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1. 发明申请

WO2017012478A1 官能团化的氰硅烷及其合成方法和应用审中-公开
公开(公告)号：WO2017012478A1
公开(公告)日：2017-01-26
申请号：PCT/CN2016/089343
申请日：2016-07-08
申请人：华东师范大学
发明人：周剑 , 曾兴平
IPC分类号： C07F7/10 , C07F7/18 , C01C3/00 , C07C45/44 , C07C49/00 , C07C49/24
CPC分类号： C07F7/0823 , C01C3/00 , C07C45/516 , C07C45/64 , C07C67/11 , C07C2601/14 , C07D307/00 , C07F7/081 , C07F7/1836 , G01N30/02 , G01N2030/884 , C07C49/245 , C07C49/248 , C07C49/173 , C07C49/24 , C07C69/16
摘要：本发明公开了官能团化的氰硅烷及其合成方法，所述方法包括，将原料硅烷和氰源MCN加入有机溶剂中，在无催化剂或者以金属盐为催化剂的条件下，合成所述官能团化的氰硅烷。所述官能团化的氰硅烷可用于经典TMSCN所能参与的反应，合成氰醇、氨基醇以及α-胺基氰类化合物等重要合成中间体，能取得更好的反应活性和选择性等。特别是与醛或酮发生亲核加成反应所得的产物，还可在在适当条件下发生分子内反应，把硅基上带有的官能团转移到产物中与硅相连的其他部分，从而提高合成效率和原子经济性，并实现一些传统TMSCN试剂不能合成的产物。本发明还公开了上述的官能团化的氰硅烷在科罗拉多马铃薯甲虫信息聚集素的全合成应用及其合成中的一种中间体化合物。

2. 发明申请

WO2005056499A3 OLIGO(P-PHENYLENE VINYLENE) AMPHIPHILES AND METHODS FOR SELF-ASSEMBLY 审中-公开
标题翻译： OLIGO（对苯乙烯乙烯基）AMPHIPHILES和自组装方法
公开(公告)号：WO2005056499A3
公开(公告)日：2006-03-16
申请号：PCT/US2004040548
申请日：2004-12-06
申请人： UNIV NORTHWESTERN , STUPP SAMUEL I , HULVAT JAMES F , SOFOS MARINA , TAJIMA KEISUKE
发明人： STUPP SAMUEL I , HULVAT JAMES F , SOFOS MARINA , TAJIMA KEISUKE
IPC分类号： C07C20060101 , C07C45/44 , C07C45/71 , C07C47/575 , C07C217/20 , C07C217/54 , C07F9/40 , C09K19/16 , C09K19/58 , H01L21/00 , H01L51/00 , H01L51/50 , C07C43/215 , C07C69/618 , C07C69/708 , C07C233/65 , C07C233/69 , C09K19/12
CPC分类号： C07C217/20 , C07C45/44 , C07C45/71 , C07C47/575 , C07F9/4056 , C09K19/16 , C09K19/582 , C09K2019/168 , H01L51/0038 , H01L51/0071 , H01L51/0073 , H01L51/0076 , H01L51/5012
摘要： Amphiphilic oligo(p-phenylene vinylene) compounds and methods of use en route to self-assembled composites and device fabrication.
摘要翻译：两亲寡聚（对亚苯基亚乙烯基）化合物和使用途径，途经自组装复合材料和器件制造。

3. 发明申请

WO01051453A1 RACEMIC AND OPTICALLY PURE METABOLITES OF SIBUTRAMINE, THEIR PREPARATION, COMPOSITIONS COMPRISING THEM AND THEIR USE AS DOPAMINE REUPTAKE INHIBITORS 审中-公开
标题翻译： SIBUTRAMINE的生物和光学纯代谢物，其制备，包含它们的组合物及其作为多巴胺反应抑制剂的用途
公开(公告)号：WO01051453A1
公开(公告)日：2001-07-19
申请号：PCT/US2001/000762
申请日：2001-01-10
IPC分类号： A61K35/48 , A61K31/00 , A61K31/11 , A61K31/135 , A61K31/137 , A61K45/06 , A61P3/04 , A61P15/10 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/30 , C07B57/00 , C07C45/44 , C07C47/395 , C07C47/457 , C07C209/60 , C07C209/88 , C07C211/29 , C07C249/02 , C07C251/18 , A61K31/205
CPC分类号： C07C251/18 , A61K31/11 , A61K31/135 , A61K45/06 , C07B2200/07 , C07C45/44 , C07C47/457 , C07C211/29 , C07C2601/04 , A61K2300/00 , A61K31/137
摘要： Methods of making and using racemic and optically pure metabolites of sibutramine, and pharmaceutically acceptable salts, solvates, and clathrates thereof, are disclosed. Pharmaceutical compositions and dosage forms are also disclosed which comprise a dopamine reuptake inhibitor, such as a racemic or optically pure sibutramine metabolite, and optionally an additional pharmacologically active compound.
摘要翻译：公开了制备和使用西布曲明的外消旋和光学纯的代谢物及其药学上可接受的盐，溶剂合物和笼形物的方法。还公开了药物组合物和剂型，其包含多巴胺再摄取抑制剂，例如外消旋或光学纯的西布曲明代谢物，以及任选的另外的药理活性化合物。

4. 发明申请

WO99014210A1 PROCESS FOR THE PREPARATION OF SUBSTITUTED 5,6-DIHYDRO-2H-PYRAN-2-ONES 审中-公开
标题翻译：制备取代的5,6-二氢-2H-吡喃-2-酮的方法
公开(公告)号：WO99014210A1
公开(公告)日：1999-03-25
申请号：PCT/US1998/017081
申请日：1998-08-18
IPC分类号： C07C59/48 , C07C59/64 , C07C69/738 , C07C255/36 , C07D261/04 , C07D275/06 , C07D309/32 , C07D417/06 , C07C45/44 , C07C47/277
CPC分类号： C07D417/06 , C07C59/48 , C07C59/64 , C07C69/738 , C07C255/36 , C07D261/04 , C07D275/06 , C07D309/32
摘要： An improved process for the preparation of substitued 5,6-dihydro-2H-pyran-2-ones is described where a hydroxy acid chloride is converted in ten steps to the desired product, as well as valuable intermediates used in the process.
摘要翻译：描述了制备取代的5,6-二氢-2H-吡喃-2-酮的改进方法，其中羟基酰氯在十个步骤中转化为所需产物，以及在该方法中使用的有价值的中间体。

5. 发明申请

WO2019096860A1 PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY AND DIASTEREOMERICALLY ENRICHED CYCLOBUTANE AMINES AND AMIDES 审中-公开
公开(公告)号：WO2019096860A1
公开(公告)日：2019-05-23
申请号：PCT/EP2018/081257
申请日：2018-11-14
申请人： SYNGENTA PARTICIPATIONS AG
发明人： DUMEUNIER, Raphael , SMEJKAL, Tomas , MISHRA, Brijnandan, Premnath , GOPALSAMUTHIRAM, Vijayagopal, Raman , GODINEAU, Edouard , O'SULLIVAN, Anthony, Cornelius
IPC分类号： C07C209/26 , C07C211/40 , C07C45/44 , C07C45/35 , C07C45/54 , C07C49/467 , C07D213/803
摘要： The present invention relates to a process for the preparation of enantiomerically and diastereomerically enriched cyclobutane amines and amides by reacting (a) cyclopropylcarbonitrile to a cyclopropylcarbaldehyde, (b) further reacting to a cyclobutanone, or (d') further reacting to an enamide, 5 (c) further reacting to enantiomerically and diastereomerically enriched cyclobutane amines, or (d) further reacting to an enamide and (e) to an enantiomerically and diastereomerically enriched cyclobutylamide to obtain (f) an enantiomerically and diastereomerically enriched cyclobutane amine, and (g) further reacting to an enantiomerically and diastereomerically enriched cyclobutane amide.

6. 发明申请

WO2015057365A3 SYNTHESIS OF DIACIDS, DIALDEHYDES, OR DIAMINES FROM THF-DIOLS 审中-公开
公开(公告)号：WO2015057365A3
公开(公告)日：2015-04-23
申请号：PCT/US2014/057399
申请日：2014-09-25
申请人： ARCHER DANIELS MIDLAND COMPANY
发明人： STENSRUD, Kenneth
IPC分类号： C07D307/08 , C07C45/44 , C07C253/14
摘要： A simple and elegant chemical process for the synthesis of oxygenated products, such as acids and aldehydes, or other derivative products, such as amines and nitriles, of cyclic bifunctional molecules made from renewable, bio-based sources such as HMF and/or its reduction product, 2,5-bis(hydroxymethyl)-tetrahydrofuran (bHMTHF) is described. In general, the process involves: a) generating a tetrahydrofuran-2,5-diyl-bis(methylene)-bis(sulfonate) from bHMTHFs using a sulfonate; b) displacing nucleophilically at least a sulfonate leaving group from the tetrahydrofuran-2,5-diyl-bis(methylene)-bis(sulfonate) to form a THF-dinitrile; and either c) oxidizing the THF-dinitrile with an acid having a pKa of ≤ 0 to generate a di-acid, or d) reducing partially the THF-dinitrile to generate a di-aldehyde, or e) reducing fully the THF-dinitrile to generate a di-amine.

7. 发明申请

WO2010141334A1 SYNTHESIS OF CERTAIN TRIFLUOROMETHYL KETONES 审中-公开
标题翻译：某些三氟乙烯酮的合成
公开(公告)号：WO2010141334A1
公开(公告)日：2010-12-09
申请号：PCT/US2010/036504
申请日：2010-05-28
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , FANDRICK, Daniel Robert , YEE, Nathan , SONG, Jinhua J. , REEVES, Jonathan Timothy
发明人： FANDRICK, Daniel Robert , YEE, Nathan , SONG, Jinhua J. , REEVES, Jonathan Timothy
IPC分类号： C07C49/233 , C07C45/44 , C07C51/38 , C07C57/58 , C07C51/15 , C07C65/32 , C07C231/02 , C07C235/84
CPC分类号： C07C51/38 , C07C45/54 , C07C51/373 , C07C231/02 , C07C49/233 , C07C65/32 , C07C63/68 , C07C57/58 , C07C235/84
摘要： A process for synthesis of a compound of Formula (X) wherein R 1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R 1 is independently C 1 -C 5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl, wherein each substituent group of R 1 is optionally independently substituted with one to three substituents selected from C 1 -C 3 alkyl, C 1 -C 3 alkoxy, phenyl, and alkoxyphenyl; and R 2 and R 3 are each independently C 1 -C 5 alkyl.
摘要翻译：一种合成式（X）化合物的方法，其中R 1是被1至3个取代基取代的芳基，其中R 1的每个取代基独立地是C 1 -C 5烷基，氨基羰基，烷基氨基羰基，二烷基氨基羰基，卤素，羧基，氰基或三氟甲基，其中R 1的每个取代基任选地独立地被一至三个选自C 1 -C 3烷基，C 1 -C 3烷氧基，苯基和烷氧基苯基的取代基取代; 并且R 2和R 3各自独立地为C 1 -C 5烷基。

8. 发明申请

WO0170693A3 DIFLUOROBUTYRIC ACID DERIVATIVES AND THEIR USE AS METALLOPROTEASE INHIBITORS 审中-公开
标题翻译：二茂铁酸衍生物及其作为金属蛋白酶抑制剂的用途
公开(公告)号：WO0170693A3
公开(公告)日：2002-01-03
申请号：PCT/US0108781
申请日：2001-03-20
申请人： PROCTER & GAMBLE , PIKUL STANISLAW , MIELING GLEN EDWARD , SOLINSKY KELLY MICHELLE , ALMSTEAD NEIL GREGORY , BISWANATH DE , NATCHUS MICHAEL GEORGE
发明人： PIKUL STANISLAW , MIELING GLEN EDWARD , SOLINSKY KELLY MICHELLE , ALMSTEAD NEIL GREGORY , DE BISWANATH , NATCHUS MICHAEL GEORGE
IPC分类号： A61K31/192 , A61K31/198 , A61K31/341 , A61K31/405 , A61K31/4164 , A61K31/426 , A61K31/428 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61P1/02 , A61P9/00 , A61P17/00 , A61P17/02 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/28 , A61P27/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/20 , A61P31/22 , A61P33/04 , A61P35/00 , C07C45/44 , C07C57/58 , C07C59/64 , C07C69/734 , C07C323/56 , C07C323/59 , C07D207/34 , C07D209/12 , C07D209/18 , C07D213/48 , C07D213/55 , C07D213/70 , C07D213/84 , C07D233/58 , C07D233/84 , C07D277/16 , C07D277/36 , C07D277/74 , C07D307/46 , C07D307/54 , C07D333/24 , C07C47/23 , C07C47/24 , C07C47/277 , C07C57/30 , C07C323/62
CPC分类号： C07D213/70 , C07C45/44 , C07C69/734 , C07C323/56 , C07D207/34 , C07D209/12 , C07D209/18 , C07D213/48 , C07D213/55 , C07D213/84 , C07D233/84 , C07D277/16 , C07D277/36 , C07D277/74 , C07D307/46 , C07D307/54 , C07D333/24 , C07C47/277
摘要： Compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess metalloprotease activity. In particular, the compounds have a structure according to the following Formula (I): where A, G, R , R , R , X, Y and Z have the meanings described in the specification. This invention also includes optical isomers, diastereomers and enantiomers of Formula I, pharmaceutically-acceptable salts, biohydrolyzable, esters thereof and conjugates thereof. Also described are pharmaceutical compositions comprising these compounds, and methods of treating metalloprotease-related maladies using the compounds or the pharmaceutical compositions. This invention also includes intermediates useful for the synthesis of the compounds of Formula (I).
摘要翻译：作为金属蛋白酶抑制剂的化合物，其有效治疗以过量金属蛋白酶活性为特征的病症。特别地，化合物具有下式（I）的结构：其中A，G，R 1，R 2，R 3，X，Y和Z具有说明书中描述的含义。本发明还包括式I的光学异构体，非对映异构体和对映异构体，其药学上可接受的盐，可生物水解的酯，其酯及其缀合物。还描述了包含这些化合物的药物组合物，以及使用该化合物或药物组合物治疗金属蛋白酶相关疾病的方法。本发明还包括可用于合成式（I）化合物的中间体。

9. 发明申请

WO00058253A1 PREPARATION OF CARVONE 审中-公开
标题翻译：卡夫的制备
公开(公告)号：WO00058253A1
公开(公告)日：2000-10-05
申请号：PCT/GB2000/001173
申请日：2000-03-27
IPC分类号： B01J27/053 , C07B53/00 , C07B61/00 , C07C45/00 , C07C45/44 , C07C45/85 , C07C49/403 , C07C49/647
CPC分类号： C07C45/00 , C07C45/85 , C07C49/647
摘要： A process for the preparation of carvone comprises hydrogenating carvoxime in the presence of a selectively poisoned catalyst. Preferred catalysts include noble metals supported on inorganic materials poisoned with a catalyst modifier. In a preferred embodiment of the process defined herein, the crude carvone reaction product produced in accordance with the process of the invention, is purified by treating the crude carvone product with an organometallic compound M(X)n wherein M is a polyvalent metal, n is the valence of M and X denotes an inorganic or organic atom or group.
摘要翻译：用于制备香芹酮的方法包括在选择性中毒的催化剂存在下氢化龋齿。优选的催化剂包括负载在用催化剂改性剂中毒的无机材料上的贵金属。在本文定义的方法的优选实施方案中，根据本发明方法生产的粗肉酮反应产物通过用有机金属化合物M（X）n处理粗制酮产物来纯化，其中M是多价金属，n 是M的化合价，X表示无机或有机原子或基团。

10. 发明申请

WO2018022580A1 FRAGRANCE AND FLAVOR COMPOSITIONS CONTAINING ISOMERIC ALKADIENYL ESTERS 审中-公开
标题翻译：含有异构烷基苯甲酸酯的芳香和香料组合物
公开(公告)号：WO2018022580A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/043659
申请日：2017-07-25
申请人： BEDOUKIAN RESEARCH, INC.
发明人： BEDOUKIAN, Matthew
IPC分类号： A23L27/20 , C07C45/44 , C07C47/21
摘要： A composition containing at least one isomeric alkadienyl ester in an amount effective to impart a fragrance or flavor to the composition. A fragrance or flavor composition containing at least one isomeric alkadienyl ester in an amount effective to impart a fragrance or flavor to the composition. A consumer product containing the fragrance or flavor composition having at least one isomeric alkadienyl ester in an amount effective to impart a fragrance or flavor to the composition. A method of imparting a fragrance or flavor to a consumer product by adding to the consumer product a fragrance or flavor composition containing at least one isomeric alkadienyl ester in an amount effective to impart a fragrance or flavor to the consumer product.
摘要翻译：含有至少一种异构链二烯基酯的组合物，其量能有效地赋予组合物香味或香味。含有至少一种异构链二烯基酯的芳香剂或香料组合物，其量能有效地赋予组合物香味或香味。含有香料或香料组合物的消费品具有至少一种异构链二烯基酯，其量能有效地赋予组合物香味或香味。通过向消费品中加入香料或香料组合物来赋予香料或香料的方法，香料或香料组合物含有至少一种异构的链二烯基酯，其量足以赋予消费品香味或香味。

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