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1. 发明申请

WO2023285329A1 USE OF 2,3,6-TRIMETHYL-2-CYCLOHEXEN-1-ONE AS AROMA INGREDIENT 审中-公开
公开(公告)号：WO2023285329A1
公开(公告)日：2023-01-19
申请号：PCT/EP2022/069210
申请日：2022-07-11
申请人： BASF SE
发明人： WEINGARTEN, Melanie , SIEGEL, Wolfgang , PELZER, Ralf , BRU ROIG, Miriam , GARLICHS, Florian
IPC分类号： C11D3/50 , C07C45/67 , C07C49/603
摘要： The present invention relates to use of 2,3,6-Trimethyl-2-cyclohexen-1-one as aroma Ingredient. 2,3,6-Trimethyl-2-cyclohexen-1-one is used to impart an aroma impression which is reminiscent of animalic note, woody note, floral note, green note, minty note, dusty note, phenolic note, and/ or camphoraceous note to a composition and alsoenhancing and/or modifying the aroma of a composition. The present invention is further directed to an aroma composition comprising 2,3,6-Trimethyl-2-cyclohexen-1-one and (i) at least one aroma chemical different from the 2,3,6-Trimethyl-2-cyclohexen-1-one or (ii) at least one non-aroma chemical carrier, or (iii) both (i) and (ii).

2. 发明申请

WO2020035604A1 SYNTHESIS OF CHROMANOL DERIVATIVES 审中-公开
公开(公告)号：WO2020035604A1
公开(公告)日：2020-02-20
申请号：PCT/EP2019/072040
申请日：2019-08-16
申请人： BASF SE
发明人： WEINGARTEN, Melanie , SIEGEL, Wolfgang , PUHL, Michael
IPC分类号： C07D311/58
摘要： The present invention relates to a process for the production of chromanol derivatives, more specifically to a process for preparing a compound of the general formula I wherein R 1 , R 2 and R 3 independently of each other are selected from hydrogen and methyl, R 4 is selected from C- 1 -C 6 -alkyl, and X is selected from C 1 -C 20 -alkyl and C 2 -C 20 -alkenyl.

3. 发明申请

WO2023012111A2 NOVEL PRODUCTION OF AROMA COMPOUNDS WITH IONYLIDENEETHANE SYNTHASES 审中-公开
公开(公告)号：WO2023012111A2
公开(公告)日：2023-02-09
申请号：PCT/EP2022/071567
申请日：2022-08-01
申请人： BASF SE
发明人： BREUER, Michael , WEINGARTEN, Melanie
IPC分类号： C12P5/00 , C12P7/26 , C12P23/00 , C12N9/88 , A23L27/20 , A61Q13/00 , C12N9/02
摘要： The present invention relates to the use of alpha-ionylideneethane as an aroma compound, and to the use of an alpha-ionylideneethane synthase in the production of one or more aroma compounds. The inventive method for preparing one or more aroma compounds comprises a) providing farnesyl diphosphate and an alpha-ionylideneethane synthase as defined herein, under conditions suitable for the alpha-ionylideneethane synthase to produce alpha-ionylideneethane, b) converting farnesyl diphosphate to alpha-ionylideneethane, in vitro or in a host cell, c) optionally, converting alpha-ionylideneethane to one or more further aroma compounds, d) isolating alpha-ionylideneethane and the optionally one or more further aroma compounds and, e) optionally, purifying alpha-ionylideneethane and the optionally one or more further aroma compounds. The invention pertains also to method for scenting a product, particularly for imparting and/or enhancing an odor or flavor, in which at least one alpha-ionylideneethane synthase is used. In addition, the invention provides an aroma compound or composition and/or fragrance composition and/or perfumed or fragranced product, comprising i) at least an alpha-ionylideneethane. Further encompassed by the invention is a perfumed or fragranced product comprising at least an alpha-ionylideneethane. The invention further relates to a method for producing alpha-ionone (4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one), comprising the steps in the following order: a) contacting farnesyl diphosphate with at least one alpha-ionylideneethane synthase, under conditions suitable to produce at least one alpha-ionylideneethane; b) producing the at least alpha-ionylideneethane; c) exposing the at least one alpha-ionylideneethane produced in step b) to conditions suitable for oxidative cleavage of alpha-ionylideneethane to produce alpha-ionone; and d) optionally, isolating the alpha-ionone produced in step c). The invention also relates to a host cell for producing alpha-ionone (4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one), wherein the host cell comprises farnesyl diphosphate and a heterologous nucleic acid encoding an alpha-ionylideneethane synthase, wherein the host cell is capable of oxidatively cleaving alpha-ionylideneethane to produce alpha-ionone. Finally, the invention relates to the use of a host cell comprising farnesyl diphosphate and a heterologous nucleic acid encoding an alpha-ionylideneethane synthase, for (i) producing alpha-ionylideneethane; (ii) producing alpha-ionone; (iii) producing vitamin A; (iv) converting alpha-ionylideneethane to alpha-ionone; (v) converting alpha-ionylideneethane to vitamin A; (vi) for heterologous reconstitution of a terpene or terpenoid; (vii) for producing an industrial product; (viii) a fermentative production system for producing a sesquiterpene.

4. 发明申请

WO2022073845A1 1-ALKOXYETHYL-3-ISOBUTYL-BENZENE AND 1-CARBOXYETHYL-3-ISOBUTYL-BENZENE AS AROMA INGREDIENTS 审中-公开
公开(公告)号：WO2022073845A1
公开(公告)日：2022-04-14
申请号：PCT/EP2021/076960
申请日：2021-09-30
申请人： BASF SE
发明人： WEINGARTEN, Melanie , SIEGEL, Wolfgang , PELZER, Ralf , BRU ROIG, Miriam
IPC分类号： C07C43/164 , A61K8/33 , A61Q19/00 , C07C69/157 , C07C69/22 , C11D3/20 , C11D3/50 , C07C49/76 , A61Q13/00 , C07C69/24 , C07C69/74
摘要： The presently claimed invention is directed to the use of compound of formula (I) to impart an aroma impression to a composition. The presently claimed invention also relates to a method of imparting such aroma impression. The compositions of compound of formula (I) are also encompassed in the present invention. The present invention also relates to a compound of formula (I').

5. 发明申请

WO2020035600A1 SYNTHESIS OF CHROMANOL DERIVATIVES 审中-公开
公开(公告)号：WO2020035600A1
公开(公告)日：2020-02-20
申请号：PCT/EP2019/072029
申请日：2019-08-16
申请人： BASF SE
发明人： WEINGARTEN, Melanie , SIEGEL, Wolfgang , PUHL, Michael
IPC分类号： C07D311/58
摘要： The present invention relates to a process for the production of chromanol derivatives, more specifically to a process for preparing a compound of the general formula (I) wherein R 1 , R 2 and R 3 independently of each other are selected from hydrogen and methyl, R 4 is selected from hydrogen and C 1 -C 6 -alkanoyl, and X is selected from C 1 -C 20 -alkyl and C 2 -C 20 -alkenyl.

6. 发明申请

WO2020035601A1 SYNTHESIS OF CHROMANOL AND 2-METHYL-1,4-NAPHTHOQUINONE DERIVATIVES 审中-公开
公开(公告)号：WO2020035601A1
公开(公告)日：2020-02-20
申请号：PCT/EP2019/072034
申请日：2019-08-16
申请人： BASF SE
发明人： WEINGARTEN, Melanie , SIEGEL, Wolfgang , PUHL, Michael
IPC分类号： C07D311/58
摘要： The present invention relates to a process for the production of chromanol and 2-methyl-1,4-naphthoquinone derivatives, more specifically to a process for preparing a compound of the general formula (I) or (II) wherein the variables are as defined in the claims and the description.

7. 发明申请

WO2017109654A1 PAMAMYCIN CONTROLLED SYSTEMS FOR GENE EXPRESSION 审中-公开
标题翻译：用于基因表达的PAMAMYCIN受控系统
公开(公告)号：WO2017109654A1
公开(公告)日：2017-06-29
申请号：PCT/IB2016/057701
申请日：2016-12-16
申请人： BASF SE , BASF (CHINA) COMPANY LIMITED
发明人： PETZKE, Lutz , HEROLD, Andrea , FLECK, Christian , MARTY, Laurent , OEDMAN, Peter , DICKHAUT, Joachim , WEINGARTEN, Melanie , LUZHETSKY, Andriy , REBETS, Yuriy , SCRIMA, Andrea , SCHMELZ, Stefan
IPC分类号： C12N15/113 , C12N15/31 , C12N15/63
CPC分类号： C12N15/63
摘要： Provided are genetic systems for inducing or repressing gene expression. The polynucleotides and polypeptides suitable to built such systems, the microorganisms comprising such systems, and the methods using such systems in combination with pamamycin to modulate gene expression are also provided.
摘要翻译：提供用于诱导或抑制基因表达的遗传系统。还提供了适合于构建这样的系统的多核苷酸和多肽，包含这种系统的微生物以及使用这些系统与帕马霉素组合以调节基因表达的方法。

8. 发明申请

WO2015092575A1 GENE CLUSTER FOR BIOSYNTHESIS OF PAMAMYCIN 审中-公开
标题翻译：氨基酸生物合成基因组
公开(公告)号：WO2015092575A1
公开(公告)日：2015-06-25
申请号：PCT/IB2014/066284
申请日：2014-11-24
申请人： BASF SE , BASF (CHINA) COMPANY LIMITED
发明人： PETZKE, Lutz , HEROLD, Andrea , FLECK, Christian , TREIER-MARXEN, Katrin , ÖDMAN, Peter , DICKHAUT, Joachim , WEINGARTEN, Melanie , LUZHETSKY, Andriy , REBETS, Yuriy , BRÖTZ, Elke , MANDERSCHEID, Niko , MYRONOVSKYI, Maksym
IPC分类号： C12N1/21 , C12N15/10 , C12N15/31 , C12N15/76 , C12P1/06 , C12Q1/04 , C12R1/47
CPC分类号： C12N15/52 , C07K14/36 , C12P17/181
摘要： Provided are polynucleotides and polypeptides involved in the biosynthesis of pamamycin and pamamycin precursors as well as vectors and recombinant microorganisms comprising the polynucleotides and polypeptides. Also provided are methods for the production of pamamycins, in particular pamamycin 607 and pamamycin 621, and their precursors.
摘要翻译：提供参与帕米霉素和帕米霉素前体的生物合成以及包含多核苷酸和多肽的载体和重组微生物的多核苷酸和多肽。还提供了生产帕拉霉素，特别是帕米霉素607和帕米霉素621及其前体的方法。

9. 发明申请

WO2021005109A1 2-(2,4,5-TRIMETHYLCYCLOHEX-2-EN-1-YL)ACETALDEHYDE AND DERIVATIVES AND THEIR USE AS AROMA CHEMICALS 审中-公开
公开(公告)号：WO2021005109A1
公开(公告)日：2021-01-14
申请号：PCT/EP2020/069251
申请日：2020-07-08
申请人： BASF SE
发明人： WEINGARTEN, Melanie , SIEGEL, Wolfgang , WEYLAND, Silke , PELZER, Ralf
IPC分类号： C07C33/14 , C07C43/162 , C07C43/188 , C07C43/303 , C07C69/145 , C11B9/00 , C11D3/20 , C11D3/50 , A61Q5/02 , A61Q13/00 , A61Q19/00 , A61Q19/10 , A61K8/33 , A61K8/44
摘要： The present invention relates to 2-(2,4,5-trimethylcyclohex-2-en-1-yl)acetaldehyde and derivatives thereof, to a process for preparing said compounds, to the use of 2-(2,4,5- trimethylcyclohex-2-en-1-yl)acetaldehyde or a specific derivative thereof or of mixtures of said compounds or of a stereoisomer thereof or of a mixture of two or more stereoisomers thereof as aroma chemicals; to the use of 2-(2,4,5-trimethylcyclohex-2- en-1-yl)acetaldehyde or a specific derivative thereof for modifying the scent character of a fragranced composition; to compositions containing 2-(2,4,5-trimethylcyclohex-2- en-1-yl)acetaldehyde or a specific derivative thereof or a mixture of said compounds or a stereoisomer thereof or a mixture of two or more stereoisomers thereof; and to a method of preparing a fragranced composition or for modifying the scent character of a fragranced composition, comprising incorporating 2-(2,4,5-trimethylcyclohex-2-en-1-yl)- acetaldehyde or a specific derivative thereof or a mixture of said compounds or a stereoisomer thereof or a mixture of two or more stereoisomers thereof into said composition.

10. 发明申请

WO2020260165A1 1-ALKOXYETHYL-4-ISOBUTYL-BENZENE AS AROMA INGREDIENTS 审中-公开
公开(公告)号：WO2020260165A1
公开(公告)日：2020-12-30
申请号：PCT/EP2020/067215
申请日：2020-06-19
申请人： BASF SE
发明人： PELZER, Ralf , SIEGEL, Wolfgang , BRU ROIG, Miriam , DANZ, Manuel , WEYLAND, Silke , GARLICHS, Florian , HICKMANN, Volker , WEINGARTEN, Melanie
IPC分类号： C11D3/20 , C11D3/50 , A61K8/33 , A61Q5/00 , A61Q19/00 , C07C43/03 , C07C43/164
摘要： The presently claimed invention is directed to the use of 1-alkoxyethyl-4-isobutyl-benzene of formula (I) to impart an aroma impression to a composition. The presently claimed invention also relates to a method of imparting such aroma impression. The present invention is further directed to compositions comprising the compound of formula (I) and at least one aroma chemical as well as to compositions comprising the compound of formula (I) and at least one further component selected from the group consisting of aroma chemicals, surfactants, oil components, anti-oxidants, deodorant-active agents and solvents. The present invention also relates to a compound of formula (Iʼ).

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