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1. 发明申请

WO02042650A1 FLUID HANDLING IN MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流体装置中的流体处理
公开(公告)号：WO02042650A1
公开(公告)日：2002-05-30
申请号：PCT/GB2001/005248
申请日：2001-11-27
IPC分类号： B01L3/00 , B81B1/00 , F15C1/06
CPC分类号： F15C1/06 , B01L3/502738 , B01L2200/0605 , B01L2200/0673 , B01L2300/165 , B01L2400/0487 , B01L2400/0688
摘要： A valve device for conveying a liquid (4) comprises a main bore (15) including a hydrophobic region (40). The main bore (15) includes a vent channel (60) in fluid communication with the hydrophobic region (40). Also disclosed is a method of passive valving using such a device and a method of introducing a gas pocket of predetermined size into a liquid.
摘要翻译：用于输送液体（4）的阀装置包括包括疏水区域（40）的主孔（15）。主孔（15）包括与疏水区域（40）流体连通的通气通道（60）。还公开了使用这种装置的无源阀的方法和将预定尺寸的气囊引入液体的方法。

2. 发明申请

WO0033965B1 NOZZLES WITH INTEGRATED OR BUILT-IN-FILTERS AND METHOD 审中-公开
标题翻译：具有集成或内置过滤器和方法的喷嘴
公开(公告)号：WO0033965B1
公开(公告)日：2000-07-20
申请号：PCT/US9927926
申请日：1999-12-10
申请人： BOWLES FLUIDICS CORP
发明人： SRINATH DHARAPURAM N , KOEHLER ERIC
IPC分类号： F15C1/06 , B05B1/08 , B05B15/00 , F15C1/22 , B05B1/14 , B05B1/30
CPC分类号： B05B15/008 , B05B1/08 , Y10S239/03 , Y10S264/76 , Y10T29/4998 , Y10T137/2224 , Y10T137/2234
摘要： A molded fluidic device (20) having a power nozzle (PN1, PN2) with a width (W) and a coupling passage (21) coupling a source of fluid (22) to said power nozzle (PN1, PN2). The coupling passage (21) has a planar enlargement and a plurality of posts (24-1, 24-2...24-N) spaced across the enlargement, the spacing (S) between each post (24-1, 24-2...24-N) being less than the width (W) of the power nozzle (PN1, PN2) with the sum of spacing (S) being greater than the width (W).
摘要翻译：具有宽度为W的功率喷嘴（PN1，PN2）和将流体源（22）耦合到所述功率喷嘴（PN1，PN2）的耦合通道（21））的模制流体装置（20）。耦合通道（21）具有平面放大和跨放大间隔开的多个柱（24-1,24-2 ... 24-N），每个柱（24-1,24- 2 ... 24-N）小于功率喷嘴（PN1，PN2）的宽度（W），间距（S）之和大于宽度（W）。

3. 发明申请

WO2023060344A1 RAISED FLUIDIC CHANNELS AND METHODS OF MANUFACTURE 审中-公开
公开(公告)号：WO2023060344A1
公开(公告)日：2023-04-20
申请号：PCT/CA2022/051498
申请日：2022-10-12
申请人： NATIONAL RESEARCH COUNCIL OF CANADA
发明人： ZHANG, Zhiyi , TAO, Ye , LU, Jianping , XIAO, Gaozhi
IPC分类号： B81B1/00 , B01L3/00 , B81C1/00 , B82Y30/00 , F15C1/06 , F15C5/00
摘要： A ridge fluidic device comprising: a substrate and a fluidic component comprising at least one fluidic channel, wherein the at least one fluidic channel is adapted to conduct a fluid and retain the fluid within the at least one fluidic channel; wherein the at least one fluidic channel comprises porous material having a hydrophilic surface; and wherein the at least one fluidic channel is formed on the substrate via a deposition process.

4. 发明申请

WO2017040981A1 VALVE INCORPORATING TEMPORARY PHASE CHANGE MATERIAL 审中-公开
标题翻译：阀门并入临时相变材料
公开(公告)号：WO2017040981A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/050175
申请日：2016-09-02
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , MUSE, Joshua , HUGHES, Meghan , CRANE, Carl, David
发明人： MUSE, Joshua , HUGHES, Meghan , CRANE, Carl, David , ANGELINI, Thomas, Ettor , SCHULZE, Kyle, D. , BHATTACHARJEE, Tapomoy , SAWYER, Wallace, Gregory , TAYLOR, Curtis
IPC分类号： F16K31/12 , F16K99/00 , F15C1/04 , F15C1/06
CPC分类号： B33Y30/00 , B29C64/106 , B29C67/00 , B33Y10/00 , B33Y70/00
摘要： Described herein are various embodiments of a valve that may be opened and closed using a thixotropic or "stress yield" material, or other material that temporarily changes phase upon application of energy to the material. More particularly, some embodiments may include a valve that is opened and closed using a granular gel that is a temporary phase change material.
摘要翻译：这里描述的阀的各种实施方案可以使用触变性或“应力屈服”材料或者在向材料施加能量时临时改变相位的其他材料打开和关闭。更具体地，一些实施例可以包括使用作为临时相变材料的颗粒状凝胶来打开和关闭的阀。

5. 发明申请

WO2006135742A3 ELECTRO-HYDRAULIC VALVE APPARATUSES 审中-公开
标题翻译：电液阀门设备
公开(公告)号：WO2006135742A3
公开(公告)日：2009-04-30
申请号：PCT/US2006022465
申请日：2006-06-09
申请人： AEROSPACE CORP , WELLE RICHARD P
发明人： WELLE RICHARD P
IPC分类号： F15C1/06 , F15C1/04 , F16K31/02 , F16K99/00 , G10D7/00 , H01L35/28 , H01L35/30 , H01L35/34 , H01L37/00
CPC分类号： F16K99/0026 , B01L3/502738 , B01L2300/0816 , B01L2300/0861 , B01L2300/1822 , B01L2400/0487 , B01L2400/0655 , F16K31/025 , F16K99/0001 , F16K99/0021 , F16K99/0032 , F16K99/0034 , F16K99/0044 , F16K99/0059 , F16K2099/0074 , F16K2099/0084 , Y10T137/2196
摘要： An electro-hydraulic valve apparatus includes a flow channel, a hydraulic control channel defining an electro-hydraulic valve junction where the hydraulic control channel is adjacent to the flow channel, a flexible wall between the flow channel and the hydraulic control channel at the electro-hydraulic valve junction, and Peltier devices adjacent to the hydraulic control channel on opposite sides of the electro-hydraulic valve junction for controllably applying a hydraulic force against the flexible wall repositioning the flexible wall in relation to the flow channel to selectively close or open the electro-hydraulic valve apparatus.
摘要翻译：一种电动液压阀装置，包括流动通道，液压控制通道，其限定了液压控制通道与流动通道相邻的电动液压阀接头，在流动通道和液压控制通道之间的柔性壁，液压阀接头和邻近液压控制通道的珀尔帖设备，用于可控地施加液压力抵靠柔性壁，该液压力相对于流动通道重新定位柔性壁，以选择性地关闭或打开电液压阀装置。

6. 发明申请

WO2016130558A1 FLUID-BASED GATING MECHANISM WITH TUNABLE MULTIPHASE SELECTIVITY AND ANTIFOULING BEHAVIOR 审中-公开
标题翻译：具有可调节多选选择性和反应行为的基于流体的获取机制
公开(公告)号：WO2016130558A1
公开(公告)日：2016-08-18
申请号：PCT/US2016/017167
申请日：2016-02-09
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： AIZENBERG, Joanna , HOU, Xu , KHAN, Mughees , TESLER, Alexander
IPC分类号： B81B1/00 , F15D1/00 , F15C1/06
CPC分类号： F16K99/0017 , F16K2099/0084
摘要： A gating mechanism that uses a capillary stabilized liquid as a reversible, reconfigurable gate that fills and seals pores in the closed state, and creates a non-fouling, liquid-lined pore in the open state is disclosed. Theoretical modeling and experiments demonstrate that for each transport substance, the gating threshold— the pressure needed to open the pores— can be rationally tuned over a wide pressure range. This enables realizing in one system differential response profiles for a variety of liquids and gases, even letting liquids flow through the pore while preventing gas from escaping. These capabilities allow dynamic modulation of gas- liquid sorting and to separate multi-phase mixtures, with the liquid lining ensuring sustained antifouling behavior. Because the liquid gating strategy enables efficient short-term and long- term operation and can be applied to a variety of pore structures and membrane materials, and to nano, micro as well as macroscale fluid systems, the gating systems is useful in a wide range of applications.
摘要翻译：公开了一种门控机构，其使用毛细管稳定的液体作为在闭合状态下填充和密封孔隙的可逆的可重新配置的门，并且在打开状态下产生非结垢的液态衬里孔。理论建模和实验表明，对于每种运输物质，门控阈值 - 打开孔隙所需的压力 - 可以在较宽的压力范围内合理调整。这使得能够在一个系统中实现各种液体和气体的差异响应曲线，甚至使液体流过孔，同时防止气体逸出。这些功能允许气液分选的动态调节和分离多相混合物，液体衬里确保持续的防污行为。由于液体浇注策略能够有效的短期和长期运行，并且可以应用于各种孔结构和膜材料，以及纳米，微观以及宏观流体系统，门控系统在广泛范围内有用的应用程序。

7. 发明申请

WO2007008609A3 METHODS AND APPARATUS FOR CELL CULTURE ARRAY 审中-公开
标题翻译：细胞培养基阵列的方法和装置
公开(公告)号：WO2007008609A3
公开(公告)日：2009-04-30
申请号：PCT/US2006026364
申请日：2006-07-06
申请人： UNIV CALIFORNIA , HUNG PAUL J , LEE PHILIP J , LEE LUKE P
发明人： HUNG PAUL J , LEE PHILIP J , LEE LUKE P
IPC分类号： C12M1/00 , B01L3/00 , B28B5/00 , B29C33/40 , C12M3/00 , F15C1/06
CPC分类号： C12M23/16 , B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L3/502761 , B01L2200/027 , B01L2200/0647 , B01L2200/0689 , B01L2300/0627 , B01L2300/0816 , B01L2400/0487 , B01L2400/086 , B01L2400/088 , C12M21/08 , C12M23/34 , C12M29/06 , C12M29/10 , C12M41/46 , C12N5/0602
摘要： Method and systems that provide improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic systems and microfluidic culture arrays.
摘要翻译：在微流体系统和微流体培养阵列中提供改进的处理和/或培养和/或测定细胞，化学活性珠或类似材料的方法和系统。

8. 发明申请

WO2007009125A3 MICROFLUIDIC DEVICES AND METHODS OF PREPARING AND USING THE SAME 审中-公开
公开(公告)号：WO2007009125A3
公开(公告)日：2007-01-18
申请号：PCT/US2006/027806
申请日：2006-07-14
申请人： NANO-DITECH CORPORATION
发明人： KIM, Young, Hoon , SON, Muntak
IPC分类号： G01N1/10 , B01L3/02 , F15C1/06
摘要： Microfluidic devices include a photoresist layer in which an inlet chamber, an optional reaction chamber and at least one detection chamber are in fluid contact, a support arranged under the photoresist layer and a cover arranged above the photoresist layer. The devices further include a set of absorbent channels downstream of the last detection chamber. Biogenic or immunoreactive substances are placed in the reaction chamber and detection chamber(s). When a liquid sample is dropped into the inlet chamber, the sample liquid is drawn through the devices by capillary action. Detection methods include electrochemical detection, colorimetric detection and fluorescence detection.

9. 发明申请

WO2004034436A3 METHOD FOR INTERFACING MACROSCALE COMPONENTS TO MICROSCALE DEVICES 审中-公开
标题翻译：用于将微孔组件接合到微结构设备的方法
公开(公告)号：WO2004034436A3
公开(公告)日：2005-03-31
申请号：PCT/US0332151
申请日：2003-10-08
申请人： CELLECTRICON AB , KARLSSON MATTIAS , ORWAR OWE , CHIU DANIEL T
发明人： KARLSSON MATTIAS , ORWAR OWE , CHIU DANIEL T
IPC分类号： B01J19/00 , B01L3/00 , B01L9/00 , F15C1/06 , C09J7/02
CPC分类号： B01J19/0093 , B01J2219/0081 , B01J2219/00891 , B01J2219/0093 , B01J2219/00952 , B01L3/5025 , B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0487
摘要： The invention provides integrated systems comprising macroscale devices interfaced with microscale devices and methods for making these systems.
摘要翻译：本发明提供了包括与微型装置接口的宏观装置和用于制造这些系统的方法的集成系统。

10. 发明申请

WO2005010377A1 MICROFLUIDICS CHIPS AND METHODS OF USING SAME 审中-公开
标题翻译：微流感胶囊及其使用方法
公开(公告)号：WO2005010377A1
公开(公告)日：2005-02-03
申请号：PCT/SG2004/000224
申请日：2004-07-29
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NATIONAL UNIVERSITY OF SINGAPORE , SAMPER, Victor , CONG, Lin , JI, Hongmiao
发明人： SAMPER, Victor , CONG, Lin , JI, Hongmiao
IPC分类号： F15C1/06
CPC分类号： B81C3/001 , B01L3/502707 , B01L2200/0689 , B01L2200/12 , B01L2200/141 , B01L2300/0887 , B01L2300/1827 , B81B2201/058 , Y10T137/2196 , Y10T156/10
摘要： Microfluidics chips and methods of use are described, comprising a pair of wafers (102, 108), at least one having a patterned surface (108), and two polymeric barrier films (104, 106) between the wafers conforming to the patterned surface. The polymeric barrier films allow the wafers of the inventive microfluidics chips to be reused without cleaning.
摘要翻译：描述了微流体芯片和使用方法，其包括一对晶片（102,108），至少一个晶片（102,108），其具有图案化表面（108），以及两个聚合物阻挡膜（104,106），其在符合图案化表面的晶片之间。聚合物阻挡膜允许本发明的微流体芯片的晶片在不进行清洁的情况下重复使用。

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