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1. 发明申请

WO2020092755A3 PACKED INCOMPRESSIBLE CHROMATOGRAPHY RESINS AND METHODS OF MAKING THE SAME 审中-公开
公开(公告)号：WO2020092755A3
公开(公告)日：2020-05-07
申请号：PCT/US2019/059141
申请日：2019-10-31
申请人： REPLIGEN CORPORATION
发明人： PEYSER, James Ronald , CHAN, Alan Kit Ho
IPC分类号： B01D15/08 , B01D15/18 , B01D53/04 , B01J19/30
摘要： This disclosure provides chromatography columns that are packed with incompressible media such as ceramic hydroxyapatite particles, which exhibit high separation performance that is robust to transportation and multiple uses. The columns can be made by applying axial compression using rigid bodies, such as porous frits and/or flow regulators.

2. 发明申请

WO2017214623A1 CHROMATOGRAPHY COLUMN PACKING MEDIUM RECOVERY 审中-公开
标题翻译：色谱柱填料中等回收率
公开(公告)号：WO2017214623A1
公开(公告)日：2017-12-14
申请号：PCT/US2017/037030
申请日：2017-06-12
申请人： REPLIGEN CORPORATION
发明人： WARD, Travis R. , PEYSER, James Ronald , PENTIA, Dana , FRANKEL, Evan
IPC分类号： B01D15/08 , B01D15/22 , G01N30/56 , G01N30/60
摘要： Systems include a chromatography column tube having an inlet and outlet and port assembly arranged in a wall of the column tube between flow distributors that together form a chamber within the tube that is filled with packing medium are described. The port assembly facilitates the removal of resin from the pre-packed column and the port assembly does not affect fluid flow in the normal use of the column for chromatographic separation or ability to maintain sanitary conditions within the column. Also described are methods that include attaching tubing to a pump and to a column inlet and a column outlet, opening the port assembly, attaching tubing to the port assembly and to a second reservoir, and pumping aqueous solution from a reservoir into the chamber and out through the port assembly into the second reservoir, thereby removing packing medium from the column along with the flowing aqueous solution.
摘要翻译：描述了系统包括色谱柱管，该色谱柱管具有布置在流量分配器之间的柱管的壁中的入口和出口以及端口组件，这些流量分配器一起在填充有填充介质的管内形成腔室。端口组件便于从预填充柱中去除树脂，并且端口组件不会影响正常使用色谱柱时的流体流动或保持色谱柱内卫生条件的能力。还描述了包括将管连接到泵以及连接到柱入口和柱出口的方法，打开端口组件，将管连接到端口组件和第二储存器，以及将水溶液从储存器泵送到腔中并且排出通过端口组件进入第二个储存器，从而从塔中随同流动的水溶液一起移除填充介质。

3. 发明申请

WO2021067565A1 DETERMINATION OF PROTEIN CONCENTRATION IN A FLUID 审中-公开
公开(公告)号：WO2021067565A1
公开(公告)日：2021-04-08
申请号：PCT/US2020/053750
申请日：2020-10-01
申请人： REPLIGEN CORPORATION
发明人： PEYSER, James Ronald , SHANBAKY, Ramsey
IPC分类号： G01D18/00 , G01N33/543 , G01N21/27
摘要： The present disclosure provides systems and methods that allow users to quickly determine titer and remove hold steps by determining a first concentration using slope spectroscopy, depleting the fluid of the expressed protein by selective adsorption, and determining a second concentration using slope spectroscopy. Further, the systems and methods of the present disclosure allows the user to forgo the use of a bioanalyzer or HPLC.

4. 发明申请

WO2019060638A1 METHODS AND SYSTEMS FOR REMOVING PRESSURE AND AIR FROM CHROMATOGRAPHY COLUMNS 审中-公开
公开(公告)号：WO2019060638A1
公开(公告)日：2019-03-28
申请号：PCT/US2018/052085
申请日：2018-09-20
申请人： REPLIGEN CORPORATION
发明人： CHAN, Alan Kit Ho , PEYSER, James Ronald
IPC分类号： A61L2/00 , B01D15/10 , G01N30/02 , F16K11/00
摘要： Methods and systems for removing gases and/or pressure formed during the sterilization, e.g., the gamma irradiation, of prepacked chromatography systems (column plus attached tube and valve set) are described. The methods include purging the gas and/or pressure through specially designed tube and valve sets without breaching the sterility of the prepacked sterile chromatography system. The systems include a sterile or aseptic pre-packed chromatography column including a column having an inlet and an outlet, a tubing and valve set attached to the inlet and the outlet, and a pump configured to pump sterile or aseptic liquid from the fluid source along the tubing and valve set, into the column tube inlet and out of the column tube outlet along a first flow path, thereby removing any entrapped gas and/or pressure from the chamber.

5. 发明申请

WO2020092755A2 PACKED INCOMPRESSIBLE CHROMATOGRAPHY RESINS AND METHODS OF MAKING THE SAME 审中-公开
公开(公告)号：WO2020092755A2
公开(公告)日：2020-05-07
申请号：PCT/US2019/059141
申请日：2019-10-31
申请人： REPLIGEN CORPORATION
发明人： PEYSER, James Ronald , CHAN, Alan Kit Ho
IPC分类号： B01D15/22
摘要： This disclosure provides chromatography columns that are packed with incompressible media such as ceramic hydroxyapatite particles, which exhibit high separation performance that is robust to transportation and multiple uses. The columns can be made by applying axial compression using rigid bodies, such as porous frits and/or flow regulators.

6. 发明申请

WO2015109246A1 STERILIZING CHROMATOGRAPHY COLUMNS 审中-公开
标题翻译：灭菌色谱柱
公开(公告)号：WO2015109246A1
公开(公告)日：2015-07-23
申请号：PCT/US2015/011839
申请日：2015-01-16
申请人： REPLIGEN CORPORATION
发明人： PEYSER, James Ronald , PENTIA, Dana Cristina
IPC分类号： B01D15/10 , A61L2/00
CPC分类号： B01D15/206 , A61L2/081 , A61L2/087 , A61L2202/11 , B01D15/20 , B01D15/327 , B01D15/361 , B01D15/3809
摘要： If one sterilizes pre-packed, plastic chromatography columns with an appropriate level of gamma irradiation, the resulting sterile chromatography columns maintain sufficient packing media function and maintain column mechanical properties and pressure ratings.
摘要翻译：如果对具有适当水平的γ照射的预先填充的塑料色谱柱进行消毒，则得到的无菌色谱柱保持足够的填充介质功能并保持色谱柱的机械性能和压力等级。

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