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1. 发明申请

WO2023081975A1 PRODUCTION OF BIOMASS 审中-公开
公开(公告)号：WO2023081975A1
公开(公告)日：2023-05-19
申请号：PCT/AU2022/051348
申请日：2022-11-11
申请人： HYDROBE PTY LTD
发明人： ANDERSON, Duncan Royce , SILVA, Cristian Coelho
IPC分类号： C12M1/00 , C12M1/02 , C12M1/107 , C12M1/26 , C12M1/34 , C12M1/36 , B01D53/84 , C12N1/12 , C12N1/20 , C12N1/32 , C12R1/07 , C12R1/11 , C12R1/125 , C12R1/22 , C12R1/89 , C05F11/08 , C12P3/00 , C12P5/00
摘要： The disclosure relates to a process for sequestering carbon from a gas stream that comprises carbon dioxide and a process for producing biomass. The process comprises: (i) producing an organic feedstock using a phototrophic source and a gas stream comprising carbon dioxide in a photosynthesis step; and (ii) converting the organic feedstock to biomass; wherein converting the organic feedstock to biomass comprises an aerobic bio-decomposition step that employs bacteria comprising at least one facultative anaerobic species. The present disclosure is also directed to biomass, and hydrogen, produced in accordance with the process and systems suitable for performing the process.

2. 发明申请

WO2023017424A1 METHODS FOR TREATING DIEASES ASSOCIATED WITH IMPAIRED MEVALONATE PRODUCTION 审中-公开
公开(公告)号：WO2023017424A1
公开(公告)日：2023-02-16
申请号：PCT/IB2022/057432
申请日：2022-08-09
申请人： MOR RESEARCH APPLICATIONS LTD.
发明人： BIRK, Ohad S. , YOGEV, Yuval
IPC分类号： A61P21/00 , A61K31/191 , A61K31/366 , A61P3/06 , C12N9/04 , C12P5/00
摘要： The use of mevalonolactone is provided for treating, preventing or alleviating diseases, disorders or conditions associated, directly or indirectly, with reduced mevalonic acid production in the mevalonate pathway, for example, due to damaged or hindered HMG CoA-reductase enzyme. Oral administration of mevalonolactone is provided for treating muscle cell and/or tissue damage caused at least in part due to impaired mevalonic acid production, as effected in diseases and disorders such as myopathy, statin-associated muscle symptom (SAMS), immune- mediated necrotizing myopathy (IMNM), rhabdomyolysis, muscular toxicity syndrome, myalgia, sarcopenia, and limb girdle muscular dystrophy (LGMD).

3. 发明申请

WO2023012111A2 NOVEL PRODUCTION OF AROMA COMPOUNDS WITH IONYLIDENEETHANE SYNTHASES 审中-公开
公开(公告)号：WO2023012111A2
公开(公告)日：2023-02-09
申请号：PCT/EP2022/071567
申请日：2022-08-01
申请人： BASF SE
发明人： BREUER, Michael , WEINGARTEN, Melanie
IPC分类号： C12P5/00 , C12P7/26 , C12P23/00 , C12N9/88 , A23L27/20 , A61Q13/00 , C12N9/02
摘要： The present invention relates to the use of alpha-ionylideneethane as an aroma compound, and to the use of an alpha-ionylideneethane synthase in the production of one or more aroma compounds. The inventive method for preparing one or more aroma compounds comprises a) providing farnesyl diphosphate and an alpha-ionylideneethane synthase as defined herein, under conditions suitable for the alpha-ionylideneethane synthase to produce alpha-ionylideneethane, b) converting farnesyl diphosphate to alpha-ionylideneethane, in vitro or in a host cell, c) optionally, converting alpha-ionylideneethane to one or more further aroma compounds, d) isolating alpha-ionylideneethane and the optionally one or more further aroma compounds and, e) optionally, purifying alpha-ionylideneethane and the optionally one or more further aroma compounds. The invention pertains also to method for scenting a product, particularly for imparting and/or enhancing an odor or flavor, in which at least one alpha-ionylideneethane synthase is used. In addition, the invention provides an aroma compound or composition and/or fragrance composition and/or perfumed or fragranced product, comprising i) at least an alpha-ionylideneethane. Further encompassed by the invention is a perfumed or fragranced product comprising at least an alpha-ionylideneethane. The invention further relates to a method for producing alpha-ionone (4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one), comprising the steps in the following order: a) contacting farnesyl diphosphate with at least one alpha-ionylideneethane synthase, under conditions suitable to produce at least one alpha-ionylideneethane; b) producing the at least alpha-ionylideneethane; c) exposing the at least one alpha-ionylideneethane produced in step b) to conditions suitable for oxidative cleavage of alpha-ionylideneethane to produce alpha-ionone; and d) optionally, isolating the alpha-ionone produced in step c). The invention also relates to a host cell for producing alpha-ionone (4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one), wherein the host cell comprises farnesyl diphosphate and a heterologous nucleic acid encoding an alpha-ionylideneethane synthase, wherein the host cell is capable of oxidatively cleaving alpha-ionylideneethane to produce alpha-ionone. Finally, the invention relates to the use of a host cell comprising farnesyl diphosphate and a heterologous nucleic acid encoding an alpha-ionylideneethane synthase, for (i) producing alpha-ionylideneethane; (ii) producing alpha-ionone; (iii) producing vitamin A; (iv) converting alpha-ionylideneethane to alpha-ionone; (v) converting alpha-ionylideneethane to vitamin A; (vi) for heterologous reconstitution of a terpene or terpenoid; (vii) for producing an industrial product; (viii) a fermentative production system for producing a sesquiterpene.

4. 发明申请

WO2022232444A1 GENETICALLY MODIFIED YEAST CELLS AND METHODS OF USE FOR INCREASED LIPID YIELD 审中-公开
公开(公告)号：WO2022232444A1
公开(公告)日：2022-11-03
申请号：PCT/US2022/026807
申请日：2022-04-28
申请人： GINKGO BIOWORKS, INC.
发明人： KAMINENI, Annapurna , SHAW, Arthur, J., IV , TSAKRAKLIDES, Vasiliki
IPC分类号： C12N15/52 , C12N1/16 , C12N9/10 , C12N9/12 , C12N9/88 , C12N15/81 , C12P5/00 , C12P7/04 , C12P7/6409 , C12P7/6454
摘要： Aspects of the disclosure are directed to genetically modified yeast cells and methods for use. Certain aspects are directed to recombinant yeast cells comprising exogenous nucleic acid sequences encoding phosphotransacetylase and/or phosphoketolase proteins, including a phosphoketolase protein from Clostridium acetobutylicum. Also disclosed are methods for generating recombinant yeast cells and methods of use of such cells for production of one or more products, including lipids, oils, fatty acids, and triacylglycerides.

5. 发明申请

WO2022136563A2 METHODS AND ENZYMES FOR PRODUCING QUILLAIC ACID DERIVATIVES 审中-公开
公开(公告)号：WO2022136563A2
公开(公告)日：2022-06-30
申请号：PCT/EP2021/087323
申请日：2021-12-22
申请人： PLANT BIOSCIENCE LIMITED
发明人： OSBOURN, Anne , REED, James , ORME, Anastasia
IPC分类号： C12P5/00 , C12P19/56 , C12P5/007
摘要： The present invention relates to a biosynthetic route to intermediates of the QS-21 molecule which are triterpenes from a saponin extract of the tree Quillaja saponaria comprising a quillaic acid backbone, as well as routes to make the QS-21 molecule, enzymes involved, the products produced and uses of the product.

6. 发明申请

WO2022075348A1 性状が改善されたディーゼル燃料の製造方法及び製造システム审中-公开
公开(公告)号：WO2022075348A1
公开(公告)日：2022-04-14
申请号：PCT/JP2021/036923
申请日：2021-10-06
申请人：吉川　直彌 , 中村　浩康
发明人：吉川　直彌 YOSHIKAWA Naoya , 中村　浩康 NAKAMURA Hiroyasu
IPC分类号： C10L1/08 , C12P5/00
摘要：出発原料の元油と比較してセタン価、セタン指数、多環芳香族質量、引火点、硫黄分質量、１０％残油の残留炭素分質量、流動点、灰分質量及び粘度からなる群から選択された性状の少なくとも１つが改善されたディーゼル燃料は第１酵素としてリパーゼ酵素０．０１～０．１０質量％を含有する酵素水溶液に、水溶性アルコールを２０～３５％濃度のアルコール水溶液なるように混合して水相を調製し、前記元油に対してブロメラインを含むパイナップル由来酵素０．０００１～０．０１質量％を軽油に溶解した第２の酵素軽油溶液を前記元油に添加して油相を調製し、油相に水相を６０℃を超えない温度を保持しながら水相：油相の容量比が２～４：８～６となるように添加し、油相と水相とを混合して、振盪や攪拌により接触させながら常温で放置して水相と油相とを反応させて油相の性状を改善するとともにディーゼル燃料を生成する。

7. 发明申请

WO2021204338A1 PRODUCTION OF GERANYL DIPHOSPHATE-DERIVED COMPOUNDS 审中-公开
公开(公告)号：WO2021204338A1
公开(公告)日：2021-10-14
申请号：PCT/DK2021/050098
申请日：2021-04-07
申请人： KØBENHAVNS UNIVERSITET
发明人： KAMPRANIS, Sotirios , DUSSÉAUX, Simon , IGNEA, Codruta , WAJN, William Thomas
IPC分类号： C12N9/04 , C12N9/02 , C12N9/00 , C12P5/00
摘要： Disclosed is yeast cells having peroxisomally localized GPP synthase and a peroxisomally localized enzyme that converts GPP into a monoterpenoids, cannabinoids, monoterpene indole alkaloids and prenylated aromatic compounds; or a precursor therefore, which yeast cells are capable of producing improved amounts of monoterpenoids, cannabinoids, monoterpene indole alkaloids and prenylated aromatic compounds, compared with the same yeast cells where the GPP synthase and the enzyme that converts GPP are located in the cytoplasm. Further disclosed is the use of the yeast cell for producing monoterpenoids, cannabinoids, monoterpene indole alkaloids and prenylated aromatic compounds.

8. 发明申请

WO2021172701A1 비브리오 속 DHG 균주 유래 고활성 MEP 회로 효소 활용을 통한 라이코펜 생산 审中-公开
公开(公告)号：WO2021172701A1
公开(公告)日：2021-09-02
申请号：PCT/KR2020/015884
申请日：2020-11-12
申请人： 포항공과대학교 산학협력단
发明人： 정규열 , 임현규 , 김민재 , 노명현
IPC分类号： C12N15/70 , C12P5/00 , C12N9/10 , C12N9/02
摘要： 본 발명은 라이코펜 생합성 대사 경로가 정교하게 조절된 라이코펜 고생산 균주 및 이를 이용한 라이코펜 생산방법에 관한 것이다. 본 발명에 따른 라이코펜 고생산 균주는 dxs 및 ispA 유전자가 도입된 것으로, 라이코펜의 생산성이 모균주에 비해 현저히 증가된 것을 확인하였다. 따라서 본 발명의 라이코펜 고생산 균주는 라이코펜이 활용되는 다양한 산업분야에서 광범위하게 적용할 수 있다.

9. 发明申请

WO2021130241A1 BIOCHEMICALLY PRODUCED SANDALWOOD OIL 审中-公开
公开(公告)号：WO2021130241A1
公开(公告)日：2021-07-01
申请号：PCT/EP2020/087658
申请日：2020-12-22
申请人： FIRMENICH SA
发明人： DAVIET, Laurent , HUANG, Yang , HARRACA, Vincent , SCHALK, Michel , BANDERA, Monica
IPC分类号： C12P5/00 , C12P7/02 , A01N27/00 , C11B9/00 , A61K8/34 , A61K31/045 , A01N31/02 , A01N49/00 , A61K2236/00 , A61K31/11 , A61K36/185 , A61K8/342 , A61K8/922 , A61Q13/00 , C11B9/02 , C12P5/007 , C12Y106/02004 , C12Y114/00 , C12Y402/03081 , C12Y402/03082 , C12Y402/03083
摘要： The present invention concerns a biochemically produced sandalwood oil, as defined herein. The present invention comprises the use of the biochemically produced sandalwood oil as part of a perfuming composition or of a perfuming consumer produce. The present invention comprises the use of the biochemically produced sandalwood oil as an anti-microbial and anti-inflammatory agent, and also as an arthropod control composition.

10. 发明申请

WO2021010101A1 融合タンパク質、物質製造方法、ベクター、形質転換細胞、空気入りタイヤの製造方法及びゴム製品の製造方法审中-公开
公开(公告)号：WO2021010101A1
公开(公告)日：2021-01-21
申请号：PCT/JP2020/024525
申请日：2020-06-23
申请人：住友ゴム工業株式会社 , 国立大学法人東北大学 , 国立大学法人金沢大学 , 国立大学法人埼玉大学
发明人：山口　晴彦 , 井之上　ゆき乃 , 高橋　征司 , 中山　亨 , 山下　哲 , 戸澤　譲
IPC分类号： C12N15/62 , C07K14/415 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/29 , C12N15/54 , C12N15/63 , C12P5/00
摘要：疎水性化合物を合成する酵素活性を有しつつ、油滴に結合可能な融合タンパク質、該融合タンパク質を用いて、疎水性化合物を油滴内に蓄積させる物質製造方法、遺伝子組換え技術により細胞に導入することで疎水性化合物の生産量を向上させることができるベクター、該ベクター若しくは該融合タンパク質をコードする遺伝子が導入された形質転換細胞を提供することを目的とする。本発明は、油滴（ｌｉｐｉｄ　ｄｒｏｐｌｅｔ）に結合可能なアミノ酸配列（第１アミノ酸配列）と、疎水性化合物を合成する酵素活性を有するアミノ酸配列（第２アミノ酸配列）とを有し、前記第１アミノ酸配列と第２アミノ酸配列とがリンカー配列（第３アミノ酸配列）を介して融合しており、第２アミノ酸配列の酵素活性が保持されている融合タンパク質に関する。

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