专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2021209486A1 SPEZIELL SUBSTITUIERTE PYRROLIN-2-ONE UND DEREN VERWENDUNG ALS HERBIZIDE 审中-公开
公开(公告)号：WO2021209486A1
公开(公告)日：2021-10-21
申请号：PCT/EP2021/059628
申请日：2021-04-14
申请人： BAYER AKTIENGESELLSCHAFT
发明人： AHRENS, Hartmut , ANGERMANN, Alfred , ARVE, Lars , BOJACK, Guido , BUSCATÓ ARSEQUELL, Estella , ASMUS, Elisabeth , GATZWEILER, Elmar , DITTGEN, Jan , ROSINGER, Christopher Hugh
IPC分类号： C07D209/54 , A01N43/38 , C07C49/403 , C07C233/45 , C07D235/02 , C07D317/12 , A01N47/06 , C07C49/517 , C07C57/42 , C07C57/60 , C07C229/46 , C07C233/52
摘要： Die vorliegende Erfindung betrifft neue herbizid wirksame Pyrrolin-2-one gemäß der allgemeinen Formel (I) oder agrochemisch akzeptable Salze davon, sowie deren Verwendung zur Bekämpfung von Unkräutern und Ungräsern in Nutzpflanzenkulturen.

2. 发明申请

WO2020024078A1 一种具有抗炎症性肠病作用的药物及其制备方法和应用审中-公开
公开(公告)号：WO2020024078A1
公开(公告)日：2020-02-06
申请号：PCT/CN2018/097685
申请日：2018-07-28
申请人：苏州沪云新药研发股份有限公司
发明人：邓世平 , 曹宇 , 李志 , 俞云会 , 张奎 , 张敏洁 , 袁高纲 , 徐涛 , 鱼刚 , 江传亮
IPC分类号： A61K31/09 , A61K31/122 , A61K31/222 , A61K31/255 , C07C43/23 , C07C41/00 , C07C49/517 , C07C45/29 , C07C69/712 , C07C67/03 , A61P1/00 , A61P29/00
摘要：本申请提供了一种具有抗炎症性肠病作用的药物及其制备方法和应用，所述药物具有如式I或式II所示的结构，本申请所提供的药物及其药学上可接受的盐、溶剂合物、前药、互变异构体、立体化学异构体或药物组合物均对于炎症性肠病有良好的作用效果，可用于制备炎症性肠病的治疗药物，具有重要的临床意义和广泛的应用前景。

3. 发明申请

WO2015197468A1 HERBICIDAL PROPYNYL-PHENYL COMPOUNDS 审中-公开
标题翻译：除草丙基苯基化合物
公开(公告)号：WO2015197468A1
公开(公告)日：2015-12-30
申请号：PCT/EP2015/063744
申请日：2015-06-18
申请人： SYNGENTA PARTICIPATIONS AG
发明人： SCUTT, James Nicholas , WILLETTS, Nigel James
IPC分类号： C07D309/32 , C07C49/517 , A01N35/06
CPC分类号： C07C49/603 , A01N35/06 , A01N37/06 , A01N41/12 , A01N43/16 , C07C49/653 , C07C49/697 , C07C49/753 , C07C321/10 , C07C2601/14 , C07C2602/22 , C07D309/32
摘要： The present invention relates to a compound of formula (I) wherein: R 1 is C 1 -C 3 alkoxy, C 1 -C 2 alkoxy-C 1 -C 3 alkoxy, C 1 -C 2 fluoroalkoxy, ethyl, n-propyl, n-butyl, cyclopropyl or ethynyl; R 2 is hydrogen, ethyl, n -propyl, cyclopropyl, vinyl, ethynyl, C 1 -C 3 alkoxy, C 1 -C 3 fluoroalkyl, C 1 -C 2 fluoroalkoxy, C 1 -C 2 alkoxy-C 1 -C 3 alkoxy-, or C 1 fluoroalkoxy-C 1 -C 3 alkoxy-; provided that when R 1 is ethyl, n-propyl, n-butyl, cyclopropyl or ethynyl, then R 2 is hydrogen, ethyl, n -propyl, cyclopropyl, vinyl or ethynyl; and Y is O, S, S(O), S(O) 2 , N(C 1 -C 2 alkyl), N(C 1 -C 2 alkoxy), C(O), CR 8 R 9 or -CR 10 R 11 CR 12 R 13 -; and and G, R 3 , R 4 , R 5 and R 6 are as defined herein; wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof.
摘要翻译：本发明涉及式（I）化合物，其中：R 1是C 1 -C 3烷氧基，C 1 -C 2烷氧基-C 1 -C 3烷氧基，C 1 -C 2氟烷氧基，乙基，正丙基，正丁基，环丙基或乙炔基; R 2是氢，乙基，正丙基，环丙基，乙烯基，乙炔基，C 1 -C 3烷氧基，C 1 -C 3氟烷基，C 1 -C 2氟烷氧基，C 1 -C 2烷氧基-C 1 -C 3烷氧基或C 1 -C 6烷氧基-C 1 -C 3烷氧基 - 条件是当R 1为乙基，正丙基，正丁基，环丙基或乙炔基时，则R 2为氢，乙基，正丙基，环丙基，乙烯基或乙炔基; 并且Y是O，S，S（O），S（O）2，N（C 1 -C 2烷基），N（C 1 -C 2烷氧基），C（O），CR 8 R 9或-CR 10 R 11 CR 12 R 13 - 且G，R 3，R 4，R 5和R 6如本文所定义; 其中式（I）化合物任选作为农业化学上可接受的盐存在。这些化合物适合用作除草剂。因此，本发明还涉及在有用植物的作物中控制杂草，特别是草单子叶杂草的方法，包括将式（I）化合物或包含这种化合物的除草组合物施用于植物或其基因座。

4. 发明申请

WO2007002433A1 PYRROLO [2, 3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译： PYRROLO [2,3-B]吡啶衍生物作为蛋白激酶抑制剂
公开(公告)号：WO2007002433A1
公开(公告)日：2007-01-04
申请号：PCT/US2006/024524
申请日：2006-06-21
申请人： PLEXXIKON, INC. , IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , HABETS, Gaston , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , ZUCKERMAN, Rebecca , WEST, Brian , SUZUKI, Yoshihisa , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxian , ZHU, Hongyao , SHI, Shenghua
发明人： IBRAHIM, Prabha, N. , ARTIS, Dean, R. , BREMER, Ryan , HABETS, Gaston , MAMO, Shumeye , NESPI, Marika , ZHANG, Chao , ZHANG, Jiazhong , ZHU, Yong-Liang , ZUCKERMAN, Rebecca , WEST, Brian , SUZUKI, Yoshihisa , TSAI, James , HIRTH, Klaus-Peter , BOLLAG, Gideon , SPEVAK, Wayne , CHO, Hanna , GILLETTE, Samuel, J. , WU, Guoxian , ZHU, Hongyao , SHI, Shenghua
IPC分类号： C07D471/04 , A61K31/435 , C07C49/517 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要： Compounds of formula III which are active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases. (Formula III).
摘要翻译：描述了对蛋白激酶有活性的式III化合物，以及使用这些化合物治疗与蛋白激酶异常活性相关的疾病和病症的方法。（式III）。

5. 发明申请

WO2019051222A1 BENZENE FUSED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
公开(公告)号：WO2019051222A1
公开(公告)日：2019-03-14
申请号：PCT/US2018/049946
申请日：2018-09-07
申请人： TAIWANJ PHARMACEUTICALS CO., LTD. , YANG, Syaulan S.
发明人： YANG, Syaulan S. , LEE, Kuang Yuan , LIU, Meng Hsien , JIANG, Yan-Feng , FAN, Yu-Shiou , CHEN, Chi-Han , LIU, Sheng Hung
IPC分类号： C07C259/10 , C07C65/21 , C07C271/30 , C07C275/30 , C07C311/16 , C07C311/51 , C07C317/18 , C07C217/76 , C07C233/66 , C07C233/67 , C07C49/517
摘要： The present disclosure provides a benzene fused heterocyclic derivative of Formula (I): --̅-̅-̅ is a single or double bond; n is an integer of 0 or 1; A is -CH 2 -, -CH(OH)-, or - C(O)-; G is C or N; X is -CH 2 -, O, or -C(O)-; Y is alkyl, aryl, or heterocyclic alkyl optionally substituted with at least one substituent independently selected from a group consisting of: H, halogen, alkyl, alkyl substituted with at least one halogen, aryl, aryl substituted with at least one halogen, -NR y1 R y2 , -OR y1 , -R y1 C(O)R y3 , -C(O)R y1 , -C(O)OR y2 , -C(O)OR y2 Ry3, - NR y1 C(O)R y2 , -NR y1 C(O)NR y2 R y3 , -NR y1 C(O)OR y2 R y3 , -NR y1 C(O)R y2 OR y3 , C(O)NR y1 (R y2 R y3 ), -C(O)NR y1 (R y2 OR y1 ), -OR y2 R y3 , and -OR y2 OR y3 , wherein each of R y1 and R y2 is independently selected from a group consisting of H, oxygen, alkyl, and aryl, and R y3 is aryl optionally substituted with at least one halogen; Z is -NR z1 R z2 , -NR z1 R z3 , -OR z1 , -OR z1 R z3 , -C(O)R z1 R z3 , -C(O)OR z1 R z3 , -NR z1 C(O)R z2 R z3 , -NR z1 C(O)OR z2 R z3 , -C(O)NR z1 R z3 , or OR z2 OR z3 , wherein each of R z1 and R z2 is independently selected from a group consisting of H, oxygen, alkyl and aryl, and R z3 is aryl optionally substituted with at least one substituent independently selected from a group consisting of halogen, OH, -R za COOR zb , -OR za COOR zb , -R za SO 2 R zb , -R za SO 2 NR zb R zc R zd , -R za C(O)R zb R zc , -R za C(O)NR zb R zc R zd , -RZ a C(O)NR zb SO 2 R zc , wherein Rza is nil or alkyl, R zb is H or alkyl, each of R zb and R zc is independently selected from a group consisting of H, OH, alkyl, aryl, alkoxyl, or NR zb R zc is a nitrogen-containing heterocyclic alkyl ring, R zd is nil or a sulfonyl alkyl group.

6. 发明申请

WO2007010483A1 SUBSTITUTED CYCLOHEXANONES 审中-公开
标题翻译：取代环己烷
公开(公告)号：WO2007010483A1
公开(公告)日：2007-01-25
申请号：PCT/IB2006/052460
申请日：2006-07-18
申请人： FIRMENICH SA , KNOPFF, Oliver , FEHR, Charles , GALINDO, José
发明人： KNOPFF, Oliver , FEHR, Charles , GALINDO, José
IPC分类号： C07C49/603 , C07C49/517 , C07C49/497 , C07C49/513 , C07C49/623 , C07F7/18 , C07C45/65 , C07C45/66
CPC分类号： C07F7/1852 , C07B2200/07 , C07C45/004 , C07C49/04 , C07C49/497 , C07C49/513 , C07C49/517 , C07C49/603 , C07C49/623 , C07C49/753
摘要： The present invention relates to a cyclohexanone derivative of formula (I) in the form of any one of its isomers or mixture thereof. The invention concerns also the preparation and the use of said derivative. The invention's compound is a useful starting material for the preparation of various optically active compounds.
摘要翻译：本发明涉及其异构体或其混合物中任何一种形式的式（I）的环己酮衍生物。本发明还涉及所述衍生物的制备和使用。本发明的化合物是制备各种光学活性化合物的有用起始材料。

7. 发明申请

WO01087866A1 CYCLOHEXYL DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS 审中-公开
标题翻译：环己酮衍生物及其作为治疗剂的用途
公开(公告)号：WO01087866A1
公开(公告)日：2001-11-22
申请号：PCT/GB2001/002136
申请日：2001-05-16
IPC分类号： C07D295/04 , A61K31/075 , A61K31/12 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/215 , A61K31/341 , A61K31/357 , A61K31/40 , A61K31/403 , A61K31/41 , A61K31/4164 , A61K31/4196 , A61K31/4355 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/451 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P1/08 , A61P25/04 , A61P25/06 , A61P25/22 , A61P25/24 , A61P29/00 , A61P43/00 , C07C43/178 , C07C45/29 , C07C49/497 , C07C49/517 , C07C49/697 , C07C49/747 , C07C49/753 , C07C69/757 , C07C69/767 , C07C217/48 , C07C217/52 , C07C229/22 , C07C233/23 , C07C233/31 , C07C233/32 , C07C233/58 , C07C233/59 , C07C235/40 , C07C235/80 , C07C235/82 , C07C237/04 , C07C237/08 , C07C237/24 , C07D207/06 , C07D207/16 , C07D211/14 , C07D211/18 , C07D211/22 , C07D211/38 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/70 , C07D211/74 , C07D213/38 , C07D217/04 , C07D233/90 , C07D241/08 , C07D257/04 , C07D265/30 , C07D275/04 , C07D277/28 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/192 , C07D295/205 , C07D307/52 , C07D317/72 , C07D333/20 , C07D401/04 , C07D401/06 , C07D413/04 , C07D417/12 , C07D487/08 , C07D491/20 , C07D295/16 , A61K31/44 , A61K31/4427 , C07C237/06 , C07D295/12 , C07D471/10
CPC分类号： C07D295/185 , C07B2200/09 , C07C45/29 , C07C49/697 , C07C49/747 , C07C49/753 , C07C217/52 , C07C233/23 , C07C233/31 , C07C233/58 , C07C233/59 , C07C235/40 , C07C235/82 , C07C237/04 , C07C237/24 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D211/48 , C07D211/58 , C07D213/38 , C07D241/08 , C07D295/096 , C07D295/15 , C07D295/155 , C07D295/192 , C07D295/205 , C07D401/06 , C07C47/228
摘要： The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R , R , R ,R , R , R , R , R , R , R , R , R , R , R and R are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
摘要翻译：本发明涉及式（I）的化合物：其中环A是苯基或吡啶环; X代表选自（a），（b），（c），（d），（e），（f），（g），（h），（i），（j），（k），（l）和R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 13，R R 14，R 15，R 16，R 17，R 18，R 19，R 21a和R 21b如本文所定义。该化合物特别用于治疗或预防抑郁，焦虑，疼痛，炎症，偏头痛，呕吐或带状疱疹后神经痛。

8. 发明申请

WO99042429A1 ANTITUMOR AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO99042429A1
公开(公告)日：1999-08-26
申请号：PCT/US1999/003660
申请日：1999-02-19
IPC分类号： A61K31/12 , A61K31/16 , A61K31/195 , A61K31/25 , A61K38/00 , A61P35/00 , C07C49/737 , C07C49/753 , C07C69/013 , C07C69/16 , C07C69/18 , C07C323/58 , C07C323/59 , C07C323/60 , C07D207/16 , C07K5/02 , C07K5/065 , C07K5/083 , C07K5/103 , C07C49/497 , C07C49/517 , A61K38/05
CPC分类号： C07C69/013 , A61K38/00 , C07C49/737 , C07C49/753 , C07C323/58 , C07C323/59 , C07C323/60 , C07D207/16 , C07K5/0215 , C07K5/081 , C07K5/1013 , Y02A50/395
摘要： The present invention provides compounds of general formula (I) or (II): wherein R1, R2, R3, R4, R5, R6, and R7 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising compounds of formula (I) or (II), intermediates and processes useful for preparing compounds of formula (I) or (II), and methods comprising inhibiting tumor growth or treating cancer by administering one or more compounds of formula (I) or (II).
摘要翻译：本发明提供通式（I）或（II）的化合物：其中R1，R2，R3，R4，R5，R6和R7具有说明书中定义的任何值及其药学上可接受的盐，以及包含式（I）或（II）化合物的药物组合物，用于制备式（I）或（II）化合物的中间体和方法，以及包括通过给予一种或多种式（I）化合物抑制肿瘤生长或治疗癌症的方法）或（II）。

9. 发明申请

WO99015499A1 VITAMIN D DERIVATIVES AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：维生素D衍生物及其生产方法
公开(公告)号：WO99015499A1
公开(公告)日：1999-04-01
申请号：PCT/JP1998/004200
申请日：1998-09-18
IPC分类号： C07C35/17 , C07C401/00 , C07F7/18 , C07C49/517 , C07F9/53
CPC分类号： C07C35/17 , C07C401/00 , C07F7/1852 , C07F7/1856 , Y02P20/55
摘要： Novel 22-oxavitamin D derivatives having hydroxyl at each of the 1 alpha - and 3 alpha - positions and represented by general formula (I), wherein R1 represents linear or branched C4-10 alkyl having one to three hydroxyl groups; and R2 and R3 each independently represents hydrogen or a protecting group; intermediates useful in synthesizing the derivatives; and processes for producing these.
摘要翻译：在1α-和3α-位各自具有由通式（I）表示的羟基的新型22-维生素D衍生物，其中R1表示具有一至三个羟基的直链或支链C 4-10烷基; R2和R3各自独立地表示氢或保护基; 用于合成衍生物的中间体; 以及制造这些的方法。

10. 发明申请

WO2023288284A1 INHIBITORS OF AMYLOID BETA OLIGOMERIZATION AND THERAPEUTIC USES THEREOF 审中-公开
公开(公告)号：WO2023288284A1
公开(公告)日：2023-01-19
申请号：PCT/US2022/073747
申请日：2022-07-14
申请人： NORTHWESTERN UNIVERSITY
发明人： SILVERMAN, Richard, B. , KLEIN, William, L. , JOHNSON, Elizabeth, A.
IPC分类号： C07C49/403 , C07C49/517 , A61K31/122 , A61P25/28
摘要： Disclosed are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating and/or preventing a disease or disorder associated with amyloid beta biological activity in a subject in need thereof. The disclosed compounds include cyclohexane 1,3 -diones which may inhibit one or more biological activities of amyloid beta, such as amyloid beta oligomerization. As such, the disclosed compounds and pharmaceutical compositions may be utilized in methods for treating and/or preventing a disease or disorder that is associated with amyloid beta activity in a subject in need thereof, which diseases and disorders may be associated with amyloid beta oligomerization.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式