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1. 发明申请

WO1998020934A1 CRURAL DIAPHRAGM PACEMARKER AND METHOD FOR TREATING ESOPHAGEAL REFLUX DISEASE 审中-公开
公开(公告)号：WO1998020934A1
公开(公告)日：1998-05-22
申请号：PCT/US1997020059
申请日：1997-11-07
申请人： UNIVERSITY OF VIRGINIA
发明人： UNIVERSITY OF VIRGINIA , MITTAL, Ravinder, K. , ROSS, Robert , LIU, Jiamnim , SCHIRMER, Bruce
IPC分类号： A61N01/36
CPC分类号： A61N1/36007
摘要： An electronic pacemaker is used to counter act crural diaphragm relaxation thereby preventing and/or treating gastroesophageal reflux. The pacemaker can be implanted, or be connected to the skeletal muscles of the crural diaphragm through the skin. A sensor (1) is used to identify spontaneous intermittent relaxations of the diaphragm. During these spontaneous intermittent relaxations, one or more electrodes (2) are used to stimulate the skeletal muscles of the crural diaphragm to cause contraction of the lower esophageal sphincter.
摘要翻译：电子起搏器用于抵抗行为性闭锁松弛，从而防止和/或治疗胃食管反流。起搏器可以植入，或通过皮肤连接到肋骨膜的骨骼肌。传感器（1）用于识别隔膜的自发间歇性松弛。在这些自发性间歇性放松期间，使用一个或多个电极（2）来刺激肋骨膜的骨骼肌引起下食道括约肌的收缩。

2. 发明申请

WO1997049454A1 SYSTEM FOR TREATMENT OF RESPIRATORY DISORDERS 审中-公开
标题翻译：治疗呼吸系统疾病的系统
公开(公告)号：WO1997049454A1
公开(公告)日：1997-12-31
申请号：PCT/US1997011147
申请日：1997-06-26
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , CHRISTOPHERSON, Mark, A. , SOMMER, John, L. , NEISZ, Johann, J.
IPC分类号： A61N01/36
CPC分类号： A61B5/03 , A61B5/7207 , A61N1/3601
摘要： An implantable sensing device includes a sensing element and a mounting element. The mounting element has a first end and a second end with a longitudinal axis therethrough. The sensing element is positioned at the first end of the mounting element with the mounting element having a length that is adjustable along the longitudinal axis. The mounting element includes a sleeve having a first open end and a second open end with the longitudinal axis therethrough. The sensing element is positioned in the second open end and includes a lead body connected thereto extending through the second open end. The sleeve includes an outer sleeve member coupled for adjustment along the longitudinal axis with respect to an inner sleeve member. Further, the mounting element may include a flexible element about the first open end extending outwardly relative to the longitudinal axis and a flange element extending outwardly relative to the longitudinal axis from at least a portion of the second end. The device can be implanted in a bone with the flange element and the flexible element for direct or indirect contact with the anterior and posterior surface of the bone.
摘要翻译：植入式感测装置包括感测元件和安装元件。安装元件具有第一端和具有穿过其的纵向轴线的第二端。感测元件位于安装元件的第一端，安装元件具有可沿着纵向轴线调节的长度。安装元件包括具有第一开口端和第二开口端的套筒，纵向轴线穿过其中。感测元件定位在第二开口端，并且包括连接到其的延伸穿过第二开口端的引线体。套筒包括外套筒构件，其联接成相对于内套筒构件沿着纵向轴线调节。此外，安装元件可以包括围绕围绕纵向轴线向外延伸的第一开口端的柔性元件和从第二端的至少一部分相对于纵向轴线向外延伸的凸缘元件。该装置可以植入到具有法兰元件和柔性元件的骨中，用于与骨的前表面和后表面直接或间接接触。

3. 发明申请

WO1997048447A1 SELF-ADJUSTING COCHLEAR IMPLANT SYSTEM AND METHOD FOR FITTING SAME 审中-公开
标题翻译：自调整COCHLEAR植入系统及其配套方法
公开(公告)号：WO1997048447A1
公开(公告)日：1997-12-24
申请号：PCT/US1997010590
申请日：1997-06-19
申请人： ADVANCED BIONICS CORPORATION , FALTYS, Michael, A. , LOEB, Gerald, E.
发明人： ADVANCED BIONICS CORPORATION
IPC分类号： A61N01/36
CPC分类号： A61N1/36036
摘要： A self-adjusting implantable cochlear implant system (46) includes an implant portion (50) and an external portion (53). The system provides a device and a way to objectively determine selected psychophysical parameters, such as stimulation threshold, comfort level and loudness resolution, used by the implant portion, which includes an implantable cochlear stimulator (ICS), as it carries out its stimulation function. The input to the system is an electrical stimulation. The outputs of the system include a middle ear reflex (MER) and evoked potentials, such as a compound action potential (CAP) along the auditory/cerebral pathways, both of which are sensed using objective measurement techniques and tools. In accordance with one embodiment, the adjustment process uses the MER for determining a coarse threshold value, and then (using such coarse threshold value as a starting point) uses evoked potentials to determine a more precise or fine threshold value, thereby zeroing in on a desired threshold. Such zeroing-in method is preferably carried out using implanted circuitry (e.g., included as part of the ICS), which implanted circuitry uses an implanted middle ear electrode (54) and a cochlear electrode (56), along with appropriate amplification (58, 64), filtering (60, 66) and processing circuitry (62, 68, 67), to respectively determine the MER response and evoked potentials. Another embodiment uses the presence or absence of the MER to adjust the intensity of electrical stimulation continuously and automatically, thereby relieving the patient from having to perform slow and tedious manual adjustments of the loudness control of a speech processor used with the ICS.
摘要翻译：自调节植入式耳蜗植入系统（46）包括植入部分（50）和外部部分（53）。该系统提供了一种装置和一种客观地确定植入部分（包括植入式耳蜗刺激器（ICS））所使用的选择的心理物理参数（例如刺激阈值，舒适度和响度分辨率）的方式，因为它执行其刺激功能。系统的输入是电刺激。系统的输出包括中耳反射（MER）和诱发电位，例如沿着听觉/脑通路的复合动作电位（CAP），这两者都使用客观测量技术和工具进行感测。根据一个实施例，调整过程使用MER来确定粗阈值，然后（使用这样的粗阈值作为起始点）使用诱发电位来确定更精确或精细的阈值，从而使所需阈值。这种归零方法优选地使用植入电路（例如，作为ICS的一部分包括在内），该植入电路使用植入的中耳电极（54）和耳蜗电极（56）以及适当的放大（58， 64），滤波（60,66）和处理电路（62,68,67），以分别确定MER响应和诱发电位。另一个实施例使用MER的存在或不存在来连续和自动地调整电刺激的强度，从而减轻患者不必执行与ICS一起使用的语音处理器的响度控制的缓慢且乏味的手动调节。

4. 发明申请

WO1997048446A1 A METHOD AND A PROBE FOR TREATMENT OF INCONTINENCE 审中-公开
标题翻译：一种治疗不孕症的方法和探索
公开(公告)号：WO1997048446A1
公开(公告)日：1997-12-24
申请号：PCT/DK1997000265
申请日：1997-06-18
申请人： EBDRUP, Lise
IPC分类号： A61N01/36
CPC分类号： A61N1/0524 , A61N1/0512 , A61N1/36007
摘要： The invention relates to a probe (1) for intrarectal or intravaginal treatment or monitoring. The probe (1) comprises means for determining the orientation of the probe in use in the form of a marking (5) on the handle (4) of the probe (1). The probe (1) thus allows a very specific treatment and monitoring of e.g. incontinence.
摘要翻译：本发明涉及用于直肠内或阴道内治疗或监测的探针（1）。探针（1）包括用于在探针（1）的手柄（4）上以标记（5）的形式确定使用中的探针的取向的装置。因此，探针（1）允许非常特定的治疗和监测。失禁。

5. 发明申请

WO1997039797A1 METHOD OF TREATING MOVEMENT DISORDERS BY BRAIN STIMULATION AND DRUG INFUSION 审中-公开
标题翻译：通过脑刺激和药物输注治疗运动障碍的方法
公开(公告)号：WO1997039797A1
公开(公告)日：1997-10-30
申请号：PCT/US1997005522
申请日：1997-04-02
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , ELSBERRY, Dennis, D. , RISE, Mark, T. , KING, Gary, W.
IPC分类号： A61N01/36
CPC分类号： A61M5/14276 , A61M5/1723 , A61N1/36067 , A61N1/36082
摘要： Techniques using one or more drugs and electrical stimulation for treating neural disorders, including movement disorders resulting in abnormal motor response, by means of an implantable signal generator and electrode and an implantable pump and catheter. A sensor is used to detect activity resulting from the neural disorder. A microprocessor algorithm analyzes the output from the sensor in order to regulate the stimulation and drug dosage delivered to the neural tissue.
摘要翻译：通过可植入信号发生器和电极以及可植入泵和导管，使用一种或多种药物和电刺激来治疗神经障碍（包括导致运动反应异常的运动障碍）的技术。传感器用于检测由神经障碍引起的活动。微处理器算法分析传感器的输出，以调节传递到神经组织的刺激和药物剂量。

6. 发明申请

WO1997026943A1 COCHLEAR ELECTRODE ARRAY EMPLOYING DIELECTRIC PARTITIONS 审中-公开
标题翻译： COCHLEAR ELECTRODE ARRAY采用电介质分隔
公开(公告)号：WO1997026943A1
公开(公告)日：1997-07-31
申请号：PCT/US1997000936
申请日：1997-01-22
申请人： ADVANCED BIONICS CORPORATION , LOEB, Gerald, E.
发明人： ADVANCED BIONICS CORPORATION
IPC分类号： A61N01/36
CPC分类号： A61N1/0541 , A61N1/36036
摘要： An electrode array (10) for stimulation of the cochlea includes an elongated tapered carrier (15) on which a multiplicity of separately controlled electrode contacts (20) are carried. A set of flexible fins (100, 110, 120) extend from the carrier in particular axes so as to cause the outside dimension of the array plus the fins to be greater than the typical cross section of the cavity in which the array is to be inserted. The fins are made from compliant, dielectric material so that they can be folded against the body of the carrier as it is inserted into the cochlea so that they slide past obstructions and accommodate variations in the cross-sectional dimensions of the cavity, e.g., the scala tympani (5). When in place; the fins unfurl so that they touch the walls of the cavity into which they are inserted, thereby forming a series of separate longitudinal compartments (35), at least most of which contain at least one separate stimulating electrode. The fins confine electrical currents injected through most of the contacts to flow preferentially through different portions of the wall of the cavity in which the electrode array is inserted, thereby selectively stimulating/activating cells encompassed by the compartments.
摘要翻译：用于刺激耳蜗的电极阵列（10）包括细长的锥形载体（15），多个独立控制的电极接触件（20）被承载在该锥形载体上。一组柔性翅片（100,110,120）从载体在特定的轴线上延伸，以便使阵列的外部尺寸加上翅片的尺寸大于阵列所在的空腔的典型横截面插入。翅片由柔顺的电介质材料制成，使得当它们被插入耳蜗时，它们能够抵靠载体的主体折叠，使得它们滑过障碍物并适应腔的横截面尺寸的变化，例如，鼓掌鼓掌（5）。到位时翅片展开，使得它们接触它们被插入到其中的腔的壁，从而形成一系列分开的纵向隔室（35），其至少大部分包含至少一个单独的刺激电极。翅片限制通过大多数触点注入的电流优先流过插入电极阵列的腔的壁的不同部分，从而选择性地刺激/激活由隔室包围的细胞。

7. 发明申请

WO1997010874A1 ASSEMBLY FOR FUNCTIONAL ELECTRICAL STIMULATION DURING MOVEMENT 审中-公开
标题翻译：组装运动期间的功能电刺激
公开(公告)号：WO1997010874A1
公开(公告)日：1997-03-27
申请号：PCT/CA1996000618
申请日：1996-09-18
申请人： NEUROMOTION INC.
发明人： NEUROMOTION INC. , STEIN, Richard, B.
IPC分类号： A61N01/36
CPC分类号： A61N1/36003
摘要： The assembly comprises a band, mountable on the leg, carrying all of the components of the assembly to provide a self-contained unit. The components comprise: electrodes for stimulating a leg nerve; a V-shaped plate for conforming with the leg's tibia to reproducibly position the band so that the electrodes are located over the nerve; a tilt sensor for measuring the angular position of the lower leg; a control circuit for processing the sensor signal information and emitting pulses through the electrodes to stimulate the leg in response to phases of body movement; and a battery for supplying power to the tilt sensor, control circuit and stimulator. By comparing the assembly's stimulation states against a known template defining optimal stimulation states, stimulation threshold parameters can be fine tuned without the need for repeated trial and error testing by the user.
摘要翻译：组件包括可安装在腿上的带，其承载组件的所有部件以提供独立的单元。组件包括：用于刺激腿部神经的电极; V形板，用于与腿的胫骨一致，以可重复地定位带，使得电极位于神经上方; 用于测量小腿的角位置的倾斜传感器; 用于处理所述传感器信号信息并通过所述电极发射脉冲以响应于身体运动的相位刺激所述腿部的控制电路; 以及用于向倾斜传感器，控制电路和刺激器供电的电池。通过将组件的刺激状态与限定最佳刺激状态的已知模板进行比较，可以微调刺激阈值参数，而不需要用户进行重复的试验和错误测试。

8. 发明申请

WO1996028211A1 THERAPY APPARATUS FOR THE FUNCTIONAL ELECTROMYOSTIMULATION OF SMOOTH MUSCLE CELLS 审中-公开
标题翻译：平滑肌细胞功能电生理疗法
公开(公告)号：WO1996028211A1
公开(公告)日：1996-09-19
申请号：PCT/EP1996001043
申请日：1996-03-12
申请人： OSBON MEDICAL SYSTEMS , NOACK, Thomas , STIEF, Christian , WELLER, Edgar
发明人： OSBON MEDICAL SYSTEMS
IPC分类号： A61N01/36
CPC分类号： A61N1/36007
摘要： The subject of the invention is an apparatus for the functional electromyostimulation of smooth muscle cells for the therapy of disturbances of the smooth muscle cell function, especially in the case of erectile dysfunction and incontinence in the case of humans and mammals.
摘要翻译：本发明的主题是用于治疗平滑肌细胞功能紊乱的平滑肌细胞的功能性电刺激的装置，特别是在人和哺乳动物的情况下为勃起功能障碍和失禁的情况。

9. 发明申请

WO1996009852A1 METHOD AND APPARATUS TO LIMIT CONTROL OF PARAMETERS OF ELECTRICAL TISSUE STIMULATORS 审中-公开
标题翻译：限制电组织刺激物参数控制的方法和装置
公开(公告)号：WO1996009852A1
公开(公告)日：1996-04-04
申请号：PCT/US1995010718
申请日：1995-08-23
申请人： MEDTRONIC, INC. , HRDLICKA, Gregory, A. , THOMPSON, David, L.
发明人： MEDTRONIC, INC.
IPC分类号： A61N01/36
CPC分类号： A61N1/37252 , A61N1/36021 , A61N1/36071 , A61N1/36146
摘要： Electrical tissue stimulator and method for limiting the programmability of stimulation pulse parameters. The tissue stimulator includes a plurality of electrodes and a memory for holding a stimulation pulse parameter limit value and a programmed parameter value of a stimulation pulse. A pulse generator applies electrical stimulation pulses to the electrodes in accordance with the programmed parameter value. Programming means is included for receiving remotely generated programming signals and altering the contents of the memory in accordance with the signals. Means is included for comparing the stimulation pulse parameter limit value and the programmed parameter value and for preventing and alteration of the programmed parameter value, unless it is within stimulation pulse parameter limits. The stimulation pulse parameters may include pulse amplitude, pulse width, and pulse rate and the programmed parameter limit values may be upper and lower limits.
摘要翻译：电脉冲组织刺激器和方法，用于限制刺激脉冲参数的可编程性。组织刺激器包括多个电极和用于保持刺激脉冲参数极限值和编程的刺激脉冲的参数值的存储器。脉冲发生器根据编程的参数值对电极施加电刺激脉冲。包括用于接收远程产生的编程信号和根据信号改变存储器的内容的编程手段。包括用于比较刺激脉冲参数极限值和编程参数值并用于防止和改变编程参数值的手段，除非它在刺激脉冲参数限制内。刺激脉冲参数可以包括脉冲幅度，脉冲宽度和脉冲速率，并且编程的参数极限值可以是上限和下限。

10. 发明申请

WO1994023791A1 ELECTRONIC DEVICE FOR ADRENERGICALLY STIMULATING THE SYMPATHETIC SYSTEM WITH RESPECT TO THE VENOUS MEDIA 审中-公开
标题翻译：电子装置，用于全面刺激相对于静脉介质的症状系统
公开(公告)号：WO1994023791A1
公开(公告)日：1994-10-27
申请号：PCT/FR1994000442
申请日：1994-04-20
申请人： KLOTZ, Antoine
IPC分类号： A61N01/36
CPC分类号： A61N1/36014 , A61N1/0456
摘要： A device comprising a system for generating electric pulses between at least two electrodes (2, 3, 4) suitably arranged on the body of a patient. The strength, voltage, shape and frequency of the electric pulses are adjustable. The device further comprises a system for measuring the impedance between said electrodes (2, 3, 4). Said device is useful for treating venous/lymphatic stasis and vascular system disorders.
摘要翻译：一种装置，包括用于在适当地布置在患者身上的至少两个电极（2,3,4）之间产生电脉冲的系统。电脉冲的强度，电压，形状和频率可调。该装置还包括用于测量所述电极（2,3,4）之间的阻抗的系统。所述装置可用于治疗静脉/淋巴淤滞和血管系统疾病。

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