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1. 发明申请

WO2022048715A1 LUER-SÄULE 审中-公开
公开(公告)号：WO2022048715A1
公开(公告)日：2022-03-10
申请号：PCT/DE2021/200112
申请日：2021-08-17
申请人： ELBATRON GMBH
发明人： HERRMANN, Rainer
IPC分类号： A61M39/10 , B01D15/22 , A61M5/31 , B01L3/00
摘要： Die Erfindung betrifft eine Luer-Säule (2, 34) mit einem Einlassende (6), einem davon beabstandeten Auslassabschnitt (8) und einem sich von dem Einlassende (6) zu dem Auslassabschnitt (8) erstreckenden Gehäusemantel (4), wobei sich der Auslassabschnitt (8) in eine von dem Einlassende (6) abgewandte Richtung erstreckt und an einem distalen Ende (16) einen männlichen Luer-Kegel (18) ausbildet, wobei ein Übergangsbereich zwischen dem Luer-Kegel (18) und dem Gehäusemantel (4) einen abgestuften Durchmesser mit mindestens einer Durchmesserstufe (20, 22) mit jeweils einer radialen Ringfläche (24, 26) aufweist.

2. 发明申请

WO2021255266A1 APPARATUS COMPRISING A GUARD COLUMN 审中-公开
公开(公告)号：WO2021255266A1
公开(公告)日：2021-12-23
申请号：PCT/EP2021/066673
申请日：2021-06-18
申请人： UNIVERSITEIT LEIDEN
发明人： HARMS, Amy C. , HANKEMEIER, Thomas , VAN DER LAAN, Tom
IPC分类号： B01D15/12 , B01D15/22 , G01N30/08 , G01N30/60 , G01N30/46 , B01D15/125 , B01D15/325 , B01D15/362 , B01D15/363 , G01N2030/085 , G01N30/468
摘要： A chromatography analysis apparatus (30) comprises: a fractionation device (32) for receiving a sample, the fractionation device (32) defining a sample flow path that includes a guard column; and a fractionation output analyser (34), wherein a fractionation output of the guard column is provided to an input of the fractionation output analyser (34) for enabling subsequent analysis of the fractionation output by the fractionation output analyser (34).

3. 发明申请

WO2021108914A1 MODIFIED COLUMN FOR EXPANDED BED ADSORPTION AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2021108914A1
公开(公告)日：2021-06-10
申请号：PCT/CA2020/051663
申请日：2020-12-04
申请人： EVOLVE BIOLOGICS INC.
发明人： MILLER, David , VANDERLEE, Gillian , BEG, Hrvoje , HOLNESS, Aryn
IPC分类号： B01D15/22 , B01D15/12
摘要： The present disclosure provides chromatography columns and methods of chromatographic separation using the same. In particular, the disclosure provides modified columns where the cross-sectional area of the column increases in an area near the end of the column in a flared manner. The modified columns can be used in Expanded Bed Absorption (EBA) systems.

4. 发明申请

WO2021089274A1 GRID-LIKE SYMMETRICAL DISTRIBUTOR OR COLLECTOR ELEMENT 审中-公开
公开(公告)号：WO2021089274A1
公开(公告)日：2021-05-14
申请号：PCT/EP2020/078522
申请日：2020-10-10
申请人： HIRSCHBERG ENGINEERING AG
发明人： HIRSCHBERG, Sebastian
IPC分类号： B01J8/02 , B01J4/00 , B01D3/00 , B01D15/22 , B01F15/02
摘要： The present invention relates to a distributor element for uniformly distributing a first fluid on a cross-sectional plane or collector element for collecting a first fluid being distributed on a cross-sectional plane, wherein a second main fluid flows in co-current flow and/or in counter-current flow with regard to the first fluid through the distributor element, wherein the distributor element comprises at least three plates being arranged at least substantially parallel to each, wherein a level is defined between each of two adjacent plates, wherein each of the plates comprises a number of openings, wherein in each of the levels walls are arranged, each of which extending from one side of a plate onto the adjacent side of an adjacent plate such that each wall defines a channel to be flowed through by the second main fluid, wherein the channels fluid-tightly connect all openings between adjacent plates, wherein in each of the levels between the walls defining the channels one or more hollow spaces are formed, through which the first fluid may flow, wherein each of the plates comprises at least one aperture not being fluid-tightly connected with one or more openings of an adjacent plate by a channel and being arranged adjacent to one of the one or more hollow spaces of the adjacent level(s) so that in each level between the apertures of the adjacent plates at least two fluid paths extend in the one or more hollow spaces of the level, wherein all of the at least two fluid paths of each level have substantially the same length, and wherein the number of fluid paths increases, seen in the direction from one outermost plate to the opposite outermost plate, at least for 75% of the plates from level to level.

5. 发明申请

WO2020092755A2 PACKED INCOMPRESSIBLE CHROMATOGRAPHY RESINS AND METHODS OF MAKING THE SAME 审中-公开
公开(公告)号：WO2020092755A2
公开(公告)日：2020-05-07
申请号：PCT/US2019/059141
申请日：2019-10-31
申请人： REPLIGEN CORPORATION
发明人： PEYSER, James Ronald , CHAN, Alan Kit Ho
IPC分类号： B01D15/22
摘要： This disclosure provides chromatography columns that are packed with incompressible media such as ceramic hydroxyapatite particles, which exhibit high separation performance that is robust to transportation and multiple uses. The columns can be made by applying axial compression using rigid bodies, such as porous frits and/or flow regulators.

6. 发明申请

WO2019073124A1 PROCEDE DE CHROMATOGRAPHIE 审中-公开
公开(公告)号：WO2019073124A1
公开(公告)日：2019-04-18
申请号：PCT/FR2017/000192
申请日：2017-10-12
申请人： PARMENTIER, François
发明人： PARMENTIER, François
IPC分类号： B01D15/20 , B01D15/22 , G01N30/60 , B01D15/18
CPC分类号： B01D15/22 , B01D15/1821 , G01N30/6043 , G01N30/6078 , G01N2030/528 , G01N2030/567
摘要： Procédé d'échange de matière dans lequel on fait circuler une phase mobile gazeuse, liquide ou supercritique contenant des espèces à séparer au travers d'un garnissage comprenant une phase stationnaire, ledit procédé étant caractérisé en ce que : - le garnissage comporte une pluralité de conduits capillaires réalisés dans au moins un premier matériau, conduits traversant le garnissage entre une face dite amont par laquelle la phase mobile pénètre dans le garnissage et une face dite aval par laquelle la phase mobile sort du garnissage, -chaque conduit comporte sur au moins une partie de sa paroi intérieure au moins un second matériau constitué d'un gel organique. ou minéral poreux. - l'épaisseur dudit second matériau définit à l'intérieur du conduit au moins un canal tubulaire vide de matière solide et ouvert au passage de la phase mobile, ledit canal s'étendant continûment entre les faces amont et aval dudit conduit capillaire -le matériau secondaire présente une épaisseur comprise entre 0,0.5 fois et 0,5 fois le diamètre du canal -le procédé est conduit avec une vitesse de la phase mobile comprise entre 5,0 fois et 50 fois la vitesse de la phase mobile optimale définie par le minimum de la courbe de Van Deemter du composé à séparer majoritaire dans les conditions du procédé -le volume cumulé des conduits capillaires représente plus de 15% du volume total du garnissage

7. 发明申请

WO2018078106A1 HYDROPHOBICITY-BASED FLOW PREVENTION IN SAMPLE PREPARATION 审中-公开
标题翻译：样品制备过程中基于疏水性的流动预防
公开(公告)号：WO2018078106A1
公开(公告)日：2018-05-03
申请号：PCT/EP2017/077618
申请日：2017-10-27
申请人： PREOMICS GMBH
发明人： PICHLER, Garwin , KULAK, Nils A.
IPC分类号： B01D15/22 , G01N30/60 , G01N1/40
摘要： The present invention relates to a cartridge comprising or consisting of, from top to bottom, the following elements: (a) an inlet; (b) a top volume; (c) at least one optional layer made of a first material; (d) adjacent to (b) or, if present, to (c), at least one layer of chromatographic material; (e) adjacent to (d) at least one layer made of first material; and (f) an outlet; wherein said first material is hydrophobic and porous.
摘要翻译：本发明涉及一种盒，该盒从上到下包括或由以下元件组成：（a）入口; （b）最高音量; （c）至少一个由第一材料制成的可选层; （d）与（b）或如果存在的话相邻的（c）至少一层色谱材料; （e）与（d）至少一层由第一材料制成的层相邻; 和（f）出口; 其中所述第一材料是疏水的和多孔的。

8. 发明申请

WO2018022099A1 GAS CHROMATOGRAPH (GC) INLET LINER WITH PLUG OF BEADS 审中-公开
标题翻译：气相色谱（气相色谱）入口衬里，带有塞珠
公开(公告)号：WO2018022099A1
公开(公告)日：2018-02-01
申请号：PCT/US2016/044791
申请日：2016-07-29
申请人： AGILENT TECHNOLOGIES, INC.
发明人： FEENEY, Michael , SONG, Wei, J. , ZUK, Jonathan , FOLK, Albert, S.
IPC分类号： G01N30/60 , G01N30/02 , B01D15/22
CPC分类号： G01N30/60 , B01D15/22 , B01D53/02 , G01N30/02 , G01N30/12 , G01N30/16 , G01N2030/165
摘要： A liner for a gas chromatograph (GC) inlet includes a tube and a plug in the tube. The plug includes a plurality of closely packed spherical beads defining a plurality of tortuous fluid flow paths running through the plug. A sample and carrier gas may be flowed through the plug and into a GC column downstream from the liner. The liner, including the beads, may be heat to evaporate liquid droplets of the sample. The liner is compatible with use of a sample injection needle.
摘要翻译：用于气相色谱仪（GC）入口的衬套包括管和管中的塞子。塞子包括多个紧密填充的球形珠子，其限定了贯穿塞子的多个曲折的流体流动路径。样品和载气可以通过塞子流入衬管下游的GC柱。包括珠子的衬垫可以被加热以蒸发样品的液滴。衬里与使用样品注射针兼容。

9. 发明申请

WO2017223048A1 FUNCTIONALIZED POLYAMIDE STATIONARY PHASE FOR CHROMATOGRAPHY AND MICROWAVE ASSISTED FORMATION THEREOF 审中-公开
标题翻译：功能化的用于色谱和微波辅助生成的聚酰胺固定相
公开(公告)号：WO2017223048A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/038268
申请日：2017-06-20
申请人： CLEMSON UNIVERSITY RESEARCH FOUNDATION
发明人： MARCUS, R. Kenneth , JIANG, Liuwei
IPC分类号： B01D15/22 , B01D15/36 , B01D71/56 , B01J20/32 , G01N33/68
CPC分类号： B01D15/20 , B01D15/22 , B01D15/305 , B01D15/361 , B01D15/3804 , B01D63/02 , B01D67/0093 , B01D69/082 , B01D71/56 , B01D2323/38 , B01J20/264 , B01J20/28023 , B01J20/286 , B01J20/3078 , B01J20/3212 , B01J20/3278 , B01J20/328 , B01J39/26 , B01J41/20 , B01J47/127 , B01J2220/58 , G01N33/68
摘要： Chromatography devices and methods for forming and using the devices are described. The devices include a polyamide-based support phase and a polymer grafted to a surface of the polyamide-based support phase. A microwave-assisted graft polymerization protocol is described to form the polymer at the surface of the support phase. Devices can be utilized in high-efficiency separation of macromolecules such as proteins.
摘要翻译：描述了用于形成和使用该装置的色谱装置和方法。该装置包括聚酰胺基载体相和接枝到聚酰胺基载体相表面的聚合物。描述了微波辅助接枝聚合方案以在载体相的表面形成聚合物。设备可用于高效分离蛋白质等大分子。

10. 发明申请

WO2017176522A1 AFFINITY CHROMATOGRAPHY DEVICES 审中-公开
标题翻译：亲和色谱装置
公开(公告)号：WO2017176522A1
公开(公告)日：2017-10-12
申请号：PCT/US2017/024686
申请日：2017-03-29
申请人： W.L. GORE & ASSOCIATES, INC.
发明人： MCMANAWAY, Michael, C. , SWETLIN, Brian, J. , ZUKOR, Kenneth, S.
IPC分类号： B01D15/22 , B01D15/38 , B01D63/08 , B01D63/10 , G01N30/60 , B01J20/28 , B01J20/286
CPC分类号： B01D15/22 , B01D15/3809 , B01D63/082 , B01D63/10 , B01D67/0093 , B01D69/148 , B01D71/024 , B01D71/027 , B01D71/028 , B01D2319/04 , B01J20/048 , B01J20/103 , B01J20/18 , B01J20/28028 , B01J20/28035 , B01J20/286 , C07K1/22 , G01N30/6017 , G01N2030/527
摘要： The present invention is directed to affinity chromatography devices that separate a targeted protein or antibody from an aqueous mixture containing the targeted protein or antibody. The chromatography device may contain a stacked membrane assembly or a wound membrane assembly. The membrane assemblies' include (1) at least one polymer membrane that contains therein inorganic particles and (2) at least one impermeable layer ( e.g. , a thermoplastic polymer in a solid state). The polymer membrane and/or the inorganic particles have an affinity ligand bonded thereto. The affinity ligand may be a protein, an antibody, or a polysaccharide that reversibly binds to the targeted protein or antibody. The chromatography device may be repeatedly used and may be cleaned with a caustic solution between uses. The chromatography devices has a dynamic binding capacity (DBC) of at least 30 mg/ml (or 0.07 micromol/ml) at 10% breakthrough at a residence time of 20 seconds or less.
摘要翻译：本发明涉及从含有靶蛋白或抗体的含水混合物中分离靶蛋白或抗体的亲和层析装置。色谱装置可以包含堆叠的膜组件或卷绕的膜组件。膜组件包括（1）至少一个其中含有无机颗粒和（2）至少一个不可渗透层（例如，固态的热塑性聚合物）的聚合物膜。聚合物膜和/或无机粒子具有与其结合的亲和配体。亲和配体可以是可逆地结合靶蛋白或抗体的蛋白质，抗体或多糖。色谱装置可以重复使用并且可以在使用之间用苛性碱溶液清洗。层析装置在20秒或更短的停留时间时在10％穿透时具有至少30mg / ml（或0.07μmol/ ml）的动态结合能力（DBC）。

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