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1. 发明申请

WO2012126745A2 METHODS AND DEVICES FOR OPERATING AN INFUSION SYSTEM 审中-公开
标题翻译：用于操作输注系统的方法和装置
公开(公告)号：WO2012126745A2
公开(公告)日：2012-09-27
申请号：PCT/EP2012/054074
申请日：2012-03-09
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , OLDE, Bo
发明人： JANSSON, Olof , OLDE, Bo
IPC分类号： A61M5/142 , A61M5/168 , A61M5/36 , A61M1/36 , A61M5/14
CPC分类号： A61M5/14216 , A61M5/16809 , A61M5/1684 , A61M5/16854 , A61M5/16859 , A61M5/36 , A61M5/365 , A61M2005/1402 , A61M2205/15 , A61M2205/3331 , A61M2205/702
摘要： An infusion system defines a fill path (4) for an infusion liquid from a source (5) to a displacement volume in a fluid chamber (8) of an infusion pump (1), and an infusion path (2) from the displacement volume to a connector (19a). The infusion pump (1) is operated to repeatedly draw infusion liquid from the source (5) into the displacement volume via the fill path (4) and push infusion liquid from the displacement volume through the connector (19a) via the infusion path (2). A controller (11) selectively effects a priming operation, by operating the infusion pump (1) to generate a priming fill stroke, in which a priming volume of the infusion liquid is drawn from the source (5) to the displacement volume, and a priming pump stroke, in which at least part of the priming volume is pushed from the displacement volume back to the source (5). The infusion system is thereby operable to be primed automatically, and proper priming may be verified by evaluating a measurement signal representative of fluid pressure in the displacement volume during either of the priming fill stroke and the priming pump stroke.
摘要翻译：输注系统限定用于输液（5）到输液泵（1）的流体室（8）中的移液量的输注液体的填充路径（4）和来自排量的输注路径（2）连接器（19a）。输液泵（1）被操作以经由填充路径（4）将来自源（5）的输注液体重复地吸入移动体积中，并且经由输注路径（2）将输注液体从置换体积通过连接器（19a）推入）。控制器（11）通过操作输液泵（1）来选择性地进行起动操作，以产生起动填充冲程，其中将输注液体的起动体积从源（5）抽取到排量体积，并且起动泵冲程，其中至少部分起动容积从排量体积推回到源（5）。输注系统由此可操作地自动启动，并且可以通过在启动填充冲程和起动泵冲程期间评估表示位移体积中的流体压力的测量信号来验证适当的起动。

2. 发明申请

WO2012126744A1 INFUSION SYSTEM AND METHOD OF INTEGRITY TESTING AND LEAK DETECTION 审中-公开
标题翻译：灌注系统及其完整性测试和漏检的方法
公开(公告)号：WO2012126744A1
公开(公告)日：2012-09-27
申请号：PCT/EP2012/054073
申请日：2012-03-09
申请人： GAMBRO LUNDIA AB , OLDE, Bo , JANSSON, Olof
发明人： OLDE, Bo , JANSSON, Olof
IPC分类号： A61M5/142 , A61M5/168 , A61M5/36 , A61M1/36 , A61M5/14
CPC分类号： A61M5/14216 , A61M5/16809 , A61M5/1684 , A61M5/16854 , A61M5/16859 , A61M5/36 , A61M5/365 , A61M2005/1402 , A61M2205/15 , A61M2205/3331 , A61M2205/702
摘要： An infusion system is controlled by driving a displacing element (3) in alternate fill and pump directions in a fluid chamber (8) to define a varying displacement volume, and by synchronously operating a valve arrangement (6, 7) to alternately open and close first and second fluid paths (4, 2) from the fluid chamber (8) to a source (5) and a connector (19a), respectively, such that an infusion liquid is repeatedly sucked into the fluid chamber (8) from the source (5) and pumped from the fluid chamber (8) through the connector (19a). The infusion system comprises a sensor (12) for generating a measurement signal representative of fluid pressure in the displacement volume. A controller (11) is connected to intermittently effect a system test, in which the valve arrangement (6, 7) is operated to close the second fluid path (2); the displacing element (3) is driven a given distance in the fill direction; and the measurement signal is obtained from the sensor (12) during at least part of the system test. The integrity of the infusion system is determined based on the measurement signal, e.g. by evaluating the temporal change in the measurement signal during and/or after the displacement. The system test may identify a shortage of infusion liquid in the source (5) or a leakage of air into the first fluid path (4).
摘要翻译：通过在流体室（8）中以交替的填充和泵送方向驱动位移元件（3）来限制输入体积，并通过同步操作阀装置（6,7）来交替地打开和关闭来控制输注系统分别从流体室（8）到源（5）和连接器（19a）的第一和第二流体路径（4,2），使得输注液体从源极重复地吸入流体室（8）（5）并且通过连接器（19a）从流体室（8）泵送。输液系统包括用于产生表示位移体积中的流体压力的测量信号的传感器（12）。连接控制器（11）以间歇地进行系统测试，其中阀装置（6,7）被操作以关闭第二流体路径（2）; 位移元件（3）沿填充方向被驱动给定的距离; 并且在系统测试的至少一部分期间从传感器（12）获得测量信号。基于测量信号确定输注系统的完整性，例如，通过评估位移期间和/或之后的测量信号的时间变化。系统测试可以识别源（5）中的输注液体不足或空气泄漏到第一流体路径（4）中。

3. 发明申请

WO2012175435A1 DISPOSABLES FOR BLOOD TREATMENT, AND METHODS OF OPERATING THE SAME 审中-公开
标题翻译：用于血液治疗的药物及其操作方法
公开(公告)号：WO2012175435A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/061551
申请日：2012-06-18
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , HOLMER, Mattias , NILSSON, Eddie , JÖNSSON, Lennart
发明人： JANSSON, Olof , HOLMER, Mattias , NILSSON, Eddie , JÖNSSON, Lennart
IPC分类号： A61M1/30 , A61M1/36
CPC分类号： A61M1/367 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/306 , A61M1/3621 , A61M2205/125 , A61M2205/128 , Y10T137/0318 , Y10T137/85986 , Y10T137/86035
摘要： A disposable for use in blood treatment comprises a blood treatment unit (8) and a pump arrangement (11) operable to pump blood through the blood treatment unit (8). The pump arrangement (11) comprises two membrane pumps (6, 7) connected in parallel on one side of the blood treatment unit (8). The disposable is operable in a single-needle mode, in which the pump arrangement (11) is operable to generate a pulsatile flow of blood through the blood treatment unit (8), and in a double-needle mode, in which the pump arrangement (11) is operable to generate an essentially continuous flow of blood through the blood treatment unit (8). The pump arrangement (11) is configured for connection to a supply system (1) of treatment fluid for the blood treatment unit (8) such that alternating flows of treatment fluid generated by the supply system (1) and supplied to the first and second membrane pumps (6, 7) causes the pump arrangement (11) to generate the desired flows of blood in the single-needle and double- needle modes. The treatment fluid may be used as motive fluid for displacing the blood in the membrane pumps (6, 7) and/or as control fluid for controlling opening and/or closing of upstream and downstream commutation valves (34, 35) in the membrane pumps (6, 7).
摘要翻译：用于血液处理的一次性用品包括血液处理单元（8）和可操作以将血液泵送通过血液处理单元（8）的泵装置（11）。泵装置（11）包括在血液处理单元（8）的一侧上并联连接的两个膜泵（6,7）。一次性可以单针模式操作，其中泵装置（11）可操作以通过血液处理单元（8）产生脉动血液流，并且在双针模式中，泵装置（11）可操作以通过血液处理单元（8）产生基本上连续的血液流。泵装置（11）构造成用于连接到用于血液处理单元（8）的处理流体的供应系统（1），使得由供应系统（1）产生并供应到第一和第二膜泵（6,7）使泵装置（11）以单针和双针模式产生所需的血液流。处理流体可以用作移动膜泵（6,7）中的血液的运动流体和/或用作控制膜泵中上游和下游换向阀（34,35）的打开和/或关闭的控制流体（6,7）。

4. 发明申请

WO2011161064A1 PREPARATION OF MEDICAL SOLUTIONS FROM POWDERY MATERIAL 审中-公开
标题翻译：从粉末材料制备医疗解决方案
公开(公告)号：WO2011161064A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060255
申请日：2011-06-20
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , JÖNSSON, Lennart , LINDEN, Torbjörn , STERNBY, Jan , TRYGGVASON, Ragnar , WIESLANDER, Anders
发明人： JANSSON, Olof , JÖNSSON, Lennart , LINDEN, Torbjörn , STERNBY, Jan , TRYGGVASON, Ragnar , WIESLANDER, Anders
IPC分类号： A61J1/20 , A61M1/16
CPC分类号： A61J1/20 , A61J1/2093 , A61M1/1656 , A61M1/1666 , A61M1/1668 , A61M1/167 , A61M1/287 , B65D31/14 , B65D81/18 , B65D81/20 , B65D81/2007 , B65D81/2023 , B65D81/2046
摘要： A package has a transport/storage state for storing powdery material which is to be mixed with a solvent to form a medical solution, e.g. for use in dialysis treatment. The package comprises a compartment (6) which is at least partially defined by two opposing wall portions, and a connector (10). In the transport/storage state, the compartment contains the powdery material in the form of at least two distinct sets (2A-2D) of powdery material of different compositions, where the opposing wall portions are brought into engagement with the powdery material so as to immobilize the sets of powdery material (2A-2D). When used for preparation of the medical solution, a fluid is selectively admitted into the package via the connector (10) so as to expand the compartment (6) and enable mixing of the sets (2A-2D) of powdery material with the solvent in the compartment (6).
摘要翻译：包装具有用于储存待与溶剂混合以形成医用溶液的粉末状材料的运输/储存状态，用于透析治疗。该包装件包括至少部分地由两个相对的壁部分限定的隔室（6）和连接器（10）。在运输/储存状态下，隔室含有至少两种不同组成的粉末材料组（2A-2D）形式的粉状材料，其中相对的壁部分与粉末材料接合，以便固定一组粉状材料（2A-2D）。当用于制备医用溶液时，通过连接器（10）将流体选择性地进入包装中，以便使隔室（6）膨胀，并使粉末材料组（2A-2D）与溶剂的组合隔室（6）。

5. 发明申请

WO2005035023A1 A DEVICE FOR CARRYING OUT A PERITONEAL DIALYSIS TREATMENT 审中-公开
标题翻译：执行腹膜透析治疗的手段
公开(公告)号：WO2005035023A1
公开(公告)日：2005-04-21
申请号：PCT/SE2004/001467
申请日：2004-10-13
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , BERNARD, Pascal , DURAND, Pierre-Yves , HOBRO, Sture , PERSSON, Eva , THELL, Bengt-Olov
发明人： JANSSON, Olof , BERNARD, Pascal , DURAND, Pierre-Yves , HOBRO, Sture , PERSSON, Eva , THELL, Bengt-Olov
IPC分类号： A61M1/28
CPC分类号： A61M1/28 , A61M1/1613 , A61M1/281 , A61M1/282
摘要： The invention concerns a device and a method for a peritoneal dialysis treatment in several cycles. A cycler (1) controlled by a processor (31) fills the abdominal cavity with dialysis fluid, and drains the abdominal cavity. A sensor (37) senses a variable related to the draining of the dialysis fluid. The draining is interrupted when the variable reaches a breakpoint at which the variable is radically changed, thereby leaving the residual volume.
摘要翻译：本发明涉及用于在几个周期中进行腹膜透析治疗的装置和方法。由处理器（31）控制的循环仪（1）用透析液填充腹腔，并排出腹腔。传感器（37）感测与透析液排出相关的变量。当变量到达变量发生彻底改变的断点时，排水中断，从而留下剩余体积。

6. 发明申请

WO2012175354A1 DIALYSIS PRECURSOR COMPOSITION 审中-公开
标题翻译： DIALYSIS前身组成
公开(公告)号：WO2012175354A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/060971
申请日：2012-06-11
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , LINDEN, Torbjörn , WIESLANDER, Anders
发明人： JANSSON, Olof , LINDEN, Torbjörn , WIESLANDER, Anders
IPC分类号： A61K9/00 , A61K31/185 , A61K31/7004 , A61K33/10
CPC分类号： A61K33/10 , A61K9/0029 , A61K9/0095 , A61K9/08 , A61K31/185 , A61K31/194 , A61K31/7004 , A61K33/14 , A61M1/1654 , B65B1/00 , B65B29/06 , A61K2300/00
摘要： The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution. Said dialysis acid precursor composition consists of powder components comprising sodium chloride, at least one dry acid and at least one calcium salt, and optionally potassium salt, magnesium salt, and glucose. According to the invention said at least one calcium salt and said optional glucose, are present as anhydrous components in said dialysis acid precursor composition.
摘要翻译：本发明涉及一种透析酸前体组合物，用于制备透析酸浓缩液，并与水和含碳酸氢盐的浓缩液混合成即用型透析溶液。所述透析酸前体组合物由包含氯化钠，至少一种干酸和至少一种钙盐，以及任选的钾盐，镁盐和葡萄糖的粉末组分组成。根据本发明，所述至少一种钙盐和任选的葡萄糖以所述透析酸前体组合物中的无水组分存在。

7. 发明申请

WO2009127624A3 BLOOD TREATMENT APPARATUS 审中-公开
公开(公告)号：WO2009127624A3
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054406
申请日：2009-04-14
申请人： GAMBRO LUNDIA AB , JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , STERNBY, Jan , NILSSON, Anders , HANSSON, Per
发明人： JÖNSSON, Lennart , JANSSON, Olof , HOLMER, Mattias , STERNBY, Jan , NILSSON, Anders , HANSSON, Per
IPC分类号： A61M1/10 , A61M1/16 , A61M1/30 , A61M1/34
摘要： A proposed blood treatment apparatus includes : a blood treatment unit (8), a pair of fluid pumps (14, 15) and a pair of blood pumps (1a, 1b). The blood treatment unit (8) is configured to receive untreated blood and fresh blood treatment fluid, and emit treated blood and used blood treatment fluid. The fluid pumps (14, 15) are configured to pass blood treatment fluid through the blood treatment unit (8). The blood pumps (1a, 1b) are configured to extract untreated blood from a blood source (S), pass extracted blood through the blood treatment unit (8) and deliver treated blood to a target vessel (T). Additionally, the fluid pumps (14, 15) are configured to control the operation of the blood pumps (1a, 1b) via the blood treatment fluid. Moreover, a flow control means (16a) is configured to control a trans- membrane flow between the blood side (8B) and the a fluid side (8F) of the blood treatment unit (8). Hence, for instance ultrafiltration can be adjusted to a desired level in a very straightforward manner.

8. 发明申请

WO2012175353A1 DIALYSIS PRECURSOR COMPOSITION 审中-公开
标题翻译： DIALYSIS前身组成
公开(公告)号：WO2012175353A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/060969
申请日：2012-06-11
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , LINDEN, Torbjörn , WIESLANDER, Anders
发明人： JANSSON, Olof , LINDEN, Torbjörn , WIESLANDER, Anders
IPC分类号： A61K31/7004 , A61K33/00 , A61K33/06 , A61K33/14 , A61K9/00
CPC分类号： A61M1/1654 , A61J1/05 , A61K31/19 , A61K31/191 , A61K31/194 , A61K31/198 , A61K31/366 , A61K31/385 , A61K31/7004 , A61K33/06 , A61K33/10 , A61K33/14 , A61M1/1666 , A61K2300/00
摘要： The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water, a sodium containing concentrate, and a bicarbonate containing concentrate into a ready-for-use dialysis solution. Said dialysis acid precursor composition consists of powder components comprising glucose, at least one dry acid and at least one calcium salt, and optionally potassium salt, and magnesium salt. According to the invention said glucose and said at least one calcium salt, are present as anhydrous components in said dialysis acid precursor composition.
摘要翻译：本发明涉及一种透析酸前体组合物，用于制备透析酸浓缩液，并与水，含钠浓缩物和含碳酸氢盐的浓缩液混合成即用型透析溶液。所述透析酸前体组合物由包含葡萄糖，至少一种干酸和至少一种钙盐，任选的钾盐和镁盐的粉末组分组成。根据本发明，所述葡萄糖和所述至少一种钙盐以所述透析酸前体组合物中的无水组分存在。

9. 发明申请

WO2012163870A1 METHOD AND DEVICE FOR DETECTING CONFIGURATIONS OF EXTRACORPOREAL BLOOD CIRCUIT, APPARATUS COMPRISING DETECTING DEVICE, AND COMPUTER PROGRAM FOR PERFORMING THE METHOD 审中-公开
标题翻译：用于检测超声波血液回路配置的方法和装置，包含检测装置的装置和用于执行方法的计算机程序
公开(公告)号：WO2012163870A1
公开(公告)日：2012-12-06
申请号：PCT/EP2012/059929
申请日：2012-05-28
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , HOLMER, Mattias , NILSSON, Anders
发明人： JANSSON, Olof , HOLMER, Mattias , NILSSON, Anders
IPC分类号： A61M1/30 , A61M1/36
CPC分类号： A61M1/301 , A61M1/14 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/306 , A61M1/34 , A61M1/3403 , A61M1/3607 , A61M1/367 , A61M2205/18 , A61M2205/276 , A61M2205/3331 , A61M2205/3334 , A61M2205/50 , A61M2205/70 , A61M2205/702
摘要： A method for detecting a property of an extracorporeal line set (2, 9) in an apparatus (1) for extracorporeal blood treatment is disclosed. The extracorporeal line set (2, 9) is arranged to be connected to a patient. The method comprises the steps of: measuring a first pressure in a flow path (2) in said apparatus, measuring a second pressure in said flow path (2), comparing said first and second pressures, determining a detected extracorporeal line set property based on said pressure comparison. The detected property is at least one of a configuration of a blood access device and a blood tubing set property. A detecting device (20) for detecting a property of an extracorporeal line set (2, 9) in an apparatus (1) for extracorporeal blood treatment is also disclosed, as well as an apparatus (1) for extracorporeal blood treatment, a computer program for performing the method, and a computer-readable medium on which such computer program is stored.
摘要翻译：公开了一种用于检测用于体外血液处理的装置（1）中的体外线组（2,9）的性质的方法。体外线组（2,9）被布置成与患者连接。该方法包括以下步骤：测量所述装置中的流路（2）中的第一压力，测量所述流动路径（2）中的第二压力，比较所述第一和第二压力，确定检测到的体外线组属性，基于说压力比较。所检测的属性是血液导入装置和血管组合属性的构造中的至少一个。还公开了一种用于检测用于体外血液处理的装置（1）中的体外线组（2）的性质的检测装置（20），以及用于体外血液处理的装置（1），计算机程序用于执行该方法的计算机可读介质，以及存储该计算机程序的计算机可读介质。

10. 发明申请

WO2011161054A1 BLOOD ACCESS DEVICE 审中-公开
标题翻译：血液接入装置
公开(公告)号：WO2011161054A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/060230
申请日：2011-06-20
申请人： GAMBRO LUNDIA AB , EKDAHL, Olof , ZANINI, Marco , HANSSON, Per , NILSSON, Eddie , JANSSON, Olof , JÖNSSON, Lennart
发明人： EKDAHL, Olof , ZANINI, Marco , HANSSON, Per , NILSSON, Eddie , JANSSON, Olof , JÖNSSON, Lennart
IPC分类号： A61M25/06 , A61M39/28
CPC分类号： A61M5/168 , A61M1/3621 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3661 , A61M5/158 , A61M5/16854 , A61M25/02 , A61M25/0637 , A61M39/281 , A61M39/284 , A61M2005/1586 , A61M2025/024
摘要： A blood access device comprises a fluid conduit (50) configured to convey a flow of fluid to a target vessel (2), a second lever element (20) pivotally and resiliently connected to a first lever element (10) such that it may move from a first position (P1) to a second position. A biasing force is exerted on the second lever element (20) for moving it from the first position (P1) to the second position, and a blocking member may be activated by the second lever element (20), such that a flow of fluid is decreased when the second lever element (20) is moved from the first position (P1) to the second position. The lever elements (10, 20) are configured to be fixed to the target vessel (2) when the second lever element (20) is in the first position (P1), and the second lever element (20) moves to the second position (P2) and activates the blocking member (14) if the fixation is at least partially lost. A related blood treatment apparatus is also described.
摘要翻译：血液进入装置包括被配置为将流体流传送到目标血管（2）的流体导管（50），枢转地并弹性地连接到第一杠杆元件（10）的第二杠杆元件（20），使得其可以移动从第一位置（P1）到第二位置。偏压力施加在第二杠杆元件20上，用于将其从第一位置（P1）移动到第二位置，并且阻挡构件可以由第二杠杆元件（20）启动，使得流体流动当第二杠杆元件（20）从第一位置（P1）移动到第二位置时减小。杠杆元件（10,20）构造成当第二杠杆元件（20）处于第一位置（P1）时固定到目标船舶（2），并且第二杠杆元件（20）移动到第二位置（P2）并且如果固定件至少部分损失则启动阻挡构件（14）。还描述了一种相关的血液处理装置。

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