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1. 发明申请

WO0137629A3 HIGH SURFACE MICROPOROUS MATERIALS WHICH ARE ACTIVE IN OXIDATION REACTIONS. TIQ-6 AND METIQ-6 审中-公开
标题翻译：在氧化反应中活性高的高表面微孔材料。 TIQ-6和METIQ-6
公开(公告)号：WO0137629A3
公开(公告)日：2002-03-14
申请号：PCT/ES0000456
申请日：2000-11-24
申请人： CONSEJO SUPERIOR INVESTIGACION , UNIV VALENCIA POLITECNICA , CORMA CANOS AVELINO , FORNES SEGUI VICENTE , DIAZ MORALES URBANO , DOMINE MARCELO EDUARDO
发明人： CORMA CANOS AVELINO , FORNES SEGUI VICENTE , DIAZ MORALES URBANO , DOMINE MARCELO EDUARDO
IPC分类号： B01J29/89 , B01J31/02 , B01J35/10 , B01J37/00 , C01B37/00 , C01B39/00 , C01B39/08 , C01B39/46 , C01B39/48 , C07B41/02 , C07B41/06 , C07B41/08 , C07B43/00 , C07B45/04 , C07B61/00 , C07C37/08 , C07C39/02 , C07C45/29 , C07C47/02 , C07C49/04 , C07C51/23 , C07C53/08 , C07C315/00 , C07C317/02 , C07D301/12 , C07D487/22
CPC分类号： B01J31/0231 , B01J29/89 , B01J31/0212 , B01J31/0274 , B01J31/0275 , B01J31/38 , B01J2231/72 , C01B37/005 , C01B39/085 , C01B39/48 , C07B41/02 , C07B41/06 , C07B41/08 , C07B43/00 , C07B45/04 , C07D301/12 , Y10S423/23
摘要： The invention relates to a microporous material formed by oxygen, silicon, germanium, aluminum, boron, gallium, zirconium and/or titanium known as TIQ-6, to a method for preparing said material and to its applications as catalyst in oxidation reactions. The TIQ-6 preparation method is based on the synthesis of a gel containing titanium and/or zirconium, hydrothermal treatment thereof under controlled conditions and treatment of the resulting laminar material with an organic compound solution, preferably having a long hydrocarbonated chain containing a proton accepting group. This swollen material is subjected to a specific treatment involving agitation, ultrasound or any other method known in prior art with the purpose of obtaining a delaminated solid with a high outer surface. The invention also relates to a material having similar characteristics as that of TIQ-6 but additionally having organic groups anchored on the surface thereof and called METIQ-6, to a method for preparing the latter and to the utilization thereof as catalyst in oxidation reactions. The incorporation of organic species during synthesis of the material called METIQ-6 is carried out by means of a post-synthesis process on the TIQ-6 material.
摘要翻译：本发明涉及一种由氧，硅，锗，铝，硼，镓，锆和/或钛称为TIQ-6形成的微孔材料，用于制备所述材料的方法及其在氧化反应中作为催化剂的应用。 TIQ-6制备方法是基于合成含有钛和/或锆的凝胶，在受控条件下进行水热处理，并用有机化合物溶液处理得到的层状材料，优选具有含有质子接受的长烃链组。该溶胀材料经受涉及搅拌，超声波或现有技术中已知的任何其它方法的具体处理，目的是获得具有高外表面的分层固体。本发明还涉及具有与TIQ-6类似的特征的材料，但另外具有锚固在其表面上的称为METIQ-6的有机基团，其制备方法和在氧化反应中用作催化剂的方法。在称为METIQ-6的材料的合成期间掺入有机物质是通过对TIQ-6材料的后合成方法进行的。

2. 发明申请

WO02044140A1 PRACTICAL AND EFFICIENT SYNTHETIC METHOD OF RETINOIC ACID AND ITS DERIVATIVES 审中-公开
标题翻译：杀真菌及其衍生物的实用有效合成方法
公开(公告)号：WO02044140A1
公开(公告)日：2002-06-06
申请号：PCT/KR2001/002078
申请日：2001-12-01
IPC分类号： C07C317/02 , C07C315/02 , C07C315/04 , C07C317/06 , C07C317/14 , C07C317/44 , C07C319/20 , C07C323/65 , C07D311/72
CPC分类号： C07C403/20 , C07C403/08 , C07C403/22 , C07C2601/16 , C07D311/72
摘要： The present invention provides allylic disulfone of Chemical Formula 1, an important intermediate which can be used for syntheses of retinoids and carotenoids, a process for preparing the same, and a process for preparing retinoid compounds by using the said intermediate, and, in particular, a process for preparing retinoic acid of Chemical Formula 2 and alkyl retinoate of Chemical Formula 3. The process for preparing allylic disulfone compound of Chemical Formula 1 employs cyclo-geranyl sulfone, which reacts with C5 haloallylic sulfide to give rise to the chain-extended C15 thio-sulfone compound. The thio-sulfone compound is selectively oxidized to give allylic disulfone of Chemical Formula 1. The C15 disulfone compound reacts with C5 halo-acid or C5 halo-ester under the condition using excess base, which induces coupling and subsequent desulfonation reactions to give retinoic acid of Chemical Formula 2 or alkyl retinoate of Chemical Formula 3.
摘要翻译：本发明提供了化学式1的烯丙基二砜，其可用于合成类视色素和类胡萝卜素的重要中间体，其制备方法和通过使用所述中间体制备类视色素化合物的方法，特别是，制备化学式2的视黄酸和化学式3的视黄酸的方法。化学式1的烯丙基二砜化合物的制备方法使用环芴基砜，其与C 5卤代硫代硫酸反应产生链延长的C15 硫代砜化合物。硫代砜化合物被选择性氧化，得到化学式1的烯丙基二砜.C15二砜化合物在使用过量碱的条件下与C5卤代酸或C5卤代酯反应，引起偶联和随后的脱磺化反应，得到视黄酸的化学式2或化学式3的视黄酸烷基酯。

3. 发明申请

WO01037629A2 HIGH SURFACE MICROPOROUS MATERIALS WHICH ARE ACTIVE IN OXIDATION REACTIONS. TIQ-6 AND METIQ-6 审中-公开
标题翻译：在氧化反应中活性高的高表面微孔材料。 TIQ-6和METIQ-6
公开(公告)号：WO01037629A2
公开(公告)日：2001-05-31
申请号：PCT/ES2000/000456
申请日：2000-11-24
IPC分类号： B01J29/89 , B01J31/02 , B01J35/10 , B01J37/00 , C01B37/00 , C01B39/00 , C01B39/08 , C01B39/46 , C01B39/48 , C07B41/02 , C07B41/06 , C07B41/08 , C07B43/00 , C07B45/04 , C07B61/00 , C07C37/08 , C07C39/02 , C07C45/29 , C07C47/02 , C07C49/04 , C07C51/23 , C07C53/08 , C07C315/00 , C07C317/02 , C07D301/12 , C07D487/22
CPC分类号： B01J31/0231 , B01J29/89 , B01J31/0212 , B01J31/0274 , B01J31/0275 , B01J31/38 , B01J2231/72 , C01B37/005 , C01B39/085 , C01B39/48 , C07B41/02 , C07B41/06 , C07B41/08 , C07B43/00 , C07B45/04 , C07D301/12 , Y10S423/23
摘要： The invention relates to a microporous material formed by oxygen, silicon, germanium, aluminum, boron, gallium, zirconium and/or titanium known as TIQ-6, to a method for preparing said material and to its applications as catalyst in oxidation reactions. The TIQ-6 preparation method is based on the synthesis of a gel containing titanium and/or zirconium, hydrothermal treatment thereof under controlled conditions and treatment of the resulting laminar material with an organic compound solution, preferably having a long hydrocarbonated chain containing a proton accepting group. This swollen material is subjected to a specific treatment involving agitation, ultrasound or any other method known in prior art with the purpose of obtaining a delaminated solid with a high outer surface. The invention also relates to a material having similar characteristics as that of TIQ-6 but additionally having organic groups anchored on the surface thereof and called METIQ-6, to a method for preparing the latter and to the utilization thereof as catalyst in oxidation reactions. The incorporation of organic species during synthesis of the material called METIQ-6 is carried out by means of a post-synthesis process on the TIQ-6 material.
摘要翻译：本发明涉及一种由氧，硅，锗，铝，硼，镓，锆和/或钛称为TIQ-6形成的微孔材料，用于制备所述材料的方法及其在氧化反应中作为催化剂的应用。 TIQ-6制备方法是基于合成含有钛和/或锆的凝胶，在受控条件下进行水热处理，并用有机化合物溶液处理所得的层状材料，优选具有含有质子接受的长烃链组。该溶胀材料经受涉及搅拌，超声波或现有技术中已知的任何其它方法的具体处理，目的是获得具有高外表面的分层固体。本发明还涉及具有与TIQ-6类似的特征的材料，但另外具有锚固在其表面上的称为METIQ-6的有机基团，其制备方法和用作氧化反应中的催化剂的方法。在称为METIQ-6的材料的合成期间掺入有机物质是通过对TIQ-6材料的后合成方法进行的。

4. 发明申请

WO2021067799A1 METHODS AND MATERIALS FOR MODULATING NRF2 PATHWAY 审中-公开
公开(公告)号：WO2021067799A1
公开(公告)日：2021-04-08
申请号：PCT/US2020/054062
申请日：2020-10-02
申请人： THE GENERAL HOSPITAL CORPORATION , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： TANNOUS, Bakhos , BADR, Christian , MAZITSCHEK, Ralph , PAYNE, Neil Connor
IPC分类号： A61K31/10 , C07C317/02 , A61P35/00
摘要： The present application provides methods and compounds of modulating Nrf2 pathway. Methods for treating cancer and neurodegenerative conditions are also provided.

5. 发明申请

WO2016196591A1 PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF 审中-公开
标题翻译：蛋白酪氨酸磷酸酶或SHP2抑制剂及其用途
公开(公告)号：WO2016196591A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035212
申请日：2016-06-01
申请人： INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION
发明人： ZHANG, Zhong-Yin , HE, Rongjun
IPC分类号： A61K8/44 , A61K31/095 , A61K31/10 , C07C317/02 , C07C317/08 , C07C317/18
CPC分类号： C07C309/24 , A61K45/06 , A61P3/10 , A61P25/28 , A61P31/06 , A61P35/00 , A61P35/02 , C07C309/17 , C07C309/18 , C07D211/16 , C07D211/18 , C07D215/08 , C07D215/38 , C07D231/40 , C07D233/61 , C07D233/64 , C07D235/10 , C07D235/14 , C07D277/46 , C07D277/82 , C07D285/135 , C07D295/135 , C07D307/68 , C07D333/20
摘要： Small molecule compounds derived from α-sulfophenylacetic amide (SPAA) are provided as novel sulfonic acid based pTyr mimetics. These compounds effectively inhibit a variety of protein tyrosine phosphatases (PTPs), such as mPTPA, mPTPB, LMWPTP, and Laforin. Use of these compounds as pharmaceutical agents for treating diseases associated with abnormal protein tyrosine phosphatase activity is also provided.
摘要翻译：提供衍生自α-磺基苯基乙酰胺（SPAA）的小分子化合物作为新的基于磺酸的pTyr模拟物。这些化合物有效抑制多种蛋白酪氨酸磷酸酶（PTPs），如mPTPA，mPTPB，LMWPTP和Laforin。还提供了这些化合物作为药物用于治疗与异常蛋白酪氨酸磷酸酶活性相关的疾病的用途。

6. 发明申请

WO9403149A3 LIPID-SOLUBLE THIOETHERS AND DITHIOETHERS IN COSMETIC PREPARATIONS TO COUNTERACT AGING OF THE HUMAN SKIN 审中-公开
标题翻译：化学制剂中的可溶性硫酸酯和脱水剂对人皮肤的反应老化
公开(公告)号：WO9403149A3
公开(公告)日：1994-06-23
申请号：PCT/CH9300187
申请日：1993-07-26
申请人： BEIERSDORF AG
发明人： HOLZNER GUENTER WOLFGANG
IPC分类号： A61K8/00 , A61K8/46 , A61K31/10 , A61K31/145 , A61K31/16 , A61K31/19 , A61K31/22 , A61K31/265 , A61K31/795 , A61P17/00 , A61Q19/00 , A61Q19/08 , C07C317/02 , C07C317/14 , C07C321/04 , C07C321/24 , C07C333/30 , A61K7/48
CPC分类号： A61K8/46 , A61K31/10 , A61K31/145 , A61K31/16 , A61K31/22 , A61K31/795 , A61Q19/08
摘要： Aging of the human skin is caused primarily by the biochemical action of free radicals, peroxides and derived products. Lipid-soluble thioethers and dithioethers in cosmetic preparations inactivate the peroxides formed in the skin and thereby retard manifestations of aging.

7. 发明申请

WO2023003882A2 COMPOUNDS HAVING SELECTIVE INACTIVATION ACTIVITY 审中-公开
公开(公告)号：WO2023003882A2
公开(公告)日：2023-01-26
申请号：PCT/US2022/037601
申请日：2022-07-19
申请人： UNIVERSITY OF NORTH CAROLINA AT WILMINGTON , THE UNIVERSITY OF TOLEDO
发明人： HALKIDES, Christopher John , VIOLA, Ronald E.
IPC分类号： C07C303/04 , A61K31/10 , C07C309/04 , C07C303/02 , C07C309/02 , C07C309/23 , C07C317/02 , C07C317/14 , C07C317/18 , C07C317/40 , C07C317/44 , C07C317/48
摘要： In one aspect, compounds and associated pharmaceutical compositions are described herein for the treatment of various fungal infections and/or other diseases. In some embodiments, for example, compounds of Formula (I) are described herein.

8. 发明申请

WO2020011750A1 FUNGICIDES TO PREVENT AND CONTROL FUNGAL PATHOGENS 审中-公开
公开(公告)号：WO2020011750A1
公开(公告)日：2020-01-16
申请号：PCT/EP2019/068336
申请日：2019-07-09
申请人： UNIVERSITÉ DE LAUSANNE
发明人： DUBEY, Olga , FARMER, Edward , NAWRATH, Christiane , GINDRO, Katia , SCHNEE, Sylvain , DUBEY, Sylvain
IPC分类号： A01N47/40 , A01N47/46 , A61K31/26 , A01P3/00 , C07C317/02
摘要： The invention relates to the field of biological fungicides with a broad range of antifungal activity coming from plant extracts from the order of Brassicales or molecules revealing similar chemical structure. In particular, Applicants surprisingly provided a new usage of a combination of sulfonyl and sulfinyl containing aliphatic glucosinolates, their by-products and synthetic analogues as efficient antifungal compounds with broad spectrum of activity.

9. 发明申请

WO02028828A1 SUBSTITUTED (E)-STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗增殖性疾病的替代（E） - 氨苄青霉素
公开(公告)号：WO02028828A1
公开(公告)日：2002-04-11
申请号：PCT/US2001/031337
申请日：2001-10-05
IPC分类号： A61P9/10 , A61K31/04 , A61K31/10 , A61K31/136 , A61P35/00 , A61P37/06 , C07C317/10 , C07C317/18 , C07C317/28 , C07C317/00 , C07C317/02
CPC分类号： C07C317/18 , A61K31/10 , C07C317/10 , C07C317/28
摘要： (E)-Styryl benzylsulfones useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: R1 is selected from the group consisting of halogen, C1-C6 alkoxy, nitro, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); and R2 and R3 are independently selected from the group consisting of halogen, C1-C6 alkoxy, C1-C6 alkyl, nitro, cyano, hydroxy, phosphonato, amino, sulfamyl, carboxy, acetoxy, and dimethylamino (C2-C6 alkoxy); provided: R1 may not be halogen when R2 and R3 are both halogen; R2 may not be 2-halogen when R3 is 4-halogen; or a pharmaceutically acceptable salt thereof; or formula II: whrein: R4 is selected from the group consisting of C1-C6 alkoxy, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); R6 is selected from the group consisting of nitro, hydrogen, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2-C6 alkoxy); and R7 is selected from the group consisting of halogen, C1-C6 alkoxy, C1-C6 alkyl, nitro, cyano, hydroxy, phosphonato, amino, sulfamyl, carboxy, acetoxy, dimethylamino (C2-C6 alkoxy) and trifluoromethyl; provided R5 and R6 may not be hydrogen in the same compound; or a pharmaceutically acceptable salt thereof.
摘要翻译：（E）根据式I提供了可用作抗增殖剂的抗增生剂的酪氨酸苄基砜：其中：R 1选自卤素，C 1 -C 6烷氧基，硝基，膦酰基，氨基，亚磺酰基，羧基，乙酰氧基和二甲基氨基（C 2 -C 6烷氧基）; R 2和R 3独立地选自卤素，C 1 -C 6烷氧基，C 1 -C 6烷基，硝基，氰基，羟基，膦酰基，氨基，氨基磺酰基，羧基，乙酰氧基和二甲基氨基（C 2 -C 6烷氧基）。条件是：当R 2和R 3都是卤素时，R 1可以不是卤素; 当R3为4-卤素时，R2不为2-卤素; 或其药学上可接受的盐; 或者式II：其中R 4选自C 1 -C 6烷氧基，膦酰基，氨基，氨基磺酰基，羧基，乙酰氧基和二甲基氨基（C 2 -C 6烷氧基）。 R 6选自硝基，氢，膦酰基，氨基，氨基磺酰基，羧基，乙酰氧基和二甲基氨基（C 2 -C 6烷氧基）; 氰基，羟基，膦酰基，氨基，氨基磺酰基，羧基，乙酰氧基，二甲基氨基（C 2 -C 6烷氧基）和三氟甲基; R 7选自卤素，C 1 -C 6烷氧基，C 1 -C 6烷基，条件是R5和R6可能不是同一化合物中的氢; 或其药学上可接受的盐。

10. 发明申请

WO2014080251A1 HYDROPHILIC LINKERS AND THEIR USES FOR CONJUGATION OF DRUGS TO CELL BINDING MOLECULES 审中-公开
标题翻译：亲水连接剂及其与细胞结合分子结合的用途
公开(公告)号：WO2014080251A1
公开(公告)日：2014-05-30
申请号：PCT/IB2012/056700
申请日：2012-11-24
申请人： HANGZHOU DAC BIOTECH CO., LTD. , ZHAO, R. Yongxin
发明人： ZHAO, R. Yongxin
IPC分类号： C07C317/02 , C07C317/06 , C07F9/30 , A61K31/10 , A61K31/662 , A61K47/48 , A61K49/00 , A61P31/00 , A61P35/00 , A61P37/00
CPC分类号： A61K47/48715 , A61K31/10 , A61K31/454 , A61K31/662 , A61K47/6889 , C07D207/46 , C07D401/12 , C07F9/301 , C07F9/302 , C07F9/3235 , C07F9/5721 , C07F9/582 , C07F9/65583 , C07F9/6561 , Y02A50/402 , Y02A50/409 , Y02A50/415 , Y02A50/463 , Y02A50/469 , Y02A50/48
摘要： Cell binding agent-drug conjugates comprising hydrophilic linkers, and methods of using such linkers and conjugates are provided.
摘要翻译：提供了包含亲水接头的细胞结合剂 - 药物共轭物，以及使用这些接头和缀合物的方法。

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