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1. 发明申请

WO2012126745A2 METHODS AND DEVICES FOR OPERATING AN INFUSION SYSTEM 审中-公开
标题翻译：用于操作输注系统的方法和装置
公开(公告)号：WO2012126745A2
公开(公告)日：2012-09-27
申请号：PCT/EP2012/054074
申请日：2012-03-09
申请人： GAMBRO LUNDIA AB , JANSSON, Olof , OLDE, Bo
发明人： JANSSON, Olof , OLDE, Bo
IPC分类号： A61M5/142 , A61M5/168 , A61M5/36 , A61M1/36 , A61M5/14
CPC分类号： A61M5/14216 , A61M5/16809 , A61M5/1684 , A61M5/16854 , A61M5/16859 , A61M5/36 , A61M5/365 , A61M2005/1402 , A61M2205/15 , A61M2205/3331 , A61M2205/702
摘要： An infusion system defines a fill path (4) for an infusion liquid from a source (5) to a displacement volume in a fluid chamber (8) of an infusion pump (1), and an infusion path (2) from the displacement volume to a connector (19a). The infusion pump (1) is operated to repeatedly draw infusion liquid from the source (5) into the displacement volume via the fill path (4) and push infusion liquid from the displacement volume through the connector (19a) via the infusion path (2). A controller (11) selectively effects a priming operation, by operating the infusion pump (1) to generate a priming fill stroke, in which a priming volume of the infusion liquid is drawn from the source (5) to the displacement volume, and a priming pump stroke, in which at least part of the priming volume is pushed from the displacement volume back to the source (5). The infusion system is thereby operable to be primed automatically, and proper priming may be verified by evaluating a measurement signal representative of fluid pressure in the displacement volume during either of the priming fill stroke and the priming pump stroke.
摘要翻译：输注系统限定用于输液（5）到输液泵（1）的流体室（8）中的移液量的输注液体的填充路径（4）和来自排量的输注路径（2）连接器（19a）。输液泵（1）被操作以经由填充路径（4）将来自源（5）的输注液体重复地吸入移动体积中，并且经由输注路径（2）将输注液体从置换体积通过连接器（19a）推入）。控制器（11）通过操作输液泵（1）来选择性地进行起动操作，以产生起动填充冲程，其中将输注液体的起动体积从源（5）抽取到排量体积，并且起动泵冲程，其中至少部分起动容积从排量体积推回到源（5）。输注系统由此可操作地自动启动，并且可以通过在启动填充冲程和起动泵冲程期间评估表示位移体积中的流体压力的测量信号来验证适当的起动。

2. 发明申请

WO2012126744A1 INFUSION SYSTEM AND METHOD OF INTEGRITY TESTING AND LEAK DETECTION 审中-公开
标题翻译：灌注系统及其完整性测试和漏检的方法
公开(公告)号：WO2012126744A1
公开(公告)日：2012-09-27
申请号：PCT/EP2012/054073
申请日：2012-03-09
申请人： GAMBRO LUNDIA AB , OLDE, Bo , JANSSON, Olof
发明人： OLDE, Bo , JANSSON, Olof
IPC分类号： A61M5/142 , A61M5/168 , A61M5/36 , A61M1/36 , A61M5/14
CPC分类号： A61M5/14216 , A61M5/16809 , A61M5/1684 , A61M5/16854 , A61M5/16859 , A61M5/36 , A61M5/365 , A61M2005/1402 , A61M2205/15 , A61M2205/3331 , A61M2205/702
摘要： An infusion system is controlled by driving a displacing element (3) in alternate fill and pump directions in a fluid chamber (8) to define a varying displacement volume, and by synchronously operating a valve arrangement (6, 7) to alternately open and close first and second fluid paths (4, 2) from the fluid chamber (8) to a source (5) and a connector (19a), respectively, such that an infusion liquid is repeatedly sucked into the fluid chamber (8) from the source (5) and pumped from the fluid chamber (8) through the connector (19a). The infusion system comprises a sensor (12) for generating a measurement signal representative of fluid pressure in the displacement volume. A controller (11) is connected to intermittently effect a system test, in which the valve arrangement (6, 7) is operated to close the second fluid path (2); the displacing element (3) is driven a given distance in the fill direction; and the measurement signal is obtained from the sensor (12) during at least part of the system test. The integrity of the infusion system is determined based on the measurement signal, e.g. by evaluating the temporal change in the measurement signal during and/or after the displacement. The system test may identify a shortage of infusion liquid in the source (5) or a leakage of air into the first fluid path (4).
摘要翻译：通过在流体室（8）中以交替的填充和泵送方向驱动位移元件（3）来限制输入体积，并通过同步操作阀装置（6,7）来交替地打开和关闭来控制输注系统分别从流体室（8）到源（5）和连接器（19a）的第一和第二流体路径（4,2），使得输注液体从源极重复地吸入流体室（8）（5）并且通过连接器（19a）从流体室（8）泵送。输液系统包括用于产生表示位移体积中的流体压力的测量信号的传感器（12）。连接控制器（11）以间歇地进行系统测试，其中阀装置（6,7）被操作以关闭第二流体路径（2）; 位移元件（3）沿填充方向被驱动给定的距离; 并且在系统测试的至少一部分期间从传感器（12）获得测量信号。基于测量信号确定输注系统的完整性，例如，通过评估位移期间和/或之后的测量信号的时间变化。系统测试可以识别源（5）中的输注液体不足或空气泄漏到第一流体路径（4）中。

3. 发明申请

WO2011080185A1 APPARATUS AND METHOD FOR PREDICTION OF RAPID SYMPTOMATIC BLOOD PRESSURE DECREASE 审中-公开
标题翻译：用于预测快速症状性血压降低的装置和方法
公开(公告)号：WO2011080185A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070546
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36 , A61B5/021 , A61B5/024
CPC分类号： A61B5/4836 , A61B5/0205 , A61B5/021 , A61B5/02108 , A61B5/02416 , A61B5/053 , A61M1/30 , A61M1/36 , A61M2230/30
摘要： A monitoring arrangement 100 is configured to predict a rapid symptomatic drop in a subject's blood pressure, e.g. during a medical treatment or when operating an aircraft. To this aim, a pulse shape parameter (p ps ) with respect to a peripheral body part (105) of the subject (P) is repeatedly registered by means of a pulse oximetry instrument (110) adapted to detect light response variations in blood vessels. A respective pulse magnitude measure is calculated based on each of a number of received pulse shape parameters (p ps ), and a statistical dispersion measure is calculated based on the thus-calculated pulse magnitude measure. It is investigated whether or not the statistical dispersion measure fulfils a decision criterion relative to a reference measure. An output signal (α) is generated if the decision criterion is found to be fulfilled.
摘要翻译：监测装置100被配置为预测受试者的血压中的快速有症状的下降，例如，在治疗期间或在操作飞行器时。为此目的，相对于被检体（P）的周边体部（105）的脉冲形状参数（pps）通过适于检测血管中的光反应变化的脉搏血氧仪（110）重复记录。基于接收的脉冲形状参数（pps）中的每一个来计算相应的脉冲幅度测量，并且基于由此计算的脉冲幅度测量值来计算统计色散测量。调查统计色散测量是否满足参考测量的决策标准。如果发现满足判定标准，则产生输出信号（a）。

4. 发明申请

WO2009156174A2 METHODS AND DEVICES FOR MONITORING THE INTEGRITY OR A FLUID CONNECTION 审中-公开
标题翻译：用于监测完整性或流体连接的方法和装置
公开(公告)号：WO2009156174A2
公开(公告)日：2009-12-30
申请号：PCT/EP2009/004640
申请日：2009-06-26
申请人： GAMBRO LUNDIA AB , HERTZ, Thomas , SOLEM, Kristian , ROSLUND, Anders , STERNBY, Jan , FURMANSKI, Martin , OLDE, Bo
发明人： HERTZ, Thomas , SOLEM, Kristian , ROSLUND, Anders , STERNBY, Jan , FURMANSKI, Martin , OLDE, Bo
IPC分类号： A61M1/36
CPC分类号： G01M3/2846 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , G01L27/002 , G01M3/2815 , G01N33/49
摘要： A surveillance device (25) monitors the integrity of a fluid connection (C) between first and second fluid containing systems (S 1, S2) based on at least one time-dependent measurement signal from a pressure sensor (4a-4c) in the first fluid containing system (Sl). The first fluid containing system (Sl) comprises a first pulse generator (3), and the second fluid containing system (S2) comprises a second pulse generator (3 '). The pressure sensor (4a-4c) is arranged to detect first pulses originating from the first pulse generator (3) and second pulses originating from the second pulse generator (3 '). The integrity of the fluid connection (C) is determined based on the presence of second pulses in the measurement signal. The second pulses may be detected by analysing the measurement signal in the time domain and/or by using timing information indicative of the timing of the second pulses in said at least one measurement signal. The analysis may be based on a parameter value that represents a distribution of signal values within a time window of the measurement signal. For example, the parameter value may be calculated as a statistical dispersion measure of the signal values, or may result from a matching of the signal values within the time window to a predicted temporal signal profile of a second pulse. The fluid connection (C) may be established between a human blood system and an extracorporeal blood flow circuit, e.g. for extracorporeal blood treatment.
摘要翻译：监视装置（25）基于来自压力传感器（4a-4c）的至少一个与时间有关的测量信号来监视第一和第二流体容纳系统（S1，S2）之间的流体连接（C）的完整性第一流体容纳系统（S1）。第一流体容纳系统（S1）包括第一脉冲发生器（3），第二流体容纳系统（S2）包括第二脉冲发生器（3'）。压力传感器（4a-4c）被布置成检测源自第一脉冲发生器（3）的第一脉冲和源自第二脉冲发生器（3'）的第二脉冲。流体连接（C）的完整性基于测量信号中第二个脉冲的存在来确定。可以通过在时域中分析测量信号和/或通过使用指示所述至少一个测量信号中的第二脉冲的定时的定时信息来检测第二脉冲。分析可以基于表示测量信号的时间窗内的信号值分布的参数值。例如，可以将参数值计算为信号值的统计色散测量值，或者可以由时间窗口内的信号值与第二脉冲的预测时间信号曲线的匹配产生。流体连接（C）可以建立在人体血液系统和体外血流回路之间，例如，用于体外血液治疗。

5. 发明申请

WO2009127683A1 METHOD AND DEVICES FOR MONITORING FLOW CIRCUITS 审中-公开
标题翻译：用于监测流量电路的方法和装置
公开(公告)号：WO2009127683A1
公开(公告)日：2009-10-22
申请号：PCT/EP2009/054514
申请日：2009-04-16
申请人： GAMBRO LUNDIA AB , FURMANSKI, Martin , ROSLUND, Anders , OLDE, Bo , SOLEM, Kristian
发明人： FURMANSKI, Martin , ROSLUND, Anders , OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36 , A61M5/168 , G01M3/00 , A61M205/15 , A61M230/06
CPC分类号： G01M3/2815 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M5/16859 , A61M2205/15 , A61M2205/18 , A61M2230/06
摘要： A device is provided for monitoring the integrity of a flow circuit in fluid communication with a receptacle. The flow circuit comprises a pumping device for transferring fluid through the flow circuit. The device operates according to a monitoring method in which a pressure signal is received (401) from a pressure sensor, the pressure signal being indicative of fluid pressure in the receptacle or the flow circuit. The pressure signal is then processed (406-407) for detection of a beating signal. The beating signal manifests itself as an amplitude modulation of the pressure signal and is formed by interference between pressure waves generated by a pulse generator associated with the receptacle and pressure waves generated by the pumping device. The integrity of the flow circuit is determined (408-409) based at least partly on the presence or absence of the beating signal. The device and the flow circuit may be part of an apparatus for extracorporeal blood treatment, and the method may be implemented as a computer program product.
摘要翻译：提供了一种用于监测与容器流体连通的流动回路的完整性的装置。流动回路包括用于通过流动回路传送流体的泵送装置。该装置根据从压力传感器接收压力信号（401）的监测方法进行操作，压力信号表示容器或流路中的流体压力。然后对压力信号进行处理（406-407）以检测跳动信号。跳动信号表现为压力信号的幅度调制，并且由与由插座相关联的脉冲发生器产生的压力波和由泵送装置产生的压力波之间的干扰形成。至少部分地基于跳动信号的存在或不存在来确定流动电路的完整性（408-409）。装置和流路可以是用于体外血液处理的装置的一部分，并且该方法可以被实现为计算机程序产品。

6. 发明申请

WO2012163738A1 MONITORING STENOSIS FORMATION IN AN ARTERIOVENOUS ACCESS 审中-公开
标题翻译：监测异常进入的STENOSIS形成
公开(公告)号：WO2012163738A1
公开(公告)日：2012-12-06
申请号：PCT/EP2012/059522
申请日：2012-05-23
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian , MANDERSSON, Bengt , MUNGUIA MENA, Marco , VASQUEZ OBANDO, Pablo
发明人： OLDE, Bo , SOLEM, Kristian , MANDERSSON, Bengt , MUNGUIA MENA, Marco , VASQUEZ OBANDO, Pablo
IPC分类号： A61M1/36
CPC分类号： A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3658 , A61M2205/3375
摘要： A device (1) is arranged to monitor, in a sequence of time- separated sessions on a human subject, an arteriovenous (AV) access (4) which is configured to be connected in fluid communication with an extracorporeal fluid circuit (14). In each session, the device obtains a current signal from an acoustic sensor (2A, 2B) arranged on the human subject to detect acoustic emission created by a flow of blood through the AV access (4), and determines an acoustic envelope of the current signal. The device (1) also obtains shape-indicating data of a reference envelope which is representative of the acoustic emission at the anastomosis of the AV access (4), and processes the acoustic envelope as a function of the shape- indicating data to calculate a parameter value indicative of the status of the AV access (4), e.g. for detection of stenosis formation in the AV access (4).
摘要翻译：设备（1）被布置成以人类对象的时间分隔的会话序列来监视被配置为与体外流体回路（14）流体连通地连接的动静脉（AV）访问（4）。在每个会话中，设备从布置在人体上的声学传感器（2A，2B）获取电流信号，以检测通过AV存取（4）的血液流产生的声发射，并确定电流的声包络信号。设备（1）还获得代表AV接入（4）的吻合处的声发射的参考包络的形状指示数据，并且根据形状指示数据处理声包络以计算指示AV接入（4）的状态的参数值，例如用于检测AV接入中的狭窄形成（4）。

7. 发明申请

WO2011080189A1 MONITORING A PROPERTY OF THE CARDIOVASCULAR SYSTEM OF A SUBJECT 审中-公开
标题翻译：监测一个主体的心脏血管系统的属性
公开(公告)号：WO2011080189A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070551
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61B5/0215 , A61M1/36
CPC分类号： A61B5/0215 , A61B5/7203 , A61B5/725 , A61B5/7257 , A61B5/7264 , A61M1/3639 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3656 , A61M2205/3331 , A61M2230/06
摘要： A device (25) is configured to monitor a cardiovascular property of a subject. The device (25) obtains measurement data from a primary pressure wave sensor (4a-4c) arranged to detect pressure waves in an extracorporeal fluid circuit (20) in fluid communication with the cardiovascular system of the subject. The device has a signal processor (29) configured to generate a time-dependent monitoring signal based on the measurement data, such that the monitoring signal comprises a sequence of heart pulses, wherein each heart pulse represents a pressure wave originating from a heart beat in the subject; determine beat classification data for each heart pulse in the monitoring signal; and calculate, based at least partly on the beat classification data, a parameter value indicative of the cardiovascular property. The beat classification data may distinguish between heart pulses originating from normal heart beats and heart pulses originating from ectopic heart beats. The cardiovascular property may be an arterial status of the cardiovascular system, a degree of calcification in the cardiovascular system, a status of a blood vessel access used for connecting the extracorporeal fluid circuit (20) to the cardiovascular system, a heart rate variability, a heart rate, a heart rate turbulence, an ectopic beat count, or an origin of ectopic beats. The device (25) may be attached to or part of a dialysis machine.
摘要翻译：设备（25）被配置为监测受试者的心血管性质。装置（25）从主压力波传感器（4a-4c）获得测量数据，所述第一压力波传感器（4a-4c）布置成检测与受试者的心血管系统流体连通的体外流体回路（20）中的压力波。该装置具有信号处理器（29），其被配置为基于测量数据产生与时间相关的监测信号，使得监测信号包括心脏脉冲序列，其中每个心脏脉搏表示源自心跳的压力波主题; 确定监测信号中每个心脏脉搏的搏动分类数据; 并且至少部分地基于节拍分类数据计算指示心血管特性的参数值。节拍分类数据可以区分源自正常心跳的心脏脉搏和源自异位心跳的心脏脉冲。心血管性质可以是心血管系统的动脉状态，心血管系统中的钙化程度，用于将体外流体回路（20）连接到心血管系统的血管通路的状态，心率变异性，心率，心率湍流，异位搏动计数或异位搏动的来源。设备（25）可以附接到透析机或其一部分。

8. 发明申请

WO2012175267A1 DETECTING BLOOD PATH DISRUPTION IN EXTRACORPOREAL BLOOD PROCESSING 审中-公开
标题翻译：检测血液中血液中的血液流失
公开(公告)号：WO2012175267A1
公开(公告)日：2012-12-27
申请号：PCT/EP2012/059521
申请日：2012-05-23
申请人： GAMBRO LUNDIA AB , HOLMER, Mattias , OLDE, Bo , SOLEM, Kristian
发明人： HOLMER, Mattias , OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36
CPC分类号： A61M1/367 , A61M1/3639 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3659 , A61M1/3661 , A61M2205/13 , A61M2205/3331 , A61M2205/3351 , G01N19/00
摘要： A device (7) monitors a blood path from a blood vessel access (3) of a human subject through an extracorporeal blood processing apparatus and back to the blood vessel access (3). A pumping device (4) in the blood path is operable to pump blood through the blood path from the blood withdrawal device (2') to the blood return device (2"). The monitoring device (7) obtains pressure data from a pressure sensor (6a) arranged upstream of the pumping device (4) in the blood path, and processes the pressure data for detection of a disruption of the blood path downstream of the pumping device (4), e.g. caused by VND (Venous Needle Dislodgement). The disruption is detected by evaluating presence/absence of cross-talk pulses at the pressure sensor (6a), where the cross-talk pulses originate from one or more pulse generators in the extracorporeal blood processing apparatus (80) and have propagated on a propagation path (P2) in a direction downstream of the pumping device (4) through the blood return device (2"), the blood vessel access (3) and the blood withdrawal device (2') to the pressure sensor (6a).
摘要翻译：装置（7）通过体外血液处理装置监测来自人体受试者的血管通路（3）的血液通路并返回到血管通路（3）。血液通道中的抽吸装置（4）可操作用于将血液从血液提取装置（2'）泵送到血液返回装置（2“），血液通过血液通道从监测装置（7）获得压力数据传感器（6a），其布置在血液路径中的泵送装置（4）的上游，并且处理用于检测泵送装置（4）下游的血液路径中断的压力数据，例如由VND（静脉针头移动）通过评估压力传感器（6a）处的串扰脉冲的存在/不存在来检测中断，其中串扰脉冲源自体外血液处理设备（80）中的一个或多个脉冲发生器，并且在在泵送装置（4）的下游方向通过血液返回装置（2“），血管通路（3）和血液提取装置（2'）到压力传感器（6a）的传播路径（P2）。

9. 发明申请

WO2011080194A1 DEVICE AND METHOD FOR MONITORING A FLUID FLOW RATE IN A CARDIOVASCULAR SYSTEM 审中-公开
标题翻译：用于监测心脏血管系统中流体流量的装置和方法
公开(公告)号：WO2011080194A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070565
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36
CPC分类号： A61B5/026 , A61M1/3639 , A61M1/3653 , A61M1/3655 , A61M1/3656 , A61M1/3658 , A61M1/3659 , A61M1/3661 , A61M2230/04 , A61M2230/42
摘要： A device in an apparatus (200) for extracorporeal blood treatment is configured to monitor a fluid flow rate (Q) of a cardiovascular system of a subject. The apparatus comprises an extracorporeal blood circuit (20) and a connection (C) for connecting the extracorporeal blood circuit (20) to the cardiovascular system. The device comprises an input (28) for obtaining a time- dependent measurement signal (d(n)) from a pressure sensor (4a-4c) in the extracorporeal blood circuit (20). The pressure sensor (4a-4c) is arranged to detect a subject pulse originating from a subject pulse generator (30 in the cardiovascular system of the subject, wherein the system further comprises a signal processor (29) connected to the input (28). The signal processor is configured to process the measurement signal to obtain a pulse profile (e(n)) which is a temporal signal profile of the subject pulse, and to calculate a fluid flow rate (Q) based at least partly on the temporal signal profile.
摘要翻译：用于体外血液处理的装置（200）中的装置被配置为监测受试者的心血管系统的流体流速（Q）。该装置包括用于将体外血液回路（20）连接到心血管系统的体外血液回路（20）和连接（C）。该装置包括用于从体外血液回路（20）中的压力传感器（4a-4c）获得与时间相关的测量信号（d（n））的输入端（28）。压力传感器（4a-4c）被布置成检测源自对象脉冲发生器（在该对象的心血管系统中的30）的被摄体脉冲，其中系统还包括连接到输入端（28）的信号处理器（29）。信号处理器被配置为处理测量信号以获得作为对象脉冲的时间信号轮廓的脉冲轮廓（e（n）），并且至少部分地基于时间信号来计算流体流速（Q）个人资料。

10. 发明申请

WO2011080193A1 METHOD AND DEVICE FOR MONITORING THE INTEGRITY OF A CONNECTION SYSTEM 审中-公开
标题翻译：用于监测连接系统完整性的方法和装置
公开(公告)号：WO2011080193A1
公开(公告)日：2011-07-07
申请号：PCT/EP2010/070560
申请日：2010-12-22
申请人： GAMBRO LUNDIA AB , OLDE, Bo , SOLEM, Kristian
发明人： OLDE, Bo , SOLEM, Kristian
IPC分类号： A61M1/36
CPC分类号： G01N19/08 , A61B5/024 , A61B2562/0247 , A61B2562/226 , A61M1/3639 , A61M1/3653 , A61M1/3656 , A61M1/3659 , A61M5/16859 , A61M2205/13 , A61M2205/15 , A61M2205/3331 , A61M2230/04 , A61M2230/06
摘要： A device is configured to monitor the integrity of a connection system between first and second fluid containing systems comprising first and second pulse generators. A pressure sensor is arranged in the first fluid containing system to detect first pulses originating from the first pulse generator and second pulses originating from the second pulse generator. The device operates a monitoring method, by generating (42) a time- dependent pressure signal based on measurement data obtained from the pressure sensor such that the pressure signal contains a sequence of apparent pulses. The apparent pulses represent a superposition of the second pulses on the first pulses when the connection system (C) is intact. The device processes (44) the pressure signal to calculate a parameter value based on a pulse feature of at least one of the apparent pulses in the pressure signal. The parameter value represents a disturbance caused by the superposition of the second pulses on the first pulses, and may be given as a measure of statistical dispersion, pulse-to- pulse symmetry, or first pulse similarity. The device determines (45) the integrity of the connection system based at least partly on the parameter value. The first fluid containing system may be an extracorporeal blood circuit, and the second fluid containing system may be a human or animal subject.
摘要翻译：设备被配置为监视包括第一和第二脉冲发生器的第一和第二流体容纳系统之间的连接系统的完整性。压力传感器布置在第一流体容纳系统中以检测源自第一脉冲发生器的第一脉冲和源自第二脉冲发生器的第二脉冲。该设备通过基于从压力传感器获得的测量数据产生（42）依赖于时间的压力信号来操作监测方法，使得压力信号包含明显脉冲序列。当连接系统（C）完好时，表观脉冲表示第一脉冲上的第二脉冲的叠加。装置处理（44）压力信号，以基于压力信号中的表观脉冲中的至少一个的脉冲特征来计算参数值。参数值表示由第二脉冲叠加在第一脉冲上引起的干扰，并且可以作为统计色散，脉冲对脉冲对称性或第一脉冲相似度的量度给出。该设备至少部分地基于参数值确定（45）连接系统的完整性。第一流体容纳系统可以是体外血液回路，并且第二流体容纳系统可以是人或动物受试者。

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