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1. 发明申请

WO2021228969A1 SAMPLE PREPARATION FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2021228969A1
公开(公告)日：2021-11-18
申请号：PCT/EP2021/062677
申请日：2021-05-12
申请人： PREOMICS GMBH
发明人： KULAK, Nils A. , HARTINGER, Katrin , KÄSEMANN, Martin , JOHANSSON, Sebastian , WÄCHTER, Jasmin
IPC分类号： G01N33/68
摘要： The present invention provides a method of preparing a sample for an analytic procedure, said sample comprising at least one protein, polypeptide or peptide molecule, and said method comprising fragmenting said molecule using at least one moving magnetic body.

2. 发明申请

WO2021228971A1 MAGNETIC CLEAVAGE OF COMPOUNDS 审中-公开
公开(公告)号：WO2021228971A1
公开(公告)日：2021-11-18
申请号：PCT/EP2021/062681
申请日：2021-05-12
申请人： PREOMICS GMBH
发明人： KULAK, Nils A. , HARTINGER, Katrin , KÄSEMANN, Martin , JOHANSSON, Sebastian , WÄCHTER, Jasmin
IPC分类号： C12M1/00 , C12N13/00
摘要： This invention provides a method of cleaving at least one covalent bond in at least one molecule, wherein said method comprises (a) colliding at least one magnetic body with said at least one molecule; and/or (b) triggering collision of at least one non- magnetic particle with said at least one molecule by moving said at least one magnetic body. In embodiments, the molecule is in suspension or solution and (a) the solution or suspension is a liquid sample such as a buffer or a bodily fluid, and the molecule is a nucleic acid; (b) the solution or suspension is drinking water or pool water, and the molecule is a macromolecular contamination; (c) the solution or suspension is sewage, and the molecule is a biological macromolecule; (d) the solution or suspension is food or beverage, and the molecule is gluten; (e) the solution or suspension comprises a protein, polypeptide and/or peptide, proteinaceous raw material for growth media and/or proteinaceous raw material for a personal care product such as a shampoo, a conditioner or soap, and the molecule is said or a protein, polypeptide and/or peptide; (f) the solution or suspension comprises a macromolecular toxin, and the molecule is said macromolecular toxin; or (g) the solution or suspension comprises undesired enzymatic activity, and the molecule is the protein exhibiting said enzymatic activity.

3. 发明申请

WO2018078106A1 HYDROPHOBICITY-BASED FLOW PREVENTION IN SAMPLE PREPARATION 审中-公开
标题翻译：样品制备过程中基于疏水性的流动预防
公开(公告)号：WO2018078106A1
公开(公告)日：2018-05-03
申请号：PCT/EP2017/077618
申请日：2017-10-27
申请人： PREOMICS GMBH
发明人： PICHLER, Garwin , KULAK, Nils A.
IPC分类号： B01D15/22 , G01N30/60 , G01N1/40
摘要： The present invention relates to a cartridge comprising or consisting of, from top to bottom, the following elements: (a) an inlet; (b) a top volume; (c) at least one optional layer made of a first material; (d) adjacent to (b) or, if present, to (c), at least one layer of chromatographic material; (e) adjacent to (d) at least one layer made of first material; and (f) an outlet; wherein said first material is hydrophobic and porous.
摘要翻译：本发明涉及一种盒，该盒从上到下包括或由以下元件组成：（a）入口; （b）最高音量; （c）至少一个由第一材料制成的可选层; （d）与（b）或如果存在的话相邻的（c）至少一层色谱材料; （e）与（d）至少一层由第一材料制成的层相邻; 和（f）出口; 其中所述第一材料是疏水的和多孔的。

4. 发明申请

WO2022180062A1 SEEDED PRECIPITATION OF POLYPEPTIDES 审中-公开
公开(公告)号：WO2022180062A1
公开(公告)日：2022-09-01
申请号：PCT/EP2022/054454
申请日：2022-02-22
申请人： PREOMICS GMBH
发明人： KULAK, Nils A. , JOHANSSON, Sebastian H. , HARTINGER, Katrin
IPC分类号： C07K1/30 , G01N33/68
摘要： The present invention relates to a method of processing or fractionating a sample comprising proteins, polypeptides and/or peptides, said method comprising (a) changing the physicochemical conditions of said sample; and (b) performing one or both of the following (i) and (ii): (i) adding solid particulate matter to said sample; and (ii) performing said method in a vessel with a rough surface; wherein steps (a) and (b) can be effected concomitantly or in any order; and wherein said processing or fractionating yields one or more first fractions of proteins, polypeptides and/or peptides as a precipitate on said particulate matter and/or said inhomogeneous surface, and a second fraction of proteins, polypeptides and/or peptides remaining in a supernatant.

5. 发明申请

WO2021249718A1 DISPERSION USING A MOVING MAGNET 审中-公开
公开(公告)号：WO2021249718A1
公开(公告)日：2021-12-16
申请号：PCT/EP2021/062680
申请日：2021-05-12
申请人： PREOMICS GMBH
发明人： KULAK, Nils A. , HARTINGER, Katrin , KÄSEMANN, Martin , JOHANSSON, Sebastian , WÄCHTER, Jasmin
IPC分类号： G01N33/543 , G01N33/54326 , G01N33/54366 , G01N33/54393
摘要： This invention relates to a method of dispersing magnetic particles, said method comprising or consisting of: (a) in a vessel, combining at least one permanent magnet and said magnetic particles in a liquid phase; and (b) triggering a fluctuating or oscillating motion of said permanent magnet using a magnetic field; thereby dispersing said particles.

6. 发明申请

WO2021204495A1 PRE-FRACTIONATION FOR MASS SPECTROMETRIC ANALYSIS 审中-公开
公开(公告)号：WO2021204495A1
公开(公告)日：2021-10-14
申请号：PCT/EP2021/056422
申请日：2021-03-12
申请人： PREOMICS GMBH
发明人： JOHANSSON, Sebastian H. , KULAK, Nils A.
IPC分类号： G01N30/34
摘要： The present invention relates to a method of fractionating a variety of analytes bound to a matrix, said method comprising: (a) eluting said analytes with a plurality of eluents, wherein a first elution step is effected with an elution buffer comprising a first numbered eluent, and a subsequent (n-th) elution step is effected with an elution buffer comprising an n-th numbered eluent, wherein said n-th numbered eluent has a lower dipole moment and/or a higher hydrophobicity than said first numbered eluent.

7. 发明申请

WO2023285692A1 MEANS AND METHODS OF OPERATING DEVICES WITH MULTIPLE MAGNETS 审中-公开
公开(公告)号：WO2023285692A1
公开(公告)日：2023-01-19
申请号：PCT/EP2022/069945
申请日：2022-07-15
申请人： PREOMICS GMBH
发明人： KÄSEMANN, Martin , KULAK, Nils A.
IPC分类号： B01L3/00 , B01F33/452 , B01F33/81 , B01F35/21 , B01F35/212 , B01F35/22
摘要： The present invention relates to a method of operating a device, said device comprising an array of vessels, one or more coils in sufficient proximity of at least two of said vessels such that an electric current flowing through said coil(s) exposes the interior of said vessels to a magnetic field, said at least two vessels each containing at least one first permanent magnet, and a power source connected to said coil(s), said method comprising: (a) delivering a fluctuating or oscillating electric current to said coil(s) to trigger movement of the first permanent magnets; and (b) intermittently applying a magnetic pulse sufficient to render first permanent magnets in nearby vessels not magnetically aligned with each other.

8. 发明申请

WO2020002577A1 MEANS AND METHODS FOR LYSING BIOLOGICAL CELLS 审中-公开
公开(公告)号：WO2020002577A1
公开(公告)日：2020-01-02
申请号：PCT/EP2019/067298
申请日：2019-06-28
申请人： PREOMICS GMBH
发明人： KULAK, Nils A. , RIBEIRO-CELINKSI, Vinicius
IPC分类号： B01L3/00 , G01N1/28 , B01J19/00 , B01L9/06
摘要： The present invention relates to a device comprising or consisting of: (a) a vessel; (b) a magnet inside said vessel; (c) means to trigger movement of said magnet with acoustic to ultrasonic frequency, preferably ultrasonic frequencies.

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