基本信息:
- 专利标题： CNS 장애의 치료를 위한 2-옥소-2,3-다이하이드로-인돌
- 专利标题（英）：2-oxo-2,3-dihydro-indoles for the treatment of cns disorders
- 专利标题（中）：CNS 2--23--2-OXO-23-二氢吲哚治疗CNS疾病
- 申请号：KR1020157009290 申请日：2013-09-10
- 公开(公告)号：KR101706877B1 公开(公告)日：2017-02-15
- 发明人： 브루너다니엘라 , 말버그제시카 , 산카르바바니지 , 콜체브스키사빈 , 림베르그앤야 , 프린쎈에릭 , 리머클라우스 , 스톨테오도르
- 申请人： 에프. 호프만-라 로슈 아게
- 申请人地址： 스위스 체하-**** 바젤 그렌짜체스트라쎄 ***
- 专利权人： 에프. 호프만-라 로슈 아게
- 当前专利权人： 에프. 호프만-라 로슈 아게
- 当前专利权人地址： 스위스 체하-**** 바젤 그렌짜체스트라쎄 ***
- 代理人： 제일특허법인
- 优先权： EP121842496 2012-09-13
- 国际申请： PCT/EP2013/068668 2013-09-10
- 国际公布： WO2014040969 2014-03-20
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D403/12 ; C07D209/34 ; A61K31/437 ; A61K31/4439 ; A61K31/506
The present invention relates to 2-oxo-2,3 of formula I - indole, or a pharmaceutically acceptable salt, racemic mixture, or their corresponding enantiomers and / or optical isomers and / or stereoisomers that It relates:
Wherein
(N
1) is phenyl or pyridinyl, pyrimidinyl, imidazolyl, heteroaryl selected from isoxazole-yl and pyrazolyl aryl group;
(N
2) is phenyl or pyridinyl, where the N atom of the pyridinyl group may be present freely in any position;
R
1 is hydrogen, a lower alkyl, halogen substituted lower alkyl, lower alkoxy or halogen;
n is 1 or 2; When n is 2, R
1 may be the same or different;
R
2 / R
2
'is lower alkyl, independently of each other, or C
3
-6 together with the carbon atom to which they are attached - form a cycloalkyl ring;
R
3 is lower alkyl, C
3
-6-cycloalkyl, CH
2 -C
3
-6-cycloalkyl, a ring-carbon atoms are replaced by -O- C
3
-6-cycloalkyl, (CH
2)
3 -OC
3
-6-cycloalkyl, hydroxy lower alkyl, lower alkyl substituted by
halogen, (CH 2) 3 -S ( O) 2 -C 3 -6 substituted with -cycloalkyl or (CH
2) 2 - S (O)
2 - lower alkyl;
R
4 is hydrogen, halogen or lower alkyl;
m is 1 or 2; if m is 2, R
4 may be the same or different.
公开/授权文献:
- KR1020150054991A CNS 장애의 치료를 위한 2-옥소-2,3-다이하이드로-인돌 公开/授权日：2015-05-20
信息查询:
EspacenetIPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D401/00 | 杂环化合物，含有两个或更多个杂环，以氮原子作为仅有的杂环原子，至少有1个环是仅含有1个氮原子的六元环 |
| --------C07D401/02 | .含有两个杂环 |
| ----------C07D401/12 | ..被含有杂原子的链作为键链连接的 |