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1. 发明申请

WO2012028167A3 ACRIDINIUM ESTER CHEMILUMINESCENCE UPON REDUCTIVE TRIGGERING 审中-公开
标题翻译：茜素酯化学发光降解触发
公开(公告)号：WO2012028167A3
公开(公告)日：2012-05-18
申请号：PCT/EP2010057017
申请日：2010-05-20
申请人： INNOHYPHEN BV , ZOMER BERT , BLOEMEN HENK
发明人： ZOMER BERT , BLOEMEN HENK
IPC分类号： C09K11/06 , C07D219/00 , C09K11/07 , G01N33/50 , H01L51/00 , H05B33/14 , H05B33/20
CPC分类号： C07D219/04 , C07D219/06 , C09K2211/1029 , F21K2/06 , G01N33/582
摘要： Acridinium esters show strong chemiluminescence under reducing conditions. Reducing conditions involve reduced metal ions or reduced aromatic quinones. This chemistry can be used in the detection and quantification of acridinium ester, (mixtures) of oxidants or (mixtures) of reducing compounds.
摘要翻译：吖啶鎓酯在还原条件下显示出强烈的化学发光。还原条件涉及还原的金属离子或还原的芳族醌。这种化学方法可用于检测和定量吖啶酯，氧化剂的混合物或还原性化合物的（混合物）。

2. 发明申请

WO2008124749A1 ACRIDINIUM PHENYL ESTERS USEFUL IN THE ANALYSIS OF BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于生物样品分析的丙酸苯酯
公开(公告)号：WO2008124749A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/059710
申请日：2008-04-09
申请人： ABBOTT LABORATORIES , MATTINGLY, Phillip G , ADAMCZYK, Maciej , BRASHEAR, Roy Jeffrey
发明人： MATTINGLY, Phillip G , ADAMCZYK, Maciej , BRASHEAR, Roy Jeffrey
IPC分类号： C07D219/00 , G01N21/76 , G01N33/53
CPC分类号： G01N33/581 , Y10T436/144444 , Y10T436/145555
摘要： The present invention relates to methods and kits for detecting an analyte in a test sample using acridinium-9-carboxylate aryl esters.
摘要翻译：本发明涉及使用吖啶-9-羧酸盐芳基酯检测测试样品中的分析物的方法和试剂盒。

3. 发明申请

WO02008193A2 THERAPEUTIC ACRIDONE AND ACRIDINE COMPOUNDS 审中-公开
标题翻译：治疗阿司匹林和阿司匹林化合物
公开(公告)号：WO02008193A2
公开(公告)日：2002-01-31
申请号：PCT/GB2001/003046
申请日：2001-07-06
IPC分类号： A61K31/473 , A61K31/496 , A61K31/5377 , A61K31/55 , A61P35/00 , C07D219/06 , C07D219/08 , C07D219/10 , C07D219/12 , C07D401/12 , C07D219/00
CPC分类号： C07D219/08 , C07D219/06 , C07D219/10
摘要： The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is =O, L is -H, alpha is a single bond, beta is a double bond, gamma is a single bond (acridones); or, (b) K is a 9-substituent, L is absent, alpha is a double bond, beta is a single bond, gamma is a double bond (acridines); and wherein: J is a 2- or 3-substituent; J is a 6- or 7-substituent; J and J are each independently a group of the formula -NHCO(CH2)nNR R , wherein: n is an integer from 1 to 5; and, R and R are independently hydrogen, C1-7alkyl, C3-20heterocyclyl, or C5-20aryl, or R and R , taken together with the nitrogen atom to which they are attached, form a heterocyclic ring having from 3 to 8 ring atoms; and wherein, when K is a 9-substituent, K is a group of the formula -N(R )Q, wherein: R is an amino substituent and is hydrogen, C1-7alkyl, C3-20heterocyclyl, or C5-20aryl; and, Q is C1-7alkyl, C3-20heterocyclyl, or C5-20aryl, and is optionally substituted; and pharmaceutically acceptable salts, esters, amides, solvates, hydrates, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo , to inhibit telomerase, to regulate cell prol iferation, and in the treatment of proliferative conditions, such as cancer.
摘要翻译：本发明涉及式（I）的吖啶酮和吖啶化合物，其中：（a）K是= O，L是-H，α是单键，β是双键，γ是单键（吖啶酮）; 或（b）K是9取代基，L不存在，α是双键，β是单键，γ是双键（吖啶）; 并且其中：J 1是2-或3-取代基; J 2是6-或7-取代基; J 1和J 2各自独立地是式-NHCO（CH 2）n NRR R 2的基团，其中：n是1至5的整数; 和R 1和R 2独立地是氢，C 1-7烷基，C 3-20杂环基或C 5-20芳基，或R 1和R 2与它们所连接的氮原子一起形成具有3至8个环原子的杂环; 并且其中当K是9-取代基时，K是式-N（R N）Q的基团，其中：R N是氨基取代基并且是氢，C 1-7烷基，C 3-20杂环基，或C5-20芳基; 且Q为C 1-7烷基，C 3-20杂环基或C 5-20芳基，并且任选被取代; 和其药学上可接受的盐，酯，酰胺，溶剂合物，水合物及其保护形式。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内均用于抑制端粒酶的调控，以调节细胞细胞治疗增生性疾病如癌症。

4. 发明申请

WO99066005A1 NOVEL CHEMILUMINESCENT LABELING COMPOUNDS 审中-公开
标题翻译：新型亮氨酸标记化合物
公开(公告)号：WO99066005A1
公开(公告)日：1999-12-23
申请号：PCT/US1999/006561
申请日：1999-05-03
IPC分类号： C07D219/00 , C07D219/02 , C07D219/04 , C07D221/08 , C07F7/18 , C07F9/113 , C07F9/64 , C07F9/6553 , C09K11/06 , C09K11/07 , C12Q1/00 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/533 , G01N33/58 , C09K3/00 , C07D219/08
CPC分类号： C07D221/08 , C07D219/02 , C07F7/1856 , C07F9/113 , C07F9/64 , C07F9/655372 , C09K11/06 , G01N33/533 , G01N33/582
摘要： Chemiluminescent labeling compounds and chemiluminescent labeled conjugates are provided. The compounds comprise an acridan ring bearing an exocyclic double bond and further contain a labeling substituent which permits attachement to compounds of interest. The novel chemiluminescent compounds and labeled conjugates generated chemiluminescence rapidly after undergoing a reaction with an acid, an oxidant and a base. The compounds and conjugates are useful in assays of an analyte in a sample and in assays employing labeled specific binding pairs.
摘要翻译：提供化学发光标记化合物和化学发光标记的缀合物。所述化合物包含带有环外双键的吖啶环，并且还含有允许附着于感兴趣的化合物的标记取代基。新型化学发光化合物和标记的共轭物在与酸，氧化剂和碱反应后迅速产生化学发光。化合物和缀合物可用于样品中分析物的测定和使用标记的特异性结合对的测定。

5. 发明申请

WO99014220A1 NOVEL COMPOUNDS FOR GENERATING CHEMILUMINESCENCE WITH A PEROXIDASE 审中-公开
标题翻译：用于过氧化物产生亮氨酸的新型化合物
公开(公告)号：WO99014220A1
公开(公告)日：1999-03-25
申请号：PCT/US1998/015734
申请日：1998-08-12
IPC分类号： C07D219/00 , C07D219/02 , C07D221/08 , C07F7/18 , C07F9/113 , C07F9/64 , C07F9/6553 , C09K11/06 , G01N33/58 , C07F7/08 , C07D221/06 , C07D221/12 , C07D327/00 , C07F7/02 , C07F9/02 , C07F9/22 , C07D335/09
CPC分类号： C07F9/113 , C07D219/02 , C07D221/08 , C07F7/1856 , C07F9/64 , C07F9/655372 , C09K11/06 , G01N33/582
摘要： Novel compounds comprising a C-C double bond substituted at one carbon with two oxygen or sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence by reaction with a peroxidase enzyme and a peroxide. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase enzymes and in assays employing enzyme-labeled specific binding pairs.
摘要翻译：公开了包含在一个碳上被两个含氧或含硫原子的基团取代的C-C双键的新型化合物。该化合物可用于通过与过氧化物酶和过氧化物反应产生化学发光的方法和组合物。由此产生的化学发光可以用作过氧化物酶测定中的可检测信号，并且在使用酶标记的特异性结合对的测定中可以使用。

6. 发明申请

WO2021125834A1 유기전기소자용 화합물, 이를 이용한 유기전기소자 및 그 전자 장치 审中-公开
公开(公告)号：WO2021125834A1
公开(公告)日：2021-06-24
申请号：PCT/KR2020/018561
申请日：2020-12-17
申请人： 덕산네오룩스 주식회사
发明人： 박형근 , 고윤종 , 김대식 , 이선희 , 문성윤 , 김남균
IPC分类号： C07C211/54 , C07D209/82 , C07D219/00 , C07D239/74 , C07D241/12 , C07D251/24 , C07D307/91 , C07D319/24 , C07D333/76 , C07D335/10
摘要： 본 발명은 소자의 발광효율, 안정성 및 수명을 향상시킬 수 있는 신규 화합물 및 이를 이용한 유기전기소자, 그 전자 장치를 제공한다.

7. 发明申请

WO2019046278A1 PAYLOAD AND LINKER DESIGNS FOR PLATINUM-ACRIDINE ANTICANCER AGENTS AND METHODS THEREOF 审中-公开
公开(公告)号：WO2019046278A1
公开(公告)日：2019-03-07
申请号：PCT/US2018/048309
申请日：2018-08-28
申请人： WAKE FOREST UNIVERSITY
发明人： BIERBACH, Ulrich , YAO, Xiyuan , WANG, Hanwen
IPC分类号： A01N43/62 , A61K31/282 , C07D219/00
CPC分类号： C07F15/0093 , A61K31/555
摘要： The present invention relates to payloads containing functionalized platinum-(benz)acridine hybrid agents as cytotoxic warheads and a method of synthesizing the payloads. The payload can be regioselectively conjugated to a biologically active moiety in order to facilitate the delivery and / or enhance the activity of the platinum compound.

8. 发明申请

WO2005051296A2 FUSED RING DICATIONIC ANTI-PROTOZOAN AGENTS AND THEIR PRODRUGS 审中-公开
标题翻译：熔合环反应原催化剂及其产品
公开(公告)号：WO2005051296A2
公开(公告)日：2005-06-09
申请号：PCT/US2004038896
申请日：2004-11-18
申请人： UNIV NORTH CAROLINA , UNIV GEORGIA STATE RES FOUND , BOYKIN DAVID W , TIDWELL RICHARD R , WILSON DAVID W , BRUN RETO , ARAFA REEM K , STEPHENS CHAD E
发明人： BOYKIN DAVID W , TIDWELL RICHARD R , WILSON DAVID W , BRUN RETO , ARAFA REEM K , STEPHENS CHAD E
IPC分类号： A01N37/52 , A01N43/42 , A61K20060101 , A61K31/155 , A61K31/44 , A61K31/444 , A61K31/473 , C07C279/18 , C07C279/24 , C07D219/00 , C07D219/08 , A61K
CPC分类号： C07D219/08 , C07C257/18 , C07C279/18 , C07C279/24 , C07C291/04 , C07C2603/18 , C07C2603/24
摘要： Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r) and Plasmodium faciparum. Prodrugs of these compounds can be used as an oral treatment for malaria and human African trypanosomiasis.
摘要翻译：新型稠环双阳离子抗原生动物化合物。代表性的原生动物物种包括但不限于布氏罗得西亚锥虫（T.b.r）和弗氏疟原虫（Plasmodium faciparum）。这些化合物的前体药物可以用作疟疾和非洲人类锥虫病的口服治疗。

9. 发明申请

WO2004092125A2 USING ALKYLMETAL REAGENTS FOR DIRECTED METALATION OF AZAAROMATICS 审中-公开
标题翻译：使用碱性试剂对AZAAROMATICS的指导金属化
公开(公告)号：WO2004092125A2
公开(公告)日：2004-10-28
申请号：PCT/US2004011661
申请日：2004-04-07
申请人： FMC CORP , WOLTERMANN CHRISTOPHER J , SUTTON DOUGLAS E
发明人： WOLTERMANN CHRISTOPHER J , SUTTON DOUGLAS E
IPC分类号： C07D20060101 , C07D213/84 , C07D217/02 , C07D219/00 , C07D253/00 , C07F1/02 , C07D
CPC分类号： C07D213/68 , C07F7/082
摘要： Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with azaaromatic compounds and/or nitrogen heterocycle compounds to produce functionalized azaaromatic compounds and functionalized nitrogen heterocycle compounds.
摘要翻译：将取代的烷基金属试剂如（三甲基甲硅烷基甲基）锂与氮杂芳族化合物和/或氮杂环化合物反应以产生官能化的氮杂芳族化合物和官能化的氮杂环化合物。

10. 发明申请

WO00024743A1 PYRANO, PIPERIDINO, AND THIOPYRANO COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：吡咯烷酮，哌啶和噻咯化合物及其使用方法
公开(公告)号：WO00024743A1
公开(公告)日：2000-05-04
申请号：PCT/US1999/025373
申请日：1999-10-28
IPC分类号： C07D335/02 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D471/04 , C07D471/14 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00 , A61K31/47 , A61P13/10 , A61P21/00 , A61P29/00
CPC分类号： C07D471/04 , C07C45/00 , C07C45/298 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/14 , C07D491/14 , C07D495/14 , C07C47/565 , C07C47/55
摘要： The present invention provides novel compounds of formula (I) which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
摘要翻译：本发明提供新的式（I）化合物，其可用于超极化细胞膜，开放钾通道，缓和平滑肌细胞和抑制膀胱收缩。

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