏病。在本发明的另外的实施例中，对于多个时间段中的每一个确定指示在一段时间内的生理特性变化的斜率。根据斜率的变化监测患者心脏病变化。

2. 发明授权

US07920913B1 Systems and methods for increasing implantable sensor accuracy 有权
标题翻译：增加植入式传感器精度的系统和方法
公开(公告)号：US07920913B1
公开(公告)日：2011-04-05
申请号：US11771514
申请日：2007-06-29
申请人： Yelena Nabutovsky , Gene A. Bornzin , Kyungmoo Ryu , Taraneh Ghaffari Farazi
发明人： Yelena Nabutovsky , Gene A. Bornzin , Kyungmoo Ryu , Taraneh Ghaffari Farazi
IPC分类号： A61B5/04
CPC分类号： A61B5/14551 , A61B2560/02
摘要： Provided herein are implantable systems, and methods for use therewith, that increase the accuracy of measurements produced using an implanted sensor, where the measurements are affected by cycles of a cyclical body function (e.g., heart beat and/or respiration). In accordance with specific embodiments of system, a measurement that is presumed to be accurate is obtained. The measurement can be of a physiologic property, such as, but not limited to, blood oxygen saturation, hematocrit, or blood glucose concentration. Additionally, the implanted is used to produce a plurality of measurements of the physiologic property. Such measurements, produced using the implanted sensor, are compared to the measurement presumed to be accurate to thereby identify when the measurements produced using the implanted sensor are most accurate. Thereafter, the implanted system is configured to use the implanted sensor to produce measurements when the measurements produced using the implanted sensor are most accurate.
摘要翻译：本文提供了可植入系统及其使用的方法，其增加使用植入式传感器产生的测量的精度，其中测量受周期性身体功能（例如心跳和/或呼吸）的周期的影响。根据系统的具体实施例，获得推测为准确的测量值。测量可以具有生理特性，例如但不限于血氧饱和度，血细胞比容或血糖浓度。另外，植入用于产生生理特性的多个测量。将使用植入的传感器产生的这种测量与推定为准确的测量进行比较，从而识别何时使用植入的传感器产生的测量是最准确的。此后，当使用植入的传感器产生的测量最准确时，植入系统被配置为使用植入的传感器来产生测量。

3. 发明申请

US20110098546A1 ASSESSING MEDICAL CONDITIONS BASED ON VENOUS OXYGEN SATURATION AND HEMATOCRIT INFORMATION 审中-公开
标题翻译：基于静脉氧饱和度和血压信息评估医疗条件
公开(公告)号：US20110098546A1
公开(公告)日：2011-04-28
申请号：US12976493
申请日：2010-12-22
申请人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Yelena Nabutovsky , Kyungmoo Ryu , Keith Victorine , Xiaoyi Min , John W. Poore
发明人： Taraneh Ghaffari Farazi , Gene A. Bornzin , Yelena Nabutovsky , Kyungmoo Ryu , Keith Victorine , Xiaoyi Min , John W. Poore
IPC分类号： A61B5/1459
CPC分类号： A61B5/1459 , A61B5/0031 , A61B5/0205 , A61B5/021 , A61B5/029 , A61B5/04001 , A61B5/0464 , A61B5/0816 , A61B5/14535 , A61B5/14539 , A61B5/7285 , A61N1/36557 , A61N1/36564 , A61N1/36585
摘要： Methods for assessing, diagnosing and treating medical conditions using SvO2 and hematocrit measurements alone, or in combination with other measurements related to cardiac activity are provided. These includes methods for distinguishing true anemia from diluted anemia, methods for anemia detection, methods for measuring disease progression based on anemia trending, methods for managing therapy delivery, methods for managing heart failure drug therapies, methods for cardiac output optimization based on SvO2, methods for cardiac resynchronization therapy lead placement, method for detection of heart failure decompensation, and methods to monitor and treat systolic versus diastolic heart failure are provided.
摘要翻译：提供了使用SvO2和血细胞比容测量单独评估，诊断和治疗医疗条件或与心脏活动相关的其他测量结合的方法。这些包括区分真正贫血与稀释性贫血的方法，贫血检测方法，基于贫血趋势测量疾病进展的方法，管理治疗递送的方法，管理心力衰竭药物治疗的方法，基于SvO2的心输出优化方法用于心脏再同步治疗铅放置，心脏失代偿失代偿检测方法以及监测和治疗心脏收缩期与舒张性心力衰竭的方法。

4. 发明授权

US09174054B1 Monitoring heart disease using implantable sensors 有权
标题翻译：使用植入式传感器监测心脏病
公开(公告)号：US09174054B1
公开(公告)日：2015-11-03
申请号：US11876560
申请日：2007-10-22
申请人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Yelena Nabutovsky , Kyungmoo Ryu , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61N1/37 , A61N1/08 , A61B5/0452 , A61N1/362 , A61B5/00
CPC分类号： A61B5/4842 , A61B5/00 , A61B5/02028 , A61B5/0205 , A61B5/0215 , A61B5/024 , A61B5/0538 , A61B5/1118 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4884 , A61B5/686 , A61B5/7275 , A61B5/746 , A61N1/08 , A61N1/3621 , A61N1/3627 , A61N1/3702 , A61N1/3704 , G06F19/00
摘要： Specific embodiments of the present invention determine a range of a physiologic property, for each of a plurality of periods of time, and monitor changes in the patient's heart disease based on changes in the range. Other embodiments determine a minimum of a physiologic property, for each of a plurality of periods of time, and monitor changes in the patient's heart disease based on changes in the minimum. Still other embodiments determine a maximum of the physiologic property, for each of a plurality of periods of time, and monitor changes in the patient's heart disease based on changes in the maximum.
摘要翻译：本发明的具体实施方案根据多个时间段中的每一个确定生理特性的范围，并基于范围的变化来监测患者心脏病变化。其他实施例对于多个时间段中的每一个确定生理特性的最小值，并基于最小值的变化来监测患者心脏疾病的变化。另外其他实施方案确定多个时间段中的每一个的生理特性的最大值，并基于最大值的变化来监测患者心脏疾病的变化。

5. 发明授权

US08449472B2 Neurostimulation and neurosensing techniques to optimize atrial anti-tachycardia pacing for prevention of atrial tachyarrhythmias 有权
标题翻译：神经刺激和神经感应技术优化房性心动过速起搏预防房性快速性心律失常
公开(公告)号：US08449472B2
公开(公告)日：2013-05-28
申请号：US12891429
申请日：2010-09-27
申请人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61B5/02 , A61N1/00
CPC分类号： A61N1/3621 , A61N1/36114 , A61N1/3624
摘要： Implantable systems and method for use therewith are provided that take advantage of various neuromodulation and neurosensing techniques for either preventing atrial fibrillation (AF) or terminating AF. Specific embodiments are for use with an implantable device that includes one or more atrial electrode for sensing atrial fibrillation (AF) and/or delivering Atrial Anti-Tachycardia Pacing (AATP) and one or more electrode for monitoring and/or stimulating atrial vagal fat pads.
摘要翻译：提供了可植入系统及其使用的方法，其利用各种神经调节和神经感应技术来预防心房颤动（AF）或终止AF。具体实施方案用于可植入装置，其包括一个或多个心房电极，用于感测心房颤动（AF）和/或递送心房抗心动过速起搏（AATP）和用于监测和/或刺激心房迷走神经脂肪垫的一个或多个电极。

6. 发明授权

US07826899B1 Neurostimulation and neurosensing techniques to optimize atrial anti-tachycardia pacing for termination of atrial tachyarrhythmias 有权
标题翻译：神经刺激和神经感应技术优化房性心动过速起搏以终止房性快速性心律失常
公开(公告)号：US07826899B1
公开(公告)日：2010-11-02
申请号：US11615488
申请日：2006-12-22
申请人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61N1/368
CPC分类号： A61N1/3621 , A61N1/36114 , A61N1/3624
摘要： Implantable systems, and method for use therewith, are provided that take advantage of various neuromodulation and neurosensing techniques for either preventing atrial fibrillation (AF) or terminating AF. Specific embodiments, as will be described below, are for use with an implantable device that include one or more atrial electrode for sensing atrial fibrillation (AF) and/or delivering AATP and one or more electrode for monitoring and/or stimulating atrial vagal fat pads.
摘要翻译：提供了可植入系统及其使用方法，其利用各种神经调节和神经感应技术来预防心房颤动（AF）或终止AF。如下所述，具体实施方案用于可植入装置，其包括一个或多个用于感测心房颤动（AF）和/或递送AATP的心房电极和用于监测和/或刺激心房迷走神经脂肪垫的一个或多个电极。

7. 发明申请

US20110015690A1 Neurostimulation and Neurosensing Techniques to Optimize Atrial Anti-Tachycardia Pacing for Prevention of Atrial Tachyarrhythmias 有权
标题翻译：神经刺激和神经感觉技术优化心房抗心动过速起搏预防房性快速性心律失常
公开(公告)号：US20110015690A1
公开(公告)日：2011-01-20
申请号：US12891429
申请日：2010-09-27
申请人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61N1/36
CPC分类号： A61N1/3621 , A61N1/36114 , A61N1/3624
摘要： Implantable systems and method for use therewith are provided that take advantage of various neuromodulation and neurosensing techniques for either preventing atrial fibrillation (AF) or terminating AF. Specific embodiments are for use with an implantable device that includes one or more atrial electrode for sensing atrial fibrillation (AF) and/or delivering AATP and one or more electrode for monitoring and/or stimulating atrial vagal fat pads.
摘要翻译：提供了可植入系统及其使用的方法，其利用各种神经调节和神经感应技术来预防心房颤动（AF）或终止AF。具体实施方案用于可植入装置，其包括用于感测心房颤动（AF）和/或递送AATP的一个或多个心房电极和用于监测和/或刺激心房迷走神经脂肪垫的一个或多个电极。

8. 发明授权

US07715915B1 Neurostimulation and neurosensing techniques to optimize atrial anti-tachycardia pacing for prevention of atrial tachyarrhythmias 有权
标题翻译：神经刺激和神经感应技术优化房性心动过速起搏预防房性快速性心律失常
公开(公告)号：US07715915B1
公开(公告)日：2010-05-11
申请号：US11615497
申请日：2006-12-22
申请人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Taraneh Ghaffari Farazi , Gene A. Bornzin
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/3621 , A61N1/395
摘要： Implantable systems, and method for use therewith, are provided that take advantage of various neuromodulation and neurosensing techniques for either preventing atrial fibrillation (AF) or terminating AF. Specific embodiments, as will be described below, are for use with an implantable device that include one or more atrial electrode for sensing atrial fibrillation (AF) and/or delivering AATP and one or more electrode for monitoring and/or stimulating atrial vagal fat pads.
摘要翻译：提供了可植入系统及其使用方法，其利用各种神经调节和神经感应技术来预防心房颤动（AF）或终止AF。如下所述，具体实施方案用于可植入装置，其包括一个或多个用于感测心房颤动（AF）和/或递送AATP的心房电极和用于监测和/或刺激心房迷走神经脂肪垫的一个或多个电极。

9. 发明授权

US08209010B2 Systems and methods for optimizing multi-site cardiac pacing and sensing configurations for use with an implantable medical device 有权
标题翻译：用于优化与可植入医疗装置一起使用的多部位心脏起搏和感测配置的系统和方法
公开(公告)号：US08209010B2
公开(公告)日：2012-06-26
申请号：US12703069
申请日：2010-02-09
申请人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel , Taraneh Ghaffari Farazi , Xiaoyi Min
发明人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel , Taraneh Ghaffari Farazi , Xiaoyi Min
IPC分类号： A61N1/00
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/368 , A61N1/3708
摘要： Techniques are provided for use with an implantable cardiac stimulation device equipped for multi-site left ventricular (MSLV) pacing using a multi-pole LV lead. In one example, referred to herein as QuickStim, cardiac pacing configurations are optimized based on an assessment of hemodynamic benefit and device longevity. In another example, referred to herein as QuickSense, cardiac sensing configurations are optimized based on sensing profiles input by a clinician. Various virtual sensing channels are also described that provide for the multiplexing or gating of sensed signals. Anisotropic oversampling is also described.
摘要翻译：提供技术用于使用多极LV引线配备用于多位点左心室（MSLV）起搏的可植入心脏刺激装置。在一个例子中，本文称为QuickStim，基于对血液动力学益处和器械寿命的评估来优化心脏起搏配置。在另一个例子中，本文称为QuickSense，基于由临床医生输入的感测曲线来优化心脏感测配置。还描述了各种虚拟感测通道，其提供感测信号的复用或门控。还描述了各向异性过采样。

10. 发明申请

US20120191154A1 System and Method for ATP Treatment Utilizing Multi-Electrode Left Ventricular Lead 审中-公开
标题翻译：使用多电极左心室铅的ATP治疗的系统和方法
公开(公告)号：US20120191154A1
公开(公告)日：2012-07-26
申请号：US13012574
申请日：2011-01-24
申请人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel , Taraneh Ghaffari Farazi , Richard Williamson , Mark Carlson
发明人： Kyungmoo Ryu , Stuart Rosenberg , Allen Keel , Taraneh Ghaffari Farazi , Richard Williamson , Mark Carlson
IPC分类号： A61N1/365
CPC分类号： A61N1/36521 , A61N1/3622 , A61N1/3684 , A61N1/3686 , A61N1/3962
摘要： An implantable medical device includes a lead configured to be located proximate to the left ventricle (LV) of the heart, the lead including multiple LV electrodes to sense cardiac activity at multiple LV sensing sites. The a detection module to detect an arrhythmia that represents at least one of a tachycardia and fibrillation based at least in part on the cardiac activity sensed at the multiple LV sensing sites. The ATP therapy module to identify at least one of an ATP configuration or an ATP therapy site based on the cardiac sensed activity at the LV sensing sites, the ATP therapy module to control delivery of antitachycardia pacing (ATP) therapy at the ATP therapy site. The ATP therapy module delivers a stimulus to electrodes at one or more of an LV site, right ventricular (RV) site and right atrial (RA) site, the detection module to sense evoked responses at the LV sensing sites, the ATP therapy module to designate the ATP therapy site to include at least the LV sensing site with a shortest activation time relative to the one or more LV site, RV site and RA site where the stimulus is delivered.
摘要翻译：可植入医疗装置包括被配置为位于心脏左心室（LV）附近的引线，该引线包括多个LV电极以感测多个LV感测部位的心脏活动。该检测模块至少部分地基于在多个LV感测位点处感测到的心脏活动来检测代表心动过速和颤动中的至少一种的心律失常。 ATP治疗模块基于LV感测位点处的心脏感测活动来鉴定ATP配置或ATP治疗部位中的至少一个，ATP治疗模块用于控制ATP治疗部位的抗心动过速起搏（ATP）治疗的递送。 ATP治疗模块向LV位点，右心室（RV）位点和右心房（RA）位点的一个或多个处的电极施加刺激，检测模块用于感测LV感测位点处的诱发反应，ATP治疗模块指定ATP治疗部位至少包括相对于传递刺激物的一个或多个LV部位，RV部位和RA部位具有最短激活时间的LV感测部位。

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