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    • 6. 发明申请
    • USE OF SUBSTITUTED 2,4-BIS(ALKYLAMINO)PYRIMIDINES
    • 取代的2,4-BIS(亚苄基)嘧啶的使用
    • WO2005011758A2
    • 2005-02-10
    • PCT/EP2004/051516
    • 2004-07-16
    • CIBA SPECIALTY CHEMICALS HOLDING INC.MARQUAIS-BIENEWALD, SophieHÖLZL, WernerPREUSS, AndreaMEHLIN, Andreas
    • MARQUAIS-BIENEWALD, SophieHÖLZL, WernerPREUSS, AndreaMEHLIN, Andreas
    • A61L2/18
    • A61Q17/005A01N43/54A61K8/4953A61L2/16A61L2/18A61Q11/00C11D3/28C11D3/48D06M13/355Y10T442/2525
    • The use of 2,4-bis(alkylamino)pyrimidines of formula (1) R 1 is C 1 -C 12 alkyl or C 6 -C 10 laryl; R 2 is hydrogen or C 1 -C 12 alkyl; or R 1 and R 2 together forma radical of formula (1 a) R' and R" are each independently of the other hydrogen, C 1 -C 6 alkyl or C 1 -C 6 alkoxy, R 3 and R 5 are each independently of the other hydrogen or C 1 -C 8 alkyl; R 4 is C 1 -C 20 alkyl, unsubstituted phenyl, C 6 -C 10 aryl, C 6 -C 10 aryl-C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, di-C 1 -C 6 al-kylamino-C 1 -C 6 aIkyl, mono-C 1 -C 6 alkylamino-C 1 -C 6 alkyl, -(CH 2 )2-(O-(CH 2 ) 2 ) 1-4 -OH or -(CH 2 ) 2 -(O-(CH 2 ) 2 ) 1-4 -NH 2 ; R 6 is C 1 -C 20 alkyl, C 6 -C 10 aryl, C 6 -C 10 aryl-C 1 -C 6 alkyl, hydroxy-C 1 -C 6 alkyl, di-C 1 ­C 6 alkylamino-C 1 -C 6 alkyl, mono-C 1 -C 6 alkylamino-C 1 -C 6 alkyl, -(CH 2 ) 2 -(O-(CH 2 ) 2 ) 1-4 -OH or -(CH 2 ) 2 -(O-(CH 2 ) 2 ) 1-4 -NH 2 ; or R 3 and R 4 and/or R 5 and R 6 , together form a pyrrolidine, piperidine, hexamethyleneimine or morpholine ring; in the antimicrobial treatment of surfaces.
    • 式(1)R 1的2,4-双(烷基氨基)嘧啶的用途是C 1 -C 12烷基或C 6 -C 10芳基; R2是氢或C1-C12烷基; 或者R 1和R 2一起形成式(1a)的基团,R'和R“各自独立地为氢,C 1 -C 6烷基或C 1 -C 6烷氧基,R 3和R 5各自独立地为氢或C 1 -C 8烷基; R 4 是C 1 -C 20烷基,未取代的苯基,C 6 -C 10芳基,C 6 -C 10芳基-C 1 -C 6烷基,羟基-C 1 -C 6烷基,二-C 1 -C 6烷基氨基-C 1 -C 6烷基,单-C 1 -C 6烷基氨基-C 1 -C 6烷基, - ( CH2)2-(O-(CH2)2)1-4-OH或 - (CH2)2-(O-(CH2)2)1-4-NH2; R6是C1-C20烷基,C6-C10芳基, C 1 -C 10芳基-C 1 -C 6烷基,羟基-C 1 -C 6烷基,二-C 1 -C 6烷基氨基-C 1 -C 6烷基,单-C 1 -C 6烷基氨基-C 1 -C 6烷基, - (CH 2)2 - (O-(CH 2)2)1-4 -OH或 - (CH2)2-(O-(CH2)2)1-4-NH2;或R3和R4和/或R5和R6一起形成吡咯烷,哌啶,六亚甲基亚胺或吗啉环;在表面的抗微生物处理中。
    • 7. 发明申请
    • POLYMERIC HAIR DYES
    • 聚合物染发剂
    • WO2009090125A1
    • 2009-07-23
    • PCT/EP2009/050098
    • 2009-01-07
    • CIBA HOLDING INC.MARQUAIS-BIENEWALD, SophieCREMER, ChristianWALLQUIST, OlofFRÖHLING, Beate
    • MARQUAIS-BIENEWALD, SophieCREMER, ChristianWALLQUIST, OlofFRÖHLING, Beate
    • C09B69/10A61K8/72A61Q5/00
    • C09B69/106A61K8/8152A61K8/817A61K8/84A61K2800/4322A61Q5/065C09B69/107
    • Disclosed are olymeric dye of formula (1a), (1b), (1c), A and B, independently from each other represent a polymer backbone; X 1 and X 2 independently from each other are a linkage group selected from -C 1 -C 30 alkylene- or -C 2 -C 12 alkenylene-, which is interrupted and/or terminated at one or both ends by one or more than one -S-, -N-, -N=-, -N(R 5 )-, -S(O)-, -SO 2 -, -(CH 2 CH 2 -O) 1-5 -, -(CH 2 CH 2 CH 2 -O) 1-5 -, -C(O)-, -C(O)O-, -OCO-, (II), -CON(R 1 )-, -C(NR 1 R 2 ) 2 -, -(R 1 )NC(O)-, -C(S)R 1 -; or an optionally substituted, saturated or unsaturated, fused or non-fused aromatic or nonaromatic (heterocyclic) bivalent radical optionally comprising at least one heteroatom; a saturated or unsaturated, fused or non-fused aromatic or nonaromatic bivalent radical comprising at least one heteroatom, which is optionally substituted by C 1 -C 30 alkyl, C 1 -C 30 alkoxy, C 2 -C 12 alkenyl, C 5 -C 10 aryl, C 5 -C 10 cycloalkyl, C 1 -C 10 alkyl(C 5 -C 10 arylene), hydroxy or halogen; R 1 and R 2 independently from each other are hydrogen; unsubstituted or substituted, straight-chain or branched, monocyclic or polycyclic, interrupted or uninterrupted C 1 - C 14 alkyl; C 2 -C 14 alkenyl; C 6 -C 10 aryl; C 6 -C 10 aryl-C 1 -C 10 alkyl; or C 5 -C 10 alkyl(C 5 -C 10 aryl); Y 1 and Y 2 independently from each other are a residue of an organic dye; or hydrogen; wherein at least one of Y 1 and Y 2 is a residue of an organic dye; An 1 , An 2 and An 3 , independently from each other are an anion; a and b independently from each other are a number from 1 to 3; m is a number from 0 to 5000; n is a number from 0 to 5000; and p is a number from 1 to 5000; wherein the sum of m + n + p ≥ 3. The dyes are distinguished by their depth of shade and their good fastness properties to washing, such as, for example, fastness to light, shampooing and rubbing.
    • 公开了式(1a),(1b),(1c),A和B的聚合染料,彼此独立地表示聚合物主链; X 1和X 2彼此独立地是选自-C 1 -C 30亚烷基或-C 2 -C 12亚烯基的连接基团,其在一个或两个末端被一个或多个-S-,-N- ,-N = - , - N(R 5) - , - S(O) - , - SO 2 - , - (CH 2 CH 2 -O)1-5 - , - (CH 2 CH 2 CH 2 -O) ) - , - (R)NC(O) - , - C(O)O-, - OCO-,(II) - ; 或任选包含至少一个杂原子的任选取代的,饱和或不饱和的稠合或非稠合芳族或非芳族(杂环)二价基团; 饱和或不饱和的,稠合或非稠合的芳族或非芳族二价基团,其包含至少一个杂原子,其任选被C 1 -C 30烷基,C 1 -C 30烷氧基,C 2 -C 12链烯基,C 5 -C 10芳基,C 5 -C 10环烷基,C 1 -C 10烷基( C5-C10亚芳基),羟基或卤素; R1和R2彼此独立地是氢; 未取代或取代的直链或支链,单环或多环,中断或不间断C 1 -C 14烷基; C2-C14alkenyl; C6-C10芳基; C6-C10芳基,C1-C10烷基; 或C 5 -C 10烷基(C 5 -C 10芳基); Y1和Y2彼此独立地是有机染料的残基; 或氢; 其中Y 1和Y 2中的至少一个是有机染料的残基; An1,An2和An3彼此独立地为阴离子; a和b彼此独立,为1-3; m是从0到5000的数字; n是从0到5000的数字; p是从1到5000的数字; 其中m + n + p = 3的总和。这些染料的特征在于它们的色调深度和它们对洗涤的良好牢度性质,例如,耐光牢度,洗发剂和摩擦性。
    • 8. 发明申请
    • POLYMERIC HAIR DYES
    • 聚合物染发剂
    • WO2008009579A1
    • 2008-01-24
    • PCT/EP2007/056945
    • 2007-07-09
    • CIBA SPECIALTY CHEMICALS HOLDING INC.MARQUAIS-BIENEWALD, SophieWALLQUIST, OlofCREMER, ChristianFRÖHLING, BeateMÖCK, Andreas
    • MARQUAIS-BIENEWALD, SophieWALLQUIST, OlofCREMER, ChristianFRÖHLING, BeateMÖCK, Andreas
    • C09B69/10A61K8/72
    • A61K8/84A61K8/8152A61K8/8158A61K8/86A61K8/898A61K2800/43A61K2800/5426A61K2800/57A61K2800/594A61Q5/02A61Q5/065A61Q5/12C09B69/105C09B69/106C09B69/107C09B69/109
    • Disclosed are polymeric dyes of formula (1a); (1b); or (1c); wherein A and B, independently from each other represent a polymer backbone; X 1 and X 2 independently from each other are a linkage group selected from -C 1 -C 10 alkylene-; -C 2 -C 12 alkenylene-; -C 5 -C 10 cycloalkylene-; C 5 -C 10 arylene; -C 5 -C 10 arylene-(C 1 -C 10 alkylene)-; -C(O)-; -(CH 2 CH 2 -O) 1-5 -; -C(O)O-; -OCO-; -N(R 1 )-; -CON(R 1 )-; -(R 1 )NC(O)-; -0-; -S-; -S(O)-; -S(O) 2 -; -S(O) 2 -N(R 1 R 2 ); or the direct bond; R 1 and R 2 independently from each other are hydrogen; or unsubstituted or substituted, straight-chain or branched, monocyclic or polycyclic, interrupted or uninterrupted C 1 - C 14 alkyl; C 2 -C 14 alkenyl; C 6 -C 10 aryl; C 6 -C 10 aryl-C 1 -C 10 alkyl; or C 5 -C 10 alky(C 5 -C 10 aryl); Y 1 and Y 2 independently from each other are a residue of an organic dye; or hydrogen; wherein at least one of Y 1 and Y 2 is a residue of an organic dye; An 1 , An 2 and An 3 , independently from each other are an anion; a and b independently from each other are a number from 1 to 3; m is a number from O to 1000; n is a number from O to 1000; and p is a number from 1 to 1000; wherein the sum of m + n + p ≥ 3.
    • 公开了式(1a)的聚合染料; (1B); 或(1c); 其中A和B彼此独立地表示聚合物主链; X 1和X 2彼此独立地是选自-C 1 -C 10亚烷基的连接基团 - ; -C 2 -C 12 烯基 - ; -C 5 -C 10 环亚烷基; ç 5 -C 10 亚芳基; -C 5 -C 10 亚芳基 - (C 1 -C 10 亚烷基) - ; -C(O) - ; - (CH 2 CH 2 -O) 1-5 - ; -C(O)O-; -OCO-; -N(R 1 ) - ; -CON(R 1 ) - ; - (R 1 )NC(O) - ; -0-; -S-; -所以)-; -S(O) 2 - ; -S(O) 2 -N(R 1 - [R 2 ); 或直接债券; R 1和R 2彼此独立地是氢; 或未取代或取代的直链或支链单环或多环,间断或不间断C 1 -C 14烷基; ç 2 -C 14 烯基; ç 6 -C 10 芳基; ç 6 -C 10 芳基-C 1 -C 10 烷基; 或C 5 -C 10烷基(C 5 -C 10芳基);或C 5 -C 10烷基(C 5 -C 10 - 芳基); Y 1和Y 2彼此独立地是有机染料的残基; 或氢; 其中Y 1和Y 2 2中的至少一个是有机染料的残基; 1个,2个和3个独立地是阴离子; a和b彼此独立,为1-3; m是从0到1000的数字; n是从0到1000的数字; p是从1到1000的数字; 其中m + n + p = 3的和。
    • 9. 发明申请
    • POLYSILOXANE ANTIMICROBIALS
    • 多晶硅抗微生物
    • WO2008006744A2
    • 2008-01-17
    • PCT/EP2007056703
    • 2007-07-04
    • CIBA SC HOLDING AGMARQUAIS-BIENEWALD SOPHIEWALLQUIST OLOFPREUSS ANDREAELDER STEWART TODD
    • MARQUAIS-BIENEWALD SOPHIEWALLQUIST OLOFPREUSS ANDREAELDER STEWART TODD
    • A01N55/10A01P1/00C07F7/08C08G77/38C08G77/388
    • C08G77/388A01N55/00
    • Disclosed are oligo- or polysiloxanes, which are characterized by containing at least 3, for example 4 - 3000, Si atoms in the main chain, and wherein at least one thereof is contained in a moiety of the formula (I) whose open bond of the O atom is linked to another Si atom of the oligo- or polysiloxane main chain, and whose open bond of the Si atom is linked either to another O atom of the oligo- or polysiloxane main chain or to R' 1, where R 1 and R' 1 independently are C 1 -C 10 alkyl, R 2 and R 3 independently are C 1 -C 18 alkylene, X is a divalent spacer group selected from O, NR 4, N(COR' 5 ), CONR' 4, OCONR' 4; .Y is selected from OCOR 5, NHCOR 5, NHR 4 , COOR 5, CONHR 4, NR' 4 R 4; R 4 is selected from C 6 -C 18 organic residues containing at least one aryl moiety; R' 4 is as defined for R 4; or is selected from H, C 1 -C 20 alkyl, C 7 -C 20 phenylalkyl, C 4 - C 12 cycloalkyl; R 5 is R 7 -Z; R' 5 is as defined for R 5; or is selected from H, C 1 -C 20 alkyl, C 7 -C 20 phenylalkyl, C 4 - C 12 cycloalkyl; R 7 is C 1 -C 20 alkylene, which may be interrupted by phenylene, C 4 -C 12 cycloalkylene, O, NR' 4; or is unsubstituted or substituted phenylene or C 4 -C 12 cycloalkylene; Z is halogen or N+R 8 R 9 R 10; R 8 , R 9 and R 10 independently are selected from C 1 -C 20 alkyl, C 7 -C 20 phenylalkyl, C 4 - C 12 cycloalkyl, unsubstituted or substituted aryl; or 2 of R 8 , R 9 and R 10 are linked together to form a quaternized aliphatic, substituted or unsubstituted N-heterocyclic ring of 4-6 carbon atoms such as a piperidine ring; or all of R 8 , R 9 and R 10 are linked together to form, together with the nitrogen atom they are bonding to, a substituted or unsubstituted N-heterocyclic ring system of 4-7 carbon atoms. The novel compounds are effective as antimicrobials.
    • 公开了低聚或聚硅氧烷,其特征在于在主链中含有至少3个,例如4-3000个Si原子,并且其中至少一个包含在式(I)的部分中,其开环键 O原子连接到寡硅烷或聚硅氧烷主链的另一个Si原子,并且其Si原子的开环键连接到寡聚或聚硅氧烷主链的另一个O原子或R'1, 其中R 1和R'1个独立地是C 1 -C 10烷基, R 2和R 3独立地是C 1 -C 18亚烷基,X是选自O, NR 4,N(COR'5 5),CONR 4,OCONR 4等; Y选择 来自OCOR 5,NHCOR 5,NHR 4,COOR 5,CONHR 4,/ SUB > NR'4 R 4; R 4选自C 6 -C 18烷基, SUB>含有至少一个芳基的有机残基 iety; R 4'如对R 4所定义;或者选自H,C 1 -C 20烷基 C 7 -C 20烷基,C 4 -C 12环烷基,C 1 -C 12烷基, R 5是R 7 -Z; R 5'如对R 5所定义;或者选自H,C 1 -C 20烷基 C 7 -C 20烷基,C 4 -C 12环烷基,C 1 -C 12烷基, R 7是C 1 -C 20亚烷基,其可以被亚苯基中间,C 4 -C 20亚烷基, O,NR'4;或未取代或取代的亚苯基或C 4 -C 12亚环烷基; Z是卤素或N + R 8 R 9 R 10; R 8,R 9, R 1和R 2独立地选自C 1 -C 20烷基,C 7 -C 20烷基, C 20 -C 20烷基,C 1-4烷基,未取代或取代的芳基; 或2个R 8,R 9和R 10连接在一起形成季铵化的脂族,取代或未取代的4-杂环 -6个碳原子,如哌啶环; 或全部R 8,R 9和R 10连接在一起,与它们键合的氮原子一起形成取代的 或未取代的4-7个碳原子的N-杂环系统。 新型化合物作为抗微生物剂是有效的。